4-phenylbutyric acid has been researched along with Fibrosis in 9 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established." | 1.62 | Role of endoplasmic reticulum stress in renal damage after myocardial infarction. ( Cachofeiro, V; de la Fuente-Chávez, L; Delgado-Valero, B; Islas, F; Luaces, M; Martínez-Martínez, E; Ramchandani, B; Romero-Miranda, A; Visitación Bartolomé, M, 2021) |
| "Joint contracture is a common complication for people with joint immobility that involves fibrosis structural alteration in the joint capsule." | 1.48 | Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model. ( He, R; Jiang, S; Liang, T; Lu, Y; Ren, J; Wang, K; Wang, Z; Xiao, D; Yi, X; Zhu, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Delgado-Valero, B | 1 |
| de la Fuente-Chávez, L | 1 |
| Romero-Miranda, A | 1 |
| Visitación Bartolomé, M | 1 |
| Ramchandani, B | 1 |
| Islas, F | 1 |
| Luaces, M | 1 |
| Cachofeiro, V | 1 |
| Martínez-Martínez, E | 1 |
| Jiang, S | 1 |
| He, R | 1 |
| Zhu, L | 1 |
| Liang, T | 1 |
| Wang, Z | 1 |
| Lu, Y | 1 |
| Ren, J | 1 |
| Yi, X | 1 |
| Xiao, D | 1 |
| Wang, K | 1 |
| Luo, T | 2 |
| Kim, JK | 1 |
| Chen, B | 2 |
| Abdel-Latif, A | 1 |
| Kitakaze, M | 1 |
| Yan, L | 1 |
| Wang, X | 1 |
| Liu, SH | 1 |
| Yang, CC | 1 |
| Chan, DC | 1 |
| Wu, CT | 1 |
| Chen, LP | 1 |
| Huang, JW | 1 |
| Hung, KY | 1 |
| Chiang, CK | 1 |
| Mohammed-Ali, Z | 1 |
| Lu, C | 1 |
| Marway, MK | 1 |
| Carlisle, RE | 1 |
| Ask, K | 1 |
| Lukic, D | 1 |
| Krepinsky, JC | 1 |
| Dickhout, JG | 1 |
| Ranga Rao, S | 1 |
| Subbarayan, R | 1 |
| Ajitkumar, S | 1 |
| Murugan Girija, D | 1 |
| Mukai, S | 1 |
| Ogawa, Y | 1 |
| Urano, F | 1 |
| Kudo-Saito, C | 1 |
| Kawakami, Y | 1 |
| Tsubota, K | 1 |
| Ayala, P | 1 |
| Montenegro, J | 1 |
| Vivar, R | 1 |
| Letelier, A | 1 |
| Urroz, PA | 1 |
| Copaja, M | 1 |
| Pivet, D | 1 |
| Humeres, C | 1 |
| Troncoso, R | 1 |
| Vicencio, JM | 1 |
| Lavandero, S | 1 |
| Díaz-Araya, G | 1 |
9 other studies available for 4-phenylbutyric acid and Fibrosis
| Article | Year |
|---|---|
Role of endoplasmic reticulum stress in renal damage after myocardial infarction.
Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Fibro | 2021 |
Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model.
Topics: Adult; Animals; Antioxidants; Cell Differentiation; Contracture; Disease Models, Animal; Endoplasmic | 2018 |
Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Surviva | 2015 |
4-PBA prevents pressure overload-induced myocardial hypertrophy and interstitial fibrosis by attenuating endoplasmic reticulum stress.
Topics: Acetylation; Animals; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Endopl | 2015 |
Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro.
Topics: Animals; Endoplasmic Reticulum Stress; Fibrosis; Kidney Failure, Chronic; Male; Molecular Chaperones | 2016 |
Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Topics: Angiotensin II; Animals; Apoptosis; Biopsy; Blood Pressure; Disease Models, Animal; Endoplasmic Reti | 2017 |
4PBA strongly attenuates endoplasmic reticulum stress, fibrosis, and mitochondrial apoptosis markers in cyclosporine treated human gingival fibroblasts.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Cells, Cultured; Cyclosporine; Cytoprotecti | 2018 |
Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endoplasmi | 2017 |
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Endoplasmic Reticulum Stress; Fibrosis; Humans; Isoproterenol; Ma | 2012 |