penicillamine has been researched along with Fibrosis in 7 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serial liver biopsy changes have been reviewed in 30 patients with Indian childhood cirrhosis (ICC) who were randomly allocated to receive treatment with penicillamine in a dose of 20 mg/kg/day, 10 of whom also received prednisolone, and five receiving placebo." | 9.08 | Reversal of Indian childhood cirrhosis by D-penicillamine therapy. ( Bavdekar, AR; Bhave, SA; Joshi, VV; Pandit, AN; Pradhan, AM; Tanner, MS, 1995) |
| "Serial liver biopsy changes have been reviewed in 30 patients with Indian childhood cirrhosis (ICC) who were randomly allocated to receive treatment with penicillamine in a dose of 20 mg/kg/day, 10 of whom also received prednisolone, and five receiving placebo." | 5.08 | Reversal of Indian childhood cirrhosis by D-penicillamine therapy. ( Bavdekar, AR; Bhave, SA; Joshi, VV; Pandit, AN; Pradhan, AM; Tanner, MS, 1995) |
| "Some of the implications are that Alzheimer's disease and other diseases of neurodegeneration and fibrotic, inflammatory, and autoimmune diseases may be treatable by lowering the availability of free copper." | 2.44 | The risks of free copper in the body and the development of useful anticopper drugs. ( Brewer, GJ, 2008) |
| "The use of D-penicillamine in systemic sclerosis (SSc) has been controversial." | 2.41 | D-penicillamine in systemic sclerosis? Yes! ( Baker, C; Lucas, M; Medsger, TA; Wildy, KS, 2001) |
| "Systemic scleroderma is an acquired disorder which typically results in fibrosis of the skin and internal organs." | 2.38 | Activation of dermal connective tissue in scleroderma. ( Kähäri, VM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brewer, GJ | 2 |
| Pradhan, AM | 1 |
| Bhave, SA | 1 |
| Joshi, VV | 1 |
| Bavdekar, AR | 1 |
| Pandit, AN | 1 |
| Tanner, MS | 1 |
| Kähäri, VM | 1 |
| Farrington, ML | 1 |
| Haas, JE | 1 |
| Nazar-Stewart, V | 1 |
| Mellins, ED | 1 |
| Medsger, TA | 1 |
| Lucas, M | 1 |
| Wildy, KS | 1 |
| Baker, C | 1 |
| Uitto, J | 1 |
| Jimenez, S | 1 |
5 reviews available for penicillamine and Fibrosis
| Article | Year |
|---|---|
The risks of free copper in the body and the development of useful anticopper drugs.
Topics: Alzheimer Disease; Angiogenesis Inhibitors; Autoimmunity; Copper; Fibrosis; Hepatolenticular Degener | 2008 |
Anticopper therapy against cancer and diseases of inflammation and fibrosis.
Topics: Animals; Copper; Fibrosis; Humans; Inflammation; Molybdenum; Neoplasms; Neovascularization, Patholog | 2005 |
Activation of dermal connective tissue in scleroderma.
Topics: Cell Adhesion Molecules; Chemotaxis, Leukocyte; Collagen; Connective Tissue; Cyclosporine; Cytokines | 1993 |
D-penicillamine in systemic sclerosis? Yes!
Topics: Antirheumatic Agents; Collagen; Dose-Response Relationship, Drug; Double-Blind Method; Fibrosis; Hum | 2001 |
Fibrotic skin diseases. Clinical presentations, etiologic considerations, and treatment options.
Topics: Collagen; Fibrosis; Gene Expression; Humans; Penicillamine; Skin Diseases | 1990 |
1 trial available for penicillamine and Fibrosis
| Article | Year |
|---|---|
Reversal of Indian childhood cirrhosis by D-penicillamine therapy.
Topics: Biopsy; Copper; Female; Fibrosis; Humans; India; Infant; Inflammation; Liver; Liver Cirrhosis; Male; | 1995 |
1 other study available for penicillamine and Fibrosis
| Article | Year |
|---|---|
Eosinophilic fasciitis in children frequently progresses to scleroderma-like cutaneous fibrosis.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Eosinophilia; Fasciitis; Female; Fibrosis; Humans; Male | 1993 |