Page last updated: 2024-12-11

serratin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

serratin: isolated from the essential oil of Clerodendron serratum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5398649
CHEMBL ID600635
CHEBI ID197005
SCHEMBL ID3787335
MeSH IDM0526426

Synonyms (48)

Synonym
OPREA1_027529
IFLAB1_001433
OPREA1_843402
5,7-dihydroxy-4-phenyl-2h-chromen-2-one
STK088787
5,7-dihydroxy-4-phenyl-chromen-2-one
5,7-dihydroxy-4-phenylcoumarin
smr000514295
MLS001210370 ,
HMS1416B03
FT-0659329
SCHEMBL3787335
AKOS000574851
AB00684264-01
CHEMBL600635
serratin
LMPK12100031
5,7-dihydroxy-4-phenylchromen-2-one
CHEBI:197005
A839139
NCGC00245137-01
2h-1-benzopyran-2-one, 5,7-dihydroxy-4-phenyl-
5,7-dihydroxy-4-phenyl-2h-1-benzopyran-2-one
7758-73-8
HMS2824C11
AB00684264-07
BBL029152
DTXSID90228251
HUQKUJNSVHEHIH-UHFFFAOYSA-N
REGID_FOR_CID_5398649
HMS3468P06
5,7-dihydroxy-4-phenyl-coumarin
bdbm69688
5,7-dihydroxy-4-phenyl-1-benzopyran-2-one
cid_5398649
5,7-bis(oxidanyl)-4-phenyl-chromen-2-one
SR-01000361755-1
sr-01000361755
mfcd01078551
AS-64358
5 7-dihydroxy-4-phenylcoumarin
HY-130259
CS-0106129
lc3-mhtt-in-an2
57-dihydroxy-4-phenylcoumarin
D95986
EN300-303110
cl-271149
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
neoflavonoidAny 1-benzopyran with an aryl substituent at position 4. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (14)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
phosphopantetheinyl transferaseBacillus subtilisPotency89.12510.141337.9142100.0000AID1490
ATAD5 protein, partialHomo sapiens (human)Potency12.58930.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency18.35640.000811.382244.6684AID686978
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency25.11893.548119.542744.6684AID743266
importin subunit beta-1 isoform 1Homo sapiens (human)Potency28.18385.804836.130665.1308AID540263
snurportin-1Homo sapiens (human)Potency28.18385.804836.130665.1308AID540263
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency35.48130.00419.962528.1838AID2675
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.81070.251215.843239.8107AID504327
Glycoprotein hormones alpha chainHomo sapiens (human)Potency1.00004.46688.344810.0000AID624291
Alpha-synucleinHomo sapiens (human)Potency11.22020.56239.398525.1189AID652106
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
high affinity choline transporter 1 isoform aHomo sapiens (human)IC50 (µMol)13.66520.00036.210228.8403AID504840
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glycogen synthase kinase-3 beta isoform 1Homo sapiens (human)EC50 (µMol)7.82300.212522.156283.9400AID434954
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (91)

Processvia Protein(s)Taxonomy
G protein-coupled receptor signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell population proliferationGlycoprotein hormones alpha chainHomo sapiens (human)
hormone-mediated signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
regulation of signaling receptor activityGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of steroid biosynthetic processGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell migrationGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid gland developmentGlycoprotein hormones alpha chainHomo sapiens (human)
luteinizing hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIGlycoprotein hormones alpha chainHomo sapiens (human)
negative regulation of organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid hormone generationGlycoprotein hormones alpha chainHomo sapiens (human)
calcium ion homeostasisAlpha-synucleinHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIAlpha-synucleinHomo sapiens (human)
microglial cell activationAlpha-synucleinHomo sapiens (human)
positive regulation of receptor recyclingAlpha-synucleinHomo sapiens (human)
positive regulation of neurotransmitter secretionAlpha-synucleinHomo sapiens (human)
negative regulation of protein kinase activityAlpha-synucleinHomo sapiens (human)
fatty acid metabolic processAlpha-synucleinHomo sapiens (human)
neutral lipid metabolic processAlpha-synucleinHomo sapiens (human)
phospholipid metabolic processAlpha-synucleinHomo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
mitochondrial membrane organizationAlpha-synucleinHomo sapiens (human)
adult locomotory behaviorAlpha-synucleinHomo sapiens (human)
response to xenobiotic stimulusAlpha-synucleinHomo sapiens (human)
response to iron(II) ionAlpha-synucleinHomo sapiens (human)
regulation of phospholipase activityAlpha-synucleinHomo sapiens (human)
negative regulation of platelet-derived growth factor receptor signaling pathwayAlpha-synucleinHomo sapiens (human)
regulation of glutamate secretionAlpha-synucleinHomo sapiens (human)
regulation of dopamine secretionAlpha-synucleinHomo sapiens (human)
synaptic vesicle exocytosisAlpha-synucleinHomo sapiens (human)
synaptic vesicle primingAlpha-synucleinHomo sapiens (human)
regulation of transmembrane transporter activityAlpha-synucleinHomo sapiens (human)
negative regulation of microtubule polymerizationAlpha-synucleinHomo sapiens (human)
receptor internalizationAlpha-synucleinHomo sapiens (human)
protein destabilizationAlpha-synucleinHomo sapiens (human)
response to magnesium ionAlpha-synucleinHomo sapiens (human)
negative regulation of transporter activityAlpha-synucleinHomo sapiens (human)
response to lipopolysaccharideAlpha-synucleinHomo sapiens (human)
negative regulation of monooxygenase activityAlpha-synucleinHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationAlpha-synucleinHomo sapiens (human)
response to type II interferonAlpha-synucleinHomo sapiens (human)
cellular response to oxidative stressAlpha-synucleinHomo sapiens (human)
SNARE complex assemblyAlpha-synucleinHomo sapiens (human)
positive regulation of SNARE complex assemblyAlpha-synucleinHomo sapiens (human)
regulation of locomotionAlpha-synucleinHomo sapiens (human)
dopamine biosynthetic processAlpha-synucleinHomo sapiens (human)
mitochondrial ATP synthesis coupled electron transportAlpha-synucleinHomo sapiens (human)
regulation of macrophage activationAlpha-synucleinHomo sapiens (human)
positive regulation of apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of neuron apoptotic processAlpha-synucleinHomo sapiens (human)
positive regulation of endocytosisAlpha-synucleinHomo sapiens (human)
negative regulation of exocytosisAlpha-synucleinHomo sapiens (human)
positive regulation of exocytosisAlpha-synucleinHomo sapiens (human)
regulation of long-term neuronal synaptic plasticityAlpha-synucleinHomo sapiens (human)
synaptic vesicle endocytosisAlpha-synucleinHomo sapiens (human)
synaptic vesicle transportAlpha-synucleinHomo sapiens (human)
positive regulation of inflammatory responseAlpha-synucleinHomo sapiens (human)
regulation of acyl-CoA biosynthetic processAlpha-synucleinHomo sapiens (human)
protein tetramerizationAlpha-synucleinHomo sapiens (human)
positive regulation of release of sequestered calcium ion into cytosolAlpha-synucleinHomo sapiens (human)
neuron apoptotic processAlpha-synucleinHomo sapiens (human)
dopamine uptake involved in synaptic transmissionAlpha-synucleinHomo sapiens (human)
negative regulation of dopamine uptake involved in synaptic transmissionAlpha-synucleinHomo sapiens (human)
negative regulation of serotonin uptakeAlpha-synucleinHomo sapiens (human)
regulation of norepinephrine uptakeAlpha-synucleinHomo sapiens (human)
negative regulation of norepinephrine uptakeAlpha-synucleinHomo sapiens (human)
excitatory postsynaptic potentialAlpha-synucleinHomo sapiens (human)
long-term synaptic potentiationAlpha-synucleinHomo sapiens (human)
positive regulation of inositol phosphate biosynthetic processAlpha-synucleinHomo sapiens (human)
negative regulation of thrombin-activated receptor signaling pathwayAlpha-synucleinHomo sapiens (human)
response to interleukin-1Alpha-synucleinHomo sapiens (human)
cellular response to copper ionAlpha-synucleinHomo sapiens (human)
cellular response to epinephrine stimulusAlpha-synucleinHomo sapiens (human)
positive regulation of protein serine/threonine kinase activityAlpha-synucleinHomo sapiens (human)
supramolecular fiber organizationAlpha-synucleinHomo sapiens (human)
negative regulation of mitochondrial electron transport, NADH to ubiquinoneAlpha-synucleinHomo sapiens (human)
positive regulation of glutathione peroxidase activityAlpha-synucleinHomo sapiens (human)
positive regulation of hydrogen peroxide catabolic processAlpha-synucleinHomo sapiens (human)
regulation of synaptic vesicle recyclingAlpha-synucleinHomo sapiens (human)
regulation of reactive oxygen species biosynthetic processAlpha-synucleinHomo sapiens (human)
positive regulation of protein localization to cell peripheryAlpha-synucleinHomo sapiens (human)
negative regulation of chaperone-mediated autophagyAlpha-synucleinHomo sapiens (human)
regulation of presynapse assemblyAlpha-synucleinHomo sapiens (human)
amyloid fibril formationAlpha-synucleinHomo sapiens (human)
synapse organizationAlpha-synucleinHomo sapiens (human)
chemical synaptic transmissionAlpha-synucleinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (28)

Processvia Protein(s)Taxonomy
hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
protein bindingGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
fatty acid bindingAlpha-synucleinHomo sapiens (human)
phospholipase D inhibitor activityAlpha-synucleinHomo sapiens (human)
SNARE bindingAlpha-synucleinHomo sapiens (human)
magnesium ion bindingAlpha-synucleinHomo sapiens (human)
transcription cis-regulatory region bindingAlpha-synucleinHomo sapiens (human)
actin bindingAlpha-synucleinHomo sapiens (human)
protein kinase inhibitor activityAlpha-synucleinHomo sapiens (human)
copper ion bindingAlpha-synucleinHomo sapiens (human)
calcium ion bindingAlpha-synucleinHomo sapiens (human)
protein bindingAlpha-synucleinHomo sapiens (human)
phospholipid bindingAlpha-synucleinHomo sapiens (human)
ferrous iron bindingAlpha-synucleinHomo sapiens (human)
zinc ion bindingAlpha-synucleinHomo sapiens (human)
lipid bindingAlpha-synucleinHomo sapiens (human)
oxidoreductase activityAlpha-synucleinHomo sapiens (human)
kinesin bindingAlpha-synucleinHomo sapiens (human)
Hsp70 protein bindingAlpha-synucleinHomo sapiens (human)
histone bindingAlpha-synucleinHomo sapiens (human)
identical protein bindingAlpha-synucleinHomo sapiens (human)
alpha-tubulin bindingAlpha-synucleinHomo sapiens (human)
cysteine-type endopeptidase inhibitor activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
tau protein bindingAlpha-synucleinHomo sapiens (human)
phosphoprotein bindingAlpha-synucleinHomo sapiens (human)
molecular adaptor activityAlpha-synucleinHomo sapiens (human)
dynein complex bindingAlpha-synucleinHomo sapiens (human)
cuprous ion bindingAlpha-synucleinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (25)

Processvia Protein(s)Taxonomy
extracellular regionGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
Golgi lumenGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone complexGlycoprotein hormones alpha chainHomo sapiens (human)
pituitary gonadotropin complexGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
platelet alpha granule membraneAlpha-synucleinHomo sapiens (human)
extracellular regionAlpha-synucleinHomo sapiens (human)
extracellular spaceAlpha-synucleinHomo sapiens (human)
nucleusAlpha-synucleinHomo sapiens (human)
cytoplasmAlpha-synucleinHomo sapiens (human)
mitochondrionAlpha-synucleinHomo sapiens (human)
lysosomeAlpha-synucleinHomo sapiens (human)
cytosolAlpha-synucleinHomo sapiens (human)
plasma membraneAlpha-synucleinHomo sapiens (human)
cell cortexAlpha-synucleinHomo sapiens (human)
actin cytoskeletonAlpha-synucleinHomo sapiens (human)
membraneAlpha-synucleinHomo sapiens (human)
inclusion bodyAlpha-synucleinHomo sapiens (human)
axonAlpha-synucleinHomo sapiens (human)
growth coneAlpha-synucleinHomo sapiens (human)
synaptic vesicle membraneAlpha-synucleinHomo sapiens (human)
perinuclear region of cytoplasmAlpha-synucleinHomo sapiens (human)
postsynapseAlpha-synucleinHomo sapiens (human)
supramolecular fiberAlpha-synucleinHomo sapiens (human)
protein-containing complexAlpha-synucleinHomo sapiens (human)
cytoplasmAlpha-synucleinHomo sapiens (human)
axon terminusAlpha-synucleinHomo sapiens (human)
neuronal cell bodyAlpha-synucleinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (132)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1366517Toxicity in wild type zebrafish embryos assessed as skeletal deformities at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366492Toxicity in wild type zebrafish embryos assessed as unhatched embryo at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366347Cytotoxicity against wild type zebrafish embryo melanocytes assessed as punctate cells at 12.5 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366515Toxicity in wild type zebrafish embryos assessed as skeletal deformities at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366550Inhibition of zebrafish embryo tyrosinase assessed as residual activity at 10 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366388Toxicity in wild type zebrafish embryos assessed as growth retardation at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366506Toxicity in wild type zebrafish embryos assessed as head malformation at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366331Toxicity in wild type zebrafish embryos assessed as dead embryo at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366400Toxicity in wild type zebrafish embryos assessed as notochord at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366423Toxicity in wild type zebrafish embryos assessed as otoliths at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366413Toxicity in wild type zebrafish embryos assessed as eyes at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366346Cytotoxicity against wild type zebrafish embryo melanocytes assessed as barely visible cells at 12.5 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366436Toxicity in wild type zebrafish embryos assessed as pericardial edema at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366353Cytotoxicity against wild type zebrafish embryo melanocytes assessed as change in morphology at 2.5 mg/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366332Toxicity in wild type zebrafish embryos assessed as dead embryo at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366424Toxicity in wild type zebrafish embryos assessed as otoliths at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366363Toxicity in wild type zebrafish embryos assessed as teratogenic embryo at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366439Toxicity in wild type zebrafish embryos assessed as pericardial edema at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366376Toxicity in wild type zebrafish embryos assessed as normal embryo at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366358Toxicity in wild type zebrafish embryos assessed as teratogenic embryo at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366489Toxicity in wild type zebrafish embryos assessed as unhatched embryo at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366328Anti-melanogenic activity in wild type zebrafish 24 hrs post fertilization embryos assessed as decrease in body pigmentation at 5 to 25 ug/ml after 48 hrs2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366334Toxicity in wild type zebrafish embryos assessed as dead embryo at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366437Toxicity in wild type zebrafish embryos assessed as pericardial edema at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366348Cytotoxicity against wild type zebrafish embryo melanocytes assessed as small and rounded cells at 12.5 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366516Toxicity in wild type zebrafish embryos assessed as skeletal deformities at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366345Cytotoxicity against wild type transgenic zebrafish 24 hrs post fertilization embryo neutrophils assessed as reduction in neutrophil at 25 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366410Toxicity in wild type zebrafish embryos assessed as eyes at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366375Toxicity in wild type zebrafish embryos assessed as normal embryo at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366438Toxicity in wild type zebrafish embryos assessed as pericardial edema at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366333Toxicity in wild type zebrafish embryos assessed as dead embryo at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366541Inhibition of zebrafish embryo tyrosinase assessed as melanin production at 5 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366352Cytotoxicity against wild type zebrafish embryo melanocytes assessed as change in morphology2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366538Inhibition of zebrafish embryo tyrosinase assessed as melanin production at 20 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366402Toxicity in wild type zebrafish embryos assessed as notochord at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366505Toxicity in wild type zebrafish embryos assessed as head malformation at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366354Cytotoxicity against wild type zebrafish embryo melanocytes assessed as number of melanocyte at 2.5 mg/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID458279Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells at 10 uM2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice.
AID1366401Toxicity in wild type zebrafish embryos assessed as notochord at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366335Toxicity in wild type zebrafish embryos assessed as dead embryo at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366539Inhibition of zebrafish embryo tyrosinase assessed as melanin production at 15 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366397Toxicity in wild type zebrafish embryos assessed as notochord at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366357Cytotoxicity against wild type zebrafish embryo melanocytes assessed as number of melanocyte at 25 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366490Toxicity in wild type zebrafish embryos assessed as unhatched embryo at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366514Toxicity in wild type zebrafish embryos assessed as skeletal deformities at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366426Toxicity in wild type zebrafish embryos assessed as otoliths at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366359Toxicity in wild type zebrafish embryos assessed as teratogenic embryo at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366532Anti-melanogenic activity in mpx:GFP transgenic zebrafish 24 hrs post fertilization embryo neutrophils assessed as decrease in pigmentation at 25 ug/ml2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366540Inhibition of zebrafish embryo tyrosinase assessed as melanin production at 10 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366476Toxicity in wild type zebrafish embryos assessed as blood circulation at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366479Toxicity in wild type zebrafish embryos assessed as blood circulation at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366451Toxicity in wild type zebrafish embryos assessed as yolk edema at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366449Toxicity in wild type zebrafish embryos assessed as yolk edema at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366537Inhibition of zebrafish embryo tyrosinase assessed as melanin production at 25 ug/ml after 48 hrs relative to control relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366441Toxicity in wild type zebrafish embryos assessed as pericardial edema at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366428Toxicity in wild type zebrafish embryos assessed as otoliths at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366491Toxicity in wild type zebrafish embryos assessed as unhatched embryo at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366504Toxicity in wild type zebrafish embryos assessed as head malformation at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366503Toxicity in wild type zebrafish embryos assessed as head malformation at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366493Toxicity in wild type zebrafish embryos assessed as unhatched embryo at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366549Inhibition of zebrafish embryo tyrosinase assessed as residual activity at 15 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366361Toxicity in wild type zebrafish embryos assessed as teratogenic embryo at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366478Toxicity in wild type zebrafish embryos assessed as blood circulation at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366384Toxicity in wild type zebrafish embryos assessed as growth retardation at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366387Toxicity in wild type zebrafish embryos assessed as growth retardation at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366501Toxicity in wild type zebrafish embryos assessed as head malformation at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366372Toxicity in wild type zebrafish embryos assessed as normal embryo at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366452Toxicity in wild type zebrafish embryos assessed as yolk edema at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366464Toxicity in wild type zebrafish embryos assessed as heart beat at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366374Toxicity in wild type zebrafish embryos assessed as normal embryo at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366462Toxicity in wild type zebrafish embryos assessed as heart beat at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366399Toxicity in wild type zebrafish embryos assessed as notochord at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366427Toxicity in wild type zebrafish embryos assessed as otoliths at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366480Toxicity in wild type zebrafish embryos assessed as blood circulation at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366453Toxicity in wild type zebrafish embryos assessed as yolk edema at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366415Toxicity in wild type zebrafish embryos assessed as eyes at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366488Toxicity in wild type zebrafish embryos assessed as unhatched embryo at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366350Anti-melanogenic activity in wild type zebrafish embryo melanocytes assessed as decrease in pigmentation at 2.5 mg/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366561Inhibition of tyrosinase in mouse B16 cells assessed as decrease in alpha-MSH stimulated melanin production at 2 ug/ml preincubated for 24 hrs followed by alpha-MSH addition measured after 48 hrs2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366362Toxicity in wild type zebrafish embryos assessed as teratogenic embryo at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366559Potency index, ratio of kojic acid IC50 to compound IC50 for zebrafish embryo tyrosinase assessed as melanin production2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366373Toxicity in wild type zebrafish embryos assessed as normal embryo at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366440Toxicity in wild type zebrafish embryos assessed as pericardial edema at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366518Toxicity in wild type zebrafish embryos assessed as skeletal deformities at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366425Toxicity in wild type zebrafish embryos assessed as otoliths at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366558Inhibition of zebrafish embryo tyrosinase assessed as residual activity after 48 hrs2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366551Inhibition of zebrafish embryo tyrosinase assessed as residual activity at 5 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366398Toxicity in wild type zebrafish embryos assessed as notochord at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366466Toxicity in wild type zebrafish embryos assessed as heart beat at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366454Toxicity in wild type zebrafish embryos assessed as yolk edema at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366530Cytotoxicity against mpx:GFP transgenic zebrafish 24 hrs post fertilization embryo neutrophils assessed as loss in neutrophil at 25 ug/ml relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366477Toxicity in wild type zebrafish embryos assessed as blood circulation at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366557Inhibition of zebrafish embryo tyrosinase assessed as melanin production after 48 hrs2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366356Cytotoxicity against wild type zebrafish embryo melanocytes assessed as size of melanocyte at to 25 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366562Inhibition of alpha-MSH stimulated tyrosinase in mouse B16 cells assessed as residual activity at 2 ug/ml preincubated for 24 hrs followed by alpha-MSH addition measured after 16 hrs2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366385Toxicity in wild type zebrafish embryos assessed as growth retardation at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366371Toxicity in wild type zebrafish embryos assessed as normal embryo at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366414Toxicity in wild type zebrafish embryos assessed as eyes at 10 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366412Toxicity in wild type zebrafish embryos assessed as eyes at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366386Toxicity in wild type zebrafish embryos assessed as growth retardation at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366349Anti-melanogenic activity in wild type zebrafish embryo melanocytes assessed as decrease in pigmentation at 25 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366519Toxicity in wild type zebrafish embryos assessed as skeletal deformities at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366547Inhibition of zebrafish embryo tyrosinase assessed as residual activity at 25 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366389Toxicity in wild type zebrafish embryos assessed as growth retardation at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366475Toxicity in wild type zebrafish embryos assessed as blood circulation at 50 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366463Toxicity in wild type zebrafish embryos assessed as heart beat at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366502Toxicity in wild type zebrafish embryos assessed as head malformation at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366411Toxicity in wild type zebrafish embryos assessed as eyes at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366465Toxicity in wild type zebrafish embryos assessed as heart beat at 15 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366467Toxicity in wild type zebrafish embryos assessed as heart beat at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366336Toxicity in wild type zebrafish embryos assessed as dead embryo at 5 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366450Toxicity in wild type zebrafish embryos assessed as yolk edema at 25 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366360Toxicity in wild type zebrafish embryos assessed as teratogenic embryo at 20 ug/ml treated for 96 hrs post fertilization starting from 6 hrs post fertilization by inverted microscopic analysis relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366548Inhibition of zebrafish embryo tyrosinase assessed as residual activity at 20 ug/ml after 48 hrs relative to control2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366355Cytotoxicity against wild type zebrafish embryo melanocytes assessed as change in morphology at to 25 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1366560Potency index, ratio of kojic acid IC50 to compound IC50 for zebrafish embryo tyrosinase assessed as residual activity2017Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies.
AID1799899NS5B Inhibition Assay from Article 10.1111/cbdd.12105: \\Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors.\\2013Chemical biology & drug design, May, Volume: 81, Issue:5
Evaluation of coumarin and neoflavone derivatives as HCV NS5B polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's9 (75.00)24.3611
2020's2 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.27 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]