A signal peptide peptidase-like 2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCT8]
SPP-like 2A;
SPPL2a;
EC 3.4.23.-;
Intramembrane protease 3;
IMP-3;
Presenilin-like protein 2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ly 411575 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| 1, 3-di-(n-carboxybenzoyl-leucyl-leucyl)amino acetone | Homo sapiens (human) | IC50 | 0.0060 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| aspartic endopeptidase activity, intramembrane cleaving | molecular function | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. [GOC:jl, ISBN:0198506732] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
This protein is located in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| lysosomal membrane | cellular component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| late endosome | cellular component | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| Golgi-associated vesicle membrane | cellular component | The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. [GOC:mah] |
| late endosome membrane | cellular component | The lipid bilayer surrounding a late endosome. [GOC:pz] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| lumenal side of endoplasmic reticulum membrane | cellular component | The side (leaflet) of the plasma membrane that faces the lumen. [GOC:ab, GOC:dos] |
| cytoplasmic side of endoplasmic reticulum membrane | cellular component | The side (leaflet) of the plasma membrane that faces the cytoplasm. [GOC:ab, GOC:dos] |
This protein is active in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| lumenal side of endoplasmic reticulum membrane | cellular component | The side (leaflet) of the plasma membrane that faces the lumen. [GOC:ab, GOC:dos] |
| Golgi-associated vesicle membrane | cellular component | The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. [GOC:mah] |
| lysosomal membrane | cellular component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| cytoplasmic side of endoplasmic reticulum membrane | cellular component | The side (leaflet) of the plasma membrane that faces the cytoplasm. [GOC:ab, GOC:dos] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane protein ectodomain proteolysis | biological process | The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). [GOC:jl, http://www.copewithcytokines.de/] |
| regulation of tumor necrosis factor-mediated signaling pathway | biological process | Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb] |
| membrane protein intracellular domain proteolysis | biological process | The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. [PMID:12808018] |
| membrane protein proteolysis | biological process | The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. [GOC:pde] |
| regulation of immune response | biological process | Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai] |