seladelpar: PPAR-delta agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 11236126 |
| CHEMBL ID | 230158 |
| SCHEMBL ID | 392331 |
| MeSH ID | M0573797 |
| Synonym |
|---|
| CHEMBL230158 , |
| rwj-800025 |
| seladelpar |
| mbx-8025 |
| (r)-2-(4-(2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propylthio)-2-methylphenoxy)acetic acid |
| bdbm50213714 |
| SCHEMBL392331 |
| (r)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)-thio)-2-methylphenoxy)acetic acid |
| seladelpar [who-dd] |
| acetic acid, (4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)- ((4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenyl)oxy)acetic acid |
| 7c00l34nb9 , |
| seladelpar [usan] |
| (+)-mbx-8025 |
| acetic acid, (4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)- |
| acetic acid, 2-(4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)- |
| 851528-79-5 |
| seladelpar [inn] |
| ((4-(((2r)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenyl)oxy)acetic acid |
| unii-7c00l34nb9 |
| seladelpar [usan:inn] |
| gtpl11137 |
| mbx8025 |
| compound 3r [pmid: 17524639] |
| (r)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid |
| DB12390 |
| mbx 8025 |
| 851528-79-5 (free base) |
| KKB , |
| EX-A1512 |
| BS-17646 |
| D11256 |
| seladelpar (usan/inn) |
| CS-0015622 |
| HY-19522 |
| C76734 |
| Q27268037 |
| mbx-8025; rwj-800025 |
| A914807 |
| 2-[4-[(2r)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid |
| AKOS037649258 |
| BJB52879 |
| jwhysedoymymnm-qgzvfwflsa-n |
| DTXSID001045332 |
| AC-36246 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 (µMol) | 3.0000 | 0.0000 | 0.9922 | 10.0000 | AID1546883; AID290901 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | EC50 (µMol) | 0.0020 | 0.0002 | 0.8460 | 9.1000 | AID1546884; AID290903 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 (µMol) | 1.2500 | 0.0006 | 1.6074 | 10.0000 | AID1546882; AID290902 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1546882 | Agonist activity at PPARalpha (unknown origin) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. |
| AID290902 | Activity at human PPARalpha receptor by cell based transactivation assay | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists. |
| AID290901 | Activity at human PPARgamma receptor by cell based transactivation assay | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists. |
| AID290904 | Efficacy at human PPARdelta receptor by cell based transactivation assay | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists. |
| AID290903 | Agonist activity at human PPARdelta receptor by cell based transactivation assay | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists. |
| AID1546883 | Agonist activity at PPARgamma (unknown origin) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. |
| AID1546884 | Agonist activity at PPARdelta (unknown origin) | 2020 | Journal of medicinal chemistry, 05-28, Volume: 63, Issue:10 | The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 11 (91.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.83) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (16.67%) | 5.53% |
| Reviews | 1 (8.33%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (75.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||