Matrix metalloproteinase-17

A matrix metalloproteinase-17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULZ9]

MMP-17;
EC 3.4.24.-;
Membrane-type matrix metalloproteinase 4;
MT-MMP 4;
MTMMP4;
Membrane-type-4 matrix metalloproteinase;
MT4-MMP;
MT4MMP

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ilomastat	Homo sapiens (human)	IC50	0.0034	1	1

This protein enables 4 target(s):

Target	Category	Definition
enzyme activator activity	molecular function	Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
metalloaminopeptidase activity	molecular function	Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]
metalloendopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
extracellular matrix	cellular component	A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]
side of membrane	cellular component	A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos]

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

This protein is involved in 5 target(s):

Target	Category	Definition
kidney development	biological process	The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
drinking behavior	biological process	The specific behavior of an organism relating to the intake of liquids, especially water. [GOC:curators, GOC:pr]
collagen catabolic process	biological process	The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194]
extracellular matrix organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah]