ZLN005: structure in first source
ID Source | ID |
---|---|
PubMed CID | 899323 |
CHEMBL ID | 4303368 |
SCHEMBL ID | 6755306 |
MeSH ID | M0584887 |
Synonym |
---|
CBMICRO_034305 |
4529-96-8 |
BIM-0034399.P001 |
STK395157 |
2-(4-tert-butylphenyl)-1h-benzimidazole |
AKOS003029495 |
49671-76-3 |
S7447 |
HY-17538 |
zln005 |
2-(4-(tert-butyl)phenyl)-1h-benzo[d]imidazole |
SCHEMBL6755306 |
AC-35224 |
2-(4-tert-butylphenyl)-1h-benzo[d]imidazole |
zln 005 |
2-(4-tert-butylphenyl)-1h-1,3-benzodiazole |
(1s,2r,3r,5s,6s,16e,18e,20r,21s)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracycl o[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2- methylpropanoate |
J-690308 |
EX-A690 |
DTXSID60358473 |
HMS3653P03 |
mfcd01560221 |
NCGC00371152-01 |
SW219815-1 |
FT-0700319 |
2-(4-t-butylphenyl) benzimidazole |
BCP08848 |
zln-005 pound>>zln 005 |
A13734 |
CCG-266970 |
CHEMBL4303368 |
AS-55878 |
A871757 |
ZBA67176 |
2-(4-tert-butylphenyl)benzimidazole |
3WT26285WB |
tqs-168 |
zln-005 |
Excerpt | Reference |
---|---|
"ZLN005 treatment upregulated the expressions of PGC-1α and mitochondrial function-related genes in hESC-CMs and induced more mature energy metabolism compared with the control group." | ( Bai, H; Feng, X; Guo, F; Guo, J; Liang, P; Liu, Y; Lu, X; Luo, X; Thai, PN; Xu, Z; Yang, C; Yang, H; Zhang, P; Zhu, D, 2020) |
"ZLN005 treatment led to ameliorated cardiomyocyte oxidative injury, enhanced cell viability, and reduced apoptosis in the high glucose environment." | ( Chen, Y; Li, W; Li, X; Ou, D; Wang, B; Xiao, A; Yan, S; Zeng, D; Zheng, Q, 2016) |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 6 (50.00) | 24.3611 |
2020's | 6 (50.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 12 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Article | Year |
---|---|
ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy. Experimental cell research, 07-01, Volume: 345, Issue: 1 | 2016 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Article | Year |
---|---|
Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes, Volume: 62, Issue: 4 | 2013 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Article | Year |
---|---|
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, Volume: 96, Issue: 5 | 2019 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |