1-hydroxyvitamin d5

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-hydroxyvitamin D5: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10025615
CHEMBL ID	4297361
MeSH ID	M0271686

Synonyms (17)

Synonym
ccris 8700
1alpha-hydroxyvitamin d5
LS-144738 ,
1-hydroxyvitamin d5
1alpha-hydroxy-24-ethylcholecalciferol
187935-17-7
xy02042od4 ,
card 024
card-024
unii-xy02042od4
1,3-cyclohexanediol, 5-((2e)-2-((1r,3as,7ar)-1-((1r,4r)-4-ethyl-1,5-dimethylhexyl)octahydro-7a-methyl-4h-inden-4-ylidene)ethylidene)-4-methylene-, (1r,3s,5z)-
mn-201
1.alpha.-hydroxyvitamin d5
DB13097
Q27294044
CHEMBL4297361
DTXSID501315324

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (6.67)	18.2507
2000's	13 (86.67)	29.6817
2010's	1 (6.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.54 (24.57)
Research Supply Index	3.00 (2.92)
Research Growth Index	4.53 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.54)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (10.53%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (89.47%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
9,10-dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.	1.99	1	ortho-fused polycyclic arene; tetraphenes	carcinogenic agent
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.	2.03	1	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
methylnitrosourea Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.	2.42	2	N-nitrosoureas	alkylating agent; carcinogenic agent; mutagen; teratogenic agent
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	2.02	1	pseudohalide anion	mitochondrial respiratory-chain inhibitor
sulfosuccinimidyl 6-((4-azido-2-nitrophenyl)amino)hexanoate sulfosuccinimidyl 6-((4-azido-2-nitrophenyl)amino)hexanoate: cross-links beta-bungarotoxinto chick brain membranes	2.02	1
calcitriol dihydroxy-vitamin D3: as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes	2.4	2	D3 vitamins; hydroxycalciol; triol	antineoplastic agent; antipsoriatic; bone density conservation agent; calcium channel agonist; calcium channel modulator; hormone; human metabolite; immunomodulator; metabolite; mouse metabolite; nutraceutical
phosphorus Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	2	1	monoatomic phosphorus; nonmetal atom; pnictogen	macronutrient
endothelin-1 Endothelin-1: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)	2.07	1
mlck peptide MLCK peptide: amino acid sequence given in first source; synthetic peptide corresponding to the sequence of calmodulin-binding domain of skeletal muscle myosin light chain kinase which acts as calmodulin antagonist	2.07	1
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.42	2
caseins Caseins: A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones.	2.02	1

Condition	Relationship Strength	Studies
Breast Cancer [description not available]	4.44	8
Hormone-Dependent Neoplasms [description not available]	2.05	1
Breast Neoplasms Tumors or cancer of the human BREAST.	4.44	8
Cirrhosis [description not available]	2.07	1
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	2.07	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.33	2
Condition, Preneoplastic [description not available]	2.02	1
Experimental Mammary Neoplasms [description not available]	3.1	5
Precancerous Conditions Pathological conditions that tend eventually to become malignant.	2.02	1
Cancer of Colon [description not available]	2.02	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.02	1
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.03	1
Animal Mammary Carcinoma [description not available]	2.03	1

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