diethylnitrosamine has been researched along with Fibrosis in 17 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the effect of combined therapy of diacerein and gold nanoparticles (AuNP) on diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in a rat model." | 8.31 | Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study. ( Baokbah, TAS, 2023) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 8.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 7.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 5.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 5.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "Our findings showed that in hepatocarcinogenesis by diethylnitrosamine, cellular senescence is associated with p16 pathway activation and is mainly localized in myofibroblast-like cells." | 5.43 | Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. ( Alemán-Lazarini, L; Arellanes-Robledo, J; Fattel-Fazenda, S; Pacheco-Rivera, R; Pérez-Carreón, J; Rodríguez-Segura, M; Serrano-Luna, J; Shibayama, M; Silva-Olivares, A; Villa-Treviño, S, 2016) |
| "Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10-14 weeks." | 5.40 | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. ( Ding, WJ; Duan, XY; Fan, JG; Pan, Q; Qiao, L; Yan, SY, 2014) |
| "The purpose of this study was to investigate the effect of combined therapy of diacerein and gold nanoparticles (AuNP) on diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in a rat model." | 4.31 | Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study. ( Baokbah, TAS, 2023) |
| " O-GlcNAc transferase-KO mice exacerbated diethylnitrosamine-induced HCC development with increased inflammation, fibrosis, and YAP signaling." | 4.31 | The essential role of O-GlcNAcylation in hepatic differentiation. ( Apte, U; Hanover, JA; Kotulkar, M; Paine-Cabrera, D; Robarts, DR; Slawson, C; Venneman, KK; Zachara, NE, 2023) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 4.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 3.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| "The Diethylnitrosamine (DEN) model has an age-related effect." | 1.56 | A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma. ( Jung, Y; Lee, JI; Lee, WK; Memon, A; Pyao, Y, 2020) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 1.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "Our findings showed that in hepatocarcinogenesis by diethylnitrosamine, cellular senescence is associated with p16 pathway activation and is mainly localized in myofibroblast-like cells." | 1.43 | Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. ( Alemán-Lazarini, L; Arellanes-Robledo, J; Fattel-Fazenda, S; Pacheco-Rivera, R; Pérez-Carreón, J; Rodríguez-Segura, M; Serrano-Luna, J; Shibayama, M; Silva-Olivares, A; Villa-Treviño, S, 2016) |
| "Many animal models of nonalcoholic steatohepatitis have been reported." | 1.43 | A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis. ( Ejima, C; Ishizaki, S; Kuroda, H, 2016) |
| "Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10-14 weeks." | 1.40 | High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma. ( Ding, WJ; Duan, XY; Fan, JG; Pan, Q; Qiao, L; Yan, SY, 2014) |
| "Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN)." | 1.35 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis. ( Bozova, S; Elpek, GO; Gokhan, GA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Ghufran, H | 1 |
| Azam, M | 1 |
| Mehmood, A | 1 |
| Butt, H | 1 |
| Riazuddin, S | 1 |
| Wu, B | 1 |
| Feng, J | 1 |
| Guo, J | 1 |
| Wang, J | 1 |
| Xiu, G | 1 |
| Xu, J | 2 |
| Ning, K | 1 |
| Ling, B | 1 |
| Fu, Q | 1 |
| Baokbah, TAS | 1 |
| Robarts, DR | 1 |
| Kotulkar, M | 1 |
| Paine-Cabrera, D | 1 |
| Venneman, KK | 1 |
| Hanover, JA | 1 |
| Zachara, NE | 1 |
| Slawson, C | 1 |
| Apte, U | 1 |
| Memon, A | 1 |
| Pyao, Y | 1 |
| Jung, Y | 1 |
| Lee, JI | 1 |
| Lee, WK | 1 |
| Kiefer, RM | 1 |
| Hunt, SJ | 1 |
| Pulido, S | 1 |
| Pickup, S | 1 |
| Furth, EE | 1 |
| Soulen, MC | 1 |
| Nadolski, GJ | 1 |
| Gade, TP | 1 |
| Fuentes-Hernández, S | 1 |
| Alarcón-Sánchez, BR | 1 |
| Guerrero-Escalera, D | 1 |
| Montes-Aparicio, AV | 1 |
| Castro-Gil, MP | 1 |
| Idelfonso-García, OG | 1 |
| Rosas-Madrigal, S | 1 |
| Aparicio-Bautista, DI | 1 |
| Pérez-Hernández, JL | 1 |
| Reyes-Gordillo, K | 1 |
| Lakshman, MR | 1 |
| Vásquez-Garzón, VR | 1 |
| Baltiérrez-Hoyos, R | 1 |
| López-González, ML | 1 |
| Sierra-Santoyo, A | 1 |
| Villa-Treviño, S | 2 |
| Pérez-Carreón, JI | 1 |
| Arellanes-Robledo, J | 2 |
| Yi, X | 1 |
| Long, L | 1 |
| Yang, C | 1 |
| Lu, Y | 1 |
| Cheng, M | 1 |
| Duan, XY | 1 |
| Pan, Q | 1 |
| Yan, SY | 1 |
| Ding, WJ | 1 |
| Fan, JG | 1 |
| Qiao, L | 1 |
| Pacheco-Rivera, R | 1 |
| Fattel-Fazenda, S | 1 |
| Silva-Olivares, A | 1 |
| Alemán-Lazarini, L | 1 |
| Rodríguez-Segura, M | 1 |
| Pérez-Carreón, J | 1 |
| Shibayama, M | 1 |
| Serrano-Luna, J | 1 |
| Ejima, C | 1 |
| Kuroda, H | 1 |
| Ishizaki, S | 1 |
| Borbath, I | 1 |
| Leclercq, IA | 1 |
| Sempoux, C | 1 |
| Abarca-Quinones, J | 1 |
| Desaeger, C | 1 |
| Horsmans, Y | 1 |
| Bychkov, VG | 1 |
| Trukhanova, LS | 1 |
| Krylov, GG | 1 |
| Kulikova, LN | 1 |
| Mal'tseva, ED | 1 |
| Smirnova, EA | 1 |
| Kondalenko, VF | 1 |
| Elpek, GO | 1 |
| Gokhan, GA | 1 |
| Bozova, S | 1 |
| Corpechot, C | 1 |
| Barbu, V | 1 |
| Wendum, D | 1 |
| Kinnman, N | 1 |
| Rey, C | 1 |
| Poupon, R | 1 |
| Housset, C | 1 |
| Rosmorduc, O | 1 |
| Gans, JH | 1 |
| Pintauro, SJ | 1 |
| Couch, JA | 1 |
| Courtney, LA | 1 |
17 other studies available for diethylnitrosamine and Fibrosis
| Article | Year |
|---|---|
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin | 2021 |
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib | 2022 |
Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study.
Topics: Animals; beta Catenin; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; Fibrosis; Gold; Int | 2023 |
The essential role of O-GlcNAcylation in hepatic differentiation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Differentiation; Diethylnitrosamine; Fibrosis; Humans; Live | 2023 |
A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2020 |
Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Emboliz | 2017 |
Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Drug Syn | 2019 |
Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice.
Topics: Alcoholic Beverages; Animals; Carcinoma, Hepatocellular; China; Diethylnitrosamine; Disease Models, | 2014 |
High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diet, High-Fat; Diet | 2014 |
Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine.
Topics: Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell Proliferation; Cel | 2016 |
A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis.
Topics: Animals; Cholesterol; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Insulin | 2016 |
Efficacy of lanreotide in preventing the occurrence of chemically induced hepatocellular carcinoma in rats.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Cell Proliferation; Diethylnitrosamine; Fibros | 2010 |
[N-nitrosodiethylamine-induced changes in the liver of syrian hamster with superinvasive opistorchiasis].
Topics: Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Fibrosis; Liver; Liver Neoplasms, Experimental | 2003 |
Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis.
Topics: Animals; Antigens, CD34; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Gene Expression Regul | 2008 |
Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis.
Topics: Alkylating Agents; Animals; Cells, Cultured; Collagen Type I; Collagen Type IV; Diethylnitrosamine; | 2002 |
Liver scarring induced by polychlorinated biphenyl administration to mice previously treated with diethylnitrosamine.
Topics: Animals; Aroclors; Body Weight; Chlorodiphenyl (54% Chlorine); Cicatrix; Diethylnitrosamine; Fibrosi | 1986 |
N-nitrosodiethylamine-induced hepatocarcinogenesis in estuarine sheepshead minnow (Cyprinodon variegatus): neoplasms and related lesions compared with mammalian lesions.
Topics: Animals; Bile Ducts; Cyprinidae; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Fish Diseases | 1987 |