| Assay ID | Title | Year | Journal | Article |
|---|
| AID17957 | Apparent bioavailability after oral dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID243379 | Binding affinity for AT1 receptor | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists. |
| AID568899 | Binding affinity to angiotensin AT1 receptor in rabbit aortic rings | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
| Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. |
| AID192970 | The compound was evaluated for the percentage of inhibition of A II pressor response in rat for intravenous administration | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID197549 | Percentage peak pressor response in rat after intravenous administration at a dose of 0.03 mg/kg of the compound. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID38276 | In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII. | 1993 | Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
| Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles. |
| AID22406 | Volume of distribution of the terminal phase (= CLp+ plasma elimination rate constant) after intravenous dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID167369 | Compound was tested for its antagonistic activity against angiotensin II-induced contractions in rabbit aorta | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID39505 | Binding affinity against AT1 receptor of rat adrenal cortical membranes | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. |
| AID37514 | Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1 | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| (Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists. |
| AID234499 | Ratio of the of A II pressor responses in rat, p.o./i.v. | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID38161 | In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII. | 1993 | Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
| Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides. |
| AID24000 | Half-life period after oral dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID231153 | Ratio of the of A II pressor responses in dog, p.o./i.v.; ND= Not determined | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID22398 | Volume of distribution of central compartment (= dose+ plasma concentration at time zero) after intravenous dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID167537 | Compound was tested for its antagonistic activity against angiotensin II-induced contractions in rabbit aorta | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID37687 | Binding affinity for rat angiotensin II receptor, type 1 | 2004 | Journal of medicinal chemistry, May-06, Volume: 47, Issue:10
| Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure. |
| AID37542 | Potency to antagonize the ability of angiotensin II to contract rabbit aorta | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID39047 | Inhibition of Angiotensin II induced contractions in rabbit aortic rings | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. |
| AID174386 | % decrease in blood pressure after 4 hours in male rats at a dose of 0.1 mg/kg by using Renal artery hypertensive model | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID39503 | In vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID197552 | Percentage peak pressor response in rat after peroral administration at a dose of 0.03 mg/kg of the compound. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID56499 | The compound was evaluated for the percentage of inhibition of A II pressor response in dogs for intravenous administration | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID39360 | The compound was tested for inhibition of angiotensin II receptor induced pressor response in rat after intravenous administration. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID37519 | Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID56383 | The compound was evaluated for the percentage of inhibition of A II pressor response in dog for peroral administration; ND= Not determined | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID15900 | Plasma clearance after intravenous dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID607038 | Partial agonist activity at human PPARgamma-LBD/Gal4 DNA binding domain by transactivation assay | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ. |
| AID23995 | Half-life period of compound after intravenous dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID38284 | Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| (Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists. |
| AID174388 | % decrease in blood pressure after 4 hours in male rats at a dose of 0.3 mg/kg by using Renal artery hypertensive model | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID174797 | The duration of action for the % peak inhibition of angiotensin II pressor response for dose of 0.1 mg/kg perol administration in conscious rats. | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID18416 | Oral bioavailability was evaluated in rat by oral administration | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID22341 | Tmax value after oral dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID231155 | Ratio of the of A II pressor responses in rhesus monkey, p.o./i.v. | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID176261 | Intravenous effective dose required for inhibition of Ang II pressor response in conscious rat | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID711558 | Antagonist activity at angiotensin 1 receptor | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| Synopsis of some recent tactical application of bioisosteres in drug design. |
| AID568926 | Binding affinity to angiotensin AT2 receptor | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
| Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. |
| AID192958 | The compound was evaluated for the % peak inhibition of angiotensin II pressor response for dose of 0.1 mg/kg intravenous administration in conscious rats. | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID607039 | Partial agonist activity at human PPARgamma-LBD/Gal4 DNA binding domain by transactivation assay relative to darglitazone | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ. |
| AID607037 | Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ. |
| AID197554 | Percentage peak pressor response in rat after peroral administration at a dose of 0.3 mg/kg of the compound. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID174247 | % decrease in blood pressure after 4 hours at a dose of 1 mg/kg in male rats by using Furosemide-treated spontaneous hypertensive model | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID39807 | In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII. | 1993 | Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
| Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles. |
| AID174250 | % decrease in blood pressure after 4 hours at a dose of 3 mg/kg in male rats by using Renal artery hypertensive model | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID174254 | % decrease in blood pressure after 4 hours in male rats at a dose of 0.03 mg/kg by using Renal artery hypertensive model | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID39808 | In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII. | 1993 | Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
| Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides. |
| AID330796 | Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems. |
| AID176434 | Oral effective dose required for inhibition of Ang II pressor response in conscious rat | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID18419 | Oral bioavailability was evaluated in rhesus monkey | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID125514 | The compound was evaluated for the percentage of inhibition of A II pressor response in rhesus monkey for peroral administration. | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID195024 | pA2 value was evaluated against angiotensin II-induced aldosterone release in rat adrenal cortical cells | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID197550 | Percentage peak pressor response in rat after intravenous administration at a dose of 0.1 mg/kg of the compound. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID18415 | Oral bioavailability in rat | 1996 | Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
| Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. |
| AID192959 | The compound was evaluated for the % peak inhibition of angiotensin II pressor response for dose of 0.1 mg/kg perol administration in conscious rats. | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID125515 | The compound was evaluated for the percentage of inhibition of A II pressor response in rhesus monkeys for intravenous administration | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID10481 | Area under curve after oral dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID174240 | % decrease in blood pressure after 24 hours at a dose of 1 mg/kg in male rats by using Furosemide-treated spontaneous hypertensive model | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID39195 | Binding affinity towards Angiotensin receptor from rabbit aorta | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID174796 | The duration of action for the % peak inhibition of angiotensin II pressor response for dose of 0.1 mg/kg intravenous administration in conscious rats. | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID192971 | The compound was evaluated for the percentage of inhibition of A II pressor response in rat for peroral administration. | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID37549 | Inhibition of Angiotensin II receptor, type 1 | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Excursions in drug discovery. |
| AID197553 | Percentage peak pressor response in rat after peroral administration at a dose of 0.1 mg/kg of the compound. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID39809 | Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1 | 1993 | Journal of medicinal chemistry, Mar-05, Volume: 36, Issue:5
| Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles. |
| AID197551 | Percentage peak pressor response in rat after intravenous administration at a dose of 0.3 mg/kg of the compound. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID39022 | Binding affinity against angiotensin II receptor from rat liver | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| AID39524 | In vitro binding affinity for angiotensin II AT2 receptor in rat midbrain | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. |
| AID15485 | Cmax value after oral dose of 3.87 mg/kg | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |