Compounds > fraxinellone
Page last updated: 2024-11-07

fraxinellone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

fraxinellone: structure given in first source; RN given for (3R-cis)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID124039
CHEMBL ID257170
CHEBI ID181043
SCHEMBL ID17503653
MeSH IDM0203176

Synonyms (36)

Synonym
CHEBI:181043
(3r,3ar)-3-(uran-3-yl)-3a,7-dimethyl-3,4,5,6-tetrahydro-2-benzouran-1-one
fraxinellone
nsc-638730
NSC638730 ,
28808-62-0
NCI60_012928
1(3h)-isobenzofuranone, 3-(3-furanyl)-3a,4,5,6-tetrahydro-3a,7-dimethyl-, (3r-cis)-
phthalide, 3-(3-furyl)-3a,4,5,6-tetrahydro-3a,7-dimethyl-
CHEMBL257170
(3r,3ar)-3-(furan-3-yl)-3a,7-dimethyl-3,4,5,6-tetrahydro-2-benzofuran-1-one
(3r,3as)-3-(furan-3-yl)-3a,7-dimethyl-3,4,5,6-tetrahydro-2-benzofuran-1-one
S9100
SCHEMBL17503653
AKOS021768192
AC-35090
Q-100363
1(3h)-isobenzofuranone, 3-(3-furanyl)-3a,4,5,6-tetrahydro-3a,7-dimethyl-, (3r,3ar)-
fraxinellone, >=98% (hplc)
NCGC00385492-02
NCGC00385492-01
(3r*,3ar*)-3-(3-furanyl)-3a,4,5,6- tetrahydro-3a,7-dimethyl-2-benzofuran-1(3h)-one
BS-16428
mfcd11101451
(3r,3ar)-3-(furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3h)-one
F1187
A13918
HMS3886L16
CCG-266803
HY-N0242
CS-0008274
A876614
3-(furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydro-2-benzofuran-1(3h)-one
DTXSID30951450
2HP328XN7C
(3r,3ar)-3-(3-furanyl)-3a,4,5,6-tetrahydro-3a,7-dimethyl-1(3h)-isobenzofuranone

Research Excerpts

Overview

Fraxinellone is a naturally occurring degraded limonoid isolated from many species of plants in Meliaceae and Rutaceae. It is an important botanical lactone compound and has been demonstrated to have insecticidal activity.

ExcerptReferenceRelevance
"Fraxinellone is a tetrahydro-benzofuranone derivative with various pharmacological activities."( Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway.
Chen, Z; Huang, C; Huang, Y; Huang, Z; Shi, J; Sun, S; Wang, Q; Wang, Y; Xing, S; Xue, X, 2022)		2.89
"Fraxinellone is an important botanical lactone compound and has been demonstrated to have insecticidal activity. "( Spectroscopy, Thermodynamics and Molecular Docking of Fraxinellone with DNA.
Gou, X; Lei, J; Li, Z; Wei, S; Zhou, J, 2020)		2.25
"Fraxinellone is a naturally occurring degraded limonoid isolated from many species of plants in Meliaceae and Rutaceae. "( Toxicology study of fraxinellone as ovicidal agents against Mythimna separata Walker and Bombyx mori Linaeus.
Chen, S; Lv, M; Xu, H; Zhang, S, 2020)		2.32
"Fraxinellone (FRA) is a degraded limonoid isolated from the root bark of Dictamnus plants. "( Fraxinellone: From pesticidal control to cancer treatment.
Bailly, C; Vergoten, G, 2020)		3.44
"Fraxinellone is a natural product isolated from the D."( Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3.
Jin, X; Li, MY; Ma, J; Mi, C; Wang, JY; Wang, Z; Xing, Y; Zhang, ZH; Zuo, HX, 2018)		2.64

Effects

Fraxinellone has been reported to possess neuroprotective and vasorelaxing activities, but the effects and the mechanism of fraxinellones in inflammation have not been fully characterized. Fraxinella has significant anti-inflammatory activity in acute liver injury model.

ExcerptReferenceRelevance
"Fraxinellone has been reported to possess neuroprotective and vasorelaxing activities, but the effects and the mechanism of fraxinellone in inflammation have not been fully characterized."( Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells.
Choi, JH; Jung, HJ; Kim, JH; Lee, KT; Park, HJ; Park, SJ; Park, YM; Shin, JS, 2009)		2.52
"Fraxinellone has significant anti-inflammatory activity in acute liver injury model."( [Improving the solubility of fraxinellone to increase its oral bioavailability and hepatoprotective action against acute liver injury in mice].
Ran, QQ; Ruan, LP; Yu, BY; Zhu, DN, 2007)		1.35

Actions

ExcerptReferenceRelevance
"Fraxinellone was found to inhibit LPS-induced nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production, and to reduce the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the mRNA and protein levels in a dose-dependent manner."( Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells.
Choi, JH; Jung, HJ; Kim, JH; Lee, KT; Park, HJ; Park, SJ; Park, YM; Shin, JS, 2009)		2.52

Treatment

ExcerptReferenceRelevance
"Treatment with fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease."( Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone.
Chen, G; Feng, LL; Guo, WJ; Ouyang, ZJ; Shen, Y; Sun, Y; Wu, XD; Wu, XF; Xu, Q, 2014)		0.94

Toxicity

ExcerptReferenceRelevance
" In order to determine the toxic components, we investigated the cytotoxicity of extracts and chosen components using CCK-8 assay in HepG2 cells."( Subchronic Toxicity Studies of Cortex Dictamni Extracts in Mice and Its Potential Hepatotoxicity Mechanisms in Vitro.
Fan, Q; Wang, C; Wang, T; Wu, J; Xu, A; Zhang, J; Zhao, B, 2018)		0.48

Pharmacokinetics

ExcerptReferenceRelevance
" This rapid and sensitive method was fully validated and successfully applied to the pharmacokinetic study of limonin, dictamnine, obacunone and fraxinellone in the rat plasma after oral administration of Cortex Dictamni extract."( Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract.
Gao, E; Qu, W; Sun, J; Wang, P; Yu, Z; Zhao, Y, 2013)		0.83
"This study aims to characterize the pharmacokinetic (PK) profiles and identify important bioavailability barriers and pharmacological pathways of the key active components (KACs) of Antitumor B (ATB), a chemopreventive agent."( Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
Bui, D; Duan, S; Hu, M; Singh, R; Wei, B; Wong, SJ; Yang, P; Yin, T; You, M, 2021)		0.62

Bioavailability

The aim of the paper is to increase oral bioavailability of fraxinellone, thus improving its hepatoprotection effect in vivo.

ExcerptReferenceRelevance
" The aim of the paper is to increase oral bioavailability of fraxinellone, thus improving its hepatoprotection effect in vivo."( [Improving the solubility of fraxinellone to increase its oral bioavailability and hepatoprotective action against acute liver injury in mice].
Ran, QQ; Ruan, LP; Yu, BY; Zhu, DN, 2007)		0.87
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
"This study aims to characterize the pharmacokinetic (PK) profiles and identify important bioavailability barriers and pharmacological pathways of the key active components (KACs) of Antitumor B (ATB), a chemopreventive agent."( Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
Bui, D; Duan, S; Hu, M; Singh, R; Wei, B; Wong, SJ; Yang, P; Yin, T; You, M, 2021)		0.62
"The pharmacological activities of dictamnine and fraxinellone have been well reported; however, only a few studies have focused on the pharmacokinetics and bioavailability of concomitant delivery of these drugs in vivo."( A Methodology for Quantitation of Dictamnine and Fraxinellone and its Application to Study Pharmacokinetics and Bioavailability in Rats Via Oral and Intravenous Administration.
Chen, M; Chen, Y; Li, L; Lu, C; Shen, X; Tian, D; Wang, F; Yan, L; Yang, X; Ye, CJ; Yin, Q, 2023)		1.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
2-benzofurans
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (161)

Assay IDTitleYearJournalArticle
AID1815104Clearance in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815129MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815103Volume of distribution in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815101AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101745Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101715Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101730Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101763Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101728Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101729Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101723Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101735Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101778Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815093Antiproliferative activity against human CAL-27 cells assessed as cell viability measured after 72 hrs by MTT assay2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101770Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815115AUC (0 to 24 hrs) in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101757Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101762Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101725Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101750Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1082881Insecticidal activity against Mythimna separata (Oriental armyworm) in wheat leaves assessed as mortality rate at 1 mg/mL at 25 degC measured after 25 days by leaf-dipping method relative to control2012Journal of agricultural and food chemistry, Jul-18, Volume: 60, Issue:28
Synthesis and insecticidal activity of some novel fraxinellone-based esters.
AID1101737Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101742Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101781Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101772Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101718Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101777Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101766Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815123AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101708Antifeedant activity against adult of Sitophilus zeamais after 3 days2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1082880Insecticidal activity against Mythimna separata (Oriental armyworm) in wheat leaves assessed as mortality rate at 1 mg/mL at 25 degC measured after 35 days by leaf-dipping method relative to control2012Journal of agricultural and food chemistry, Jul-18, Volume: 60, Issue:28
Synthesis and insecticidal activity of some novel fraxinellone-based esters.
AID1101707Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) after 3 days2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815094Antiproliferative activity against human SCC-9 cells assessed as cell viability measured after 72 hrs by MTT assay2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101779Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815106Oral bioavailability in C57BL/6 mouse at 4000 mg/kg2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1092158Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in compound treated fresh corn leaves assessed as corrected mortality at 1 mg/ml measured after 10 days by leaf-dipping method2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents.
AID1101720Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101761Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101753Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101709Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101783Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101716Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815099Half life in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815105MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1092156Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in compound treated fresh corn leaves assessed as corrected mortality at 1 mg/ml measured after 35 days by leaf-dipping method2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents.
AID1101721Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815095Antiinflammatory activity against human SCC-9 cells assessed as inhibition of LPS-induced PGE2 production at 10 ug/ml preincubated for 30 mins followed by stimulation with LPS and measured after 12 hrs by LC-MS/MS analysis2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101712Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101714Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101764Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815114Cmax in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1092157Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in compound treated fresh corn leaves assessed as corrected mortality at 1 mg/ml measured after 20 days by leaf-dipping method2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents.
AID1101773Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101780Antifeedant activity against adult of Sitophilus zeamais assessed as relative growth rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101749Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101713Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815097Stability in mouse blood assessed as compound remaining measured at 20 degC for 8 hrs2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101736Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101739Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101765Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101740Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101706Antifeedant activity against adult of Tribolium castaneum (red flour beetle) after 3 days2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815113Tmax in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101760Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815096Stability in mouse blood assessed as compound recovery measured at 25 degC for 4 hrs2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID328118Neuroprotective activity against rat cortical cells at 0.1 uM assessed as glutamate-induced neurotoxicity by MTT assay2008Journal of natural products, Feb, Volume: 71, Issue:2
Neuroprotective limonoids of root bark of Dictamnus dasycarpus.
AID1101741Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101751Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101758Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101727Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101775Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101722Antifeedant activity against adult of Sitophilus zeamais assessed as feeding deterrence index at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101747Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1082882Insecticidal activity against Mythimna separata (Oriental armyworm) in wheat leaves assessed as mortality rate at 1 mg/mL at 25 degC measured after 10 days by leaf-dipping method relative to control2012Journal of agricultural and food chemistry, Jul-18, Volume: 60, Issue:28
Synthesis and insecticidal activity of some novel fraxinellone-based esters.
AID1101759Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID328116Neuroprotective activity against rat cortical cells assessed as glutamate-induced neurotoxicity by MTT assay2008Journal of natural products, Feb, Volume: 71, Issue:2
Neuroprotective limonoids of root bark of Dictamnus dasycarpus.
AID1101755Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101768Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101782Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101719Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101717Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101776Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815098Stability in mouse blood assessed as compound remaining measured at - 80 degC for 4 months2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815121Cmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101726Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101774Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101756Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101748Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101746Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815118MRT (0 to 24 hrs) in C57BL/6 mouse at 4000 mg/kg, po2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101711Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101724Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as mortality at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101744Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815100Cmax in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101771Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101732Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101767Antifeedant activity against adult of Sitophilus zeamais assessed as relative consumption rate at 10 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101769Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative growth rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101752Antifeedant activity against adult of Sitophilus zeamais assessed as efficiency of conversion of ingested food at 30 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101734Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101743Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as efficiency of conversion of ingested food at 3 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101733Antifeedant activity against adult of Sitophilus zeamais assessed as mortality at 300 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815102AUC (0 to infinity) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101754Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as relative consumption rate at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1815119Tmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day2021Journal of natural products, 09-24, Volume: 84, Issue:9
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1101710Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) assessed as feeding deterrence index at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1101731Antifeedant activity against adult of Tribolium castaneum (red flour beetle) assessed as mortality at 100 ppm after 3 days relative to control2002Journal of agricultural and food chemistry, Mar-13, Volume: 50, Issue:6
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
AID1347393qHTS for inhibitors of ER calcium dysfunction: SERCaMP assay screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347361HEK293 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347401Redox Reaction Profiling qHTS: Assay Interference Panel against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347358HPAF-II 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347366KB-3-1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347345OV-KATE Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347375qHTS for Hypoxia signaling pathway (HIF-1) agonists against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347362Diaphorse counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347360HPAF-II 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347396qHTS for inhibitors of Wild type Zika virus screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347377DH5-alpha competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347370qHTS for ATAD5 Antagonist screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347359HEK293 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347367qHTS for ATAD5 Agonist screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347388qHTS for Activators of p53 Stress Response Pathway screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347357HEK293 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347400Viability qHTS for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347364KB-8-5-11 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347355HEK-293 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347378qHTS for H2AX Agonists against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347394Vero-766 cells viability qHTS against the NCATS CANVASS Library: Counterscreen for Zika virus inhibition assay2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347363Firefly luciferase counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347389qHTS assay for small molecule disruptors of mitochondrial membrane potential screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347352COV-362 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347354UWB1.289-WTBRCA1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347392qHTS for activators of dead-cell proteases activity screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347369MCF7 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347381Inflammasome Signaling qHTS Counterscreen: IL-1-beta AlphaLISA counterscreen against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347380qHTS for Antimalaria activity screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347379qHTS for Inflammasome Signaling Inhibitors: IL-1-beta AlphaLISA screen against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347391qHTS for activators of Nrf2/ARE signaling pathway screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347402qHTS for inhibitors of Rabies Virus screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID134737610-beta competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347350SW1088 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347365SDT Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347356HPAF-II 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347347UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347374qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347368G06 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347371J3T Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347373qHTS for Constitutive Androstane Receptor (CAR) Agonist screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347348OV-SAHO Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347351U-118MG Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347346HPAF-II Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347353A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347349Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347387Cytotoxicity qHTS for assessment of Hepg2 cells membrane integrity screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347372qHTS for Constitutive Androstane Receptor (CAR) Antagonist screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347390Secretion counterscreen for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (46)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (2.17)18.2507
2000's10 (21.74)29.6817
2010's21 (45.65)24.3611
2020's14 (30.43)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.45

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.45 (24.57)
Research Supply Index3.85 (2.92)
Research Growth Index5.66 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.45)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other45 (97.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gallic acid
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.		2.1710trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
indoleacetic acid
indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841. auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").. indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.		2.1710indole-3-acetic acids;
monocarboxylic acid		auxin;
human metabolite;
mouse metabolite;
plant hormone;
plant metabolite
melatonin
[no description available]		2.1710acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
n-acetylserotonin
N-acetylserotonin : An N-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid.		2.1710acetamides;
N-acylserotonin;
phenols		antioxidant;
human metabolite;
mouse metabolite;
tropomyosin-related kinase B receptor agonist
naringenin
[no description available]		2.17104'-hydroxyflavanones;
trihydroxyflavanone
phenethylamine
phenethylamine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7016. 2-phenylethylamine : A phenylethylamine having the phenyl substituent at the 2-position.		2.1710alkaloid;
aralkylamine;
phenylethylamine		Escherichia coli metabolite;
human metabolite;
mouse metabolite
tryptamine
[no description available]		2.1710aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite
5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
[no description available]		2.1710catechin
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.110aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
hydroxyindoleacetic acid
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.		2.1710indole-3-acetic acidsdrug metabolite;
human metabolite;
mouse metabolite
5-methoxytryptamine
5-Methoxytryptamine: Serotonin derivative proposed as potentiator for hypnotics and sedatives.. 5-methoxytryptamine : A member of the class of tryptamines that is the methyl ether derivative of serotonin.		2.1710aromatic ether;
primary amino compound;
tryptamines		5-hydroxytryptamine 2A receptor agonist;
5-hydroxytryptamine 2B receptor agonist;
5-hydroxytryptamine 2C receptor agonist;
antioxidant;
cardioprotective agent;
human metabolite;
mouse metabolite;
neuroprotective agent;
radiation protective agent;
serotonergic agonist
7,8-dihydroxyflavone
7,8-dihydroxyflavone : A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's.		2.1710dihydroxyflavoneantidepressant;
antineoplastic agent;
antioxidant;
plant metabolite;
tropomyosin-related kinase B receptor agonist
4',7-dihydroxyflavanone
[no description available]		2.17104'-hydroxyflavanones;
dihydroxyflavanone;
polyphenol		Brassica napus metabolite;
fungal xenobiotic metabolite
bay-k-8644
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.. Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644. methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.		1.9810(trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		1.9810aromatic ether;
nitrile;
polyether;
tertiary amino compound
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.3110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
glyburide
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide. glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.		1.9810monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
harmaline
Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.. harmaline : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.		2.1710harmala alkaloidoneirogen
octopamine
Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.. octopamine : A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.		2.1710phenylethanolamines;
tyramines		neurotransmitter
potassium chloride
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion.		1.9810inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
tyramine
[no description available]		2.1710monoamine molecular messenger;
primary amino compound;
tyramines		EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		2.0310chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.		2.1710adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
n-methyltryptamine
N-methyltryptamine: RN given refers to parent cpd		2.1710tryptamine alkaloid;
tryptamines		metabolite
gramine
gramine : An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.		2.1710aminoalkylindole;
indole alkaloid;
tertiary amino compound		antibacterial agent;
antiviral agent;
plant metabolite;
serotonergic antagonist
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		1.9810pyrrole;
secondary amine
yohimbine
Yohimbine: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.. yohimbine : An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.		2.1710methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
methyl-4-tyramine
methyl-4-tyramine: found in barley malt; RN given refers to parent cpd; structure given in first source		2.1710tyraminesmouse metabolite
paeonol
paeonol: structure		7.4620methoxybenzenes;
phenols		metabolite
n-methylphenethylamine
N-methylphenethylamine: substrate for type A & B monoamine oxidase; RN given refers to parent cpd		2.1710
tabersonine
[no description available]		2.1710alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		antineoplastic agent;
metabolite
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		3.0310D-glucopyranoseepitope;
mouse metabolite
betulinic acid
[no description available]		2.1710hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose
pentagalloylglucose: pentahydroxy gallic acid ester of glucose; a phytogenic antineoplastic agent and antibacterial agent. 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose : A galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions.		2.1710gallate ester;
galloyl beta-D-glucose		anti-inflammatory agent;
antineoplastic agent;
geroprotector;
hepatoprotective agent;
plant metabolite;
radiation protective agent;
radical scavenger
dictamnine
dictamnine: furanoquinoline alkaloid; crosslinks DNA in presence of ultraviolet light		4.5990alkaloid antibiotic;
organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
cromakalim
Cromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)		6.9810
maslinic acid
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria		2.1710dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite
matrine
[no description available]		2.3110alkaloid
inermin
inermin: phytoalexin produced in plants after injection with fungi; RN given refers to (cis-(+-))-isomer; RN for cpd without isomeric designation; structure. (-)-maackiain : The (-)-enantiomer of maackiain.		3.520maackiain
quindoline
quindoline: a fused indole-quinoline alkaloid from CRYPTOLEPIS sanguinolenta; structure		2.1710
tryptoline
tryptoline: neurotoxic factor that may be involved in development of Parkinson's disease; enzymatic prep from human brain converts tryptamine to tryptoline; RN given refers to parent cpd; structure		2.1710beta-carbolines
pumiliotoxin c
pumiliotoxin C: isolated from skin of Dendrobates pumilio (frog); see also records for pumiliotoxin A, pumiliotoxin B & pumiliotoxins		2.1710
obacunone
obacunone: from bark of Chinese plant Phellodendron amurense; shortens sleeping time induced in mice by alpha-chloralose-urethane		8.9240limonoid
diazaquinomycin a
diazaquinomycin A: structure given in first source		2.1710quinolone
glabridin
[no description available]		2.1710hydroxyisoflavansantiplasmodial drug
6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene
6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene: structure given in first source		2.1710monoterpenoid;
organobromine compound;
organochlorine compound		algal metabolite;
antineoplastic agent;
marine metabolite
pseudonicotine
pseudonicotine: structure. (R)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has R-configuration.		2.17103-(1-methylpyrrolidin-2-yl)pyridine
deferrioxamine e
deferrioxamine E: may act as siderophore in Streptomyces. desferrioxamine E : A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.		2.1710cyclic desferrioxamine;
cyclic hydroxamic acid;
macrocycle		antineoplastic agent;
bacterial metabolite;
marine metabolite;
siderophore
4'-hydroxyflavanone
4'-hydroxyflavanone: structure in first source. 4'-hydroxyflavanones : Any hydroxyflavanone having a hydroxy substituent located at position 4'.		2.17104'-hydroxyflavanones;
monohydroxyflavanone
limonin
[no description available]		8.6830epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound		inhibitor;
metabolite;
volatile oil component
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		7.14400
lupeol
[no description available]		2.1710pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite
maackiain
[no description available]		2.3110phenols;
pterocarpans
crinine
crinine: structure in first source		2.1710alkaloid
strychnine
Strychnine: An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.. strychnine : A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.		2.1710monoterpenoid indole alkaloid;
organic heteroheptacyclic compound		avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide
rutaevin
rutaevin: from root bark of Dictamnus daycarpus Turcz.		3.3920steroid lactone
micheliolide
micheliolide: has antineoplastic activity; structure in first source		2.1710sesquiterpene lactone
trifolirhizin
trifolirhizin: from Sophora flavescens; has inhibitory effect on tyrosinase and melanin synthesis; structure in first source		3.0310pterocarpans
pancracine
pancracine: structure in first source		2.1710isoquinoline alkaloid fundamental parent;
isoquinoline alkaloid
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		2.1710ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
piperine
piperine : A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.		2.1710benzodioxoles;
N-acylpiperidine;
piperidine alkaloid;
tertiary carboxamide		food component;
human blood serum metabolite;
NF-kappaB inhibitor;
plant metabolite
trichodermamide b
trichodermamide B: from cultures of the marine-derived fungus Trichoderma virens; structure in first source		2.1710
helvolic acid
helvolic acid: structure. helvolic acid : A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.		2.17103-oxo-Delta(1) steroid;
acetate ester;
monocarboxylic acid;
steroid acid		antibacterial agent;
fungal metabolite;
mycotoxin
mitragynine
[no description available]		2.1710monoterpenoid indole alkaloid
paynantheine
paynantheine: structure in first source		2.1710
chimonanthine
chimonanthine: structure in first source. chimonanthine : A ring assembly that is 2,2',3,3',8,8',8a,8a'-octahydro-1H,1'H-3a,3a'-bipyrrolo[2,3-b]indole substituted by methyl groups at positions 1 and 1'.		2.1710chimonanthine
3-deoxyisoochracinic acid
3-deoxyisoochracinic acid: structure in first source		2.1710
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0510prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
luteolin-7-glucoside
luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum. luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.		2.1710beta-D-glucoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		antioxidant;
plant metabolite
rutin
Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.		2.1710disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
harmine
Harmine: Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920's.. harmine : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.		2.1710harmala alkaloidanti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite
baicalein
[no description available]		2.1710trihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger
fisetin
[no description available]		2.17103'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
wogonin
wogonin: structure in first source. wogonin : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.		2.1710dihydroxyflavone;
monomethoxyflavone		angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite
cytochalasin b
Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.		2.1710cytochalasin;
lactam;
lactone;
organic heterotricyclic compound		actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor
kaempferol 3-o-rhamnoside
kaempferol 3-O-rhamnoside: from apple (Malus domestica) leaves; structure in first source. afzelin : A glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage.		2.1710glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		anti-inflammatory agent;
antibacterial agent;
plant metabolite
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one: isolated from the Chinese herb Scutellariae radix. oroxylin A : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6.		2.1710dihydroxyflavone;
monomethoxyflavone		antineoplastic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor
radicinin
radicinin: mold metabolite from plant pathogen Stemphylium radicinum; RN given refers to (2S-(2alpha,3beta,7E))-isomer; structure		2.1710aromatic ketone
calycanthine
calycanthine: the principal alkaloid of the plant family Calycanthaceae; RN given refers to (4bS)-(4balpha,5alpha,10balpha,11alpha)-isomer. calycanthine : The principal alkaloid of the plant family Calycanthaceae.		2.1710aminal;
calycanthaceous alkaloid;
organonitrogen heterocyclic compound
xanthoepocin
Xanthoepocin: an antibiotic from Penicillium simplicissimum IFO5762; structure in first source		2.1710
dizocilpine maleate
Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.. dizocilpine maleate : A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.		2.0410maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
herboxidiene
herboxidiene: structure in first source; isolated from Streptomyces chromofuscus; a potent and selective herbicide (e.g. inactive against wheat); up-regulates the gene expression of LDL receptor		2.1710
(1Ar,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
[no description available]		2.1710germacranolide
panduratin a
panduratin A: isolated from Kaempferia pandurata; structure in first source		2.1710diarylheptanoidmetabolite
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone
[no description available]		2.1710oligopeptide
13-epi-sclareol
13-epi-sclareol: an unusual labdane diterpene from the roots of Coleus forskohlii with cell growth inhibitory action in breast and uterine cancers in vitro; structure in first source		2.1710
toosendanin
[no description available]		2.7430limonoid
akuammicine
akuammicine: from Strychnos sp;; structure in first source. akuammicine : A monoterpenoid indole alkaloid with formula C20H22N2O2, isolated from several plant species including Alstonia spatulata, Catharanthus roseus and Vinca major.		2.1710methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		plant metabolite
hermitamide b
hermitamide B: isolated from Lyngbya majuscula; structure in first source		2.1710
trans-delta-tocotrienoloic acid
tocotrienoloic acid: from leaves of Tovomitopsis psychotriifolia; structure given in first source		2.1710tocotrienol
nodulisporic acid a
nodulisporic acid A: a novel indole diterpene insecticide; structure in first source		2.1710
sauchinone
sauchinone: isolated from Saururus chinensis; structure in first source		7.0510
scopadulcic acid b
scopadulcic acid B: isolated from Scorparia dulcis		2.1710
gliocladin c
gliocladin C: structure in first source		2.1710
zincophorin
zincophorin: 25 carbon polypropionate from Streptomyces griseus; griseochelin and M 144255 are the same monocarboxylic acid ionophore		2.1710pyransbacterial metabolite;
ionophore
streptazolin
streptazolin: from culture of Streptomyces sp.; structure in first source		2.1710
chatancin
chatancin: structure in first source		2.1710
morelloflavone
morelloflavone: also inhibits cruzain; RN given for (2S-trans)-isomer; structure in first source. (+)-morelloflavone : A biflavonoid found in Rheedia edulis and Garcinia livingstonei.		2.1710biflavonoid;
hydroxyflavanone;
hydroxyflavone		plant metabolite
cinnamosmolide
cinnamosmolide: isolated from several species of Canellaceae family; structure in first source		2.1710
15-deoxygoyazensolide
15-deoxygoyazensolide: an NSAID with schistossomicidal and trypanosomicidal activities; structure in first source		2.1710
mitragynine
speciogynine: structure in first source		2.1710
ceruletide
Ceruletide: A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.. ceruletide : A decapeptide comprising 5-oxoprolyl, glutamyl, aspartyl, O-sulfotyrosyl, threonyl, glycyl, tryptopyl, methionyl, aspartyl and phenylalaninamide residues in sequence. Found in the skins of certain Australian amphibians, it is an analogue of the gastrointestinal peptide hormone cholecystokinin and stimulates gastric, biliary, and pancreatic secretion. It is used in cases of paralysis of the intestine (paralytic ileus) and as a diagnostic aid in pancreatic malfunction.		2.2110oligopeptidediagnostic agent;
gastrointestinal drug
spongia-13(16),14-dien-19-oic acid
spongia-13(16),14-dien-19-oic acid : A tetracyclic diterpenoid that is 3b,4,5,5a,6,7,8,9,9a,9b,10,11-dodecahydrophenanthro[1,2-c]furan substituted by methyl groups at positions 3b, 6 and 9 and a carboxy group at position 6. Isolated from Spongia, it exhibits inhibitory activity against androgen receptor.		2.1710cyclic ether;
monocarboxylic acid;
tetracyclic diterpenoid		androgen antagonist;
metabolite
roquefortine
[no description available]		2.1710pyrroloindole
3-(3,4-dihydroxyphenyl)lactate
3-(3,4-dihydroxyphenyl)lactate : A hydroxy monocarboxylic acid anion that is the conjugate base of 3-(3,4-dihydroxyphenyl)lactic acid; major species at pH 7.3.		2.1710hydroxy monocarboxylic acid anion
marinopyrrole a
marinopyrrole A: antibiotic from a marine Streptomyces sp.; structure in first source. (-)-marinopyrrole A : A member of the class of pyrroles that is 1'H-1,3'-bipyrrole substituted by four chloro groups at positions 4, 4', 5 and 5' and two 2-hydroxybenzoyl moieties at positions 2 and 2'. It is isolated from Streptomyces sp.CNQ-418 and exhibits cytotoxic and antibacterial activities.		2.1710aromatic ketone;
organochlorine compound;
phenols;
pyrroles		antibacterial agent;
antimicrobial agent;
antineoplastic agent;
bacterial metabolite;
marine metabolite
colletoic acid
colletoic acid: an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides; structure in first source		2.1710
ipomoeassin f
ipomoeassin F: a cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest		2.1710
6,8-dihydroxy-2,2,4,4-tetramethyl-7-(3-methylbutanoyl)-9-(2-methylpropyl)-9h-xanthene-1,3-dione
[no description available]		2.1710xanthenes
7-hydroxymitragynine
7-hydroxymitragynine: an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa; structure in first source		2.1710alkaloid
dorrigocin b
dorrigocin B: isolated from the fermentation broth & mycelium of Streptomyces platensis; structure given in first source		2.1710
dorrigocin a
dorrigocin A: isolated from the fermentation broth & mycelium of Streptomyces platensis; structure given in first source		2.1710
tatanan a
tatanan A: from the rhizomes of Acorus tatarinowii Schott; structure in first source		2.1710
ilicicolin h
ilicicolin H: structure in first source. ilicicolin H : An aromatic ketone in which the ketone carbonyl group is attached to a (1R,2R,4aS,7S,8aR)-4,7-dimethyl-1-[(1E)-prop-1-en-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-2-yl group and a 4-hydroxy-5-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridin-3-yl group. Isolated from the from the "imperfect" fungus Cylindrocladium iliciola strain MFC-870.		2.1710aromatic ketone;
carbobicyclic compound;
ilicicolin;
monohydroxypyridine;
octahydronaphthalenes;
phenols;
pyridone		antimicrobial agent;
mitochondrial respiratory-chain inhibitor
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.5720
tatanan b
tatanan B: from the rhizomes of Acorus tatarinowii Schott; structure in first source		2.1710
gracilioether f
gracilioether F: structure in first source		2.1710
cryptocaryol a
cryptocaryol A: from Cryptocarya spp.; structure in first source. cryptocaryol A : A member of the class of 2-pyranones that is 5,6-dihydro-2H-pyran-2-one substituted by a 2,4,6,8,10-pentahydroxypentacosyl group at position 6. It has been isolated from Cryptocarya species.		2.17102-pyranones;
pentol		plant metabolite
tetrahydroamentoflavone
tetrahydroamentoflavone: isolated from Semecarpus anacardium; structure in first source		2.1710
cyclic gmp
Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.		1.98103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
folic acid
folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.		2.3110folic acids;
N-acyl-amino acid		human metabolite;
mouse metabolite;
nutrient
nataxazole
nataxazole: has antineoplastic activity; isolated from Streptomyces; structure in first source		2.1710
concanavalin a
Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.		7.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Congenital Zika Syndrome
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.4560
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510
Cancer of Mouth
[description not available]		02.3110
Mouth Neoplasms
Tumors or cancer of the MOUTH.		02.3110
Brain Swelling
[description not available]		02.3110
Acute Brain Injuries
[description not available]		02.3110
Brain Hemorrhage, Cerebral
[description not available]		02.3110
Brain Edema
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)		02.3110
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.		02.3110
Cerebral Hemorrhage
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.		07.3110
Acute Liver Injury, Drug-Induced
[description not available]		02.9430
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		02.9430
Benign Neoplasms, Brain
[description not available]		02.4110
Astrocytoma, Grade IV
[description not available]		02.4110
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.4110
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		07.4110
Innate Inflammatory Response
[description not available]		02.6620
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.6620
Cirrhosis
[description not available]		02.3110
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.		07.3110
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues.		02.3110
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.1710
Rheumatoid Arthritis
[description not available]		02.1710
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		02.1710
Malignant Melanoma
[description not available]		02.1710
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.1710
Benign Neoplasms
[description not available]		02.1710
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.1710
Acute Edematous Pancreatitis
[description not available]		02.2110
Acute Disease
Disease having a short and relatively severe course.		02.2110
Pancreatitis
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.		07.2110
Cancer of Pancreas
[description not available]		02.2110
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.2110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0810
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		07.110
Cirrhosis, Liver
[description not available]		02.1310
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.		02.1310
Hepatitis, Animal
INFLAMMATION of the LIVER in non-human animals.		02.0510
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9810
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		01.9810