nifedipine has been researched along with Fibrosis in 19 studies
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to compare the effect of Neoral cyclosporin- and tacrolimus-based therapy on the development of renal allograft fibrosis (chronic allograft nephropathy; CAN) in a prospective randomized trial." | 9.10 | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. ( Furness, PN; Murphy, GJ; Nicholson, ML; Sandford, RS; Waller, JR, 2003) |
| "To compare the degree of interstitial fibrosis in renal transplant biopsy specimens from immunosuppressed patients using conventional doses of cyclosporin with and without calcium channel blockade with a combination of low dose cyclosporin and azathioprine; to correlate the degree of interstitial fibrosis with the glomerular filtration rate." | 9.07 | Influence of nifedipine on interstitial fibrosis in renal transplant allografts treated with cyclosporin A. ( Bell, PR; Donnelly, PK; Feehally, J; Furness, PN; Harper, SJ; McCulloch, TA; Moorhouse, J; Walls, J, 1994) |
| "The effects of nifedipine and enalapril on age-associated renal interstitial fibrosis were investigated in 60 CF1 female mice." | 7.69 | Renal interstitial sclerosis in aging: effects of enalapril and nifedipine. ( de Cavanagh, EM; Ercole, L; Ferder, LF; Gomez, RA; Inserra, F; Romano, LA, 1996) |
| "The aim of this study was to compare the effect of Neoral cyclosporin- and tacrolimus-based therapy on the development of renal allograft fibrosis (chronic allograft nephropathy; CAN) in a prospective randomized trial." | 5.10 | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. ( Furness, PN; Murphy, GJ; Nicholson, ML; Sandford, RS; Waller, JR, 2003) |
| "To compare the degree of interstitial fibrosis in renal transplant biopsy specimens from immunosuppressed patients using conventional doses of cyclosporin with and without calcium channel blockade with a combination of low dose cyclosporin and azathioprine; to correlate the degree of interstitial fibrosis with the glomerular filtration rate." | 5.07 | Influence of nifedipine on interstitial fibrosis in renal transplant allografts treated with cyclosporin A. ( Bell, PR; Donnelly, PK; Feehally, J; Furness, PN; Harper, SJ; McCulloch, TA; Moorhouse, J; Walls, J, 1994) |
| "Treatment with efonidipine improved tubulointerstitial fibrosis more effectively than treatment with nifedipine in UUO." | 3.77 | Inhibitory effects of T/L-type calcium channel blockers on tubulointerstitial fibrosis in obstructed kidneys in rats. ( Hayashi, T; Inoue, T; Ishizaka, N; Kitada, K; Kitaura, Y; Kurumazuka, D; Matsuda, H; Matsumura, Y; Mori, T; Nagatoya, K; Ukimura, A, 2011) |
| "Nifedipine-induced gingival overgrowth is known to be characterized by fibrosis and some degree of inflammation." | 3.73 | Effects of nifedipine and interleukin-1alpha on the expression of collagen, matrix metalloproteinase-1, and tissue inhibitor of metalloproteinase-1 in human gingival fibroblasts. ( Kameyama, Y; Kosaka, T; Kubo, K; Maeda, H; Sakagami, G; Sato, E; Sugita, Y, 2006) |
| "Gingival overgrowth samples were obtained from patients undergoing therapy with phenytoin (n = 9), nifedipine (n = 4), cyclosporin A (n = 5), and control tissues from systemically healthy donors (n = 9)." | 3.71 | Connective tissue growth factor in drug-induced gingival overgrowth. ( Firatli, E; Hong, HH; Kantarci, A; Sheff, MC; Trackman, PC; Uygur, C; Uzel, MI, 2001) |
| " We treated 16-week-old rats having established LVH and myocardial fibrosis due to 8-week renovascular hypertension (RHT) with either 6 mg/kg/day zofenopril (ZOF), 30 mg/kg/day nifedipine (NIF) or 40 mg/kg/day labetalol (LAB) for 12 weeks." | 3.70 | Regression of myocardial fibrosis in hypertensive heart disease: diverse effects of various antihypertensive drugs. ( Brilla, CG, 2000) |
| "The effects of nifedipine and enalapril on age-associated renal interstitial fibrosis were investigated in 60 CF1 female mice." | 3.69 | Renal interstitial sclerosis in aging: effects of enalapril and nifedipine. ( de Cavanagh, EM; Ercole, L; Ferder, LF; Gomez, RA; Inserra, F; Romano, LA, 1996) |
| " Gingival overgrowth associated with cyclosporin (immunosuppressant agent) and nifedipine (calcium channel blocker) is well documented." | 3.69 | Periodontal management of gingival overgrowth in the heart transplant patient: a case report. ( Khocht, A; Schneider, LC, 1997) |
| "The aim was to determine if long term treatment with nifedipine or nisoldipine affects structural remodelling of cardiac myocytes and is effective in attenuating or preventing reparative and reactive myocardial fibrosis in essential hypertension." | 3.68 | Cardiac structural remodelling after treatment of spontaneously hypertensive rats with nifedipine or nisoldipine. ( Campbell, SE; Kazda, S; Rakusan, K; Turek, Z, 1993) |
| " To investigate if inhibition of phagocytosis could be replicated in vitro, cells were incubated with the fibrosis-inducing drugs nifedipine or dilantin." | 3.68 | Deficiencies in collagen phagocytosis by human fibroblasts in vitro: a mechanism for fibrosis? ( Knowles, GC; McCulloch, CA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hammoud, SH | 1 |
| Alkhansa, S | 1 |
| Mahjoub, N | 1 |
| Omar, AG | 1 |
| El-Mas, MM | 1 |
| Eid, AA | 1 |
| Jia, Y | 1 |
| Xu, J | 1 |
| Yu, Y | 1 |
| Guo, J | 1 |
| Liu, P | 1 |
| Chen, S | 1 |
| Jiang, J | 1 |
| Yamada, T | 1 |
| Nagata, K | 1 |
| Cheng, XW | 1 |
| Obata, K | 1 |
| Saka, M | 1 |
| Miyachi, M | 1 |
| Naruse, K | 1 |
| Nishizawa, T | 1 |
| Noda, A | 1 |
| Izawa, H | 1 |
| Kuzuya, M | 1 |
| Okumura, K | 1 |
| Murohara, T | 1 |
| Yokota, M | 1 |
| Matsui, T | 1 |
| Takeuchi, M | 1 |
| Yamagishi, S | 1 |
| Matsuda, H | 1 |
| Mori, T | 2 |
| Kurumazuka, D | 1 |
| Kitada, K | 1 |
| Hayashi, T | 1 |
| Nagatoya, K | 1 |
| Inoue, T | 1 |
| Ukimura, A | 1 |
| Matsumura, Y | 1 |
| Ishizaka, N | 1 |
| Kitaura, Y | 2 |
| Lei, B | 1 |
| Hitomi, H | 1 |
| Nagai, Y | 1 |
| Deguchi, K | 1 |
| Mori, H | 1 |
| Masaki, T | 1 |
| Nakano, D | 1 |
| Kobori, H | 1 |
| Nishiyama, A | 1 |
| Sakurada, T | 1 |
| Ishizawa, K | 1 |
| Imanishi, M | 1 |
| Izawa-Ishizawa, Y | 1 |
| Fujii, S | 1 |
| Tominaga, E | 1 |
| Tsuneishi, T | 1 |
| Horinouchi, Y | 1 |
| Kihira, Y | 1 |
| Ikeda, Y | 1 |
| Tomita, S | 1 |
| Aihara, K | 1 |
| Minakuchi, K | 1 |
| Tsuchiya, K | 1 |
| Tamaki, T | 1 |
| Akiyama-Uchida, Y | 1 |
| Ashizawa, N | 1 |
| Ohtsuru, A | 1 |
| Seto, S | 1 |
| Tsukazaki, T | 1 |
| Kikuchi, H | 1 |
| Yamashita, S | 1 |
| Yano, K | 1 |
| Murphy, GJ | 1 |
| Waller, JR | 1 |
| Sandford, RS | 1 |
| Furness, PN | 2 |
| Nicholson, ML | 1 |
| Sakagami, G | 1 |
| Sato, E | 1 |
| Sugita, Y | 1 |
| Kosaka, T | 1 |
| Kubo, K | 1 |
| Maeda, H | 1 |
| Kameyama, Y | 1 |
| McCulloch, TA | 1 |
| Harper, SJ | 1 |
| Donnelly, PK | 1 |
| Moorhouse, J | 1 |
| Bell, PR | 1 |
| Walls, J | 1 |
| Feehally, J | 1 |
| Campbell, SE | 1 |
| Turek, Z | 1 |
| Rakusan, K | 1 |
| Kazda, S | 1 |
| McCulloch, CA | 1 |
| Knowles, GC | 1 |
| Inserra, F | 1 |
| Romano, LA | 1 |
| de Cavanagh, EM | 1 |
| Ercole, L | 1 |
| Ferder, LF | 1 |
| Gomez, RA | 1 |
| Neumann, C | 1 |
| Willershausen-Zönnchen, B | 1 |
| Klug, C | 1 |
| Darius, H | 1 |
| Khocht, A | 1 |
| Schneider, LC | 1 |
| Brilla, CG | 1 |
| Uzel, MI | 1 |
| Kantarci, A | 1 |
| Hong, HH | 1 |
| Uygur, C | 1 |
| Sheff, MC | 1 |
| Firatli, E | 1 |
| Trackman, PC | 1 |
| Zou, Y | 1 |
| Yamazaki, T | 1 |
| Nakagawa, K | 1 |
| Yamada, H | 1 |
| Iriguchi, N | 1 |
| Toko, H | 1 |
| Takano, H | 1 |
| Akazawa, H | 1 |
| Nagai, R | 1 |
| Komuro, I | 1 |
2 trials available for nifedipine and Fibrosis
| Article | Year |
|---|---|
Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis.
Topics: Adult; Analysis of Variance; Aspirin; Cyclosporine; Extracellular Matrix; Female; Fibrosis; Graft Re | 2003 |
Influence of nifedipine on interstitial fibrosis in renal transplant allografts treated with cyclosporin A.
Topics: Azathioprine; Cyclosporine; Fibrosis; Glomerular Filtration Rate; Humans; Immunosuppression Therapy; | 1994 |
17 other studies available for nifedipine and Fibrosis
| Article | Year |
|---|---|
Molecular basis of the counteraction by calcium channel blockers of cyclosporine nephrotoxicity.
Topics: Animals; Biomarkers; Blood Urea Nitrogen; Calcium Channel Blockers; Collagen Type IV; Creatinine; Cy | 2018 |
Nifedipine inhibits angiotensin II-induced cardiac fibrosis via downregulating Nox4-derived ROS generation and suppressing ERK1/2, JNK signaling pathways.
Topics: Actins; Angiotensin II; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Signaling; Cel | 2013 |
Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Collagen; Disease Models, Animal; Fibros | 2009 |
Nifedipine, a calcium channel blocker, inhibits inflammatory and fibrogenic gene expressions in advanced glycation end product (AGE)-exposed fibroblasts via mineralocorticoid receptor antagonistic activity.
Topics: Aldosterone; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Cell Line; Fibroblas | 2010 |
Inhibitory effects of T/L-type calcium channel blockers on tubulointerstitial fibrosis in obstructed kidneys in rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridi | 2011 |
Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridi | 2011 |
Nitrosonifedipine ameliorates angiotensin II-induced vascular remodeling via antioxidative effects.
Topics: Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Calcium; Cell Movement; Cell Proliferation; | 2013 |
Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.
Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Blotting, Western; Cell Division; Coll | 2002 |
Effects of nifedipine and interleukin-1alpha on the expression of collagen, matrix metalloproteinase-1, and tissue inhibitor of metalloproteinase-1 in human gingival fibroblasts.
Topics: Adolescent; Adult; Calcium Channel Blockers; Cells, Cultured; Collagen Type I; Enzyme-Linked Immunos | 2006 |
Cardiac structural remodelling after treatment of spontaneously hypertensive rats with nifedipine or nisoldipine.
Topics: Animals; Cell Size; Fibrosis; Heart; Hypertension; Male; Myocardium; Nifedipine; Nisoldipine; Organ | 1993 |
Deficiencies in collagen phagocytosis by human fibroblasts in vitro: a mechanism for fibrosis?
Topics: Adolescent; Adult; Cell Division; Cell Line; Collagen; Fibroblasts; Fibrosis; Flow Cytometry; Fluore | 1993 |
Renal interstitial sclerosis in aging: effects of enalapril and nifedipine.
Topics: Actins; Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Biomarkers; Calcium Channel Blocke | 1996 |
Clinical assessment of periodontal conditions in patients treated with nifedipine.
Topics: Bicuspid; Calcium Channel Blockers; Cuspid; Edema; Female; Fibrosis; Gingiva; Gingival Diseases; Hum | 1996 |
Periodontal management of gingival overgrowth in the heart transplant patient: a case report.
Topics: Calcium Channel Blockers; Candidiasis, Oral; Connective Tissue; Cyclosporine; Epithelium; Fibrosis; | 1997 |
Regression of myocardial fibrosis in hypertensive heart disease: diverse effects of various antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Captopril; Collagen; Fibrosis; Hypertension, Renovascular; Hypertr | 2000 |
Connective tissue growth factor in drug-induced gingival overgrowth.
Topics: Adult; Antibodies; Anticonvulsants; Calcium Channel Blockers; Carrier Proteins; Coloring Agents; Con | 2001 |
Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Calcineurin Inhibitors; Calcium Channel Blockers | 2002 |