ciglitazone has been researched along with Fibrosis in 5 studies
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes
ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To test the hypothesis that PPARgamma decreased LVH and cardiac fibrosis in chronic pressure overload, in part, by increasing SOD, eNOS and elastin and decreasing NOX4, MMP and collagen synthesis and degradation, chronic pressure overload analogous to systemic hypertension was created in C57BL/6J mice by occluding the abdominal aorta above the kidneys (aortic stenosis-AS)." | 7.74 | Reversal of systemic hypertension-associated cardiac remodeling in chronic pressure overload myocardium by ciglitazone. ( Henderson, BC; Kartha, GK; Moshal, KS; Ovechkin, A; Reynolds, C; Rodriguez, WE; Sen, U; Tyagi, N; Tyagi, SC, 2007) |
| " To test the hypothesis that PPARgamma decreased LVH and cardiac fibrosis in chronic pressure overload, in part, by increasing SOD, eNOS and elastin and decreasing NOX4, MMP and collagen synthesis and degradation, chronic pressure overload analogous to systemic hypertension was created in C57BL/6J mice by occluding the abdominal aorta above the kidneys (aortic stenosis-AS)." | 3.74 | Reversal of systemic hypertension-associated cardiac remodeling in chronic pressure overload myocardium by ciglitazone. ( Henderson, BC; Kartha, GK; Moshal, KS; Ovechkin, A; Reynolds, C; Rodriguez, WE; Sen, U; Tyagi, N; Tyagi, SC, 2007) |
| "Ciglitazone has been shown to be dependent on NF-κB- and STAT3-related pathways, thus, the PPAR-γ agonist may have therapeutic potential for the treatment of airway remodelling in asthma." | 1.91 | Anti-fibrotic effect of ciglitazone in HRV-induced airway remodelling cell model. ( Pawliczak, R; Wieczfinska, J, 2023) |
| "Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting in excessive extracellular matrix accumulation and anatomic remodeling." | 1.35 | PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis. ( Gangireddy, SR; Hogaboam, CM; Hu, B; Keshamouni, VG; Milam, JE; Phan, SH; Reddy, RC; Standiford, TJ; Thannickal, VJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wieczfinska, J | 1 |
| Pawliczak, R | 1 |
| Smiley, LM | 1 |
| Camp, TM | 1 |
| Lucchesi, PA | 1 |
| Tyagi, SC | 3 |
| Tyagi, N | 2 |
| Moshal, KS | 2 |
| Lominadze, D | 1 |
| Ovechkin, AV | 1 |
| Henderson, BC | 1 |
| Sen, U | 1 |
| Reynolds, C | 1 |
| Ovechkin, A | 1 |
| Kartha, GK | 1 |
| Rodriguez, WE | 1 |
| Milam, JE | 1 |
| Keshamouni, VG | 1 |
| Phan, SH | 1 |
| Hu, B | 1 |
| Gangireddy, SR | 1 |
| Hogaboam, CM | 1 |
| Standiford, TJ | 1 |
| Thannickal, VJ | 1 |
| Reddy, RC | 1 |
5 other studies available for ciglitazone and Fibrosis
| Article | Year |
|---|---|
Anti-fibrotic effect of ciglitazone in HRV-induced airway remodelling cell model.
Topics: Airway Remodeling; Asthma; Fibrosis; Heart Rate; Humans; NF-kappa B; PPAR gamma; Rhinovirus; Thiazol | 2023 |
Peroxisome proliferator ameliorates endocardial endothelial and muscarinic dysfunction in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Cholinergic Agents; Endothelium; Fibrosis; Heart; Hypertension; Hypertrophy, | 2004 |
Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model.
Topics: Acetylcholine; Animals; Blotting, Western; Collagen; Endothelin-1; Endothelium, Vascular; Fibrosis; | 2005 |
Reversal of systemic hypertension-associated cardiac remodeling in chronic pressure overload myocardium by ciglitazone.
Topics: Animals; Collagen; Elastin; Fibrosis; Heart; Hypertension; Hypertrophy, Left Ventricular; Hypoglycem | 2007 |
PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Differentiation; Cell Division; Cells, Culture | 2008 |