deoxyelephantopin profile

ID Source	ID
PubMed CID	6325056
SCHEMBL ID	19036253
CHEBI ID	4409
MeSH ID	M0520845

Synonym
isodeoxyelephantopin
deoxyelephantopin
29307-03-7
C09388
LMPR0103090003
CHEBI:4409
38927-54-7
AC-35039
SCHEMBL19036253
AKOS037515406
HY-N2585
Q27106374
[(3s,4r,8r,9e,12r)-10-methyl-5-methylidene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.04,8]pentadeca-1(15),9-dien-3-yl] 2-methylprop-2-enoate
CS-0022928

Class	Description
sesquiterpenoid	Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (5.26)	29.6817
2010's	24 (63.16)	24.3611
2020's	12 (31.58)	2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (5.13%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (94.87%)	84.16%

Substance	Classes	Roles	Relationship Strength
chamazulene	sesquiterpenoid		low
mansonone c	1,2-naphthoquinones; sesquiterpenoid		low
artemether	artemisinin derivative; cyclic acetal; organic peroxide; semisynthetic derivative; sesquiterpenoid	antimalarial	low
elemol	olefinic compound; sesquiterpenoid; tertiary alcohol	fragrance; plant metabolite	low
spathulenol	carbotricyclic compound; olefinic compound; sesquiterpenoid; tertiary alcohol	anaesthetic; plant metabolite; vasodilator agent; volatile oil component	low
xanthorrhizol	sesquiterpenoid		low
phomenone	sesquiterpenoid		low
judaicin (eudesmane naphthofuran)	sesquiterpenoid		low
hernandulcin	sesquiterpenoid		low
ar-turmerone	enone; sesquiterpenoid	EC 3.1.1.7 (acetylcholinesterase) inhibitor; plant metabolite	low
frullanolide	sesquiterpenoid		low
albicanol	carbobicyclic compound; homoallylic alcohol; primary alcohol; sesquiterpenoid	antifeedant; antifungal agent; antineoplastic agent; fungal metabolite; mammalian metabolite; marine metabolite; plant metabolite	low
valeranone	sesquiterpenoid		low
aromadendrene	sesquiterpenoid		low
procurcumenol	sesquiterpenoid		low
fumagillol	secondary alcohol; sesquiterpenoid; spiro-epoxide	antimicrobial agent	low
illudin m	sesquiterpenoid		low
illudin s	sesquiterpenoid		low
o-(chloroacetylcarbamoyl)fumagillol	carbamate ester; organochlorine compound; semisynthetic derivative; sesquiterpenoid; spiro-epoxide	angiogenesis inhibitor; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; methionine aminopeptidase 2 inhibitor; retinoic acid receptor alpha antagonist	low
bakkenolide a	sesquiterpenoid		low
bisabolol	sesquiterpenoid		low
solavetivone	cyclic ketone; sesquiterpenoid; spiro compound	phytoalexin; plant metabolite	low
macrocarpal b	sesquiterpenoid		low
bucladesine	sesquiterpenoid		low
elatol	sesquiterpenoid		low
7-hydroxycadalin	sesquiterpenoid		low
2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(3-pyridinyl)methyl]-5,5-dimethylcyclohexane-1,3-dione	sesquiterpenoid		low
2-hydroxy-2,2-bis(4-methylphenyl)-N'-(2-pyridinyl)acetohydrazide	sesquiterpenoid		low
nootkatone	carbobicyclic compound; enone; sesquiterpenoid	fragrance; insect repellent; plant metabolite	low
bisabolol	sesquiterpenoid		low
drimenol	homoallylic alcohol; octahydronaphthalenes; primary alcohol; sesquiterpenoid		low
atractylon	sesquiterpenoid		low
zoapatanol	sesquiterpenoid		low
budlein a	sesquiterpenoid		low
petasin	alicyclic ketone; enoate ester; enone; sesquiterpenoid	anti-allergic agent; EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator; plant metabolite; vasodilator agent	low
astrogorgiadiol	sesquiterpenoid		low
anhydrovitamin a	sesquiterpenoid		low
rotundone	sesquiterpenoid		low
4-nerolidylcatechol	sesquiterpenoid		low
alpha-isomethylionone	sesquiterpenoid		low
grifolin	sesquiterpenoid		low
s-trans,trans-farnesylthiosalicylic acid	sesquiterpenoid		low
zerumbone	cyclic ketone; sesquiterpenoid	anti-inflammatory agent; glioma-associated oncogene inhibitor; plant metabolite	low
aurachin d	sesquiterpenoid		low
ascofuranone	dihydroxybenzaldehyde; meroterpenoid; monochlorobenzenes; olefinic compound; resorcinols; sesquiterpenoid; tetrahydrofuranone	angiogenesis inhibitor; antilipemic drug; antineoplastic agent; antiprotozoal drug; fungal metabolite	low
fusarin c	sesquiterpenoid		low
n-acetyl-s-farnesylcysteine	sesquiterpenoid		low
tautomycetin	sesquiterpenoid		low
valerenic acid	carbobicyclic compound; monocarboxylic acid; sesquiterpenoid	GABA modulator; plant metabolite; sedative; volatile oil component	low
artesunate	artemisinin derivative; cyclic acetal; dicarboxylic acid monoester; hemisuccinate; semisynthetic derivative; sesquiterpenoid	antimalarial; antineoplastic agent; ferroptosis inducer	low
dihydroartemisinin	sesquiterpenoid	antimalarial	low
xenovulene a	cyclic ether; enone; organic heterotetracyclic compound; sesquiterpenoid	GABA antagonist; metabolite	low
LSM-1328	sesquiterpenoid		low
jaeschkeanadiol	sesquiterpenoid		low
hypnophilin	sesquiterpenoid		low
artemisic acid	carbobicyclic compound; monocarboxylic acid; octahydronaphthalenes; sesquiterpenoid	metabolite	low
dihydroartemisinic acid	carbobicyclic compound; monocarboxylic acid; octahydronaphthalenes; sesquiterpenoid	plant metabolite	low
ascochlorin	cyclohexanones; dihydroxybenzaldehyde; meroterpenoid; monochlorobenzenes; olefinic compound; resorcinols; sesquiterpenoid	angiogenesis inhibitor; antifungal agent; antineoplastic agent; antiprotozoal drug; fungal metabolite	low
cubebol	carbotricyclic compound; sesquiterpenoid; tertiary alcohol		low
5-methyl-2-(3-oxo-1,2,2-trimethylcyclopentyl)benzoquinone	sesquiterpenoid		low
laurinterol	organobromine compound; phenols; sesquiterpenoid	antibacterial agent; apoptosis inducer; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; metabolite	low
pyripyropene a	organic heterotetracyclic compound; sesquiterpenoid	acyl-CoA:cholesterol acyltransferase 2 inhibitor; metabolite	low
viridiflorol	carbotricyclic compound; sesquiterpenoid; tertiary alcohol	anti-inflammatory agent; antifeedant; antimycobacterial drug; plant metabolite; volatile oil component	low
cyperotundone	sesquiterpenoid		low
oplodiol	carbobicyclic compound; octahydronaphthalenes; secondary alcohol; sesquiterpenoid; tertiary alcohol	plant metabolite	low
curcumol	sesquiterpenoid		low
isotrichodermin	sesquiterpenoid		low
saliniketal a	sesquiterpenoid		low
saliniketal b	sesquiterpenoid		low
Pechueloic acid	sesquiterpenoid		low
atheronal-a	sesquiterpenoid		low
albaflavenone	carbocyclic antibiotic; carbotricyclic compound; cyclic terpene ketone; enone; sesquiterpenoid	bacterial metabolite	low
(+)-(7S)-sydonic acid	aromatic alcohol; monohydroxybenzoic acid; sesquiterpenoid	Aspergillus metabolite	low
armillaridin	benzoate ester; sesquiterpenoid		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
fluorouracil	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic	2022	2022	2.0	low	0	0	1
tyrosine	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical	2013	2013	11.0	low	0	1	0
acetylcysteine	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary	2017	2017	7.0	low	0	1	0
deoxycytidine	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2020	2020	4.0	low	0	1	0
galactosamine	1	D-galactosamine; primary amino compound	toxin	2013	2013	11.0	low	0	1	0
paclitaxel	2	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent	2010	2010	14.0	low	2	0	0
gemcitabine	1	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic	2020	2020	4.0	low	0	1	0
sorafenib	1	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide	angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor	2023	2023	1.0	low	0	0	1
3-nitrotyrosine	1	2-nitrophenols; C-nitro compound; nitrotyrosine; non-proteinogenic alpha-amino acid		2013	2013	11.0	low	0	1	0
sesquiterpenes	36			2007	2023	7.8	high	4	26	6
cysteine	1	cysteinium	fundamental metabolite	2016	2016	8.0	low	0	1	0
cytochrome c-t	1			2011	2011	13.0	low	0	1	0
calpain	1			2012	2012	12.0	low	0	1	0
plx4032	1	aromatic ketone; difluorobenzene; monochlorobenzenes; pyrrolopyridine; sulfonamide	antineoplastic agent; B-Raf inhibitor	2016	2016	8.0	low	0	1	0
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	1			2017	2017	7.0	low	0	1	0
germacranolide	1			2015	2015	9.0	low	0	1	0
enhydrin	1	sesquiterpene lactone		2015	2015	9.0	medium	0	1	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
Acute Confusional Senile Dementia	1	2018	2018	6.0	low	0	1	0
Acute Hepatic Failure	1	2013	2013	11.0	low	0	1	0
Adenocarcinoma	4	2010	2013	12.8	low	2	2	0
Adenocarcinoma of Lung	1	2013	2013	11.0	low	0	1	0
Adenocarcinoma, Basal Cell	4	2010	2013	12.8	low	2	2	0
African Sleeping Sickness	1	2014	2014	10.0	low	0	1	0
Age-Related Memory Disorders	1	2018	2018	6.0	low	0	1	0
Alzheimer Disease	1	2018	2018	6.0	low	0	1	0
Benign Neoplasms	3	2016	2022	5.7	low	0	2	1
Blood Poisoning	2	2020	2022	3.0	low	0	1	1
Bone Cancer	1	2017	2017	7.0	low	0	1	0
Bone Neoplasms	1	2017	2017	7.0	low	0	1	0
Breast Cancer	2	2010	2019	9.5	low	1	1	0
Breast Neoplasms	2	2010	2019	9.5	low	1	1	0
Cancer of Colon	1	2022	2022	2.0	low	0	0	1
Cancer of Liver	3	2023	2023	1.0	low	0	0	3
Cancer of Lung	4	2010	2023	8.8	low	1	2	1
Cancer of Nasopharynx	2	2011	2013	12.0	low	0	2	0
Cancer of Pancreas	1	2020	2020	4.0	low	0	1	0
Cancer of Skin	1	2016	2016	8.0	low	0	1	0
Cancer of the Uterus	1	2020	2020	4.0	low	0	1	0
Carcinoma	1	2013	2013	11.0	low	0	1	0
Carcinoma, Anaplastic	1	2013	2013	11.0	low	0	1	0
Carcinoma, Hepatocellular	3	2023	2023	1.0	low	0	0	3
Cardiac Failure	1	2023	2023	1.0	low	0	0	1
Cardiac Hypertrophy	1	2023	2023	1.0	low	0	0	1
Cardiomegaly	1	2023	2023	1.0	low	0	0	1
Chronic Lung Injury	1	2022	2022	2.0	low	0	0	1
Cirrhosis	1	2023	2023	1.0	low	0	0	1
Cirrhosis, Liver	1	2019	2019	5.0	low	0	1	0
Colonic Neoplasms	1	2022	2022	2.0	low	0	0	1
Disease Models, Animal	2	2013	2020	7.5	low	0	2	0
ER-Negative PR-Negative HER2-Negative Breast Cancer	2	2016	2023	4.5	low	0	1	1
Experimental Mammary Neoplasms	2	2010	2012	13.0	low	1	1	0
Fibroid	1	2020	2020	4.0	low	0	1	0
Fibrosis	1	2023	2023	1.0	low	0	0	1
Heart Failure	1	2023	2023	1.0	low	0	0	1
Hepatitis	1	2013	2013	11.0	low	0	1	0
Hepatocellular Carcinoma	3	2023	2023	1.0	low	0	0	3
Invasiveness, Neoplasm	1	2010	2010	14.0	low	1	0	0
Leiomyoma	1	2020	2020	4.0	low	0	1	0
Liver Cirrhosis	1	2019	2019	5.0	low	0	1	0
Liver Failure, Acute	1	2013	2013	11.0	low	0	1	0
Liver Neoplasms	3	2023	2023	1.0	low	0	0	3
Lung Adenocarcinoma	1	2013	2013	11.0	low	0	1	0
Lung Neoplasms	4	2010	2023	8.8	low	1	2	1
Malignant Melanoma	1	2016	2016	8.0	low	0	1	0
Melanoma	1	2016	2016	8.0	low	0	1	0
Memory Disorders	1	2018	2018	6.0	low	0	1	0
Metastase	2	2015	2016	8.5	low	0	2	0
Nasopharyngeal Carcinoma	1	2013	2013	11.0	low	0	1	0
Nasopharyngeal Neoplasms	2	2011	2013	12.0	low	0	2	0
Neoplasm Metastasis	2	2015	2016	8.5	low	0	2	0
Neoplasms	3	2016	2022	5.7	low	0	2	1
Osteogenic Sarcoma	1	2017	2017	7.0	low	0	1	0
Osteosarcoma	1	2017	2017	7.0	low	0	1	0
Pancreatic Neoplasms	1	2020	2020	4.0	low	0	1	0
Sepsis	2	2020	2022	3.0	low	0	1	1
Skin Neoplasms	1	2016	2016	8.0	low	0	1	0
Triple Negative Breast Neoplasms	2	2016	2023	4.5	low	0	1	1
Trypanosomiasis, African	1	2014	2014	10.0	low	0	1	0
Uterine Neoplasms	1	2020	2020	4.0	low	0	1	0