A serine palmitoyltransferase 2 that is encoded in the genome of human. [PRO:CNA]
EC 2.3.1.50;
Long chain base biosynthesis protein 2;
LCB 2;
Long chain base biosynthesis protein 2a;
LCB2a;
Serine-palmitoyl-CoA transferase 2;
SPT 2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| thermozymocidin | Homo sapiens (human) | IC50 | 0.0001 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| serine C-palmitoyltransferase activity | molecular function | Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA. [EC:2.3.1.50, RHEA:14761] |
| pyridoxal phosphate binding | molecular function | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| serine C-palmitoyltransferase complex | cellular component | An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine. [PMID:19416851] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| sphingomyelin biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732] |
| sphingolipid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732] |
| sphinganine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol. [GOC:ai] |
| sphingosine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. [GOC:ma, ISBN:0198506732] |
| adipose tissue development | biological process | The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. [GOC:dph] |
| ceramide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. [GOC:ai] |