thioctic acid has been researched along with Fibrosis in 16 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arsenic trioxide was predicted to induce fibrosis by AP1-driven TGFβ expression and MMP2-driven TGFβ activation." | 1.62 | Network model-based screen for FDA-approved drugs affecting cardiac fibrosis. ( Chandrabhatla, AS; Christiansen, SL; Holmes, JW; Nelson, AR; Saucerman, JJ; Zeigler, AC, 2021) |
| "Ulcerative colitis affects many people worldwide." | 1.39 | Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis. ( Jena, GB; Trivedi, PP, 2013) |
| "Peridural fibrosis is an inevitable healing process causing failed back surgery syndrome after lumbar spinal operations." | 1.38 | Alpha-lipoic acid reduces peridural fibrosis after laminectomy of lumbar vertebrae in rabbits. ( Akbasak, A; Erdogan, H; Huseyinoglu, U; Kaya, M; Kosemehmetoglu, K; Tasdemiroglu, E; Yildirim, CH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (75.00) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, HF | 1 |
| Liu, HM | 1 |
| Xiang, JY | 1 |
| Zhou, XC | 1 |
| Wang, D | 1 |
| Chen, RY | 1 |
| Tan, WL | 1 |
| Liang, LQ | 1 |
| Liu, LL | 1 |
| Shi, MJ | 1 |
| Zhang, F | 1 |
| Xiao, Y | 1 |
| Zhou, YX | 1 |
| Zhang, T | 1 |
| Tang, L | 1 |
| Guo, B | 1 |
| Wang, YY | 1 |
| Li, W | 1 |
| Yin, L | 1 |
| Sun, X | 1 |
| Wu, J | 1 |
| Dong, Z | 1 |
| Hu, K | 1 |
| Sun, A | 1 |
| Ge, J | 1 |
| Dong, J | 1 |
| Wang, Y | 1 |
| Yi, S | 1 |
| Zhao, T | 1 |
| Xu, Y | 1 |
| Zeigler, AC | 1 |
| Chandrabhatla, AS | 1 |
| Christiansen, SL | 1 |
| Nelson, AR | 1 |
| Holmes, JW | 1 |
| Saucerman, JJ | 1 |
| Cho, HS | 1 |
| Kim, JH | 2 |
| Jang, HN | 1 |
| Lee, TW | 1 |
| Jung, MH | 2 |
| Kim, TH | 1 |
| Chang, SH | 1 |
| Park, DJ | 1 |
| Trivedi, PP | 1 |
| Jena, GB | 1 |
| Ekinci, M | 1 |
| Cagatay, HH | 1 |
| Ceylan, E | 1 |
| Keles, S | 1 |
| Koban, Y | 1 |
| Gokce, G | 1 |
| Huseyinoğlu, U | 2 |
| Ozcan, E | 1 |
| Oba, ME | 1 |
| Jung, JH | 1 |
| Jung, J | 1 |
| Kim, SK | 2 |
| Woo, SH | 1 |
| Kang, KM | 1 |
| Jeong, BK | 1 |
| Hahm, JR | 1 |
| Yildirim, CH | 2 |
| Yucetas, SC | 1 |
| Kaya, M | 2 |
| Ozic, C | 1 |
| Balioğlu, MB | 1 |
| Ustun, H | 1 |
| Tasdemiroglu, E | 2 |
| Akbasak, A | 2 |
| Mao, ZM | 1 |
| Shen, SM | 1 |
| Wan, YG | 1 |
| Sun, W | 1 |
| Chen, HL | 1 |
| Huang, MM | 1 |
| Yang, JJ | 1 |
| Wu, W | 1 |
| Tang, HT | 1 |
| Tang, RM | 1 |
| Sikora, V | 1 |
| Bojko, V | 1 |
| Tkach, G | 1 |
| Kyptenko, L | 1 |
| Lyndin, M | 1 |
| Ryu, SH | 1 |
| Park, EY | 1 |
| Kwak, S | 1 |
| Heo, SH | 1 |
| Ryu, JW | 1 |
| Park, JH | 1 |
| Choi, KC | 1 |
| Lee, SW | 1 |
| Kosemehmetoglu, K | 1 |
| Erdogan, H | 1 |
| Li, CJ | 1 |
| Lv, L | 1 |
| Li, H | 1 |
| Yu, DM | 1 |
| Lee, JE | 1 |
| Yi, CO | 1 |
| Jeon, BT | 1 |
| Shin, HJ | 1 |
| Jung, TS | 1 |
| Choi, JY | 1 |
| Roh, GS | 1 |
| Kaya-Dagistanli, F | 1 |
| Tanriverdi, G | 1 |
| Altinok, A | 1 |
| Ozyazgan, S | 1 |
| Ozturk, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for thioctic acid and Fibrosis
| Article | Year |
|---|---|
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
Topics: Animals; beta Catenin; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus, Type | 2023 |
Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Angiotensin II; Animals; Animals, Newborn; Aorta; Apoptosis; | 2020 |
α-Lipoic acid ameliorates renal fibrosis in diabetic rats through TGF-β1/Smads signaling pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Fibrosis; Humans; Kidney Diseases; Rats; Signal Transducti | 2022 |
Network model-based screen for FDA-approved drugs affecting cardiac fibrosis.
Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Arsenic Trioxide; Biphenyl Compounds; Com | 2021 |
Alpha-lipoic acid ameliorates the epithelial mesenchymal transition induced by unilateral ureteral obstruction in mice.
Topics: Animals; Epithelial-Mesenchymal Transition; Fibrosis; Inflammation; Intercellular Adhesion Molecule- | 2017 |
Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis.
Topics: Animals; Antioxidants; Blood Cells; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Ani | 2013 |
Reduction of conjunctival fibrosis after trabeculectomy using topical α-lipoic acid in rabbit eyes.
Topics: Administration, Topical; Animals; Antioxidants; Conjunctiva; Fibrosis; Intraocular Pressure; Male; O | 2014 |
Alpha lipoic acid attenuates radiation-induced thyroid injury in rats.
Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Fibrosis; Male; Oxidative Stress; Radiatio | 2014 |
Alpha-lipoic acid inhibits peridural fibrosis following laminectomy through the inactivation of TGF-β1, PDGF, PAI-1 and IL-6 expressions.
Topics: Animals; Antioxidants; Dura Mater; Failed Back Surgery Syndrome; Fibrosis; Injections, Intramuscular | 2015 |
Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid.
Topics: Abelmoschus; Animals; Antioxidants; Capsules; Diabetes Mellitus, Experimental; Diabetic Nephropathie | 2015 |
STRUCTURAL CHANGES IN SUBMANDIBULAR SALIVARY GLAND, CAUSED BY HEAVY METAL SALTS, AND THEIR CORRECTION WITH DIALIPON (EXPERIMENTAL STUDY).
Topics: Aging; Animals; Antioxidants; Fibrosis; Histocytochemistry; Male; Metals, Heavy; Rats; Salts; Subman | 2015 |
Protective effect of α-lipoic acid against radiation-induced fibrosis in mice.
Topics: Animals; Antioxidants; Fibrosis; Mice; Mice, Inbred BALB C; Radiation Injuries; Radiation-Protective | 2016 |
Alpha-lipoic acid reduces peridural fibrosis after laminectomy of lumbar vertebrae in rabbits.
Topics: Administration, Topical; Animals; Antioxidants; Dura Mater; Failed Back Surgery Syndrome; Fibrosis; | 2012 |
Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid.
Topics: Actins; Animals; Blotting, Western; Cardiac Catheterization; Cardiotonic Agents; Cell Differentiatio | 2012 |
α-Lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Cardiomyop | 2012 |
The effects of alpha lipoic acid on liver cells damages and apoptosis induced by polyunsaturated fatty acids.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Fatty Acids, Omega-6; Fatty Liver; Fibrosis; Hepatic St | 2013 |