succinic acid has been researched along with Fibrosis in 8 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fibrosis is an important pathological mechanism in heart failure (HF) and is associated with poor prognosis." | 1.72 | Transcriptome analysis of a dog model of congestive heart failure shows that collagen-related 2-oxoglutarate-dependent dioxygenases contribute to heart failure. ( Isono, T; Kageyama, S; Kawauchi, A; Kubota, S; Matsumoto, T; Suzaki, M; Wada, A, 2022) |
| "To induce the progression of NAFLD to nonalcoholic steatohepatitis (NASH), C57BL/6J mice were fed a Western-style diet (WD) or control diet for 30 weeks." | 1.62 | Western Diet Decreases the Liver Mitochondrial Oxidative Flux of Succinate: Insight from a Murine NAFLD Model. ( Červinková, Z; Elkalaf, M; Kučera, O; Melek, J; Peterová, E; Podhola, M; Rychtrmoc, D; Staňková, P; Zubáňová, V, 2021) |
| "The pathogenesis of Crohn's disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process." | 1.56 | Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development. ( Alós, R; Barrachina, MD; Bauset, C; Calatayud, S; Coll, S; Cosín-Roger, J; Esplugues, JV; Gisbert-Ferrándiz, L; Mamie, C; Navarro, F; Ortiz-Masiá, D; Scharl, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 6 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Isono, T | 1 |
| Matsumoto, T | 1 |
| Suzaki, M | 1 |
| Kubota, S | 1 |
| Kageyama, S | 1 |
| Kawauchi, A | 1 |
| Wada, A | 1 |
| Wu, KK | 1 |
| Liu, XJ | 1 |
| Xie, L | 1 |
| Du, K | 1 |
| Liu, C | 1 |
| Zhang, NP | 1 |
| Gu, CJ | 1 |
| Wang, Y | 1 |
| Abdelmalek, MF | 1 |
| Dong, WY | 1 |
| Liu, XP | 1 |
| Niu, C | 1 |
| Yang, C | 1 |
| Diehl, AM | 1 |
| Wu, J | 1 |
| Ortiz-Masiá, D | 2 |
| Gisbert-Ferrándiz, L | 2 |
| Bauset, C | 1 |
| Coll, S | 1 |
| Mamie, C | 1 |
| Scharl, M | 1 |
| Esplugues, JV | 2 |
| Alós, R | 2 |
| Navarro, F | 2 |
| Cosín-Roger, J | 2 |
| Barrachina, MD | 2 |
| Calatayud, S | 2 |
| Staňková, P | 1 |
| Kučera, O | 1 |
| Peterová, E | 1 |
| Elkalaf, M | 1 |
| Rychtrmoc, D | 1 |
| Melek, J | 1 |
| Podhola, M | 1 |
| Zubáňová, V | 1 |
| Červinková, Z | 1 |
| Winther, S | 1 |
| Trauelsen, M | 1 |
| Schwartz, TW | 1 |
| Macias-Ceja, DC | 1 |
| Salvador, P | 1 |
| Hernández, C | 1 |
| Hausmann, M | 1 |
| Rogler, G | 1 |
| Hinojosa, J | 1 |
| Fukuda, H | 1 |
| Ebara, M | 1 |
| Okuyama, M | 1 |
| Sugiura, N | 1 |
| Yoshikawa, M | 1 |
| Saisho, H | 1 |
| Shimizu, R | 1 |
| Motoji, N | 1 |
| Shigematsu, A | 1 |
| Watayo, T | 1 |
1 review available for succinic acid and Fibrosis
| Article | Year |
|---|---|
Extracellular Succinate: A Physiological Messenger and a Pathological Trigger.
Topics: Cell Membrane; Fibrosis; Humans; Signal Transduction; Succinates; Succinic Acid | 2023 |
7 other studies available for succinic acid and Fibrosis
| Article | Year |
|---|---|
Transcriptome analysis of a dog model of congestive heart failure shows that collagen-related 2-oxoglutarate-dependent dioxygenases contribute to heart failure.
Topics: Animals; Collagen; Dioxygenases; Dogs; Fibrosis; Gene Expression Profiling; Heart Failure; Humans; K | 2022 |
Succinate-GPR-91 receptor signalling is responsible for nonalcoholic steatohepatitis-associated fibrosis: Effects of DHA supplementation.
Topics: Animals; Dietary Supplements; Docosahexaenoic Acids; Fibrosis; Liver; Mice; Mice, Inbred C57BL; Non- | 2020 |
Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development.
Topics: Animals; Cadherins; Crohn Disease; Epithelial Cells; Fibrosis; Fistula; Humans; Inflammation; Intest | 2020 |
Western Diet Decreases the Liver Mitochondrial Oxidative Flux of Succinate: Insight from a Murine NAFLD Model.
Topics: Animals; Apoptosis; Biomarkers; Cell Respiration; Diet, Western; Disease Models, Animal; Disease Sus | 2021 |
Protective succinate-SUCNR1 metabolic stress signaling gone bad.
Topics: Animals; Fibrosis; Mice; Receptors, G-Protein-Coupled; Signal Transduction; Stress, Physiological; S | 2021 |
Succinate receptor mediates intestinal inflammation and fibrosis.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Colitis; Crohn Disease; Disease Models, Animal; Female; | 2019 |
Increased metabolizing activities of the tricarboxylic acid cycle and decreased drug metabolism in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Chromatography, Thin Layer; Citric Acid Cycle; Diazepam; Fibrosis; Humans | 2002 |