Compounds > ap 10
Page last updated: 2024-11-11

ap 10

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5708351
CHEMBL ID361568
CHEBI ID69808
SCHEMBL ID20668923
MeSH IDM0079599

Synonyms (37)

Synonym
MEGXP0_000982
ap-10
NCGC00163645-01
MLS001215174
smr000543109
chebi:69808 ,
CHEMBL361568
3-{(e)-2-[(1r,4as,5r,6r,8ar)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethenyl}furan-2(5h)-one
STK802121
4-[(e)-2-[(1r,4as,5r,6r,8ar)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethenyl]-2h-furan-5-one
AKOS005622504
HMS2881G03
BBL010995
2(5h)-furanone, 3-((1e)-2-((1r,4as,5r,6r,8ar)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethenyl)-
unii-5s0x4yzj0e
14-deoxy-11,12-dehydroandrographolide
42895-58-9
11,12-didehydro-14-deoxyandrographolide
5s0x4yzj0e ,
14-deoxy-11,12-dehydroandrographolide (constituent of andrographis) [dsc]
AC-34799
14-deoxy-11,12-didehydro andrographolide
A1-06836
CS-7534
mfcd07778081
sr-01000814886
SR-01000814886-4
14-deoxy-11,12-didehydroandrographolide, analytical standard
NCGC00163645-02
HY-N1490
Q27138150
SCHEMBL20668923
14-dehydro andrographolide;ap10
14-dehydro andrographolide
E80829
DTXSID301347789
14-deoxy-11,12-didehydroandrographolide;ap10

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
diterpene lactone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency31.62280.003245.467312,589.2998AID2517
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency53.88200.004023.8416100.0000AID485290; AID489007
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency89.12510.631035.7641100.0000AID504339
TDP1 proteinHomo sapiens (human)Potency29.09290.000811.382244.6684AID686978
thioredoxin glutathione reductaseSchistosoma mansoniPotency39.81070.100022.9075100.0000AID485364
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency20.59620.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency50.11873.548119.542744.6684AID743266
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
DNA polymerase kappa isoform 1Homo sapiens (human)Potency89.12510.031622.3146100.0000AID588579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (130)

Assay IDTitleYearJournalArticle
AID610935Antiinflammatory activity in ovalbumin-sensitized ip dosed BALB/c mouse asthma model assessed as reduction in IL-4 level in bronchoalveolar lavage fluid administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID781156Antimigratory activity against human SGC7901 cells at 10 uM after 12 to 48 hrs by wound-healing assay relative to control2013Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23
Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.
AID1544513Induction of neurite outgrowth in rat PC12 cells assessed as neurite bearing cells in absence of 20 ng/ml NGF incubated for 48 hrs by light microscopy2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID249073Concentration causing 50% inhibition of cancer cell growth against human lung H522 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID1204914Cytotoxicity against human Jurkat T cells assessed as appearance of viable cells at 25 uM after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID376608Neuroprotective effect against amyloid beta(25 to 35)-induced cell death in Harlan Sprague-Dawley rat pups cortical neurons assessed as cell viability at 10 uM treated 2 hrs before amyloid beta(25 to 35) treatment after 40 hrs by MTT assay2006Journal of natural products, Apr, Volume: 69, Issue:4
Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.
AID1408139Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of alpha-SMA mRNA level at 500 nM measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID1544507Cytotoxicity in mouse BV2 cells assessed as reduction in cell viability2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID611021Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in Ym-2 mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID781151Cytotoxicity against human PC3 cells assessed as growth inhibition at 10 uM after 48 hrs by MTT assay relative to control2013Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23
Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.
AID1761539Cytotoxicity against C57BL/6 mouse BMM cells assessed as reduction in cell viability measured after 48 hrs in presence of M-CSF by CCK8 assay2021European journal of medicinal chemistry, Mar-05, Volume: 213Synthesis and evaluation of andrographolide derivatives as potent anti-osteoporosis agents in vitro and in vivo.
AID1367187Growth inhibition of human KB cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID383495Antiproliferative activity against human HL60 cells by trypan blue assay2008Journal of natural products, May, Volume: 71, Issue:5
ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata.
AID611032Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model assessed as reduction in goblet cell hyperplasia at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs using hematoxylin and eosin st2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1204904Binding affinity to 6His-tagged recombinant human NF-kappaB p50 N-terminal domain expressed in Escherichia coli BL21 (DE3) up to 50:1 compound to protein molar ratio after 2 hrs by mass spectrometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID1140535Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of DNA replication2014Bioorganic & medicinal chemistry letters, May-15, Volume: 24, Issue:10
Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents.
AID1367192Growth inhibition of human KKU-M213 cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID380105Antimicrobial activity against Candida sake at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID380106Antimicrobial activity against Aspergillus niger at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID610929Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability at 3 to 120 uM after 24 to 48 hrs by MTS assay2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1204911Cytotoxicity against human Jurkat T cells assessed as appearance of early apoptotic cells at 25 uM after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID1140530Cytotoxicity against human HepG2.2.15 cells by MTT assay2014Bioorganic & medicinal chemistry letters, May-15, Volume: 24, Issue:10
Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents.
AID1544494Lipophilicity, log P of the compound2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID1544514Induction of neurite outgrowth in NGF-induced rat PC12 cells assessed as neurite bearing cells at 20 uM cotreated with 20 ng/ml NGF incubated for 48 hrs by methylene blue staining based light microscopy2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID611027Antiinflammatory activity in ip dosed BALB/c mouse asthma model assessed as reduction in ovalbumin-induced eosinophil counts in bronchoalveolar lavage fluid administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by cell count2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID610930Cytotoxicity against rat RBL2H3 cells assessed as reduction in cell viability at 3 to 120 uM after 24 to 48 hrs by MTS assay2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID610932Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as reduction in NF-kappaB DNA binding activity at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by immunoblotting2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611022Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in YLK-40 mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID610934Inhibition of NF-kappaB p65 subunit in TNFalpha-stimulated human A549 cells assessed as reduction in DNA binding activity at 30 uM after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID380102Antimicrobial activity against Escherichia coli at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1544506Induction of neurite outgrowth in NGF-induced rat PC12 cells assessed as neurite bearing cells cotreated with 20 ng/ml NGF incubated for 48 hrs by light microscopy2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID376606Neuroprotective effect against amyloid beta(25 to 35)-induced cell death in Harlan Sprague-Dawley rat pups cortical neurons assessed as cell viability at 1 uM treated 2 hrs before amyloid beta(25 to 35) treatment after 40 hrs by MTT assay2006Journal of natural products, Apr, Volume: 69, Issue:4
Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.
AID249075Concentration causing 50% inhibition of cancer cell growth against human colon SW620 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID611031Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model assessed as reduction in mucus production in lung at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs using PAS staining by histolo2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID380100Antimicrobial activity against Bacillus subtilis at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1544501Neuroprotective activity against H2O2-induced toxicity in rat PC12 cells assessed as increase in cell viability at 20 uM pretreated for 24 hrs followed by H2O2 challenge and measured after 24 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID1367193Growth inhibition of human HuCCa1 cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID610936Antiinflammatory activity in ovalbumin-sensitized ip dosed BALB/c mouse asthma model assessed as reduction in IL-5 level in bronchoalveolar lavage fluid administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1367189Growth inhibition of human MCF7 cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID611025Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in COX-2 mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611118Toxicity in BALB/c mouse assessed as reduction in white blood cell count at 1 mg/kg, ip2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611026Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in Muc5ac mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID610938Antiinflammatory activity in ovalbumin-sensitized ip dosed BALB/c mouse asthma model assessed as reduction in eotaxin level in bronchoalveolar lavage fluid administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID610941Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model assessed as reduction in IgG1 level in serum at 0.1 to 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID380103Antimicrobial activity against Micrococcus luteus at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1204910Inhibition of TNF-alpha-stimulated NF-kappaB p50 (unknown origin) expressed in HEK293 cells at 1 to 100 uM preincubated for 4 hrs followed by TNF-alpha challenge measured after 24 hrs by secreted alkaline phosphatase reporter assay2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID1204913Cytotoxicity against human Jurkat T cells assessed as appearance of necrotic cells at 25 uM after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID376609Neuroprotective effect against amyloid beta(25 to 35)-induced cell death in Harlan Sprague-Dawley rat pups cortical neurons assessed as cell viability at 20 uM treated 2 hrs before amyloid beta(25 to 35) treatment after 40 hrs by MTT assay2006Journal of natural products, Apr, Volume: 69, Issue:4
Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.
AID376607Neuroprotective effect against amyloid beta(25 to 35)-induced cell death in Harlan Sprague-Dawley rat pups cortical neurons assessed as cell viability at 5 uM treated 2 hrs before amyloid beta(25 to 35) treatment after 40 hrs by MTT assay2006Journal of natural products, Apr, Volume: 69, Issue:4
Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.
AID1544504Induction of neurite outgrowth in NGF-induced rat PC12 cells assessed as neurite bearing cells at 20 uM cotreated with 20 ng/ml NGF incubated for 48 hrs by light microscopy2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID610943Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in VCAM-1 mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID610940Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model assessed as reduction in IgE level in serum at 0.1 to 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611024Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in IL-33 mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611029Antiinflammatory activity in BALB/c mouse asthma model assessed as reduction in ovalbumin-induced macrophage counts in bronchoalveolar lavage fluid at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by cell2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID781155Cytotoxicity against human SGC7901 cells assessed as growth inhibition at 10 uM after 48 hrs by MTT assay relative to control2013Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23
Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.
AID1367190Growth inhibition of human A549 cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID1741322Aqueous stability of compound2020European journal of medicinal chemistry, Oct-15, Volume: 204From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action.
AID1408132Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID1367186Growth inhibition of mouse P388 cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID781157Cytotoxicity against human 5637 cells assessed as growth inhibition at 10 uM after 48 hrs by MTT assay relative to control2013Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23
Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.
AID611023Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in IL-17 mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID781159Antimigratory activity against human 5637 cells at 10 uM after 12 to 48 hrs by wound-healing assay relative to control2013Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23
Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.
AID264791Inhibition of alpha glucosidase at 100 uM2006Bioorganic & medicinal chemistry letters, May-15, Volume: 16, Issue:10
Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues.
AID1367195Growth inhibition of human HEK293 cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID611020Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in Ym-1 mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1408141Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of COL1A1 mRNA level at 500 nM measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID1544503Neuroprotective activity against 6-OHDA -induced toxicity in rat PC12 cells assessed as increase in cell viability at 20 uM pretreated for 24 hrs followed by 6-OHDA challenge and measured after 24 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID611107Cytotoxicity against human A549 cells assessed as reduction in cell viability at 3 to 120 uM after 24 to 48 hrs by MTS assay2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611104Inhibition of IgE-mediated rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosaminidase release2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1140536Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for HBV infected in human HepG2.2.15 cells assessed as inhibition of DNA replication2014Bioorganic & medicinal chemistry letters, May-15, Volume: 24, Issue:10
Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents.
AID610937Antiinflammatory activity in ovalbumin-sensitized ip dosed BALB/c mouse asthma model assessed as reduction in IL-13 level in bronchoalveolar lavage fluid administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1367188Growth inhibition of human HT-29 cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID380104Antimicrobial activity against Candida albicans at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1408138Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of TGFbeta1-induced increase in COL1A1 mRNA level at 500 nM preincubated for 1 hr followed by TGFbeta-1 addition measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID611119Toxicity in BALB/c mouse assessed as reduction in hematocrit at 1 mg/kg, ip2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID307364Inhibition of alpha-glucosidase at 100 uM2007Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
Synthesis of andrographolide derivatives: a new family of alpha-glucosidase inhibitors.
AID1140537Octanol-water partition coefficient, log P of the compound at 30 degC by HPLC analysis2014Bioorganic & medicinal chemistry letters, May-15, Volume: 24, Issue:10
Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents.
AID249081Concentration causing 50% inhibition of cancer cell growth against human ovarian SKOV3 cell line; nd = not done2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID1367191Growth inhibition of rat ASK cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID611103Inhibition of ovalbumin-induced mast cell degranulation in BALB/c mouse asthma model at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs using toluidine blue staining by cell counting2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611028Antiinflammatory activity in ip dosed BALB/c mouse asthma model assessed as reduction in ovalbumin-induced total cell counts in bronchoalveolar lavage fluid administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by cell count2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1408140Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of FN mRNA level at 500 nM measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID1408136Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of TGFbeta1-induced increase in alpha-SMA mRNA level at 500 nM preincubated for 1 hr followed by TGFbeta-1 addition measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID611106Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model assessed as reduction in methacholine-induced distensibility of the lung at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID249072Concentration causing 50% inhibition of cancer cell growth against human CNS U251 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID610933Inhibition of NF-kappaB p65 subunit translocation in TNFalpha-stimulated human A549 cells assessed as reduction in p65 level in nuclear extract at 30 uM after 24 hrs by immunoblotting2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID781152Antimigratory activity against human PC3 cells at 10 uM after 12 to 48 hrs by wound-healing assay relative to control2013Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23
Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.
AID610931Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as Inhibition of NF-kappaB p65 subunit nuclear translocation at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by i2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID264793Inhibition of beta glucosidase at 100 uM2006Bioorganic & medicinal chemistry letters, May-15, Volume: 16, Issue:10
Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues.
AID380101Antimicrobial activity against Staphylococcus aureus at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID610939Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model assessed as reduction in total IgE level in serum at 0.1 to 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID249080Concentration causing 50% inhibition of cancer cell growth against human renal A498 cell line; nd = not done2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID1367194Growth inhibition of human KKU100 cells after 72 hrs by SRB assay2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.
AID611117Toxicity in BALB/c mouse assessed as reduction in red blood cell count at 1 mg/kg, ip2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID610942Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model assessed as reduction in IgG2a level in serum at 0.1 to 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by ELISA2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID610944Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in E-selectin mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1408137Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of TGFbeta1-induced increase in FN mRNA level at 500 nM preincubated for 1 hr followed by TGFbeta-1 addition measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID249077Concentration causing 50% inhibition of cancer cell growth against human prostate DU145 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID611105Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model assessed as reduction in methacholine-induced maximum total lung resistance at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611018Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in MCP-1 mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1204912Cytotoxicity against human Jurkat T cells assessed as appearance of late apoptotic cells at 25 uM after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID249078Concentration causing 50% inhibition of cancer cell growth against human breast MCF-7/ADR cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID611019Antiinflammatory activity in ovalbumin-sensitized BALB/c mouse asthma model lung assessed as suppression in AMCase mRNA level at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by RT-PCR analysis2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID611030Antiinflammatory activity in BALB/c mouse asthma model assessed as reduction in ovalbumin-induced lymphocyte counts in bronchoalveolar lavage fluid at 1 mg/kg, ip administered 2 hrs before and 10 hrs after ovalbumin challenge measured after 24 hrs by cell2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1761538Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-sta2021European journal of medicinal chemistry, Mar-05, Volume: 213Synthesis and evaluation of andrographolide derivatives as potent anti-osteoporosis agents in vitro and in vivo.
AID1741323Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 release at 5 to 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA2020European journal of medicinal chemistry, Oct-15, Volume: 204From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action.
AID1741327Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha release at 5 to 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs by ELISA2020European journal of medicinal chemistry, Oct-15, Volume: 204From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action.
AID611120Toxicity in BALB/c mouse assessed as reduction in hemoglobin concentration at 1 mg/kg, ip2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation.
AID1544493Antiinflammatory activity in mouse BV2 cells assessed as reduction in LPS-induced NO production at 20 uM incubated for 24 hrs by Griess method2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347087qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Confirmatory Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347088qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): Viability assay - Alamar blue signal for LCMV Confirmatory Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347084qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Confirmatory Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347081qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Confirmatory Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (28.00)29.6817
2010's11 (44.00)24.3611
2020's7 (28.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 51.08

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index51.08 (24.57)
Research Supply Index3.26 (2.92)
Research Growth Index4.61 (4.65)
Search Engine Demand Index90.26 (26.88)
Search Engine Supply Index2.33 (0.95)

This Compound (51.08)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other25 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.1510indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
acarbose
[no description available]		2.0310amino cyclitol;
glycoside
tenofovir
tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.		2.110nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
acetyl-aspartyl-glutamyl-valyl-aspartal
acetyl-aspartyl-glutamyl-valyl-aspartal: a capase inhibitor. Ac-Asp-Glu-Val-Asp-H : A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.		2.0310tetrapeptideprotease inhibitor
andrographolide
[no description available]		4.02130carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol		anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite
neoandrographolide
neoandrographolide: structure in first source; isolated from Andrographis paniculata		2.9940
14-deoxyandrographolide
14-deoxyandrographolide: from Andrographis paniculata; structure in first source		3.3260
andrograpanin
andrograpanin: an NSAID isolated from Andrographis paniculata; structure in first source		2.4420
alendronate sodium
[no description available]		2.3110
andrographoside
[no description available]		2.4420
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Asthma, Bronchial
[description not available]		02.0610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.8530
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		02.0610
Benign Neoplasms
[description not available]		02.0810
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0810
Cholangiocellular Carcinoma
[description not available]		02.1510
Bile Duct Cancer
[description not available]		02.1510
Bile Duct Neoplasms
Tumors or cancer of the BILE DUCTS.		02.1510
Cholangiocarcinoma
A malignant tumor arising from the epithelium of the BILE DUCTS.		02.1510
Cirrhosis
[description not available]		02.1710
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.		02.1710
Acute Confusional Senile Dementia
[description not available]		02.2110
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.2110
Lung Injury, Acute
[description not available]		02.2510
Acute Lung Injury
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).		02.2510
Congenital Zika Syndrome
[description not available]		02.2510
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510
Bone Loss, Osteoclastic
[description not available]		02.3110
Age-Related Osteoporosis
[description not available]		02.3110
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.		02.3110