aloperine profile

aloperine: RN refers to (7,alpha,9alpha)-isomer; from Sophora alopecuroides; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Sophora	genus	A plant genus of the family FABACEAE.[MeSH]	Fabaceae	The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

ID Source	ID
PubMed CID	10752071
MeSH ID	M0173416

Synonym
aloperine
56293-29-9
(1r,2s,9r,10r)-3,15-diazatetracyclo[7.7.1.02,7.010,15]heptadec-7-ene
(1s,2s,9s,10r)-3,15-diazatetracyclo[7.7.1.02,7.010,15]heptadec-7-ene

Research Excerpts

Overview

Aloperine (ALO) is an important active component of quinolizidine alkaloids in Sophora flavescens A and Sophora alopecuroides L. Aloperine has effective anticancer activity against multiple cancers.

Excerpt	Reference	Relevance
"Aloperine (ALO) is a natural quinolizidine alkaloid with marked anti-cancer effects on multiple malignancies as well as favorable activity in relieving inflammation, allergies and infection."	( The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop. Cai, FY; Chen, W; Chen, YD; Fan, WW; Jiang, FQ; Liu, XF; Mao, YZ; Xu, K; Yang, YS; Zhang, H, 2021)	1.62
"Aloperine (ALO) is an important active component of quinolizidine alkaloids in Sophora flavescens A and Sophora alopecuroides L, and has effective anticancer activity against multiple cancers. "	( Aloperine Prevents Migration, Invasion, and Adhesion by Upregulating TIMP-4 in Human Bladder Cancer Cells. Liang, J; Liu, J; Qiu, M; Wang, X; Xia, J; Yu, L, 2023)	3.8
"Aloperine is an alkaloid extracted from the leaves and seeds of Sophora alopecuroides L."	( Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF-κB pathway. Tao, L; Wang, Y; Yang, Y; Ye, Y, 2020)	2.72
"Aloperine is a major active component in Sophora alopecuroides L that plays diverse pharmacological properties. "	( Cytochrome P450s regulates aloperine-induced pathological changes in mouse liver and kidney. Feng, P; Guo, R; Liu, J; Qiu, M; Shi, F; Su, Y; Wang, S; Zhao, B, 2020)	2.3
"Aloperine is a new alkaloid extracted from the leaves and seeds of sophora bean."	( Aloperine improves osteoporosis in ovariectomized mice by inhibiting RANKL-induced NF-κB, ERK and JNK approaches. Chen, L; Chen, X; Chen, Y; Hu, R; Xia, C; Xie, Z, 2021)	2.79
"Aloperine (ALO) is a novel type of alkaloid drug that is extracted from S. "	( Aloperine induces apoptosis and inhibits invasion in MG-63 and U2OS human osteosarcoma cells. Chen, S; Dai, L; Gao, W; Jin, Z; Wang, J; Wang, L; Wu, H; Yang, L; Zhou, Z, 2018)	3.37
"Aloperine is a quinolizidine alkaloid extracted from Sophora alopecuroides. "	( Aloperine Protects Mice against Bleomycin-induced Pulmonary Fibrosis by Attenuating Fibroblast Proliferation and Differentiation. Han, J; Han, Z; Wang, S; Yin, W; Zhang, Z, 2018)	3.37
"Aloperine (ALO) is a quinolizidine alkaloid extracted from the leaves of Sophora alopecuroides (S. "	( Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells. Deng, H; Liang, L; Peng, J; Zhang, L; Zheng, Y, 2014)	3.29
"Aloperine is an isolated alkaloid found in the plant of Sophora alopecuroides L."	( Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Guo, JY; Liu, W; Wang, RY; Yuan, XY; Zhang, P, 2010)	1.38

Effects

Excerpt	Reference	Relevance
"Aloperine has been shown to inhibit 2,4-dinitrofluorobenzene (DNFB) induced allergic contact dermatitis in BALB/c mice. "	( Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Guo, JY; Li, RZ; Liu, W; Ma, HM; Wang, RY; Yuan, XY, 2011)	2.12

Treatment

Aloperine pretreatment (10 mg/kg) did not affect baseline cardiac electrical stability. It reduced ventricular arrhythmogenesis and susceptibility to SCD. Aloperine treatment significantly inhibited dermatitis index and ear thickness in DNFB-treated NC/Nga mice.

Excerpt	Reference	Relevance
"Aloperine pretreatment (10 mg/kg) did not affect baseline cardiac electrical stability; yet, it reduced ventricular arrhythmogenesis and susceptibility to SCD (mortality rate: control: 64.3%; aloperine: 0%) induced by reperfusion injury."	( The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death. Abbott, GW; Hu, Z; Li, J; Liu, Q; Manville, RW, 2023)	1.93
"Aloperine treatment significantly inhibited dermatitis index and ear thickness in DNFB-treated NC/Nga mice in a dose-dependent manner."	( Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Guo, JY; Li, RZ; Liu, W; Ma, HM; Wang, RY; Yuan, XY, 2011)	1.4
"Treatment with Aloperine inhibited NO production through suppressing inducible nitric oxide synthase (iNOS) expression and the secretion of prostaglandin E"	( Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF-κB pathway. Tao, L; Wang, Y; Yang, Y; Ye, Y, 2020)	2.34

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (1.96)	18.7374
1990's	1 (1.96)	18.2507
2000's	3 (5.88)	29.6817
2010's	24 (47.06)	24.3611
2020's	22 (43.14)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (1.96%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	50 (98.04%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dinitrofluorobenzene Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.. 1-fluoro-2,4-dinitrobenzene : The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.	2.46	2	C-nitro compound; organofluorine compound	agrochemical; allergen; chromatographic reagent; EC 2.7.3.2 (creatine kinase) inhibitor; protein-sequencing agent; spectrophotometric reagent
chlorobenzene [no description available]	2.17	1	monochlorobenzenes	solvent
monocrotaline Monocrotaline: A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.	7.55	2	pyrrolizidine alkaloid
cytisine [no description available]	2.06	1	alkaloid; bridged compound; lactam; organic heterotricyclic compound; secondary amino compound	nicotinic acetylcholine receptor agonist; phytotoxin; plant metabolite
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.41	1	metal allergen; nickel group element atom; platinum group metal atom
sophocarpine [no description available]	2.45	2
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.25	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
oxymatrine oxymatrine: structure in first source; has anti-apoptosis effects	2.47	2
piperidines Piperidines: A family of hexahydropyridines.	6.24	40
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.61	2
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2.1	1
oxysophocarpine [no description available]	2.06	1

Condition	Relationship Strength	Studies
Cancer of Cervix [description not available]	2.31	1
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	2.31	1
Metastase [description not available]	2.41	1
Colorectal Cancer [description not available]	2.76	2
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.41	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.76	2
Alloxan Diabetes [description not available]	2.41	1
Autoimmune Diabetes [description not available]	2.41	1
Diabetes Mellitus, Type 1 A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.	2.41	1
Lung Injury, Acute [description not available]	2.9	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.14	4
Innate Inflammatory Response [description not available]	2.74	3
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.74	3
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	2.9	2
Bladder Cancer [description not available]	7.6	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.6	1
Arrhythmia [description not available]	2.82	2
Injury, Myocardial Reperfusion [description not available]	2.6	1
Cardiac Arrest, Sudden [description not available]	2.6	1
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	2.82	2
Death, Sudden, Cardiac Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)	2.6	1
Congenital Zika Syndrome [description not available]	2.6	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	7.6	1
Cancer of the Thyroid [description not available]	2.59	2
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	2.59	2
Carcinoma, Non-Small Cell Lung [description not available]	2.25	1
Cancer of Lung [description not available]	2.25	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.25	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.25	1
Cancer of Ovary [description not available]	2.25	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.25	1
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted [description not available]	2.25	1
Hepatitis C INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.	7.25	1
Cirrhosis [description not available]	2.25	1
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	2.25	1
Bone Loss, Perimenopausal [description not available]	2.31	1
Osteoporosis, Postmenopausal Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.	2.31	1
Pulmonary Arterial Remodeling [description not available]	2.15	1
Cardiac Hypertrophy Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.	2.15	1
Pulmonary Hypertension [description not available]	7.55	2
Cardiomegaly Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.	2.15	1
Hypertension, Pulmonary Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.	2.55	2
Bowel Diseases, Inflammatory [description not available]	2.15	1
Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.	7.15	1
Inflammatory Bowel Diseases Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.	2.15	1
Bone Cancer [description not available]	2.17	1
Osteogenic Sarcoma [description not available]	2.17	1
Invasiveness, Neoplasm [description not available]	2.58	2
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	2.17	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	7.17	1
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.17	1
Alveolitis, Fibrosing [description not available]	2.17	1
Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.	7.17	1
Breast Cancer [description not available]	7.17	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.17	1
Acute Confusional Senile Dementia [description not available]	2.17	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.17	1
Allergic Reaction [description not available]	2.17	1
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	2.17	1
Hepatocellular Carcinoma [description not available]	7.21	1
Cancer of Liver [description not available]	2.21	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.21	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.21	1
Allodynia [description not available]	2.1	1
Nerve Pain [description not available]	2.1	1
Neuralgia Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	2.1	1
Kahler Disease [description not available]	2.11	1
Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	7.11	1
Injury, Ischemia-Reperfusion [description not available]	2.11	1
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.11	1
Hypertrophy, Right Ventricular Enlargement of the RIGHT VENTRICLE of the heart. This increase in ventricular mass is often attributed to PULMONARY HYPERTENSION and is a contributor to cardiovascular morbidity and mortality.	2.15	1
Allergic Contact Dermatitis [description not available]	7.05	1
Erythema Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	2.05	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2.05	1
Eczema, Atopic [description not available]	2.06	1
Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	2.06	1
Adjuvant Arthritis [description not available]	1.97	1
Arthus Phenomenon [description not available]	1.97	1
Delayed Hypersensitivity [description not available]	1.97	1

aloperine

Description

Cross-References

Synonyms (4)

Research Excerpts

Overview

Effects

Treatment

Research

Studies (51)

Market Indicators

Research Demand Index: 27.54

Study Types

aloperine

Description

Related Flora

Cross-References

Synonyms (4)

Research Excerpts

Overview

Effects

Treatment

Research

Studies (51)

Market Indicators

Research Demand Index: 27.54

Study Types

Related Drugs (12)

Related Conditions (79)