lufironil profile

Lufironil is a fungicide that belongs to the chemical class of strobilurins. It is a broad-spectrum fungicide that is used to control a wide range of fungal diseases in various crops, including wheat, barley, rice, and fruits. It is known for its high efficacy and long-lasting activity. Lufironil inhibits the mitochondrial cytochrome bc1 complex, which is essential for fungal respiration. This mechanism of action disrupts fungal energy production, leading to their death. Lufironil is applied to crops in various formulations, including sprays and seed treatments. It is highly effective in controlling diseases caused by fungal pathogens such as Septoria tritici, Puccinia striiformis, and Erysiphe graminis. Lufironil is studied extensively for its potential to improve crop yields and reduce crop losses due to fungal diseases. Research is ongoing to explore its environmental impact, efficacy against emerging fungal strains, and potential for resistance development.'

lufironil: structure given in first source; inhibits CCl4-induced liver fibrosis in rats and inhibits proline hydroxylase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	60788
CHEMBL ID	2106793
SCHEMBL ID	344625
MeSH ID	M0201434

Synonym
lufironil
hoe-077
n,n'-bis(2-methoxyethyl)-2,4-pyridinedicarboxamide
lufironilum [inn-latin]
lufironil [usan:inn]
hoe 077
2,4-pyridinedicarboxamide,n,n'-bis(2-methoxyethyl)-
lufironilo [inn-spanish]
2,4-pyridinedicarboxamide, n,n'-bis(2-methoxyethyl)-
D04793
lufironil (usan/inn)
128075-79-6
2-n,4-n-bis(2-methoxyethyl)pyridine-2,4-dicarboxamide
CHEMBL2106793
unii-8mmu177964
8mmu177964 ,
lufironilum
lufironilo
lufironil [usan]
lufironil [inn]
SCHEMBL344625
DTXSID00155802
AKOS028356325
Q27270759

Excerpt	Reference	Relevance
" HOE 077 is well absorbed from the gastrointestinal tract."	( Beneficial effects of inhibitors of prolyl 4-hydroxylase in CCl4-induced fibrosis of the liver in rats. Baader, E; Bickel, M; Brocks, DG; Engelbart, K; Günzler, V; Schmidts, HL; Vogel, GH, 1991)	0.28

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	14 (87.50)	18.2507
2000's	2 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (12.50%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (87.50%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
choline [no description available]	1.98	1	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite
thymidine [no description available]	1.97	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
hydroxyproline Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.	3.08	5	4-hydroxyproline; L-alpha-amino acid zwitterion	human metabolite; mouse metabolite; plant metabolite
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	1.99	1	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	1.97	1	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	1.98	1	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	3.11	1	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
bilirubin [no description available]	7.38	2	biladienes; dicarboxylic acid	antioxidant; human metabolite; mouse metabolite
barium Barium: An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.	2	1	alkaline earth metal atom; elemental barium
(2e,4e,6e,10e)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid: an acyclic retinoid that suppresses hepatocellular carcinoma recurrence; structure in first source	3.11	1
ceruletide Ceruletide: A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.. ceruletide : A decapeptide comprising 5-oxoprolyl, glutamyl, aspartyl, O-sulfotyrosyl, threonyl, glycyl, tryptopyl, methionyl, aspartyl and phenylalaninamide residues in sequence. Found in the skins of certain Australian amphibians, it is an analogue of the gastrointestinal peptide hormone cholecystokinin and stimulates gastric, biliary, and pancreatic secretion. It is used in cases of paralysis of the intestine (paralytic ileus) and as a diagnostic aid in pancreatic malfunction.	1.99	1	oligopeptide	diagnostic agent; gastrointestinal drug

Condition	Relationship Strength	Studies
Choline Deficiency A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)	2.39	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.39	2
Cirrhoses, Experimental Liver [description not available]	4.69	11
Experimental Hepatoma [description not available]	1.98	1
Acute Edematous Pancreatitis [description not available]	1.99	1
Acute Disease Disease having a short and relatively severe course.	1.99	1
Pancreatitis INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.	1.99	1
Cirrhosis [description not available]	2	1
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	2	1
Hepatitis B Virus Infection [description not available]	2.92	1
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted [description not available]	2.92	1
Hepatocellular Carcinoma [description not available]	2.92	1
Cancer of Liver [description not available]	2.92	1
Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	2.92	1
Hepatitis C INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.	2.92	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.92	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.92	1
Carbon Tetrachloride Poisoning Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.	2.38	2
Biliary Cirrhosis [description not available]	1.97	1
Liver Cirrhosis, Biliary FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.	1.97	1
Liver Dysfunction [description not available]	2.89	1
Liver Diseases Pathological processes of the LIVER.	2.89	1

lufironil

Description

Cross-References

Synonyms (24)

Research Excerpts

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Research

Studies (16)

Study Types