Compounds > edgeworin
Page last updated: 2024-11-12

edgeworin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

edgeworin: from Dirca occidentalis Gray; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Dircagenus[no description available]ThymelaeaceaeA plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]
Dirca occidentalisspecies[no description available]ThymelaeaceaeA plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]

Cross-References

ID SourceID
PubMed CID10925304
CHEMBL ID259025
SCHEMBL ID13784418
MeSH IDM0246931

Synonyms (14)

Synonym
edgeworin
CHEMBL259025 ,
7-hydroxy-3-(2-oxo-2h-chromen-7-yloxy)chromen-2-one
bdbm50237597
7-hydroxy-3,7''-dicoumaryl ether
SCHEMBL13784418
120028-43-5
AKOS032962620
3-(7-coumarinyloxy)-7-hydroxycoumarin
7-hydroxy-3-(2-oxochromen-7-yl)oxychromen-2-one
7-hydroxy-3-((2-oxo-2h-chromen-7-yl)oxy)-2h-chromen-2-one
STARBLD0001917
CS-0369085
HY-N10169
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA polymerase betaHomo sapiens (human)IC50 (µMol)35.15501.40006.56679.0000AID328030; AID328031
DNA polymerase betaRattus norvegicus (Norway rat)IC50 (µMol)22.50003.70006.20008.5000AID333321
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (22)

Processvia Protein(s)Taxonomy
nucleotide-excision repair, DNA gap fillingDNA polymerase betaHomo sapiens (human)
in utero embryonic developmentDNA polymerase betaHomo sapiens (human)
DNA-templated DNA replicationDNA polymerase betaHomo sapiens (human)
DNA repairDNA polymerase betaHomo sapiens (human)
base-excision repairDNA polymerase betaHomo sapiens (human)
base-excision repair, gap-fillingDNA polymerase betaHomo sapiens (human)
pyrimidine dimer repairDNA polymerase betaHomo sapiens (human)
inflammatory responseDNA polymerase betaHomo sapiens (human)
DNA damage responseDNA polymerase betaHomo sapiens (human)
salivary gland morphogenesisDNA polymerase betaHomo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damageDNA polymerase betaHomo sapiens (human)
response to gamma radiationDNA polymerase betaHomo sapiens (human)
somatic hypermutation of immunoglobulin genesDNA polymerase betaHomo sapiens (human)
response to ethanolDNA polymerase betaHomo sapiens (human)
lymph node developmentDNA polymerase betaHomo sapiens (human)
spleen developmentDNA polymerase betaHomo sapiens (human)
homeostasis of number of cellsDNA polymerase betaHomo sapiens (human)
neuron apoptotic processDNA polymerase betaHomo sapiens (human)
response to hyperoxiaDNA polymerase betaHomo sapiens (human)
immunoglobulin heavy chain V-D-J recombinationDNA polymerase betaHomo sapiens (human)
DNA biosynthetic processDNA polymerase betaHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA polymerase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
damaged DNA bindingDNA polymerase betaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase betaHomo sapiens (human)
DNA-(apurinic or apyrimidinic site) endonuclease activityDNA polymerase betaHomo sapiens (human)
protein bindingDNA polymerase betaHomo sapiens (human)
microtubule bindingDNA polymerase betaHomo sapiens (human)
lyase activityDNA polymerase betaHomo sapiens (human)
enzyme bindingDNA polymerase betaHomo sapiens (human)
metal ion bindingDNA polymerase betaHomo sapiens (human)
5'-deoxyribose-5-phosphate lyase activityDNA polymerase betaHomo sapiens (human)
class I DNA-(apurinic or apyrimidinic site) endonuclease activityDNA polymerase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
nucleusDNA polymerase betaHomo sapiens (human)
nucleoplasmDNA polymerase betaHomo sapiens (human)
cytoplasmDNA polymerase betaHomo sapiens (human)
microtubuleDNA polymerase betaHomo sapiens (human)
spindle microtubuleDNA polymerase betaHomo sapiens (human)
protein-containing complexDNA polymerase betaHomo sapiens (human)
nucleusDNA polymerase betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID328032Inhibition of DNA-polymerase beta binary complex formation by DNA binding mobility shift assay2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Inhibitors of DNA polymerase beta: activity and mechanism.
AID333322Cytotoxicity against human A549 cells at 6 uM after 48 hrs2004Journal of natural products, Sep, Volume: 67, Issue:9
Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta.
AID333324Cytotoxicity against human A549 cells at 6 uM after 48 hrs in presence of 0.5 uM blenoxane2004Journal of natural products, Sep, Volume: 67, Issue:9
Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta.
AID328030Inhibition of lyase activity of DNA polymerase beta2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Inhibitors of DNA polymerase beta: activity and mechanism.
AID1675381Disruption of interaction between Nrf2/Keap1 (unknown origin) in mesangial cells assessed as reduction in high glucose-induced collagen IV secretion at 10 uM by ELISA2020Bioorganic & medicinal chemistry letters, 10-15, Volume: 30, Issue:20
Discovery of a coumarin derivative as Nrf2 activator mitigating oxidative stress and fibrosis in mesangial cells under high glucose.
AID333321Inhibition of lyase activity of rat DNA polymerase beta after 30 mins2004Journal of natural products, Sep, Volume: 67, Issue:9
Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta.
AID328031Inhibition of polymerase activity of DNA polymerase beta2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Inhibitors of DNA polymerase beta: activity and mechanism.
AID333413Inhibition of rat DNA polymerase beta-mediated DNA polymerization up to 100 ug/mL after 1 hr2004Journal of natural products, Sep, Volume: 67, Issue:9
Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta.
AID328033Cytotoxicity against human A549 cells after 1 hr by MTT assay2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Inhibitors of DNA polymerase beta: activity and mechanism.
AID328038Inhibition of bleomycin-induced unscheduled DNA synthesis in human A549 cells at 6 uM2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Inhibitors of DNA polymerase beta: activity and mechanism.
AID328035Effect on DNA polymerase beta expression in human A549 cells at 6 uM after 48 hrs by Western blot analysis2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Inhibitors of DNA polymerase beta: activity and mechanism.
AID1675386Disruption of interaction between Nrf2/Keap1 (unknown origin) in mesangial cells assessed as reduction in high glucose-induced intracellular MDA level at 10 uM2020Bioorganic & medicinal chemistry letters, 10-15, Volume: 30, Issue:20
Discovery of a coumarin derivative as Nrf2 activator mitigating oxidative stress and fibrosis in mesangial cells under high glucose.
AID1675391Inhibition of glucose-induced cell proliferation in Mesangial cell (unknown origin) at 10 uM by CCK8 assay2020Bioorganic & medicinal chemistry letters, 10-15, Volume: 30, Issue:20
Discovery of a coumarin derivative as Nrf2 activator mitigating oxidative stress and fibrosis in mesangial cells under high glucose.
AID1675394Cytotoxicity against Mesangial cell (unknown origin) at 0.01 to 100 uM by CCK8 assay2020Bioorganic & medicinal chemistry letters, 10-15, Volume: 30, Issue:20
Discovery of a coumarin derivative as Nrf2 activator mitigating oxidative stress and fibrosis in mesangial cells under high glucose.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's1 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetic acid
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.		2.0410monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
oleanolic acid
[no description available]		2.0410hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
betulinic acid
[no description available]		2.0410hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
stigmasterol
stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.		2.04103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite
daphnoretin
daphnoretin: isolated from the whole plant Wikstroemia indica. daphnoretin : A member of the class of coumarins that is coumarin substituted by a hydroxy group at position 7, a methoxy group at position 6 and a (2-oxo-2H-chromen-7-yl)oxy group at position 3.		2.4820aromatic ether;
hydroxycoumarin		antineoplastic agent;
antiviral agent;
metabolite
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.7230benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Diabetic Glomerulosclerosis
[description not available]		02.2510
Cirrhosis
[description not available]		02.2510
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.		02.2510
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.		02.2510
Anasarca
[description not available]		02.0410
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0410