| Assay ID | Title | Year | Journal | Article |
|---|
| AID670040 | Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate at 20 uM after 30 mins by spectrophotometric analysis | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors. |
| AID648277 | Inhibition of Dengue virus NS2B-NS3 protease using Abz-NleKRRS-3-(NO2)Y as substrate at 50 uM preincubated for 15 mins measured every sec for 15 mins by fluorimetric analysis | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry. |
| AID155860 | Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10
| Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium. |
| AID444574 | Toxicity in BALB/c mouse assessed as pathological changes in spleen at 50 mg/kg, ig after 20 hrs by H and E staining based histopathology study | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID444576 | Toxicity in BALB/c mouse assessed as pathological changes in kidney at 50 mg/kg, ig after 20 hrs by H and E staining based histopathology study | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID1782519 | Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 12-15, Volume: 52 | Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase. |
| AID1782516 | Inhibition of Escherichia coli recombinant his-tagged DHDPS using (S)-aspartate-semialdehyde as a substrate preincubated for 12 mins followed by substrate addition by UV-Vis spectrophotometer based coupled DHDPS-DHDPR assay | 2021 | Bioorganic & medicinal chemistry, 12-15, Volume: 52 | Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase. |
| AID19643 | Partition coefficient (logP) | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10
| Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium. |
| AID155855 | Tested for the intracellular Ca+2 release in PC12 cells; - = No release | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10
| Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium. |
| AID1782518 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 12-15, Volume: 52 | Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase. |
| AID444567 | Inhibition of MCP1-induced chemotaxis in mouse RAW264.7 cells at 25 ug/mL relative to control | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID444580 | Half life in BALB/c mouse at 30 mg/kg, po | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID444581 | Oral bioavailability in BALB/c mouse at 30 mg/kg | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID444573 | Toxicity in BALB/c mouse assessed as pathological changes in liver at 50 mg/kg, ig after 20 hrs by H and E staining based histopathology study | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID410273 | Inhibition of human recombinant Pim2 by ATP depletion assay | 2009 | Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
| Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. |
| AID444568 | Inhibition of MCP1-induced chemotaxis in mouse RAW264.7 cells | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID444570 | Effect on serum aspartate aminotransaminase level in concanavalin A-induced acute hepatitis model of BALB/c mouse at 50 mg/kg, po treated 0.5 hrs after concanavalin A challenge measured after 20 hrs (Rvb= 4997.9 +/- 2619.6) | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID155858 | Phosphorylation of eukaryotic initiation factor 2 alpha (eIF2alpha) in PC12 cells, - = No phosphorylation | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10
| Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium. |
| AID410272 | Inhibition of human recombinant Pim1 by ATP depletion assay | 2009 | Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
| Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. |
| AID549698 | Inhibition of aldose reductase | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors. |
| AID444571 | Decrease in concanavalin A-induced hepatic cell necrosis in acute hepatitis model of BALB/c mouse at 50 mg/kg, ig treated 0.5 hrs after concanavalin A challenge measured after 20 hrs by H and E staining based histopathology study | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID410274 | Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay | 2009 | Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
| Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. |
| AID444575 | Toxicity in BALB/c mouse assessed as pathological changes in lung at 50 mg/kg, ig after 20 hrs by H and E staining based histopathology study | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID648280 | Inhibition of Escherichia coli MetAP at 10 uM after 15 mins by fluorescence analysis | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry. |
| AID648278 | Inhibition of bovine plasma thrombin using Boc-Val-Pro-Arg-AMC as substrate at 25 uM preincubated for 15 mins measured after 10 mins by fluorimetric assay | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry. |
| AID444577 | Toxicity in BALB/c mouse liver assessed as change in transaminase level at 50 mg/kg, ig after 20 hrs by H and E staining based histopathology study | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID444569 | Effect on serum alanine aminotransaminase level in concanavalin A-induced acute hepatitis model of BALB/c mouse at 50 mg/kg, po treated 0.5 hrs after concanavalin A challenge measured after 20 hrs (Rvb= 5734.5 +/- 2599.5) | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID444572 | Toxicity in BALB/c mouse assessed as pathological changes in heart at 50 mg/kg, ig after 20 hrs by H and E staining based histopathology study | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID444579 | Plasma concentration in BALB/c mouse at 30 mg/kg, po | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID648279 | Inhibition of Escherichia coli MurA using PEP as substrate assessed as inorganic phosphate release at 25 uM preincubated for 10 mins measured after 60 mins by fluorimetric assay | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry. |
| AID444578 | Tmax in BALB/c mouse at 30 mg/kg, po | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
| Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. |
| AID1798713 | Pim Kinase Assay from Article 10.1021/jm800937p: \\Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.\\ | 2009 | Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
| Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |