Page last updated: 2024-10-30

metformin and Fibrosis

metformin has been researched along with Fibrosis in 79 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

Research Excerpts

ExcerptRelevanceReference
" The potential protective outcome of the antidiabetic and pleiotropic drug metformin against TAA-induced chronic kidney disease in association with the modulation of AMP-activated protein kinase (AMPK), oxidative stress, inflammation, dyslipidemia, and systemic hypertension has not been investigated before."8.31Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension. ( Al-Ani, B; Albawardi, A; Alqahtani, SM; Alshahrani, MY; Bayoumy, NM; Ebrahim, HA; Haidara, MA; Kamar, SS; ShamsEldeen, AM, 2023)
"These findings show that metformin provides substantial protection against diabetic cardiomyopathy-induced ROS-p53 mediated fibrosis and dyslipidemia."8.31Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury. ( Al-Ani, B; Al-Hashem, F; Alzamil, NM; Bin-Jaliah, I; Dawood, AF; Haidara, MA; Hewett, PW; Kamar, SS; Latif, NSA; Shatoor, AS, 2023)
" Metformin, one of the most extensively used oral drugs against type 2 diabetes has recently been found to suppress tissue fibrosis as well."8.02Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization. ( Kawasaki, M; Mano, Y; Nakamura, E; Sakai, A; Suzuki, H; Tajima, T; Tokuda, K; Tsukamoto, M; Uchida, S; Wang, KY; Yamanaka, Y, 2021)
"This study demonstrates that metformin is able to attenuate HHcy-induced cardiac hypertrophy by decreasing myocardial fibrosis and apoptosis."8.02Metformin decreased myocardial fibrosis and apoptosis in hyperhomocysteinemia -induced cardiac hypertrophy. ( Huang, J; Song, W; Wang, D; Xu, C; Zhao, Q, 2021)
"This study aimed at comparing the effects of metformin on tubulointerstitial fibrosis (TIF) in different stages of diabetic nephropathy (DN) in vivo and evaluating the mechanism in high glucose (HG)-treated renal tubular epithelial cells (RTECs) in vitro."8.02Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy. ( Shi, K; Sun, D; Sun, H; Wang, F; Zhang, C; Zhang, X; Zuo, B, 2021)
"These data support a novel hypothesis that unifies the primary nonhereditary ovarian cancer risk factors through the development of ovarian fibrosis and the formation of a premetastatic niche, and suggests a potential use for metformin in ovarian cancer prophylaxis."7.96Metformin Abrogates Age-Associated Ovarian Fibrosis. ( Allen, CH; Azzi, F; Boyd, RW; Cook, DP; Forsyth, A; Gray, DA; Kelly, BS; Lo, B; McCloskey, CW; Murugkar, S; Rayner, KJ; Senterman, MK; Trudel, D; Upham, J; Vanderhyden, BC, 2020)
"Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro."7.91Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019)
"In conclusion, our study revealed new therapeutic potential of metformin to attenuate calcineurin inhibitor-induced renal fibrosis, which was closely related to the suppression of MEK/ERK1/2 pathway."7.91Metformin Attenuates Cyclosporine A-induced Renal Fibrosis in Rats. ( Huang, YX; Li, Y; Liang, S; Lin, CX; Liu, SY; Su, YF; Tao, J; Zhang, LS; Zhao, ZK; Zheng, JM, 2019)
"Metformin is a well-known AMP-activated protein kinase (AMPK) activator, and it has been shown to inhibit organ fibrosis."7.85Metformin attenuates renal fibrosis in both AMPKα2-dependent and independent manners. ( Feng, Y; Wang, S; Xiao, H; Zhang, Y, 2017)
"The purpose of this study is to assess the potential effects of metformin on the development of EMT and tubulointerstitial fibrosis 12 weeks after acute renal ischemia-reperfusion."7.83Metformin alleviated EMT and fibrosis after renal ischemia-reperfusion injury in rats. ( Chen, Z; Guo, J; Jiang, G; Liu, X; Wang, M; Weng, X, 2016)
"Oral administration of metformin or resveratrol prevented hypoxia and reduced HIF-1α accumulation with dephosphorylation of inositol-requiring enzyme 1α and eukaryotic initiation factor 2α, indicative of suppression of hypoxic HIF-1α activation and endoplasmic reticulum stress."7.83The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue. ( Huang, F; Kou, J; Li, A; Li, J; Li, X; Liu, B; Liu, K; Qi, LW; Qiu, Z; Wang, L, 2016)
"  Earlier studies from our group have revealed that clinically-relevant concentrations of the biguanide derivative metformin, the most widely used oral agent to lower blood glucose concentration in patients with type 2 diabetes and metabolic syndrome, notably decreased both the self-renewal and the proliferation of trastuzumab-refractory breast cancer stem cell populations."7.76Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis. ( Cufí, S; Joven, J; Martin-Castillo, B; Menendez, JA; Oliveras-Ferraros, C; Vazquez-Martin, A, 2010)
"Metformin inhibited cardiac fibrosis induced by pressure overload in vivo and inhibited collagen synthesis in CFs probably via inhibition of the TGF-beta(1)-Smad3 signalling pathway."7.76Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway. ( Feng, W; Fu, Y; Lu, Z; Ma, X; Shen, Q; Xiao, H; Xu, M; Zhang, Y; Zhu, Y, 2010)
"Metformin attenuated oxidative stress-induced cardiomyocyte apoptosis and prevented the progression of heart failure in dogs, along with activation of AMPK."7.75Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. ( Asakura, M; Asanuma, H; Fujita, M; Ito, S; Kim, J; Kitakaze, M; Komamura, K; Minamino, T; Mochizuki, N; Ogai, A; Sanada, S; Sasaki, H; Sugimachi, M; Takahama, H; Takashima, S; Wakeno, M, 2009)
"Liver fibrosis is a disease with significant morbidity and mortality."7.01Research progress of metformin in the treatment of liver fibrosis. ( Hu, C; Huang, Y; Li, B; Li, Y; Qian, F; Sun, W; Yang, F; Zhang, A, 2023)
"Glaucoma is the leading cause of irreversible blindness globally."6.72Metformin and Glaucoma-Review of Anti-Fibrotic Processes and Bioenergetics. ( Hurley, DJ; Irnaten, M; O'Brien, C, 2021)
"Metformin, which is a potent AMPK activator and is the only recommended first-line drug for the treatment of type 2 diabetes, has emerged as a promising method of fibrosis reduction or reversion."6.72Metformin and Fibrosis: A Review of Existing Evidence and Mechanisms. ( Guo, M; Liu, J; Long, Y; Tan, X; Wan, S; Wu, M; Xu, H; Xu, Y, 2021)
"Metformin, a type 2 diabetes mellitus (T2DM) medication, has been noted for its potent anti-fibrotic effects."5.91Metformin Attenuates TGF-β1-Induced Fibrosis in Salivary Gland: A Preliminary Study. ( Chen, Z; Cheng, Y; Li, B; Li, Y; Peng, B; Wang, L; Wang, X; Wei, L; Zhong, NN, 2023)
"As metformin has multiple therapeutic effects in many autoimmune diseases, we explored the effects of metformin on TAO in an in vitro fibroblast model."5.72Metformin Attenuates Inflammation and Fibrosis in Thyroid-Associated Ophthalmopathy. ( Sha, X; Sun, A; Xiao, W; Xu, Z; Yang, H; Yang, S; Ye, H; Zhang, T, 2022)
"Tofacitinib is a pan-JAK inhibitör."5.72Tofacitinib and metformin reduce the dermal thickness and fibrosis in mouse model of systemic sclerosis. ( Akar, ZA; Akkoc, RF; Celik, C; Dagli, AF; Etem, EO; Karatas, A; Koca, SS; Oz, B, 2022)
"Metformin is a well-known pharmacological agent for the treatment of diabetes; however, the application of large doses of the drug is limited by its side effects."5.72Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy. ( Bai, J; Hong, X; Liu, J; Nie, C; Pan, S; Wang, B; Xi, S; Yang, W; Yu, M; Zou, R, 2022)
"Suppression of inflammation is an effective therapeutic strategy for treating cardiac fibrosis and HF."5.72Gentiopicroside alleviates cardiac inflammation and fibrosis in T2DM rats through targeting Smad3 phosphorylation. ( Hu, XP; Huang, P; Huang, ZJ; Liu, T; Pan, ZF; Shi, JN; Sun, ZY; Xu, YN; Yuan, MN; Zhang, YW; Zou, XZ, 2022)
"Ovarian fibrosis is a pathological condition associated with aging and is responsible for a variety of ovarian dysfunctions."5.72Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. ( Cook, DP; Fasih, S; Landry, DA; Upham, J; Vanderhyden, BC; Yakubovich, E, 2022)
"Metformin treatment markedly reduced postinfarction fibrotic remodeling and CD68-positive cell population in mice."5.62Metformin Attenuates Postinfarction Myocardial Fibrosis and Inflammation in Mice. ( Boal, F; Cussac, D; Korda, M; Kramar, S; Kunduzova, O; Laborde, C; Loi, H; Marsal, D; Oleshchuk, O; Pizzinat, N; Roncalli, J; Tronchere, H, 2021)
"Although the pathogenesis of systemic sclerosis is not exactly known, it is thought that immune activation has prominent roles in pathogenesis."5.62Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin-17 levels in bleomycin-induced dermal fibrosis. ( Akar, ZA; Celik, C; Dagli, AF; Etem, EO; Karatas, A; Koca, SS; Oz, B, 2021)
" In the present study, we took advantage of a transgenic mouse (TG221) characterized by microRNA-221 overexpression, with cirrhotic liver background induced by chronic administration of carbon tetrachloride (CCl4)."5.51Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019)
"Metformin has been the most prescribed glucose-lowering medicine worldwide, and its potential for many other therapeutic applications is also being explored intensively."5.48Metformin attenuates folic-acid induced renal fibrosis in mice. ( Cao, Q; Chen, J; Chen, XM; Huang, C; Pollock, CA; Shi, Y; Yi, H; Zhang, L; Zhao, Y, 2018)
"Skin fibrosis was analyzed by staining with H&E and Masson's trichrome stain."5.48Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3. ( Byeon, HJ; Cho, J; Choi, WH; Han, SY; Kang, JW; Kim, CS; Kim, JM; Kim, JY; Lee, EJ; Lee, WJ; Lee, YS; Oh, SH; Yoo, BR; Yoo, H, 2018)
" The main risk factors for developing HCC are well known and include hepatitis B and C virus infection, alcohol intake and ingestion of the fungal metabolite aflatoxin B1."4.93Hepatocellular carcinoma. ( Gores, G; Llovet, JM; Pikarsky, E; Sangro, B; Schwartz, M; Sherman, M; Zucman-Rossi, J, 2016)
" We will discuss a range of adverse events to iodinated and gadolinium-based contrast agents, including allergic-like reactions, nephrotoxicity, extravasation, and nephrogenic systemic fibrosis."4.91Intravenous Imaging Contrast Media Complications: The Basics That Every Clinician Needs to Know. ( Choi, JW; Rose, TA, 2015)
" The potential protective outcome of the antidiabetic and pleiotropic drug metformin against TAA-induced chronic kidney disease in association with the modulation of AMP-activated protein kinase (AMPK), oxidative stress, inflammation, dyslipidemia, and systemic hypertension has not been investigated before."4.31Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension. ( Al-Ani, B; Albawardi, A; Alqahtani, SM; Alshahrani, MY; Bayoumy, NM; Ebrahim, HA; Haidara, MA; Kamar, SS; ShamsEldeen, AM, 2023)
" We tested the drugs metformin (AMPK activator) and baicalin (CPT1A activator) in different experimental models mimicking COVID-19 associated inflammation in lung and kidney."4.31Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney. ( Alcalde-Estévez, E; Castillo, C; Castro, A; Costa, IG; Fernández, L; Herrero, JI; Jansen, J; Kramann, R; Lamas, S; Miguel, V; Nagai, J; Ranz, I; Reimer, KC; Rey-Serra, C; Rodríguez González-Moro, JM; Sancho, D; Sevilla, L; Sirera, B; Tituaña, J, 2023)
"These findings show that metformin provides substantial protection against diabetic cardiomyopathy-induced ROS-p53 mediated fibrosis and dyslipidemia."4.31Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury. ( Al-Ani, B; Al-Hashem, F; Alzamil, NM; Bin-Jaliah, I; Dawood, AF; Haidara, MA; Hewett, PW; Kamar, SS; Latif, NSA; Shatoor, AS, 2023)
"5 % cholic acid and 60 % cocoa butter for 6 weeks causing a number of metabolic and hepatic alterations including insulin resistance, dyslipidemia, systemic inflammation, increased hepatic oxidative stress and lipid peroxidation, hepatic steatosis, lobular inflammation, as well as increased markers of liver inflammation and hepatocyte apoptosis."4.12Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms. ( Aly, RG; Alzaim, I; El-Mallah, A; El-Yazbi, AF; Shaaban, HH; Wahid, A, 2022)
"This study aimed at comparing the effects of metformin on tubulointerstitial fibrosis (TIF) in different stages of diabetic nephropathy (DN) in vivo and evaluating the mechanism in high glucose (HG)-treated renal tubular epithelial cells (RTECs) in vitro."4.02Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy. ( Shi, K; Sun, D; Sun, H; Wang, F; Zhang, C; Zhang, X; Zuo, B, 2021)
" Metformin, one of the most extensively used oral drugs against type 2 diabetes has recently been found to suppress tissue fibrosis as well."4.02Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization. ( Kawasaki, M; Mano, Y; Nakamura, E; Sakai, A; Suzuki, H; Tajima, T; Tokuda, K; Tsukamoto, M; Uchida, S; Wang, KY; Yamanaka, Y, 2021)
"This study demonstrates that metformin is able to attenuate HHcy-induced cardiac hypertrophy by decreasing myocardial fibrosis and apoptosis."4.02Metformin decreased myocardial fibrosis and apoptosis in hyperhomocysteinemia -induced cardiac hypertrophy. ( Huang, J; Song, W; Wang, D; Xu, C; Zhao, Q, 2021)
"These data support a novel hypothesis that unifies the primary nonhereditary ovarian cancer risk factors through the development of ovarian fibrosis and the formation of a premetastatic niche, and suggests a potential use for metformin in ovarian cancer prophylaxis."3.96Metformin Abrogates Age-Associated Ovarian Fibrosis. ( Allen, CH; Azzi, F; Boyd, RW; Cook, DP; Forsyth, A; Gray, DA; Kelly, BS; Lo, B; McCloskey, CW; Murugkar, S; Rayner, KJ; Senterman, MK; Trudel, D; Upham, J; Vanderhyden, BC, 2020)
"Metformin, an AMP-activated protein kinase (AMPK) activator, has been shown in previous studies to reduce kidney fibrosis in different models of experimental chronic kidney disease (CKD)."3.96Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease. ( Borges, CM; de Ávila, VF; Formigari, GP; Fujihara, CK; Lopes de Faria, JB; Malheiros, DMAC, 2020)
"Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro."3.91Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019)
"In conclusion, our study revealed new therapeutic potential of metformin to attenuate calcineurin inhibitor-induced renal fibrosis, which was closely related to the suppression of MEK/ERK1/2 pathway."3.91Metformin Attenuates Cyclosporine A-induced Renal Fibrosis in Rats. ( Huang, YX; Li, Y; Liang, S; Lin, CX; Liu, SY; Su, YF; Tao, J; Zhang, LS; Zhao, ZK; Zheng, JM, 2019)
"Metformin is a well-known AMP-activated protein kinase (AMPK) activator, and it has been shown to inhibit organ fibrosis."3.85Metformin attenuates renal fibrosis in both AMPKα2-dependent and independent manners. ( Feng, Y; Wang, S; Xiao, H; Zhang, Y, 2017)
"Oral administration of metformin or resveratrol prevented hypoxia and reduced HIF-1α accumulation with dephosphorylation of inositol-requiring enzyme 1α and eukaryotic initiation factor 2α, indicative of suppression of hypoxic HIF-1α activation and endoplasmic reticulum stress."3.83The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue. ( Huang, F; Kou, J; Li, A; Li, J; Li, X; Liu, B; Liu, K; Qi, LW; Qiu, Z; Wang, L, 2016)
"The purpose of this study is to assess the potential effects of metformin on the development of EMT and tubulointerstitial fibrosis 12 weeks after acute renal ischemia-reperfusion."3.83Metformin alleviated EMT and fibrosis after renal ischemia-reperfusion injury in rats. ( Chen, Z; Guo, J; Jiang, G; Liu, X; Wang, M; Weng, X, 2016)
" What is the main finding and its importance? We demonstrated, for the first time, that DPP-4 inhibitor, but not metformin, exerted similar efficacy in improving cardiac function and attenuating cardiac fibrosis compared with enalapril in rats with chronic MI."3.81Dipeptidyl peptidase-4 inhibitor improves cardiac function by attenuating adverse cardiac remodelling in rats with chronic myocardial infarction. ( Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Inthachai, T; Kumfu, S; Lekawanvijit, S; Pongkan, W, 2015)
"  Earlier studies from our group have revealed that clinically-relevant concentrations of the biguanide derivative metformin, the most widely used oral agent to lower blood glucose concentration in patients with type 2 diabetes and metabolic syndrome, notably decreased both the self-renewal and the proliferation of trastuzumab-refractory breast cancer stem cell populations."3.76Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis. ( Cufí, S; Joven, J; Martin-Castillo, B; Menendez, JA; Oliveras-Ferraros, C; Vazquez-Martin, A, 2010)
"Metformin inhibited cardiac fibrosis induced by pressure overload in vivo and inhibited collagen synthesis in CFs probably via inhibition of the TGF-beta(1)-Smad3 signalling pathway."3.76Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway. ( Feng, W; Fu, Y; Lu, Z; Ma, X; Shen, Q; Xiao, H; Xu, M; Zhang, Y; Zhu, Y, 2010)
"Metformin attenuated oxidative stress-induced cardiomyocyte apoptosis and prevented the progression of heart failure in dogs, along with activation of AMPK."3.75Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. ( Asakura, M; Asanuma, H; Fujita, M; Ito, S; Kim, J; Kitakaze, M; Komamura, K; Minamino, T; Mochizuki, N; Ogai, A; Sanada, S; Sasaki, H; Sugimachi, M; Takahama, H; Takashima, S; Wakeno, M, 2009)
"Liver fibrosis is a disease with significant morbidity and mortality."3.01Research progress of metformin in the treatment of liver fibrosis. ( Hu, C; Huang, Y; Li, B; Li, Y; Qian, F; Sun, W; Yang, F; Zhang, A, 2023)
"Metformin, which is a potent AMPK activator and is the only recommended first-line drug for the treatment of type 2 diabetes, has emerged as a promising method of fibrosis reduction or reversion."2.72Metformin and Fibrosis: A Review of Existing Evidence and Mechanisms. ( Guo, M; Liu, J; Long, Y; Tan, X; Wan, S; Wu, M; Xu, H; Xu, Y, 2021)
"Glaucoma is the leading cause of irreversible blindness globally."2.72Metformin and Glaucoma-Review of Anti-Fibrotic Processes and Bioenergetics. ( Hurley, DJ; Irnaten, M; O'Brien, C, 2021)
"Fibrosis is a general term encompassing a plethora of pathologies that span all systems and is marked by increased deposition of collagen."2.53AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation. ( Beauloye, C; Bertrand, L; Daskalopoulos, EP; Dufeys, C; Horman, S, 2016)
"Obesity is known to be the most common cause of simple steatosis in the preadolescent and adolescent population with a consequent serious health risk."2.47[Fatty liver and its clinical management in obese adolescents]. ( Álvarez Ferre, J; González Jiménez, E; Schmidt Río-Valle, J, 2011)
"Metformin, a type 2 diabetes mellitus (T2DM) medication, has been noted for its potent anti-fibrotic effects."1.91Metformin Attenuates TGF-β1-Induced Fibrosis in Salivary Gland: A Preliminary Study. ( Chen, Z; Cheng, Y; Li, B; Li, Y; Peng, B; Wang, L; Wang, X; Wei, L; Zhong, NN, 2023)
"Cardiac fibrosis was analyzed using immunohistochemistry, Masson's trichrome staining, and Western blot analysis."1.91Metformin suppresses cardiac fibroblast proliferation under high-glucose conditions via regulating the mitochondrial complex I protein Grim-19 involved in the Sirt1/Stat3 signaling pathway. ( Cui, X; Han, B; Li, Y; Liu, X; Ma, S; Pan, H; Wan, L; Wei, J, 2023)
"Metformin was administered via drinking water to mice with a unilateral ureteric obstruction (UUO) model of renal fibrosis."1.91Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney. ( Gleich, K; Harley, G; Katerelos, M; Lee, M; Mount, PF; Power, DA, 2023)
"Ascites is associated with a high risk of death."1.72Incidence of, Risk Factors for, and Outcomes After Ascites in a Population-Based Cohort of Older Americans. ( Mazumder, N; Parikh, ND; Tapper, EB; Zhao, Z, 2022)
"Tofacitinib is a pan-JAK inhibitör."1.72Tofacitinib and metformin reduce the dermal thickness and fibrosis in mouse model of systemic sclerosis. ( Akar, ZA; Akkoc, RF; Celik, C; Dagli, AF; Etem, EO; Karatas, A; Koca, SS; Oz, B, 2022)
"As metformin has multiple therapeutic effects in many autoimmune diseases, we explored the effects of metformin on TAO in an in vitro fibroblast model."1.72Metformin Attenuates Inflammation and Fibrosis in Thyroid-Associated Ophthalmopathy. ( Sha, X; Sun, A; Xiao, W; Xu, Z; Yang, H; Yang, S; Ye, H; Zhang, T, 2022)
"Ovarian fibrosis is a pathological condition associated with aging and is responsible for a variety of ovarian dysfunctions."1.72Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. ( Cook, DP; Fasih, S; Landry, DA; Upham, J; Vanderhyden, BC; Yakubovich, E, 2022)
"Suppression of inflammation is an effective therapeutic strategy for treating cardiac fibrosis and HF."1.72Gentiopicroside alleviates cardiac inflammation and fibrosis in T2DM rats through targeting Smad3 phosphorylation. ( Hu, XP; Huang, P; Huang, ZJ; Liu, T; Pan, ZF; Shi, JN; Sun, ZY; Xu, YN; Yuan, MN; Zhang, YW; Zou, XZ, 2022)
"Metformin is a well-known pharmacological agent for the treatment of diabetes; however, the application of large doses of the drug is limited by its side effects."1.72Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy. ( Bai, J; Hong, X; Liu, J; Nie, C; Pan, S; Wang, B; Xi, S; Yang, W; Yu, M; Zou, R, 2022)
"Metformin was administered in the drinking water (200 mg/kg/d) for 24 weeks."1.62AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice. ( Han, YC; Li, AM; Liu, YT; Peng, CH; Song, N; Tang, SQ; Wu, XQ; Yang, M; Yang, S; Zhan, M; Zhang, H; Zhang, W, 2021)
"Although the pathogenesis of systemic sclerosis is not exactly known, it is thought that immune activation has prominent roles in pathogenesis."1.62Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin-17 levels in bleomycin-induced dermal fibrosis. ( Akar, ZA; Celik, C; Dagli, AF; Etem, EO; Karatas, A; Koca, SS; Oz, B, 2021)
" This study aimed to evaluate the role of Met as anti-schistosomal and anti-fibrotic agents alone or in combination with PZQ treatment."1.62An adjuvant effect of Metformin as an anti-fibrotic agent when administered with the anti-schistosomal Praziquantel in Schistosoma mansoni infected mice. ( El-Naggar, SA; El-Said, KS; Harras, SF; Salama, WM, 2021)
"Treatment with metformin suppressed the activation of Smad3 and compensated the diminished autophagy in 9-wk pBOO rat bladders."1.62Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction. ( Chen, L; Cui, J; Gao, Z; Jiang, X; Li, Y; Liu, Y; Lv, L; Shi, B; Wang, S; Xia, Y; Zhang, L; Zhang, X; Zhou, N, 2021)
"Metformin treatment markedly reduced postinfarction fibrotic remodeling and CD68-positive cell population in mice."1.62Metformin Attenuates Postinfarction Myocardial Fibrosis and Inflammation in Mice. ( Boal, F; Cussac, D; Korda, M; Kramar, S; Kunduzova, O; Laborde, C; Loi, H; Marsal, D; Oleshchuk, O; Pizzinat, N; Roncalli, J; Tronchere, H, 2021)
"Metformin is an AMP kinase (AMPK) activator, the widest used antidiabetic drug."1.62Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats. ( Ammar, HI; Ashour, H; Dhingra, S; Fadel, M; Kamar, SS; Rashed, LA; Shamseldeen, AM; Shoukry, HS; Srivastava, A, 2021)
"Fibrosis was significantly less in treated mice atria."1.62Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation. ( Dixit, G; Li, Z; Ozcan, C, 2021)
" In the present study, we took advantage of a transgenic mouse (TG221) characterized by microRNA-221 overexpression, with cirrhotic liver background induced by chronic administration of carbon tetrachloride (CCl4)."1.51Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019)
"Metformin is a biguanide derivative widely used for the treatment of type 2 diabetes mellitus."1.51Metformin inhibits TGF-beta 1-induced MCP-1 expression through BAMBI-mediated suppression of MEK/ERK1/2 signalling. ( Li, Y; Liang, D; Liang, W; Liu, S; Song, Z, 2019)
"Metformin (MET) has anti-inflammatory and anti-fibrotic effects, but its effect on the in vivo pathogenesis of scleroderma remains unknown."1.51Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg/Teff cells and reducing spleen germinal center formation. ( Feng, M; Gao, C; Guo, H; Li, X; Liang, Z; Luo, J; Qin, K; Wang, Y; Zhang, S; Zhao, X, 2019)
"Non-alcoholic fatty liver disease (NAFLD) may be associated with changes in bile acid (BA) metabolism."1.51Non-alcoholic fatty liver disease is associated with dysregulated bile acid synthesis and diarrhea: A prospective observational study. ( Appleby, RN; Khan, S; Manousou, P; Moghul, I; Neal, TD; Walters, JRF; Yee, M, 2019)
"Metformin was injected intraperitoneally after surgery."1.51Metformin Promotes Regeneration of the Injured Endometrium Via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis. ( Ansong, E; Lin, HL; Lin, Q; Shen, LE; Wu, XQ; Xu, XX; Zhang, SS, 2019)
"Skin fibrosis was analyzed by staining with H&E and Masson's trichrome stain."1.48Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3. ( Byeon, HJ; Cho, J; Choi, WH; Han, SY; Kang, JW; Kim, CS; Kim, JM; Kim, JY; Lee, EJ; Lee, WJ; Lee, YS; Oh, SH; Yoo, BR; Yoo, H, 2018)
"Metformin has been the most prescribed glucose-lowering medicine worldwide, and its potential for many other therapeutic applications is also being explored intensively."1.48Metformin attenuates folic-acid induced renal fibrosis in mice. ( Cao, Q; Chen, J; Chen, XM; Huang, C; Pollock, CA; Shi, Y; Yi, H; Zhang, L; Zhao, Y, 2018)
"This study suggests that atherosclerotic plaques in subjects with DM II are more prone to rupture because of impaired repair responses rather than to increased vascular inflammation."1.40Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes. ( Bengtsson, E; Björkbacka, H; Dunér, P; Edsfeldt, A; Gonçalves, I; Grufman, H; Melander, O; Mollet, IG; Nilsson, J; Nilsson, M; Nitulescu, M; Orho-Melander, M; Persson, A, 2014)
"Myocardial fibrosis is a key process in diabetic cardiomyopathy."1.39Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms. ( Ares-Carrasco, S; Caro-Vadillo, A; Egido, J; Iborra, C; Lorenzo, O; Picatoste, B; Ramírez, E; Tuñón, J, 2013)

Research

Studies (79)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (1.27)29.6817
2010's36 (45.57)24.3611
2020's42 (53.16)2.80

Authors

AuthorsStudies
Loi, H1
Kramar, S1
Laborde, C1
Marsal, D1
Pizzinat, N1
Cussac, D1
Roncalli, J1
Boal, F1
Tronchere, H1
Oleshchuk, O1
Korda, M1
Kunduzova, O1
Tokuda, K1
Yamanaka, Y1
Mano, Y1
Tsukamoto, M1
Tajima, T1
Suzuki, H1
Kawasaki, M1
Uchida, S1
Nakamura, E1
Wang, KY1
Sakai, A1
Hua, Z1
Wei, P1
Han, YC1
Tang, SQ1
Liu, YT1
Li, AM1
Zhan, M1
Yang, M1
Song, N1
Zhang, W1
Wu, XQ2
Peng, CH1
Zhang, H1
Yang, S2
Dong, X1
Jin, X1
Karatas, A2
Oz, B2
Celik, C2
Akar, ZA2
Akkoc, RF1
Etem, EO2
Dagli, AF2
Koca, SS2
Tapper, EB1
Zhao, Z1
Mazumder, N1
Parikh, ND1
Zou, R1
Nie, C1
Pan, S1
Wang, B1
Hong, X1
Xi, S1
Bai, J1
Yu, M1
Liu, J5
Yang, W1
Baeri, A1
Levraut, M1
Diazzi, S1
Camuzard, O1
Cegarra-Escolano, M1
Ploumellec, MA1
Balaguer, T1
Fassy, J1
Rezzonico, R1
Bellusci, S1
Mari, B1
Vassaux, G1
Zheng, D1
Chen, L2
Wei, Q1
Zhu, Z1
Liu, Z2
Jin, L1
Yang, G1
Xie, X1
Sun, H2
Shi, K2
Zuo, B2
Zhang, X4
Liu, Y4
Sun, D2
Wang, F3
Zou, XZ1
Zhang, YW1
Pan, ZF1
Hu, XP1
Xu, YN1
Huang, ZJ1
Sun, ZY1
Yuan, MN1
Shi, JN1
Huang, P1
Liu, T1
Landry, DA1
Yakubovich, E1
Cook, DP2
Fasih, S1
Upham, J2
Vanderhyden, BC2
Mahmoud, MF1
Elmaghraby, AM1
Ali, N1
Mostafa, I1
El-Shazly, AM1
Abdelfattah, MAO1
Sobeh, M1
Shaaban, HH1
Alzaim, I1
El-Mallah, A1
Aly, RG1
El-Yazbi, AF1
Wahid, A1
Lu, J2
Zhang, L4
Zhang, Y4
Gao, Y2
Yuan, X2
Xiang, M2
Tang, Q2
Septembre-Malaterre, A1
Boina, C1
Douanier, A1
Gasque, P1
Xu, Z1
Ye, H1
Xiao, W1
Sun, A1
Zhang, T1
Sha, X1
Yang, H1
Zhang, A1
Qian, F1
Li, Y6
Li, B2
Yang, F1
Hu, C1
Sun, W1
Huang, Y1
Harley, G1
Katerelos, M1
Gleich, K1
Lee, M1
Mount, PF1
Power, DA1
Alshahrani, MY1
Ebrahim, HA1
Alqahtani, SM1
Bayoumy, NM1
Kamar, SS3
ShamsEldeen, AM2
Haidara, MA2
Al-Ani, B2
Albawardi, A1
Li, D1
Zhao, A1
Zhu, J1
Wang, C1
Shen, J1
Zheng, Z1
Pan, F1
Chen, Q2
Yang, Y1
Liu, X2
Wan, L1
Han, B1
Ma, S1
Pan, H1
Wei, J1
Cui, X1
Petrocelli, JJ2
McKenzie, AI2
de Hart, NMMP1
Reidy, PT2
Mahmassani, ZS2
Keeble, AR1
Kaput, KL1
Wahl, MP1
Rondina, MT1
Marcus, RL1
Welt, CK1
Holland, WL1
Funai, K2
Fry, CS1
Drummond, MJ2
Miguel, V1
Rey-Serra, C1
Tituaña, J1
Sirera, B1
Alcalde-Estévez, E1
Herrero, JI1
Ranz, I1
Fernández, L1
Castillo, C1
Sevilla, L1
Nagai, J1
Reimer, KC1
Jansen, J1
Kramann, R1
Costa, IG1
Castro, A1
Sancho, D1
Rodríguez González-Moro, JM1
Lamas, S1
Wang, L2
Zhong, NN1
Wang, X1
Peng, B1
Chen, Z2
Wei, L1
Cheng, Y1
Shankaraiah, RC1
Callegari, E1
Guerriero, P1
Rimessi, A1
Pinton, P1
Gramantieri, L1
Silini, EM1
Sabbioni, S1
Negrini, M1
McCloskey, CW1
Kelly, BS1
Azzi, F1
Allen, CH1
Forsyth, A1
Rayner, KJ1
Gray, DA1
Boyd, RW1
Murugkar, S1
Lo, B1
Trudel, D1
Senterman, MK1
Gao, J1
Yuan, J1
Wang, Q1
Lei, T1
Shen, X1
Cui, B1
Zhang, F1
Ding, W1
Lu, Z2
Borges, CM1
Fujihara, CK1
Malheiros, DMAC1
de Ávila, VF1
Formigari, GP1
Lopes de Faria, JB1
Ozcan, C1
Dixit, G1
Li, Z1
Jeon, HB1
Roh, H1
Ahn, HM1
Lee, JH1
Yun, CO1
Roh, TS1
Lee, WJ2
Zhao, Q1
Song, W1
Huang, J1
Wang, D1
Xu, C1
Alzamil, NM1
Hewett, PW1
Al-Hashem, F1
Bin-Jaliah, I1
Shatoor, AS1
Latif, NSA1
Dawood, AF1
Ammar, HI1
Shoukry, HS1
Ashour, H1
Rashed, LA1
Fadel, M1
Srivastava, A1
Dhingra, S1
Song, Z2
Wu, T1
Sun, J1
Wang, H1
Hua, F1
Nicolas, YSM1
Kc, R1
Chen, K2
Jin, Z1
Zhang, M1
Lv, L1
Gao, Z1
Wang, S2
Zhou, N1
Xia, Y1
Cui, J2
Jiang, X1
Shi, B1
Wu, M1
Xu, H1
Tan, X1
Wan, S1
Guo, M1
Long, Y1
Xu, Y1
Salama, WM1
El-Naggar, SA1
Harras, SF1
El-Said, KS1
Zhang, C2
Fix, DK1
Montgomery, JA1
de Hart, NM1
Ferrara, PJ1
Kelley, JJ1
Eshima, H1
Hurley, DJ1
Irnaten, M1
O'Brien, C1
Nesti, L1
Natali, A1
Yi, H1
Huang, C1
Shi, Y1
Cao, Q1
Zhao, Y1
Chen, J1
Pollock, CA1
Chen, XM1
Sudhakara, G1
Mallaiah, P1
Rajendran, R1
Saralakumari, D1
Asensio-Lopez, MDC1
Lax, A1
Fernandez Del Palacio, MJ1
Sassi, Y1
Hajjar, RJ1
Pascual-Figal, DA1
Liang, D1
Liang, W1
Liu, S1
Kim, JM1
Yoo, H1
Kim, JY1
Oh, SH1
Kang, JW1
Yoo, BR1
Han, SY1
Kim, CS1
Choi, WH1
Lee, EJ1
Byeon, HJ1
Lee, YS1
Cho, J1
Dong, G1
Ma, M1
Lin, X1
Liu, H1
Gao, D1
Ren, Z1
Chen, R1
Melendez, GC1
Lesnefsky, EJ1
Abdel-Hamid, AAM1
Firgany, AEL1
Xu, XX1
Zhang, SS1
Lin, HL1
Lin, Q1
Shen, LE1
Ansong, E1
Appleby, RN1
Moghul, I1
Khan, S1
Yee, M1
Manousou, P1
Neal, TD1
Walters, JRF1
Lin, CX1
Liang, S1
Tao, J1
Zhang, LS1
Su, YF1
Huang, YX1
Zhao, ZK1
Liu, SY1
Zheng, JM1
Wang, Y2
Zhang, S1
Liang, Z1
Feng, M1
Zhao, X1
Qin, K1
Gao, C1
Li, X3
Guo, H1
Luo, J1
Malekpour-Dehkordi, Z1
Teimourian, S1
Nourbakhsh, M1
Naghiaee, Y1
Sharifi, R1
Mohiti-Ardakani, J1
Ianiro, G1
Ponziani, FR1
Gasbarrini, A1
Cammarota, G1
Shen, S1
Xia, Yj1
Yi, L1
Gao, Q1
Picatoste, B1
Ramírez, E1
Caro-Vadillo, A1
Iborra, C1
Ares-Carrasco, S1
Egido, J1
Tuñón, J1
Lorenzo, O1
Edsfeldt, A1
Gonçalves, I1
Grufman, H1
Nitulescu, M1
Dunér, P1
Bengtsson, E1
Mollet, IG1
Persson, A1
Nilsson, M1
Orho-Melander, M1
Melander, O1
Björkbacka, H1
Nilsson, J1
Han, Y1
Jung, HW1
Park, YK1
Kim, H1
Moon, SY1
Kim, JS1
Baek, CH1
Kim, M1
Min, JY1
Lee, SK1
Rose, TA1
Choi, JW1
Inthachai, T1
Lekawanvijit, S1
Kumfu, S1
Apaijai, N1
Pongkan, W1
Chattipakorn, SC1
Chattipakorn, N1
Cavaglieri, RC1
Day, RT1
Feliers, D1
Abboud, HE1
Daskalopoulos, EP1
Dufeys, C1
Bertrand, L1
Beauloye, C1
Horman, S1
Wang, M1
Weng, X1
Guo, J1
Jiang, G1
Li, J2
Li, A1
Qiu, Z1
Qi, LW1
Kou, J1
Liu, K1
Liu, B1
Huang, F1
Llovet, JM1
Zucman-Rossi, J1
Pikarsky, E1
Sangro, B1
Schwartz, M1
Sherman, M1
Gores, G1
Ursini, F1
Grembiale, RD1
D'Antona, L1
Gallo, E1
D'Angelo, S1
Citraro, R1
Visca, P1
Olivieri, I1
De Sarro, G1
Perrotti, N1
Russo, E1
Mummidi, S1
Das, NA1
Carpenter, AJ1
Kandikattu, H1
Krenz, M1
Siebenlist, U1
Valente, AJ1
Chandrasekar, B1
Duan, W1
Jiang, Z1
Chen, X1
Sun, L1
Lei, J1
Xu, Q1
Ma, J1
Han, L1
Wang, Z1
Wu, Z1
Wu, E1
Ma, Q1
Ma, Z1
Feng, Y1
Xiao, H2
Sasaki, H1
Asanuma, H1
Fujita, M1
Takahama, H1
Wakeno, M1
Ito, S1
Ogai, A1
Asakura, M1
Kim, J1
Minamino, T1
Takashima, S1
Sanada, S1
Sugimachi, M1
Komamura, K1
Mochizuki, N1
Kitakaze, M1
Ma, X1
Feng, W1
Fu, Y1
Xu, M1
Shen, Q1
Zhu, Y1
Cufí, S1
Vazquez-Martin, A1
Oliveras-Ferraros, C1
Martin-Castillo, B1
Joven, J1
Menendez, JA1
González Jiménez, E1
Schmidt Río-Valle, J1
Álvarez Ferre, J1
Yin, M1
van der Horst, IC1
van Melle, JP1
Qian, C1
van Gilst, WH1
Silljé, HH1
de Boer, RA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Use of Metformin in Prevention and Treatment of Cardiac Fibrosis in PAI-1 Deficient Population[NCT05317806]Phase 415 participants (Anticipated)Interventional2022-10-10Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for metformin and Fibrosis

ArticleYear
Research progress of metformin in the treatment of liver fibrosis.
    International immunopharmacology, 2023, Volume: 116

    Topics: Fibrosis; Humans; Hypoglycemic Agents; Liver; Liver Cirrhosis; Metformin

2023
Metformin and Fibrosis: A Review of Existing Evidence and Mechanisms.
    Journal of diabetes research, 2021, Volume: 2021

    Topics: AMP-Activated Protein Kinases; Animals; Enzyme Activation; Enzyme Activators; Extracellular Matrix;

2021
Metformin and Glaucoma-Review of Anti-Fibrotic Processes and Bioenergetics.
    Cells, 2021, 08-19, Volume: 10, Issue:8

    Topics: Animals; Fibrosis; Glaucoma; Humans; Metformin; Signal Transduction

2021
Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2017, Volume: 27, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Diseases; Diabetes Mellitus; Disease

2017
Intravenous Imaging Contrast Media Complications: The Basics That Every Clinician Needs to Know.
    The American journal of medicine, 2015, Volume: 128, Issue:9

    Topics: Contrast Media; Extravasation of Diagnostic and Therapeutic Materials; Fibrosis; Gadolinium; Humans;

2015
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation.
    Journal of molecular and cellular cardiology, 2016, Volume: 91

    Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Berberine; Cardiomegaly; Extracell

2016
Hepatocellular carcinoma.
    Nature reviews. Disease primers, 2016, 04-14, Volume: 2

    Topics: Aflatoxin B1; Alcohol Drinking; Carcinoma, Hepatocellular; Fibrosis; Hepatitis B; Hepatitis B Vaccin

2016
[Fatty liver and its clinical management in obese adolescents].
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2011, Volume: 58, Issue:1

    Topics: Adiponectin; Adolescent; Apoptosis; Biomarkers; Chemokines; Disease Progression; Fatty Liver; Fibros

2011

Trials

1 trial available for metformin and Fibrosis

ArticleYear
Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment.
    Aging cell, 2023, Volume: 22, Issue:11

    Topics: Cellular Senescence; Collagen; Female; Fibrosis; Humans; Inflammation; Male; Metformin; Muscle, Skel

2023

Other Studies

70 other studies available for metformin and Fibrosis

ArticleYear
Metformin Attenuates Postinfarction Myocardial Fibrosis and Inflammation in Mice.
    International journal of molecular sciences, 2021, Aug-30, Volume: 22, Issue:17

    Topics: Animals; Fibrosis; Hypoglycemic Agents; Inflammation; Male; Metformin; Mice; Mice, Inbred C57BL; Myo

2021
Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization.
    Scientific reports, 2021, 09-09, Volume: 11, Issue:1

    Topics: Animals; Contracture; Disease Models, Animal; Fibrosis; Gene Expression; Immobilization; Immunohisto

2021
Letter to the Editor: Comment on Jeon HB, et al. Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids ( Ann Plast Surg . 2021;86:406-411).
    Annals of plastic surgery, 2022, 09-01, Volume: 89, Issue:3

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta;

2022
AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice.
    Cell death & disease, 2021, 10-09, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2'-Deoxyguanosine; AMP-Activated Protein Kinases; Animals; Blood Glucose; Blood Urea Nitro

2021
Letter to the Editor: Comment on Jeon HB, et al. Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids ( Ann Plast Surg . 2021;86:406-411).
    Annals of plastic surgery, 2022, 09-01, Volume: 89, Issue:3

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta;

2022
Tofacitinib and metformin reduce the dermal thickness and fibrosis in mouse model of systemic sclerosis.
    Scientific reports, 2022, 02-15, Volume: 12, Issue:1

    Topics: Animals; Drug Therapy, Combination; Female; Fibrosis; Metformin; Mice; Mice, Inbred BALB C; Piperidi

2022
Incidence of, Risk Factors for, and Outcomes After Ascites in a Population-Based Cohort of Older Americans.
    Digestive diseases and sciences, 2022, Volume: 67, Issue:11

    Topics: Aged; Anticoagulants; Antiviral Agents; Ascites; Atorvastatin; Carvedilol; Diuretics; Fibrosis; Huma

2022
Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.
    Free radical biology & medicine, 2022, Volume: 183

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Hydrogen; Metformin;

2022
A role for metformin in the treatment of Dupuytren disease?
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 150

    Topics: Cells, Cultured; Dupuytren Contracture; Fibroblasts; Fibrosis; Humans; Metformin; Neoplasm Recurrenc

2022
[Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetic rats].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022, May-20, Volume: 42, Issue:5

    Topics: Animals; Antioxidants; Atrial Natriuretic Factor; Cardiomegaly; Diabetes Mellitus, Experimental; Fib

2022
Kidney-Targeted Drug Delivery System Based on Metformin-Grafted Chitosan for Renal Fibrosis Therapy.
    Molecular pharmaceutics, 2022, 09-05, Volume: 19, Issue:9

    Topics: Chitosan; Drug Carriers; Drug Delivery Systems; Fibrosis; Humans; Kidney; Low Density Lipoprotein Re

2022
Gentiopicroside alleviates cardiac inflammation and fibrosis in T2DM rats through targeting Smad3 phosphorylation.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 106

    Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Diabetes Mellitus, Type 2; Fibrosis; Heart Failure

2022
Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice.
    Science advances, 2022, 09-02, Volume: 8, Issue:35

    Topics: Animals; Female; Fibroblasts; Fibrosis; Humans; Metformin; Mice; Myofibroblasts; Ovary

2022
Black pepper oil (Piper nigrum L.) mitigates dexamethasone induced pancreatic damage via modulation of oxidative and nitrosative stress.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 153

    Topics: Animals; Blood Glucose; COVID-19 Drug Treatment; Dexamethasone; Dyslipidemias; Fibrosis; Insulin Res

2022
Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms.
    Life sciences, 2022, Nov-01, Volume: 308

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzhydryl Compounds; Biomarkers; Cholesterol; Chol

2022
The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB-mediated inflammatory response.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 157

    Topics: Animals; Diabetic Cardiomyopathies; Fibrosis; Interleukin-6; Metformin; Mice; NF-kappa B; Transformi

2023
The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB-mediated inflammatory response.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 157

    Topics: Animals; Diabetic Cardiomyopathies; Fibrosis; Interleukin-6; Metformin; Mice; NF-kappa B; Transformi

2023
The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB-mediated inflammatory response.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 157

    Topics: Animals; Diabetic Cardiomyopathies; Fibrosis; Interleukin-6; Metformin; Mice; NF-kappa B; Transformi

2023
The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB-mediated inflammatory response.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 157

    Topics: Animals; Diabetic Cardiomyopathies; Fibrosis; Interleukin-6; Metformin; Mice; NF-kappa B; Transformi

2023
Deciphering the Antifibrotic Property of Metformin.
    Cells, 2022, 12-16, Volume: 11, Issue:24

    Topics: Antigens, CD; Antigens, Neoplasm; Fibrosis; Humans; Lung; Metformin; Phosphatidylinositol 3-Kinases;

2022
Metformin Attenuates Inflammation and Fibrosis in Thyroid-Associated Ophthalmopathy.
    International journal of molecular sciences, 2022, Dec-07, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Fibrosis; Graves Ophthalmopathy; Humans; Inflammation; Metformin

2022
Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney.
    PloS one, 2023, Volume: 18, Issue:2

    Topics: Animals; Disease Models, Animal; Fibrosis; Kidney; Kidney Diseases; Metformin; Mice; Mutation; Phosp

2023
Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension.
    Molecules (Basel, Switzerland), 2023, Mar-18, Volume: 28, Issue:6

    Topics: AMP-Activated Protein Kinases; Animals; Down-Regulation; Dyslipidemias; Fibrosis; Hypertension; Infl

2023
Inhaled Lipid Nanoparticles Alleviate Established Pulmonary Fibrosis.
    Small (Weinheim an der Bergstrasse, Germany), 2023, Volume: 19, Issue:30

    Topics: COVID-19; Fibrosis; Humans; Liposomes; Lung; Metformin; Pulmonary Fibrosis; SARS-CoV-2

2023
Metformin suppresses cardiac fibroblast proliferation under high-glucose conditions via regulating the mitochondrial complex I protein Grim-19 involved in the Sirt1/Stat3 signaling pathway.
    Free radical biology & medicine, 2023, Volume: 206

    Topics: Animals; Cell Proliferation; Diabetic Cardiomyopathies; Electron Transport Complex I; Fibroblasts; F

2023
Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney.
    Redox biology, 2023, Volume: 68

    Topics: AMP-Activated Protein Kinases; Animals; COVID-19; Fatty Acids; Fibrosis; Humans; Inflammation; Kidne

2023
Metformin Attenuates TGF-β1-Induced Fibrosis in Salivary Gland: A Preliminary Study.
    International journal of molecular sciences, 2023, Nov-13, Volume: 24, Issue:22

    Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Fibroblasts; Fibrosis; Humans; Me

2023
Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma.
    Oncogene, 2019, Volume: 38, Issue:45

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Disease M

2019
Metformin Abrogates Age-Associated Ovarian Fibrosis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 02-01, Volume: 26, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Ovarian Epithelial; Child, Preschool; Female; Fi

2020
Metformin protects against PM
    Redox biology, 2020, Volume: 28

    Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Biopsy; Cell Line; Disease Models, Animal; Disea

2020
Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease.
    American journal of physiology. Renal physiology, 2020, 05-01, Volume: 318, Issue:5

    Topics: Albuminuria; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Disease Progression; En

2020
Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation.
    Journal of cardiovascular translational research, 2021, Volume: 14, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Atrial

2021
Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids.
    Annals of plastic surgery, 2021, 04-01, Volume: 86, Issue:4

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta;

2021
Metformin decreased myocardial fibrosis and apoptosis in hyperhomocysteinemia -induced cardiac hypertrophy.
    Current research in translational medicine, 2021, Volume: 69, Issue:1

    Topics: Adult; Animals; Apoptosis; Cardiomegaly; Cells, Cultured; Fibrosis; Heart; Humans; Hyperhomocysteine

2021
Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury.
    Archives of physiology and biochemistry, 2023, Volume: 129, Issue:3

    Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dyslipidemias; Fibros

2023
Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats.
    American journal of physiology. Heart and circulatory physiology, 2021, 04-01, Volume: 320, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cell Movement; Cell Survival; Cells, Cultured

2021
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
    Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:7

    Topics: Animals; Failed Back Surgery Syndrome; Fibrosis; HMGB1 Protein; Humans; Male; Metformin; Mice; Mice,

2021
Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction.
    American journal of physiology. Renal physiology, 2021, 05-01, Volume: 320, Issue:5

    Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytokines; Diseas

2021
Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin-17 levels in bleomycin-induced dermal fibrosis.
    International journal of rheumatic diseases, 2021, Volume: 24, Issue:6

    Topics: Animals; Antibodies, Monoclonal, Humanized; Bleomycin; Collagen; Disease Models, Animal; Female; Fib

2021
An adjuvant effect of Metformin as an anti-fibrotic agent when administered with the anti-schistosomal Praziquantel in Schistosoma mansoni infected mice.
    Tropical biomedicine, 2021, Jun-01, Volume: 38, Issue:2

    Topics: Adjuvants, Pharmaceutic; Animals; Anthelmintics; Diabetes Mellitus, Type 2; Fibrosis; Granuloma; Mal

2021
Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy.
    Scientific reports, 2021, 08-11, Volume: 11, Issue:1

    Topics: Animals; Autophagy; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial

2021
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:9

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Collagen; Fibrosis; Hindlimb Suspension;

2021
Metformin attenuates folic-acid induced renal fibrosis in mice.
    Journal of cellular physiology, 2018, Volume: 233, Issue:9

    Topics: Albuminuria; Animals; Cell Line; Chemokine CCL2; Collagen Type IV; Disease Models, Animal; Extracell

2018
Caralluma fimbriata and metformin protection of rat pancreas from high fat diet induced oxidative stress.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2018, Volume: 93, Issue:3

    Topics: Animals; Antioxidants; Apocynaceae; Diet, High-Fat; Fibrosis; Lipid Peroxidation; Male; Metformin; O

2018
Pharmacological inhibition of the mitochondrial NADPH oxidase 4/PKCα/Gal-3 pathway reduces left ventricular fibrosis following myocardial infarction.
    Translational research : the journal of laboratory and clinical medicine, 2018, Volume: 199

    Topics: Adenylate Kinase; Animals; Cells, Cultured; Culture Media, Conditioned; Enzyme Induction; Fibrosis;

2018
Metformin inhibits TGF-beta 1-induced MCP-1 expression through BAMBI-mediated suppression of MEK/ERK1/2 signalling.
    Nephrology (Carlton, Vic.), 2019, Volume: 24, Issue:4

    Topics: Animals; Cell Line; Chemokine CCL2; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fi

2019
Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 48, Issue:3

    Topics: Animals; Cells, Cultured; Class Ia Phosphatidylinositol 3-Kinase; Down-Regulation; Fibroblasts; Fibr

2018
Treatment-damaged hepatocellular carcinoma promotes activities of hepatic stellate cells and fibrosis through GDF15.
    Experimental cell research, 2018, 09-15, Volume: 370, Issue:2

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fibrosis; Growth Dif

2018
Metformin as a modulator of myocardial fibrosis postmyocardial infarction via regulation of cardiomyocyte-fibroblast crosstalk.
    Translational research : the journal of laboratory and clinical medicine, 2018, Volume: 199

    Topics: Fibroblasts; Fibrosis; Humans; Infarction; Metformin; Myocardial Infarction; Myocardium; Myocytes, C

2018
Favorable outcomes of metformin on coronary microvasculature in experimental diabetic cardiomyopathy.
    Journal of molecular histology, 2018, Volume: 49, Issue:6

    Topics: Animals; Coronary Vessels; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Hypoglycemic

2018
Metformin Promotes Regeneration of the Injured Endometrium Via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis.
    Reproductive sciences (Thousand Oaks, Calif.), 2019, Volume: 26, Issue:4

    Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Endometrium; Endoplasmic Reticulum S

2019
Non-alcoholic fatty liver disease is associated with dysregulated bile acid synthesis and diarrhea: A prospective observational study.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Bile Acids and Salts; Cholestenones; Diarrhea;

2019
Metformin Attenuates Cyclosporine A-induced Renal Fibrosis in Rats.
    Transplantation, 2019, Volume: 103, Issue:10

    Topics: Animals; Creatinine; Cyclosporine; Disease Models, Animal; Fibrosis; Humans; Immunosuppressive Agent

2019
Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg/Teff cells and reducing spleen germinal center formation.
    Molecular immunology, 2019, Volume: 114

    Topics: Animals; Bleomycin; Cell Differentiation; Collagen; Disease Models, Animal; Female; Fibrosis; Germin

2019
Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction.
    Life sciences, 2019, Sep-15, Volume: 233

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; Cell Differentiation; Collagen Type IV; Extracellular

2019
Letter: improvement of clinical outcomes by metformin in metabolic liver disease-a microbiota-dependent mechanism?
    Alimentary pharmacology & therapeutics, 2019, Volume: 50, Issue:4

    Topics: Diabetes Mellitus; Fibrosis; Humans; Liver; Liver Cirrhosis; Metformin; Microbiota; Non-alcoholic Fa

2019
Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats.
    Human reproduction (Oxford, England), 2013, Volume: 28, Issue:11

    Topics: Animals; Dehydroepiandrosterone; Female; Fibrosis; Hypoglycemic Agents; Hypolipidemic Agents; Metfor

2013
Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Diabetes Mellitus, Type 2; Di

2013
Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes.
    Arteriosclerosis, thrombosis, and vascular biology, 2014, Volume: 34, Issue:9

    Topics: Aged; Antihypertensive Agents; Carotid Artery Diseases; Cytokines; Diabetes Mellitus, Type 2; Diseas

2014
Selective therapeutic effect of cornus officinalis fruits on the damage of different organs in STZ-induced diabetic rats.
    The American journal of Chinese medicine, 2014, Volume: 42, Issue:5

    Topics: Actins; Animals; Cornus; Diabetes Mellitus, Experimental; Fibrosis; Fruit; Hypoglycemic Agents; Insu

2014
Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis.
    American journal of physiology. Renal physiology, 2015, Feb-01, Volume: 308, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP;

2015
Dipeptidyl peptidase-4 inhibitor improves cardiac function by attenuating adverse cardiac remodelling in rats with chronic myocardial infarction.
    Experimental physiology, 2015, Volume: 100, Issue:6

    Topics: Adamantane; Angiotensin-Converting Enzyme Inhibitors; Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Pe

2015
Metformin prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.
    Molecular and cellular endocrinology, 2015, Sep-05, Volume: 412

    Topics: Adenylate Kinase; Animals; Anti-Inflammatory Agents; Drug Evaluation, Preclinical; Fibrosis; Kidney

2015
Metformin alleviated EMT and fibrosis after renal ischemia-reperfusion injury in rats.
    Renal failure, 2016, Volume: 38, Issue:4

    Topics: Animals; Epithelial-Mesenchymal Transition; Fibrosis; Kidney; Male; Metformin; Random Allocation; Ra

2016
The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue.
    British journal of pharmacology, 2016, Volume: 173, Issue:12

    Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibrosis;

2016
Oral Metformin Ameliorates Bleomycin-Induced Skin Fibrosis.
    The Journal of investigative dermatology, 2016, Volume: 136, Issue:9

    Topics: Administration, Oral; Animals; Bleomycin; Disease Models, Animal; Female; Fibrosis; Humans; Metformi

2016
Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo.
    Journal of molecular and cellular cardiology, 2016, Volume: 98

    Topics: Adaptor Proteins, Signal Transducing; Aldosterone; AMP-Activated Protein Kinases; Animals; Cardiomeg

2016
Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression.
    Cancer letters, 2017, 01-28, Volume: 385

    Topics: AMP-Activated Protein Kinases; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Che

2017
Metformin attenuates renal fibrosis in both AMPKα2-dependent and independent manners.
    Clinical and experimental pharmacology & physiology, 2017, Volume: 44, Issue:6

    Topics: AMP-Activated Protein Kinases; Animals; Fibrosis; Gene Expression Regulation; Kidney; Metformin; Mic

2017
Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
    Circulation, 2009, May-19, Volume: 119, Issue:19

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; C

2009
Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway.
    Cardiovascular research, 2010, Aug-01, Volume: 87, Issue:3

    Topics: Active Transport, Cell Nucleus; Animals; Aorta, Thoracic; Cardiotonic Agents; Cells, Cultured; Colla

2010
Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.
    Cell cycle (Georgetown, Tex.), 2010, Nov-15, Volume: 9, Issue:22

    Topics: Animals; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cellular Senescence; Dogs; Epithelial-Mesenc

2010
Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Atrial Natriuretic Factor; Blood Glucose; Cardiotonic Agents

2011