pyrroles has been researched along with Fibrosis in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.39) | 18.2507 |
| 2000's | 10 (13.89) | 29.6817 |
| 2010's | 49 (68.06) | 24.3611 |
| 2020's | 12 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Basta, MD; Paulson, H; Walker, JL | 1 |
| Chen, Y; Cheng, L; Hu, X; Jing, J; Li, Y; Li, Z; Liu, Y; Tian, D; Xiao, Z; Xu, X; Yu, S; Zheng, M | 1 |
| Chang, Y; Gao, X; Han, Y; Hao, J; Liang, L; Qiang, P; Shimosawa, T; Xian, Y; Xiong, Y; Xu, Q; Yang, F | 1 |
| Abe, M; Endo, M; Fukuda, N; Horikoshi, S; Inoue, T; Mineshige, T; Otsuki, M; Otsuki, T | 1 |
| Gao, L; Li, R; Li, Y; Lu, W; Peng, M; Qiu, C; Shan, Y; Wang, X; Zheng, X | 1 |
| Cheng, Q; Jia, X; Sheng, D; Wu, J; Xiao, C; Yang, M; Zhang, S | 1 |
| Akaike, T; Kuga, K; Kusakari, Y; Minamisawa, S; Semba, K; Uesugi, K; Urashima, T | 1 |
| El-Kashef, DH; Makled, MN | 1 |
| Hanada, K; Itoh, K; Kato, T; Kawamura, Y; Kitayama, K; Kudo, N; Miura, N; Nakata, M; Narita, M; Nozaka, M; Tatara, Y; Tomita, H; Toyama, Y; Tsushima, M; Yokono, Y | 1 |
| Bikou, O; Hadri, L; Hajjar, RJ; Sassi, Y | 1 |
| Kanasaki, K; Koya, D; Kumagai, A; Liu, H; Takagaki, Y | 1 |
| Bin, Y; Chen, X; Chen, Y; Li, G; Yan, H; Zhou, X | 1 |
| Al-Gayyar, MMH; Alattar, A; Alshaman, R; El-Kannishy, SMH; Hamdan, AM; Hassan, HM | 1 |
| Hossain, A; Imamura, T; Jahan, N; Kitada, K; Kobara, H; Kosaka, S; Masaki, T; Nakano, D; Nishiyama, A; Ohsaki, H; Rahman, A; Sawano, T; Sen, A | 1 |
| Asano, Y; Fukushima, S; Hashizume, Y; Ide, M; Ihn, H; Jinnin, M; Kajihara, I; Tomizawa, Y; Wang, Z | 1 |
| Melnyk, O; Shults, NV; Suzuki, YJ; Zungu-Edmondson, M | 1 |
| Ji, X; Li, J; Liu, Y; Tan, R; Wang, H; Wang, L; Wu, Z; Zhang, Y; Zhong, X; Zhu, M | 1 |
| Huang, XR; Lan, HY; Meng, XM; Zhang, Y | 1 |
| Adhyatmika, A; Adlia, A; de Jong, KP; Luangmonkong, T; Mutsaers, HAM; Olinga, P; Oosterhuis, D; Suriguga, S; Suthisisang, C | 1 |
| Bogaard, HJ; da Silva Gonçalves Bos, D; de Man, FS; de Raaf, MA; Dickhoff, C; Goumans, MJ; Guignabert, C; Happé, C; Herrmann, FE; Koolwijk, P; Kuiper, VP; Kurakula, K; Lodder, K; Pan, X; Rol, N; Schalij, I; Sun, XQ; Szulcek, R; Thuillet, R; Tu, L; van Nieuw Amerongen, GP; Vonk-Noordegraaf, A; Wollin, L | 1 |
| Guo, Y; Han, C; Han, G; Liu, L; Tan, X; Wei, G; Xu, Q; Zhang, C; Zhang, H | 1 |
| Chesler, NC; Hacker, TA; Schmuck, EG; Schreier, DA; Wang, Z | 1 |
| Bayliss, G; Guan, Y; Liu, L; Masucci, MV; Xiong, C; Zhang, W; Zhang, Y; Zhao, TC; Zhou, X; Zhuang, MA; Zhuang, S | 1 |
| Abe, K; Alzoubi, A; Fagan, KA; McMurtry, IF; O'Neill, KD; Oka, M; Rocic, P; Toba, M | 1 |
| Harmann, LM; Meyer, J; Petersen, M; Routhu, KV; Sonin, DL; Strande, JL; Wakatsuki, T | 1 |
| Fukumoto, Y; Kudo, S; Liao, JK; Minami, T; Nochioka, K; Shiba, N; Shimokawa, H; Takai, Y; Tanaka, S; Williams, CL | 1 |
| Cao, S; Fang, W; He, Y; Li, R; Li, Y; Wang, J; Xi, S; Zhang, B | 1 |
| Dong, QT; Gao, RL; Geng, YJ; Gersh, BJ; He, ZX; Lu, MJ; Qian, HY; Qiao, SB; Shen, R; Song, L; Yang, YJ; Zhao, SH | 1 |
| An, Z; Dong, N; Ge, LL; He, YQ; Li, SM; Yang, G; Zhang, WQ | 1 |
| Cooley, C; Dobberfuhl, AD; Goldschmeding, R; Higgins, PJ; Meldrum, KK; Overstreet, JM; Patel, S; Samarakoon, R | 1 |
| Akahori, H; Eguchi, A; Hirotani, S; Iwasaku, T; Masuyama, T; Matsumoto, M; Naito, Y; Sasaki, N; Sawada, H; Tsujino, T | 1 |
| Akdemir, A; Aktug, H; Erbas, O; Ergenoglu, M; Taskiran, D; Yavasoglu, A; Yildirim, N; Zeybek, B | 1 |
| Arévalo, M; Docherty, NG; Eleno, N; Fuentes-Calvo, I; Grande, MT; López-Novoa, JM; Pérez-Barriocanal, F; Rodríguez-Peña, AB | 1 |
| Lu, R; Lv, P; Su, W; Zhang, K; Zhao, J | 1 |
| Bedi, A; Davis, ME; Flood, MD; Gumucio, JP; Harning, JA; Lynch, EB; Mendias, CL; Oak, NR; Roche, SM; Saripalli, AL | 1 |
| Abbate, A; Bogaard, HJ; Byron, PR; Farkas, L; Gomez-Arroyo, J; Kraskauskas, D; Mizuno, S; Sakagami, M; Syed, AA; Van Tassell, B; Voelkel, NF | 1 |
| Galvis-Carvajal, E; Gomer, RH; White, MJ | 1 |
| Ago, T; Arimura, K; Kamouchi, M; Kitazono, T; Kuroda, J; Makihara, N; Matsuo, R; Nakamura, K; Nishimura, A; Sugimori, H; Tachibana, M; Wakisaka, Y | 1 |
| Akman, L; Akman, T; Aktug, H; Artunc Ulkumen, B; Erbas, O; Oltulu, F; Pala, EE; Pala, HG; Yavasoglu, A | 1 |
| Cheng, WP; Lo, HM; Shyu, KG; Wang, BW | 1 |
| Bertram, JF; Caruana, G; Dai, L; Fu, P; Howard, V; Jiang, X; Li, J; Nikolic-Paterson, DJ; Puelles, VG; Qu, X; Ren, Y; Sleeman, MW; Sun, YB | 1 |
| Mitch, WE; Wang, Y; Yan, J; Yang, J; Zhang, Z | 1 |
| Deng, X; Gu, W; Jin, K; Li, Y; Liu, M; Zhou, L | 1 |
| Gao, Z; Liu, W; Wang, X; Wu, X; Zhang, W; Zhou, G | 1 |
| Fukuda, N; Fukushima, A; Inami, M; Matsumoto, Y; Moriyama, M; Soma, M; Tsunemi, A; Ueno, T; Yamada, T | 1 |
| Crijns, HJ; De Boer, HC; De Jong, AM; Kamphuisen, PW; Kuiper, M; Lau, DH; Linz, D; Lumeij, S; Maass, AH; Rienstra, M; Schotten, U; Spronk, HM; Ten Cate, H; Van Gelder, IC; van Hunnik, A; van Zonneveld, AJ; Verheule, S; Zeemering, S | 1 |
| Cho, H; Choi, KS; Jeong, DS; Jeong, MH; Kang, JS; Kim, HJ; Lee, DI; O'Rourke, B; Pyun, JH; Solhjoo, S; Tomaselli, GF | 1 |
| Carvajal-González, G; Egido, J; Mezzano, S; Ortiz, A; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M; Sánchez-López, E; Selgas, R | 1 |
| Dolman, ME; Fretz, MM; Goldschmeding, R; Hennink, WE; Kok, RJ; Lacombe, M; Nguyen, TQ; Pato, J; Prakash, J; Storm, G | 1 |
| Clementi, F; Di Luozzo, M; Luciani, G; Mango, R; Martuscelli, E; Mehta, JL; Pizzuto, F; Romeo, F; Trivisonno, A | 1 |
| Boyle, A; Connelly, KA; Gilbert, RE; Kelly, D; Kompa, A; Krum, H; Martin, JH; Zhang, Y | 1 |
| Cui, W; Du, J; Han, M; Liu, DM; Liu, F; Lu, JC; Yin, HN; Zhang, HL; Zhang, K | 1 |
| Geng, J; Kang, W; Wang, W; Zhang, Y; Zhao, Z; Zhiming, GE | 1 |
| Chou, SY; Fitzgerald, JP; Franco, I; Gulmi, FA; Kim, H; Mooppan, UM; Saini, R | 1 |
| Aoyama, T; Bando, T; Fukuda, N; Katakawa, M; Matsuda, H; Matsui, S; Matsumoto, K; Matsumoto, Y; Nagase, H; Saito, K; Sugiyama, H; Ueno, T; Wang, X; Watanabe, T | 1 |
| Civantos, E; Egido, J; Lavoz, C; Mezzano, S; Ortiz, A; Rayego-Mateos, S; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M | 1 |
| Ghilencea, L; Mario, CD; Moreno-Ambroj, C; Tyczyński, P; Witkowska, AB | 1 |
| Aguilar, C; Rodríguez-Delfín, L; Ventura, F | 1 |
| Chu, B; Dong, L; Hatsukami, T; Lane, T; Lee, C; Monick, D; Moore, A; Neradilek, MB; Phan, BA; Polissar, N; Underhill, H; Yuan, C; Zhao, XQ | 1 |
| Chuang, WL; Chuang, YH; Huang, CH; Huang, SP; Liu, CK | 1 |
| Asteriou, C; Ballas, KD; Giakoustidis, DE; Lalountas, M; Michalakis, A; Nikolaidou, C; Pavlidis, TE; Psarras, K; Sakantamis, AK; Venizelos, I | 1 |
| Fujita, Y; Imai, E; Ito, Y; Kinashi, H; Maruyama, S; Matsui, K; Matsuo, S; Mizuno, M; Mizuno, T; Noda, Y; Sawai, A; Shimizu, H; Suzuki, Y; Takei, Y | 1 |
| Dolman, ME; Harmsen, S; Hennink, WE; Kéri, G; Kok, RJ; Lacombe, M; Orfi, L; Pieters, EH; Sparidans, RW; Storm, G; Szokol, B | 1 |
| Ike, A; Iwata, A; Kawamura, A; Miura, S; Nishikawa, H; Saku, K; Sugihara, M; Tanaka, T | 1 |
| Li, W; Liu, K; Ma, A; Shao, L; Wang, J; Wang, Z; Wu, D; Zhang, P; Zhang, Y | 1 |
| Chu, LM; Elmadhun, NY; Feng, J; Lassaletta, AD; Liu, Y; Sellke, FW | 1 |
| Bahlmann, FH; Drexler, H; Engberding, N; Fuchs, M; Haller, H; Heineke, A; Hilfiker-Kleiner, D; Hornig, B; Kotlarz, D; Landmesser, U; Mueller, M; Schaefer, A; Spiekermann, S; Templin, C; Wiencke, A | 1 |
| Greenberg, A; Verbalis, JG | 1 |
| Amrani, M; Chester, AH; Latif, N; Osman, L; Yacoub, MH | 1 |
| Gu, M; Liu, M; Wu, Y; Yin, C; Zhang, W; Zhu, P | 1 |
| Bezerra, DG; Lacerda Andrade, LM; Mandarim-de-Lacerda, CA; Pinto da Cruz, FO | 1 |
| Cheah, AY; Dawood, F; Lee, JK; Liu, P; Rabinovitch, M; Saiki, Y; Wen, WH; Zaidi, SH | 1 |
1 review(s) available for pyrroles and Fibrosis
| Article | Year |
|---|---|
Vasopressin receptor antagonists.
Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Clinical Trials as Topic; Diabetes Insipidus, Nephrogenic; Fibrosis; Heart Failure; Humans; Hyponatremia; Osmolar Concentration; Polycystic Kidney Diseases; Pyrroles; Receptors, Vasopressin; Sodium; Tolvaptan; United States; United States Food and Drug Administration; Vasopressins | 2006 |
2 trial(s) available for pyrroles and Fibrosis
| Article | Year |
|---|---|
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cardiomegaly; Cells, Cultured; Cholesterol; Cholesterol, LDL; Coronary Vessels; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA Interference; Signal Transduction; Transfection | 2013 |
MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time course.
Topics: Apolipoproteins B; Atorvastatin; Biomarkers; Calcium; Carotid Arteries; Carotid Artery Diseases; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Idaho; Lipid Metabolism; Magnetic Resonance Angiography; Male; Middle Aged; Necrosis; Predictive Value of Tests; Prospective Studies; Pyrroles; Time Factors; Treatment Outcome; Washington | 2011 |
69 other study(ies) available for pyrroles and Fibrosis
| Article | Year |
|---|---|
The local wound environment is a key determinant of the outcome of TGFβ signaling on the fibrotic response of CD44
Topics: Actins; Animals; Blotting, Western; Capsule Opacification; Cataract Extraction; Cell Proliferation; Chick Embryo; Collagen Type I; Disease Models, Animal; Fibronectins; Fibrosis; Hyaluronan Receptors; Imidazoles; Integrin alphaVbeta3; Microscopy, Fluorescence; Myofibroblasts; Posterior Capsule of the Lens; Postoperative Complications; Pyrazoles; Pyrroles; Quinoxalines; Receptor, Transforming Growth Factor-beta Type I; Signal Transduction; Transforming Growth Factor beta; Wound Healing | 2021 |
SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway.
Topics: Animals; Axons; Cicatrix; Fibrosis; Indoles; Locomotion; Mice; Nerve Regeneration; Proto-Oncogene Proteins c-sis; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Recovery of Function; Spinal Cord; Spinal Cord Injuries | 2022 |
Esaxerenone inhibits the macrophage-to-myofibroblast transition through mineralocorticoid receptor/TGF-β1 pathway in mice induced with aldosterone.
Topics: Aldosterone; Animals; Eplerenone; Fibrosis; Macrophages; Mice; Myofibroblasts; Pyrroles; Rats; Receptors, Mineralocorticoid; Renal Insufficiency, Chronic; Sulfones; Transforming Growth Factor beta1 | 2022 |
Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset.
Topics: Animals; Base Sequence; Cadherins; Callithrix; Cyclosporine; DNA; Fibrosis; Humans; Imidazoles; Kidney; Kidney Diseases; Nylons; Peptides; Promoter Regions, Genetic; Pyrroles; RNA, Messenger; Snail Family Transcription Factors; Transforming Growth Factor beta1; Urethral Obstruction | 2019 |
Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.
Topics: AMP-Activated Protein Kinases; Animals; Antimicrobial Cationic Peptides; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Echocardiography; Endothelial Cells; Endothelium; Epithelial-Mesenchymal Transition; Fibrosis; Glucose; Hemodynamics; Hyperglycemia; Male; Mice; Mice, Inbred C57BL; Pyrazoles; Pyrroles; Signal Transduction; Transforming Growth Factor beta | 2019 |
TRPV4 Mediates Cardiac Fibrosis via the TGF-β1/Smad3 Signaling Pathway in Diabetic Rats.
Topics: Animals; Cell Proliferation; Cells, Cultured; Collagen Type I; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibroblasts; Fibrosis; Male; Morpholines; Myocardium; Phosphorylation; Pyrroles; Rats, Sprague-Dawley; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; TRPV Cation Channels | 2020 |
Fibrosis growth factor 23 is a promoting factor for cardiac fibrosis in the presence of transforming growth factor-β1.
Topics: Actins; Animals; Cells, Cultured; Disease Models, Animal; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibrosis; Heart Diseases; Male; Myocytes, Cardiac; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Transforming Growth Factor beta1; Up-Regulation | 2020 |
Saroglitazar attenuates renal fibrosis induced by unilateral ureteral obstruction via inhibiting TGF-β/Smad signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Fibrosis; Inflammation; Kidney Diseases; Male; Oxidative Stress; Phenylpropionates; PPAR alpha; PPAR gamma; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; Ureteral Obstruction | 2020 |
Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.
Topics: Animals; Collagen Type III; Cytokines; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; HEK293 Cells; Humans; Hypertension; Hypertrophy, Left Ventricular; Inflammation Mediators; Macrophages; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Pyrroles; Quinazolines; Receptor, PAR-1; Renin; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model.
Topics: Animals; Cell Hypoxia; Disease Models, Animal; Fibrosis; Heart Ventricles; Humans; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Mice; Pulmonary Artery; Pulmonary Circulation; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Remodeling; Ventricular Remodeling | 2020 |
The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Fibrosis; Glycolysis; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Mice; Oxidative Phosphorylation; Pyridazines; Pyrroles; Pyruvate Kinase; Streptozocin | 2021 |
Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways.
Topics: Animals; Antioxidants; beta Catenin; Capsule Opacification; Cataract; Cell Proliferation; Cell Survival; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Lens, Crystalline; Mice; Oxidative Stress; Oxygen; Pyrazoles; Pyrroles; Swine; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tropicamide; Wnt Signaling Pathway | 2021 |
Therapeutic effects of blocking β-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; beta Catenin; Cell Movement; Cytokines; Fibroblast Growth Factor 2; Fibrosis; Inflammation Mediators; Liver Neoplasms, Experimental; Male; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyridines; Pyrroles; Rats, Sprague-Dawley; Thiazolidinediones; Thioacetamide; Transforming Growth Factor beta1; Wnt Signaling Pathway | 2021 |
Cardioprotective Effects of a Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, in Dahl Salt-Sensitive Hypertensive Rats.
Topics: Animals; Cardiotonic Agents; Electrocardiography; Fibrosis; Hypertension; Inflammation; Male; Mineralocorticoid Receptor Antagonists; Pyrroles; Rats, Inbred Dahl; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Sulfones; Survival Analysis; Ventricular Remodeling | 2021 |
Transforming growth factor β-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.
Topics: Actins; Amino Acids; Aminopyridines; Animals; Bleomycin; Collagen Type I; Collagen Type I, alpha 1 Chain; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Humans; Inhibitory Concentration 50; Mice; Phenols; Pyrazoles; Pyridines; Pyrroles; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta; Up-Regulation; Xanthenes | 2017 |
Natural reversal of pulmonary vascular remodeling and right ventricular remodeling in SU5416/hypoxia-treated Sprague-Dawley rats.
Topics: Animals; Blotting, Western; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Lung; Male; Metabolomics; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2017 |
Specific Inhibitor of Smad3 (SIS3) Attenuates Fibrosis, Apoptosis, and Inflammation in Unilateral Ureteral Obstruction Kidneys by Inhibition of Transforming Growth Factor β (TGF-β)/Smad3 Signaling.
Topics: Animals; Apoptosis; Fibrosis; Inflammation; Isoquinolines; Kidney; Male; Mice, Inbred BALB C; Myofibroblasts; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Ureteral Obstruction | 2018 |
The preventive and therapeutic implication for renal fibrosis by targetting TGF-β/Smad3 signaling.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrosis; Isoquinolines; Kidney; Male; Mice, Inbred C57BL; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Ureteral Obstruction | 2018 |
In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β.
Topics: Adenosine Triphosphate; Animals; Cell Line; Collagen Type I; Down-Regulation; Fibrosis; Gene Expression; Humans; In Vitro Techniques; Liver; Male; Phosphorylation; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Smad1 Protein; Smad2 Protein; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta | 2018 |
Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension.
Topics: Adult; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Extracellular Matrix; Female; Fibroblasts; Fibrosis; Humans; Indoles; Male; Myocardium; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling; Young Adult | 2019 |
LY2109761 reduces TGF-β1-induced collagen production and contraction in hypertrophic scar fibroblasts.
Topics: Actins; Cells, Cultured; Cicatrix, Hypertrophic; Collagen; Fibroblasts; Fibrosis; Humans; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Signal Transduction; Skin; Smad3 Protein; Transforming Growth Factor beta1 | 2018 |
Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats.
Topics: Animals; Arterial Pressure; Cells, Cultured; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mesenchymal Stem Cell Transplantation; Myocardial Contraction; Myocardium; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Recovery of Function; Regeneration; Tissue Scaffolds; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling; von Willebrand Factor | 2019 |
Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis.
Topics: Animals; Bone Morphogenetic Protein 7; Cell Line, Transformed; Fibrosis; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Kidney Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Pyrroles; Smad7 Protein; Transforming Growth Factor beta1; Ureteral Obstruction | 2019 |
Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension.
Topics: Animals; Apoptosis; Blood Pressure; Dehydroepiandrosterone; Fibrosis; Gene Expression; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; NADP; NFATC Transcription Factors; Oxidative Stress; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; STAT3 Transcription Factor; Ventricular Dysfunction | 2013 |
Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Imaging, Three-Dimensional; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Transforming Growth Factor beta; Ventricular Remodeling | 2013 |
Differential expression of Nad(P)H oxidase isoforms and the effects of atorvastatin on cardiac remodeling in two-kidney two-clip hypertensive rats.
Topics: Animals; Atorvastatin; Atrial Natriuretic Factor; Blotting, Western; Fibrosis; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Renovascular; Isoenzymes; Male; Membrane Glycoproteins; Myocardium; Myosin Heavy Chains; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2013 |
Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase.
Topics: Animals; Apoptosis; Atorvastatin; C-Reactive Protein; Disease Models, Animal; Enzyme Activation; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mesenchymal Stem Cell Transplantation; Myocardial Infarction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrroles; Swine; Tomography, Emission-Computed, Single-Photon; Ventricular Function, Left | 2013 |
Atorvastatin reduces myocardial fibrosis in a rat model with post-myocardial infarction heart failure by increasing the matrix metalloproteinase-2/tissue matrix metalloproteinase inhibitor-2 ratio.
Topics: Animals; Atorvastatin; Collagen; Disease Models, Animal; Female; Fibrosis; Heart Failure; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase 2; Myocardial Infarction; Myocardium; Pyrroles; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-2; Ventricular Remodeling | 2013 |
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.
Topics: Animals; Benzothiazoles; Connective Tissue Growth Factor; Endothelium, Vascular; ErbB Receptors; Fibroblasts; Fibrosis; Gene Expression Regulation; Isoquinolines; Mice; Mink; Myocytes, Smooth Muscle; Pyridines; Pyrroles; Quinazolines; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Serpin E2; Signal Transduction; Smad2 Protein; Smad3 Protein; Toluene; Transforming Growth Factor beta1; Tumor Suppressor Protein p53; Tyrphostins | 2013 |
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats.
Topics: Animals; Atorvastatin; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Failure, Diastolic; Heptanoic Acids; HSP47 Heat-Shock Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocardium; Pyrroles; Rats; Rats, Inbred Dahl; rho-Associated Kinases; Ventricular Function, Left | 2014 |
High-dose atorvastatin ameliorates the uterine microenvironment in streptozotocin-induced diabetic rats.
Topics: Animals; Atorvastatin; Diabetes Mellitus, Experimental; Endometrium; ErbB Receptors; Female; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Uterus; Vascular Endothelial Growth Factor A | 2014 |
Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy.
Topics: Angiotensin II; Animals; Atorvastatin; Disease Models, Animal; Fibrosis; Heptanoic Acids; Humans; Kidney; Kidney Diseases; Mice; Monomeric GTP-Binding Proteins; Pyrroles; Receptor, Angiotensin, Type 1; Signal Transduction; Ureteral Obstruction | 2014 |
Immunomodulatory effectiveness of licofelone in preventing epidural fibrosis in post-laminectomy rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Disease Models, Animal; Double-Blind Method; Epidural Space; Failed Back Surgery Syndrome; Fibrosis; Gene Expression; Hydroxyproline; Interleukin-6; Laminectomy; Lumbar Vertebrae; Male; Pyrroles; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Tissue Adhesions; Transforming Growth Factor beta1 | 2015 |
Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Apoptosis Regulatory Proteins; Autophagy-Related Protein 5; Beclin-1; Biomechanical Phenomena; Carrier Proteins; Diacylglycerol O-Acyltransferase; Enzyme Inhibitors; Fibrocartilage; Fibrosis; Hydroxyproline; Interleukin-10; Intracellular Signaling Peptides and Proteins; Lipid Metabolism; Male; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Proteins; Muscle, Skeletal; Perilipin-1; Phosphoproteins; PPAR gamma; Proteins; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Rotator Cuff; Vesicular Transport Proteins; Wound Healing | 2014 |
Iloprost reverses established fibrosis in experimental right ventricular failure.
Topics: Animals; Collagen; Cyclic AMP-Dependent Protein Kinases; Echocardiography; Fibroblasts; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Iloprost; Indoles; Male; Matrix Metalloproteinase 9; Microscopy, Phase-Contrast; Physical Conditioning, Animal; Procollagen; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta1; Vasodilator Agents; Ventricular Function, Right | 2015 |
A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
Topics: Albumins; Cell Differentiation; Cell Movement; Cells, Cultured; Cicatrix; Fibroblasts; Fibrosis; Humans; Interferon-gamma; Lactones; Leukocytes, Mononuclear; Monocytes; Pyridines; Pyrroles; Quinazolines; Receptor, PAR-1; Receptor, PAR-2; Serum Amyloid P-Component; Signal Transduction; Thrombin; Trypsin; Tryptases; Wound Healing | 2015 |
Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke.
Topics: Animals; Brain; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Indoles; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Pericytes; Pyrroles; Rats; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Time Factors | 2015 |
Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study.
Topics: Angiogenesis Inhibitors; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Fibrosis; Immunohistochemistry; Indoles; NF-kappa B; Ovary; Primary Ovarian Insufficiency; Pyrroles; Rats; Sunitinib | 2015 |
MicroRNA-208a Increases Myocardial Endoglin Expression and Myocardial Fibrosis in Acute Myocardial Infarction.
Topics: Animals; Atorvastatin; Blotting, Western; Cells, Cultured; Disease Models, Animal; Endoglin; Fibrosis; Gene Expression Regulation; Hemodynamics; Heptanoic Acids; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; MicroRNAs; Muscle Cells; Myocardial Infarction; Polymerase Chain Reaction; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tetrazoles; Valine; Valsartan; Ventricular Remodeling | 2015 |
Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance.
Topics: Animals; Cells, Cultured; Dietary Fats; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Knockdown Techniques; Insulin; Insulin Resistance; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Mitochondria; Obesity; Palmitic Acid; Phosphorylation; Piperidines; Podocytes; Protective Factors; Protein Kinase Inhibitors; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein | 2015 |
JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis.
Topics: Actins; Animals; Apoptosis; Bone Marrow Transplantation; Cells, Cultured; Collagen Type I; Extracellular Matrix Proteins; Fibroblasts; Fibronectins; Fibrosis; Interleukin-13; Interleukin-4; Janus Kinase 3; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Myofibroblasts; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT6 Transcription Factor; Ureteral Obstruction | 2015 |
Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways.
Topics: Actins; Cell Line; Cell Proliferation; Collagen Type I; Fetus; Fibroblasts; Fibrosis; Flavonoids; Gene Expression Regulation; Humans; Isoquinolines; Lung; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1 | 2015 |
Inhibitory effect of TGF-β peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts.
Topics: Adult; Cell Movement; Cell Proliferation; Cells, Cultured; Cicatrix, Hypertrophic; Female; Fibrillar Collagens; Fibroblasts; Fibronectins; Fibrosis; Gene Expression Regulation; Humans; Male; Middle Aged; Peptides; Phenotype; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Skin; Time Factors; Transforming Growth Factor beta1; Young Adult | 2016 |
Reduction of Dimethylnitrosamine-Induced Liver Fibrosis by the Novel Gene Regulator PI Polyamide Targeting Transforming Growth Factor β1 Gene.
Topics: Actins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; End Stage Liver Disease; Fibrosis; Gene Silencing; Hepatic Stellate Cells; Imidazoles; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta | 2015 |
Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation.
Topics: Analysis of Variance; Animals; Antithrombins; Atrial Fibrillation; Cell Proliferation; Dabigatran; Female; Fibrinolytic Agents; Fibroblasts; Fibrosis; Goats; Heart Atria; Indazoles; Mice, Transgenic; Nadroparin; Peptide Hydrolases; Pyrroles; Quinazolines; Rats; Receptors, Thrombin; Thrombin; Thrombophilia; Urea | 2017 |
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling.
Topics: Animals; beta Catenin; Cell Adhesion Molecules; Connexin 43; Connexins; Fibrosis; Gap Junctions; Heart; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Up-Regulation; Ventricular Remodeling; Wnt Signaling Pathway | 2017 |
Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.
Topics: Angiotensin II; Atorvastatin; Cell Line; Cell Transdifferentiation; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase Kinases; Phenotype; Protein Kinase Inhibitors; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Time Factors; Transfection | 2008 |
Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors.
Topics: Cells, Cultured; Chemistry, Pharmaceutical; Drug Carriers; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Fibrosis; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Kinetics; Muramidase; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Quinazolines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2008 |
Regression and shift in composition of coronary atherosclerotic plaques by pioglitazone: insight from an intravascular ultrasound analysis.
Topics: Aged; Atorvastatin; Calcinosis; Coronary Artery Disease; Diabetes Mellitus; Drug Therapy, Combination; Female; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Middle Aged; Necrosis; Pilot Projects; Pioglitazone; Prospective Studies; Pyrroles; Registries; Thiazolidinediones; Time Factors; Treatment Outcome; Ultrasonography, Interventional; User-Computer Interface | 2009 |
Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction.
Topics: Animals; Atorvastatin; Body Weight; Cardiac Volume; Collagen Type I; Collagen Type III; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Myocardial Infarction; Myocardium; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2010 |
Additive beneficial effects of amlodipine and atorvastatin in reversing advanced cardiac hypertrophy in elderly spontaneously hypertensive rats.
Topics: Aging; Amlodipine; Animals; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Cardiomegaly; Drug Synergism; Drug Therapy, Combination; Fibrosis; Heart Failure, Diastolic; Hemodynamics; Heptanoic Acids; Myocytes, Cardiac; NADPH Oxidases; Natriuretic Peptide, Brain; Oxidative Stress; Pyrroles; Random Allocation; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Superoxide Dismutase; Ventricular Dysfunction, Left | 2009 |
Atorvastatin reverses cardiac remodeling possibly through regulation of protein kinase D/myocyte enhancer factor 2D activation in spontaneously hypertensive rats.
Topics: Animals; Atorvastatin; Blood Pressure; Disease Models, Animal; Enzyme Activation; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxyproline; Hypertension; Hypertrophy, Left Ventricular; Lipids; Male; MEF2 Transcription Factors; Myocardium; Protein Kinase C; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Time Factors; Transcription Factors; Ventricular Remodeling | 2010 |
Atorvastatin ameliorates tubulointerstitial fibrosis and protects renal function in chronic partial ureteral obstruction cases.
Topics: Animals; Atorvastatin; Chronic Disease; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Tubules; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Ureteral Obstruction | 2009 |
Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-β1 promoter.
Topics: Amino Acids; Animals; Fibrosis; Gene Expression Regulation; Gene Silencing; Genetic Therapy; Glomerulosclerosis, Focal Segmental; Imidazoles; Kidney Glomerulus; Male; Nylons; Promoter Regions, Genetic; Pyrroles; Rats; Rats, Inbred Dahl; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta1 | 2011 |
Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
Topics: Angiotensin II; Animals; Aorta; Atorvastatin; Blotting, Western; Cells, Cultured; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Simvastatin; Smad Proteins; Transforming Growth Factor beta; Vasoconstrictor Agents | 2010 |
Long term observation of thin-cap fibroatheroma by optical coherence tomography.
Topics: Atorvastatin; Coronary Artery Disease; Coronary Vessels; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Necrosis; Pyrroles; Time Factors; Tomography, Optical Coherence; Treatment Outcome | 2010 |
[Atorvastatin induced increase in homologous angiotensin I converting enzyme (ACE2) mRNA is associated to decreased fibrosis and decreased left ventricular hypertrophy in a rat model of diabetic cardiomyopathy].
Topics: Animals; Atorvastatin; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Male; Peptidyl-Dipeptidase A; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2011 |
Atorvastatin ameliorates tissue damage of obstructed ureter in rats.
Topics: Animals; Apoptosis; Atorvastatin; Cytokines; Female; Fibrosis; Heptanoic Acids; Hydronephrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Muscle, Smooth; Proliferating Cell Nuclear Antigen; Pyrroles; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Ureter; Ureteral Obstruction | 2011 |
Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model.
Topics: Animals; Atorvastatin; Biocompatible Materials; Carboxymethylcellulose Sodium; Fibrosis; Heptanoic Acids; Hyaluronic Acid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pyrroles; Random Allocation; Rats; Rats, Wistar; Tissue Adhesions | 2012 |
Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction.
Topics: Animals; Cell Line; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Kidney Tubules; Lymphangiogenesis; Macrophages; Male; Membrane Glycoproteins; Mice; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Transforming Growth Factor-beta Type I; Receptors, Cell Surface; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction; Vascular Endothelial Growth Factor C | 2012 |
Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells.
Topics: Animals; Area Under Curve; Cell Line; Cell Survival; Drug Carriers; Drug Delivery Systems; Fibrosis; Humans; Immunohistochemistry; Indoles; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Muramidase; Organoplatinum Compounds; Protein-Tyrosine Kinases; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Sunitinib | 2012 |
Plasma pentraxin-3 levels are associated with coronary plaque vulnerability and are decreased by statin.
Topics: Aged; Angina, Stable; Atorvastatin; Biomarkers; C-Reactive Protein; Case-Control Studies; Chi-Square Distribution; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Down-Regulation; Female; Fibrosis; Glycated Hemoglobin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Lipids; Male; Middle Aged; Plaque, Atherosclerotic; Predictive Value of Tests; Pyrroles; Serum Amyloid P-Component; Time Factors; Treatment Outcome; Ultrasonography, Interventional; Uric Acid | 2012 |
Atorvastatin preconditioning improves the forward blood flow in the no-reflow rats.
Topics: Animals; Atorvastatin; Echocardiography; Fibrinogen; Fibrosis; Hemodynamics; Heptanoic Acids; Inflammation; Male; Microcirculation; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tumor Necrosis Factor-alpha | 2014 |
Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome.
Topics: Angiogenesis Inducing Agents; Angiogenic Proteins; Animals; Atorvastatin; Biomarkers; Collateral Circulation; Coronary Circulation; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Metabolic Syndrome; Microvessels; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardium; Neovascularization, Physiologic; Oxidative Stress; Pyrroles; Signal Transduction; Swine; Swine, Miniature; Vasodilation; Vasodilator Agents | 2012 |
Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase.
Topics: Animals; Atorvastatin; Biological Availability; Capillaries; Cells, Cultured; Collateral Circulation; Drug Resistance; Endothelial Cells; Fibrosis; Heart Failure; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Random Allocation; Ultrasonography; Vasodilation; Ventricular Function, Left; Ventricular Remodeling | 2004 |
Role of human valve interstitial cells in valve calcification and their response to atorvastatin.
Topics: Aged; Alkaline Phosphatase; Aortic Valve; Aortic Valve Stenosis; Atorvastatin; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Calcinosis; Cell Differentiation; Cells, Cultured; Connective Tissue Cells; Culture Media; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Osteoblasts; Osteocalcin; Pyrroles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta3 | 2006 |
Protective effects of atorvastatin on chronic allograft nephropathy in rats.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Chemokines; Chronic Disease; Cyclosporine; Cytokines; Drug Therapy, Combination; Extracellular Matrix Proteins; Fibrosis; Gene Expression; Graft Rejection; Heptanoic Acids; Immunosuppressive Agents; Kidney Transplantation; Male; Monocytes; Proteinuria; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Homologous | 2007 |
Atorvastatin attenuates cardiomyocyte loss in adult rats from protein-restricted dams.
Topics: Animals; Atorvastatin; Blood Pressure; Body Mass Index; Cardiomegaly; Diet, Protein-Restricted; Fibrosis; Heptanoic Acids; Hypertrophy, Left Ventricular; Male; Myocardial Reperfusion; Myocytes, Cardiac; Perfusion; Pyrroles; Rats; Rats, Wistar | 2008 |
A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis.
Topics: Administration, Oral; Animals; Cardiovirus Infections; Disease Models, Animal; Encephalomyocarditis virus; Fibrosis; Heart; Inflammation; Male; Mice; Mice, Inbred DBA; Microcirculation; Myocarditis; Myocardium; Perfusion; Peroxidase; Pyrroles; Serine Proteinase Inhibitors; Sulfonamides | 1998 |