glucose, (beta-d)-isomer has been researched along with Fibrosis in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (2.56) | 29.6817 |
| 2010's | 31 (39.74) | 24.3611 |
| 2020's | 45 (57.69) | 2.80 |
| Authors | Studies |
|---|---|
| Droebner, K; Eitner, F; Goea, L; Grundmann, M; Hartmann, E; Klar, J; Kolkhof, P; Nordlohne, J; Pavkovic, M | 1 |
| Chen, X; Jin, R; Kan, M; Liu, Q; Meng, X; Pu, T; Xing, T; Yang, J; Yang, Y; Zang, H | 1 |
| Guo, H; Jiao, X; Li, H; Li, X; Liu, J; Liu, Q; Qi, C; Wan, Z; Wang, R; Wang, Z; Wu, X; Zhang, H; Zhao, H | 1 |
| Jiang, L; Ke, Q; Luo, J; Lv, Y; Shi, C; Wang, L; Yang, J; Zhou, Y | 1 |
| Cao, Y; Chen, X; Chu, C; Delic, D; Frankenreiter, S; Gaballa, MMS; Hasan, AA; Hocher, B; Klein, T; Krämer, BK; Luo, T; Stadermann, K; Xiong, Y; Xue, Y; Yin, L; Zeng, S | 1 |
| Huang, H; Shen, W; Xie, ML; Xue, J | 1 |
| Bhardwaj, N; Sharma, A; Tirpude, NV | 1 |
| Inzucchi, SE; Kahl, S; Ofstad, AP; Roden, M; Sattar, N; Schüler, E; Wanner, C; Zinman, B | 1 |
| Chen, J; Huang, Y; Li, T; Lin, X; Lin, Y; Lu, H; Xian, J; Yang, Z; Zhang, Q | 1 |
| Arai, K; Goto, H; Harada, K; Honda, M; Iida, N; Kaneko, S; Kita, Y; Mizukoshi, E; Nakamura, H; Nakano, Y; Takamura, T; Takata, N; Takeshita, Y; Tanaka, T; Tsujiguchi, H; Yamashita, T | 1 |
| Alam, MJ; Arava, S; Banerjee, SK; Bugga, P; Katare, P; Maulik, SK; Meghwani, H; Mohammed, SA | 1 |
| Algara-Suarez, P; Amissi, S; Auger, C; Belcastro, E; Bruckert, C; Chaker, AB; Houngue, U; Jesel, L; Matsushita, K; Morel, O; Mroueh, A; Ohlmann, P; Park, SH; Remila, L; Schini-Kerth, VB | 1 |
| Ding, L; Liao, L; Tian, L; Tian, Y; Wang, H; Zhao, J | 1 |
| Choi, D; Hong, GR; Jeon, OH; Kim, C; Kim, D; Kim, JS; Lee, CJ; Lee, HJ; Lee, JJ; Lee, OH; Lee, SG; Lee, SJ; Lee, YH; Lee, YJ; Moon, RK; Oh, J; Park, S | 1 |
| Chan, SH; Cheng, HC; Chou, WC; Chu, PM; Hsieh, PL; Huang, YT; Tsai, KL | 1 |
| Aly, RG; Alzaim, I; El-Mallah, A; El-Yazbi, AF; Shaaban, HH; Wahid, A | 1 |
| Chen, K; Liu, J; Qin, S; Qin, Y; Wang, C; Wu, X; Xiao, W; Yang, Y; Zhang, X | 1 |
| Liang, Y; Liu, X; Lu, L; Qu, B; Zhang, C; Zheng, K | 1 |
| Cheng, W; Li, W; Pei, T; Wang, L; Xiao, W; Yan, S; Yang, S; Zeng, Y | 1 |
| Ding, Y; Liu, Y; Peng, Y; Wang, H; Wang, Y; Zhang, X; Zhang, Y | 1 |
| Feng, B; Ma, X; Sun, K; Xu, G; Zhang, N; Zhou, Y | 1 |
| Hashimoto, K; Hashimoto, T; Kariya, T; Koyano, T; Kumrungsee, T; Matsuyama, M; Sakurai, H; Sanada, Y; Sotomaru, Y; van de Loo, FAJ; Yanaka, N; Yazawa, N | 1 |
| Hsu, JC; Lin, LY; Su, MM; Wang, CY; Yang, WS | 1 |
| Han, H; Kim, SR; Lee, JH; Oh, EY; Park, HJ; Park, JW; Park, KH | 1 |
| Ferrannini, E; Gastaldelli, A; Guja, C; Han, J; Hardy, E; Jabbour, SA; Repetto, E | 1 |
| Hirose, M; Ibi, M; Ishida, N; Matsushita, N; Morino, Y; Saito, M; Sawa, Y; Taira, E | 1 |
| Chen, P; Han, B; Liu, J; Ruan, H; Wu, P; Yimei, D; Zhang, M | 1 |
| Barzaghi, F; Carletti, R; Castoldi, G; Colzani, M; di Gioia, CRT; Ippolito, S; Perseghin, G; Stella, A; Zerbini, G | 1 |
| Abraham, NG; Arad, M; Aravot, D; Arow, M; Freimark, D; Hochhauser, E; Kornowski, R; Nudelman, V; Shainberg, A; Waldman, M; Yadin, D | 1 |
| Al-Omran, M; Bhatt, DL; Chowdhury, B; Connelly, KA; Hess, DA; Kabir, MG; Luu, AZ; Luu, VZ; Mazer, CD; Pan, Y; Quan, A; Sabongui, S; Teoh, H; Verma, S | 1 |
| Balogh, DB; Besztercei, B; Fekete, A; Genovese, F; Hodrea, J; Hosszu, A; Koszegi, S; Lenart, L; Sparding, N; Szabo, AJ; Wagner, LJ | 1 |
| Birnbaum, Y; Chen, H; Nylander, S; Tran, D; Yang, HC; Ye, Y | 1 |
| Ai, J; Du, Q; Feng, J; Liu, M; Lv, Z | 1 |
| Liu, CM; Ma, JQ; Ming, QL; Sun, YZ; Tian, ZK; Zhang, YJ | 1 |
| Amorosi, A; De Rosa, S; Iaconetti, C; Indolfi, C; Mignogna, C; Polimeni, A; Sabatino, J; Sorrentino, S; Spaccarotella, C; Tammè, L; Yasuda, M | 1 |
| Li, J; Tan, R; Wang, L; Zhao, S; Zhong, X | 1 |
| Chen, ZQ; Huang, HQ; Li, XJ; Lin, ZY; Quan, SJ; Sun, XH; Xiao, HM; Xu, ZC; Yang, Y; Zhang, M | 1 |
| Boogerd, CJ; de Boer, RA; Dokter, MM; Lam, CSP; Markousis-Mavrogenis, G; Meems, LMG; Schouten, EM; Silljé, HHW; Voors, AA; Westenbrink, BD; Withaar, C | 1 |
| Fan, K; Shen, W; Xie, M; Zhang, J; Zhao, Y | 1 |
| Cai, S; Connelly, K | 1 |
| Badimon, JJ; Flores-Umanzor, EJ; Fuster, V; Garcia-Ropero, A; Ishikawa, K; Picatoste, B; Requena-Ibanez, JA; San Antonio, R; Santos-Gallego, CG; Sanz, J; Vargas-Delgado, AP; Watanabe, S | 1 |
| Chen, YJ; Cheng, WL; Chung, CC; Huang, SY; Kao, YH; Lee, TI; Lee, TW; Trang, NN | 1 |
| El Fayoumi, HM; Elkazzaz, SK; Khodeer, DM; Moustafa, YM | 1 |
| Barzaghi, F; Carletti, R; Castoldi, G; Colzani, M; di Gioia, CRT; Ippolito, S; Perseghin, G; Stella, A; Zatti, G; Zerbini, G | 1 |
| Baines, DL; Dockrell, MEC; Pan, X; Phanish, MK | 1 |
| Chai, D; Chen, X; Chu, Y; Du, H; Lin, J; Lin, X; Liu, J; Ma, K; Ruan, Q; Xie, H; Xu, C; Zeng, J; Zhang, H; Zhang, Y | 1 |
| An, F; Jin, T; Liu, D; Liu, M; Pan, J; Suo, M; Tian, J; Wang, X; Zhang, M | 1 |
| Atar, S; Bandel, N; Daud, E; Ertracht, O; Moady, G; Reuveni, T; Shehadeh, M | 1 |
| Altucci, L; Barbieri, A; Botti, G; Canale, ML; Carbone, A; Conte, M; De Laurentiis, M; Maurea, N; Monti, MG; Paccone, A; Quagliariello, V; Rea, D | 1 |
| Bajaj, M; Birnbaum, Y; Perez-Polo, JR; Yang, HC; Ye, Y | 1 |
| Li, J; Ren, J; Tang, QZ; Wan, CX; Xu, CR; Xu, SC; Yuan, YP; Zeng, XF; Zhang, N | 1 |
| Cao, M; Li, Y; Qin, Y; Wang, T; Xu, Y; Zhai, Q; Zhao, K | 1 |
| Abbas, NAT; Awad, MM; El Salem, A | 1 |
| Angayarkanni, N; Shanmuganathan, S | 1 |
| Ma, X; Ma, Y; Pan, X; Wu, Z | 1 |
| Alvarez-Suarez, D; Camacho, J; Casas-Grajales, S; Dayana Buendía-Montaño, L; Lakshman, MR; Muriel, P; Ramos-Tovar, E; Reyes-Gordillo, K; Tsutsumi, V | 1 |
| Jiang, A; Li, F; Shi, L; Wang, S; Zhu, D | 1 |
| Chen, L; Cheng, Y; Han, F; Li, C; Li, T; Li, X; Liu, X; Lu, Y; Sun, B; Xu, L; Xue, M; Yu, X; Zhang, J | 1 |
| Jia, CH; Shen, W; Wang, J; Xie, ML; Zhang, JY | 1 |
| Guo, Y; Li, R; Yan, T; Zhang, X; Zhang, Y; Zhu, L | 1 |
| Khan, RS; Newsome, PN | 1 |
| Chang, CY; Chen, WY; Chen, YF; Dai, ZK; Jhuang, WJ; Jhuo, SJ; Lee, AS; Lee, HC; Liu, PL; Shiou, YL | 1 |
| Fan, S; Gu, K; Li, Y; Luo, H; Wang, X; Wang, Y; Wu, Y; Zhang, T; Zhang, Y | 1 |
| Akagi, S; Akazawa, K; Ito, H; Kimura, T; Kondo, M; Miura, D; Miyoshi, T; Nakamura, K; Ohno, Y; Saito, Y; Wada, J; Yoshida, M | 1 |
| Kitamura, K; Miyachi, Y; Mori, K; Nakamura, S; Ogawa, Y; Shiba, K; Tsuchiya, K | 1 |
| Bian, ZY; Dai, J; Deng, W; Tang, QZ; Yang, HX; Yuan, Y; Zhang, JY; Zhou, H; Zong, J | 1 |
| Dai, Y; Dou, Y; Guo, J; Wu, X; Zeng, J | 1 |
| Arguiri, E; Busch, TM; Cengel, KA; Christofidou-Solomidou, M; Dukes, F; Gallagher-Colombo, SM; Pietrofesa, R; Solomides, CC; Turowski, J; Tyagi, S | 1 |
| Cai, X; Cao, P; Gu, Z; Guan, X; Hu, C; Lu, W; Qian, S; Wang, D; Yang, J; Yao, Y; Zhou, F | 1 |
| Baniene, R; Barauskas, G; Cesna, V; Gulbinas, A; Kmieliute, K; Maziukiene, A; Trumbeckaite, S; Venclauskas, L | 1 |
| Gilbert, RE; Kepecs, DM; Thai, K; Zhang, Y | 1 |
| Gao, L; Huang, C; Huang, Y; Li, HD; Li, J; Li, XF; Li, Z; Lv, XW; Ma, TT; Meng, XM; Ren, GL; Wang, XF; Wu, WF; Xu, T; Zhang, L | 1 |
| Huang, XL; Peng, Y; Xu, J; Xu, XL; Zeng, Y; Zhang, W | 1 |
| Li, SZ; Sun, LL; Xu, JJ; Zhang, L; Zhang, Y | 1 |
| Chang, NC; Lee, TM; Lin, SZ | 1 |
| Bouchard, M; Donahay, T; Haubner, R; Johnson, LL; Poppas, A; Schofield, L | 1 |
| Sinusas, AJ | 1 |
| Bian, Z; Chen, C; Dai, J; Dong, X; Guo, H; Shu, C; Tang, Q; Zhang, DP; Zhang, Y; Zhou, H; Zong, J | 1 |
2 review(s) available for glucose, (beta-d)-isomer and Fibrosis
| Article | Year |
|---|---|
Empagliflozin reduces diffuse myocardial fibrosis by extracellular volume mapping: A meta-analysis of clinical studies.
Topics: Benzhydryl Compounds; Cardiomyopathies; Fibrosis; Glucosides; Humans; Myocardium | 2022 |
Salidroside in the Treatment of NAFLD/NASH.
Topics: Fibrosis; Glucosides; Humans; Liver; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease | 2022 |
3 trial(s) available for glucose, (beta-d)-isomer and Fibrosis
| Article | Year |
|---|---|
Effects of empagliflozin on markers of liver steatosis and fibrosis and their relationship to cardiorenal outcomes.
Topics: Benzhydryl Compounds; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Humans; Non-alcoholic Fatty Liver Disease; Treatment Outcome | 2022 |
Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial.
Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Humans; Inflammation; Liver; Non-alcoholic Fatty Liver Disease; Sulfonylurea Compounds | 2022 |
Exenatide and dapagliflozin combination improves markers of liver steatosis and fibrosis in patients with type 2 diabetes.
Topics: Benzhydryl Compounds; Biomarkers; Diabetes Mellitus, Type 2; Exenatide; Fibrosis; Glucosides; Humans; Hypoglycemic Agents; Non-alcoholic Fatty Liver Disease; Prospective Studies | 2020 |
73 other study(ies) available for glucose, (beta-d)-isomer and Fibrosis
| Article | Year |
|---|---|
Direct Blood Pressure-Independent Anti-Fibrotic Effects by the Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone in Progressive Models of Kidney Fibrosis.
Topics: Actins; Adaptor Proteins, Signal Transducing; Albuminuria; Animals; Benzhydryl Compounds; Blood Pressure; Calcium-Binding Proteins; Collagen; Creatinine; Disease Models, Animal; Fibrosis; Gene Expression; Glucosides; Kidney; Kidney Diseases; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Monocytes; Myofibroblasts; Naphthyridines; Reperfusion Injury; RNA, Messenger; Serpin E2; Sodium-Glucose Transporter 2 Inhibitors; Ureteral Obstruction | 2021 |
Eleutheroside B-loaded poly (lactic-co-glycolic acid) nanoparticles protect against renal fibrosis via Smad3-dependent mechanism.
Topics: Animals; Fibrosis; Glucosides; Glycolates; Kidney Diseases; Mice; Molecular Docking Simulation; Nanoparticles; Phenylpropionates; Polylactic Acid-Polyglycolic Acid Copolymer; Smad3 Protein | 2021 |
The combination of ursolic acid and empagliflozin relieves diabetic nephropathy by reducing inflammation, oxidative stress and renal fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antifibrotic Agents; Antioxidants; Apoptosis; Benzhydryl Compounds; Cell Line; Cell Proliferation; Diabetic Nephropathies; Drug Therapy, Combination; Fibrosis; Glucosides; Inflammation Mediators; Kidney; Male; Nephritis; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Triterpenes; Ursolic Acid | 2021 |
SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney.
Topics: Animals; Benzhydryl Compounds; Citric Acid Cycle; Fibrosis; Glucosides; Inflammasomes; Kidney Diseases; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Succinates | 2022 |
Antifibrotic effects of low dose SGLT2 Inhibition with empagliflozin in comparison to Ang II receptor blockade with telmisartan in 5/6 nephrectomised rats on high salt diet.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzhydryl Compounds; Dose-Response Relationship, Drug; Fibrosis; Glucosides; Glycosuria; Heart Diseases; Iron; Kidney Diseases; Male; Nephrectomy; Rats; Rats, Wistar; Sequence Analysis, RNA; Sodium-Glucose Transporter 2 Inhibitors; Sodium, Dietary; Telmisartan | 2022 |
Stevioside inhibits lipopolysaccharide-induced epithelial-to-mesenchymal transition of NRK-52E cells by PPARγ activation.
Topics: Cell Line; Diterpenes, Kaurane; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Glucosides; Humans; Lipopolysaccharides; PPAR gamma; Transforming Growth Factor beta1 | 2022 |
Agnuside mitigates OVA-LPS induced perturbed lung homeostasis via modulating inflammatory, autophagy, apoptosis-fibrosis response and myeloid lineages in mice model of allergic asthma.
Topics: Animals; Apoptosis; Asthma; Autophagy; Bronchoalveolar Lavage Fluid; Cell Lineage; Cytokines; Disease Models, Animal; Fibrosis; Glucosides; Homeostasis; Lung; Mice; Mice, Inbred BALB C; Ovalbumin | 2022 |
SGLT2 inhibitor dapagliflozin attenuates cardiac fibrosis and inflammation by reverting the HIF-2α signaling pathway in arrhythmogenic cardiomyopathy.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Benzhydryl Compounds; Cardiomyopathies; Collagen; Diabetes Mellitus, Type 2; Fibrosis; Glucose; Glucosides; Heart Diseases; Inflammation; Mice; NF-kappa B; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors | 2022 |
Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress.
Topics: Animals; Benzhydryl Compounds; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Fibrosis; Fructose; Glucose; Glucosides; Heart Diseases; Insulin Resistance; Mitochondria; Oxidative Stress; Palmitates; Palmitic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2022 |
Empagliflozin prevents angiotensin II-induced hypertension related micro and macrovascular endothelial cell activation and diastolic dysfunction in rats despite persistent hypertension: Role of endothelial SGLT1 and 2.
Topics: Angiotensin II; Animals; Benzhydryl Compounds; Blood Pressure; Collagen; Endothelial Cells; Fibrosis; Glucosides; Hypertension; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats; Rats, Wistar; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Vascular Cell Adhesion Molecule-1 | 2022 |
Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling.
Topics: Animals; Benzhydryl Compounds; Diabetes Mellitus; Fibrosis; Glucosides; Male; Rabbits; Sodium-Glucose Transporter 2 Inhibitors | 2022 |
Dapagliflozin Mitigates Doxorubicin-Caused Myocardium Damage by Regulating AKT-Mediated Oxidative Stress, Cardiac Remodeling, and Inflammation.
Topics: Animals; Apoptosis; Benzhydryl Compounds; Cardiotoxicity; Doxorubicin; Fibrosis; Glucosides; Hypertrophy; Inflammation; Myocardium; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Ventricular Remodeling | 2022 |
Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzhydryl Compounds; Biomarkers; Cholesterol; Cholic Acid; Diet, High-Fat; Fibrosis; Glucosides; Inflammation; Insulin Resistance; Liver; Metformin; Non-alcoholic Fatty Liver Disease; Pioglitazone; Rats | 2022 |
Effect of Dapagliflozin on Indicators of Myocardial Fibrosis and Levels of Inflammatory Factors in Heart Failure Patients.
Topics: Benzhydryl Compounds; C-Reactive Protein; Cardiomyopathies; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Heart Failure; Humans; Interleukin-6; Tumor Necrosis Factor-alpha | 2022 |
Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis.
Topics: Animals; Ferroptosis; Fibrosis; Glucosides; Kidney Diseases; Mice | 2022 |
Diosmetin-7-O-β-D-glucopyranoside suppresses endothelial-mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis.
Topics: Animals; Cardiomyopathies; Cardiovascular Diseases; Collagen; Endoplasmic Reticulum Stress; Endothelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Flavonoids; Glucosides; Mice; Molecular Docking Simulation | 2023 |
Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction.
Topics: Animals; Aorta; Benzhydryl Compounds; Biomarkers; Blood Pressure; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytokines; Disease Models, Animal; Female; Fibrosis; Glucosides; Heart Failure; Hypertension; Inflammation Mediators; Lipids; Nitric Oxide; Norepinephrine; Sodium-Glucose Transporter 2 Inhibitors; Sus scrofa; Sympathetic Nervous System; Ventricular Function, Left; Ventricular Remodeling | 2019 |
The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Fibrosis; Flavonoids; Glucosides; Hesperidin; Humans; Kidney; Kidney Diseases; Luciferases; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Serum Amyloid A Protein; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2019 |
Effect of Empagliflozin on Cardiac Function, Adiposity, and Diffuse Fibrosis in Patients with Type 2 Diabetes Mellitus.
Topics: Adiposity; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Female; Fibrosis; Glucosides; Heart Function Tests; Heart Ventricles; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Myocardium; Triglycerides | 2019 |
Empagliflozin and Dulaglutide are Effective against Obesity-induced Airway Hyperresponsiveness and Fibrosis in A Murine Model.
Topics: Animals; Benzhydryl Compounds; Cell Differentiation; Cytokines; Diet, High-Fat; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Glucagon-Like Peptides; Glucosides; Immunoglobulin Fc Fragments; Mice; Obesity; Recombinant Fusion Proteins; Respiratory Hypersensitivity; RNA, Messenger; Th1 Cells; Th17 Cells | 2019 |
Pretreatment with KGA-2727, a selective SGLT1 inhibitor, is protective against myocardial infarction-induced ventricular remodeling and heart failure in mice.
Topics: Animals; Fibrosis; Gene Expression Regulation; Glucosides; Heart Failure; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Pyrazoles; RNA, Messenger; Sodium-Glucose Transporter 1; Ventricular Remodeling | 2020 |
Protective effects of Salidroside on cardiac function in mice with myocardial infarction.
Topics: Animals; Apoptosis; Cardiotonic Agents; Coronary Vessels; Cytokines; Disease Models, Animal; Fibrosis; Glucosides; Heart; Ligation; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Phenols; Ventricular Remodeling | 2019 |
Renal Anti-Fibrotic Effect of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension.
Topics: Angiotensin II; Animals; Benzhydryl Compounds; Fibrosis; Glucosides; Hypertension; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
Sodium-glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy.
Topics: Angiotensin II; Animals; Benzhydryl Compounds; Biomarkers; Blood Glucose; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Diabetes Mellitus; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Glucosides; Inflammation Mediators; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Sodium-Glucose Transporter 2 Inhibitors; Sodium-Hydrogen Exchanger 1; Ventricular Function, Left | 2020 |
The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension.
Topics: Animals; Benzhydryl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Lung; Male; Models, Animal; Monocrotaline; Mortality; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Risk Assessment; Sodium-Glucose Transporter 2 Inhibitors; Vascular Remodeling | 2020 |
Reduced
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Cell Hypoxia; Cell Line; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Fibronectins; Fibrosis; Glucosides; Glycosylation; Humans; Kidney Tubules, Proximal; Male; Rats, Wistar; Sodium-Glucose Transporter 2 Inhibitors; Streptozocin | 2020 |
Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK-mTOR Interplay.
Topics: AMP-Activated Protein Kinases; Animals; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Disease Progression; Enzyme Activation; Fibrosis; Glucosides; Inflammasomes; Male; Mechanistic Target of Rapamycin Complex 2; Mice, Inbred C57BL; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Purinergic P2Y Receptor Antagonists; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Stroke Volume; Ticagrelor; TOR Serine-Threonine Kinases; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats via Inhibiting P38 MAPK Pathway.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fibrosis; Gene Expression Regulation; Glucosides; Heart Function Tests; Isoproterenol; Male; MAP Kinase Signaling System; Monoterpenes; Rats; Transforming Growth Factor beta1 | 2020 |
Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Benzyl Alcohols; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Glucosides; HMGB1 Protein; Inflammation; Kidney Diseases; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Phytotherapy; Protein Kinases | 2020 |
Empagliflozin prevents doxorubicin-induced myocardial dysfunction.
Topics: Animals; Benzhydryl Compounds; Cardiomyopathies; Cardiotoxicity; Diastole; Disease Models, Animal; Doxorubicin; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Glucosides; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Sodium-Glucose Transporter 2 Inhibitors; Systole; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Nodakenin alleviated obstructive nephropathy through blunting Snail1 induced fibrosis.
Topics: Angelica; Animals; Anti-Inflammatory Agents; Coumarins; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Glucosides; Humans; Kidney; Kidney Failure, Chronic; Macrophages; Mice; NF-kappa B; Phosphorylation; Plant Roots; Signal Transduction; Smad3 Protein; Snail Family Transcription Factors; Transforming Growth Factor beta1; Ureteral Obstruction | 2020 |
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Topics: Animals; Connexins; Diabetes Mellitus, Experimental; Fibronectins; Fibrosis; Gap Junction beta-1 Protein; Glucosides; Intercellular Adhesion Molecule-1; Kidney; Male; Mice, Inbred C57BL; NADPH Oxidase 4; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Stilbenes; Ubiquitination | 2020 |
The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction.
Topics: Angiotensin II; Animals; Benzhydryl Compounds; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Female; Fibrosis; Gene Expression Regulation; Glucagon-Like Peptide-1 Receptor; Glucosides; Heart Failure, Diastolic; Hypertrophy, Left Ventricular; Incretins; Liraglutide; Mice, Inbred C57BL; Myocardium; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Ventricular Function, Left; Ventricular Remodeling | 2021 |
Stevioside inhibits unilateral ureteral obstruction-induced kidney fibrosis and upregulates renal PPARγ expression in mice.
Topics: Animals; Diterpenes, Kaurane; Fibrosis; Glucosides; Kidney; Mice; PPAR gamma; Ureteral Obstruction | 2020 |
Softening the Stiff Heart: SGLT2 Inhibition and Diastolic Function.
Topics: Benzhydryl Compounds; Fibrosis; Glucosides; Heart Failure; Humans; Predictive Value of Tests; Sodium-Glucose Transporter 2 | 2021 |
Empagliflozin Ameliorates Diastolic Dysfunction and Left Ventricular Fibrosis/Stiffness in Nondiabetic Heart Failure: A Multimodality Study.
Topics: Animals; Benzhydryl Compounds; Diastole; Fibrosis; Glucosides; Heart Failure; Heart Ventricles; Predictive Value of Tests; Stroke Volume; Swine; Ventricular Dysfunction, Left; Ventricular Function, Left | 2021 |
Empagliflozin and Liraglutide Differentially Modulate Cardiac Metabolism in Diabetic Cardiomyopathy in Rats.
Topics: Animals; Apoptosis; Benzhydryl Compounds; Biomarkers; Cytokines; Diabetic Cardiomyopathies; Disease Models, Animal; Echocardiography; Energy Metabolism; Fatty Acids; Fibrosis; Glucose; Glucosides; Heart Function Tests; Hypoglycemic Agents; Immunohistochemistry; Inflammation Mediators; Liraglutide; Myocardium; Rats; Sodium-Glucose Transporter 2 Inhibitors | 2021 |
Role of sodium glucose cotransporter type 2 inhibitors dapagliflozin on diabetic nephropathy in rats; Inflammation, angiogenesis and apoptosis.
Topics: Animals; Apoptosis; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fibrosis; Glucosides; Inflammation; Kidney; Male; Rats; Sodium-Glucose Transporter 2 Inhibitors; Vascular Endothelial Growth Factor A | 2021 |
Sodium-glucose cotransporter 2 inhibition prevents renal fibrosis in cyclosporine nephropathy.
Topics: Animals; Benzhydryl Compounds; Blood Pressure; Cyclosporine; Fibrosis; Glucosides; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2021 |
High glucose-induced Smad3 linker phosphorylation and CCN2 expression are inhibited by dapagliflozin in a diabetic tubule epithelial cell model.
Topics: Benzhydryl Compounds; Cells, Cultured; Connective Tissue Growth Factor; Diabetic Nephropathies; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Glucose; Glucosides; Humans; Kidney Tubules, Proximal; Phosphorylation; Signal Transduction; Smad2 Protein; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1 | 2021 |
Dapagliflozin: a sodium-glucose cotransporter 2 inhibitor, attenuates angiotensin II-induced cardiac fibrotic remodeling by regulating TGFβ1/Smad signaling.
Topics: Angiotensin II; Animals; Antifibrotic Agents; Benzhydryl Compounds; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Glucosides; Hypertrophy, Left Ventricular; Male; Myocardium; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2021 |
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF-β/Smad signalling in type 2 diabetic rats.
Topics: AMP-Activated Protein Kinases; Animals; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Diet, High-Fat; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Glucosides; Male; Mesoderm; Rats; Signal Transduction; Smad4 Protein; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta | 2021 |
The impact of empagliflozin on cardiac physiology and fibrosis early after myocardial infarction in non-diabetic rats.
Topics: Animals; Benzhydryl Compounds; Collagen; Disease Models, Animal; Fibrosis; Glucosides; Hydroxyproline; Male; Myocardial Infarction; Myocardium; Rats, Sprague-Dawley; Smad3 Protein; Sodium-Glucose Transporter 2 Inhibitors; Stroke Volume; Time Factors; Transforming Growth Factor beta1; Ventricular Function, Left | 2021 |
The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin.
Topics: Animals; Anti-Inflammatory Agents; Antifibrotic Agents; Apoptosis; Benzhydryl Compounds; Cardiotoxicity; Cell Line; Cytokines; Disease Models, Animal; Doxorubicin; Female; Ferroptosis; Fibrosis; Glucosides; Heart Diseases; Inflammasomes; Inflammation Mediators; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Ventricular Function, Left | 2021 |
SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.
Topics: Adamantane; AMP-Activated Protein Kinases; Animals; Apoptosis; Benzhydryl Compounds; CARD Signaling Adaptor Proteins; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fibroblasts; Fibrosis; Glucosides; Hypoglycemic Agents; Inflammasomes; Inflammation Mediators; Kidney Tubules, Proximal; Male; Mice, Inbred C57BL; Mice, Obese; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stroke Volume; Time Factors; Ventricular Function, Left | 2017 |
Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.
Topics: Administration, Oral; Animals; Arctium; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibrosis; Furans; Glucosides; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocytes, Cardiac; Phytotherapy; Proto-Oncogene Proteins c-akt; Signal Transduction | 2017 |
Cyanidin-3-O-glucoside ameliorates diabetic nephropathy through regulation of glutathione pool.
Topics: Animals; Anthocyanins; Buthionine Sulfoximine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Glucose; Glucosides; Glutathione; Inflammation; Kidney; Lipid Metabolism; Male; Mice, Inbred C57BL; Obesity; Protective Agents | 2018 |
Empagliflozin, SGLT
Topics: Animals; Benzhydryl Compounds; Fibrosis; Glucosides; Glucuronidase; Kidney; Kidney Diseases; Klotho Proteins; Male; Rats, Wistar; Sodium-Glucose Transporter 2 Inhibitors; Ureteral Obstruction | 2018 |
Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation.
Topics: Animals; Benzopyrans; Binding Sites; Cell Movement; Cell Proliferation; Cells, Cultured; Choroid; Diabetic Retinopathy; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Glucosides; Hydrolyzable Tannins; Macaca mulatta; Molecular Docking Simulation; Neovascularization, Pathologic; Phosphorylation; Plant Extracts; Protein Binding; Receptors, Transforming Growth Factor beta; Retinal Vessels; Signal Transduction; Transforming Growth Factor beta1 | 2019 |
[Polydatin ameliorates myocardial fibrosis in rats by up-regulating SIRT3 and SDF-1].
Topics: Animals; Chemokine CXCL12; Fibrosis; Glucosides; Heart Diseases; Male; Rats; Rats, Sprague-Dawley; Sirtuin 1; Sirtuin 3; Stilbenes; Superoxide Dismutase | 2018 |
Stevioside inhibits experimental fibrosis by down-regulating profibrotic Smad pathways and blocking hepatic stellate cell activation.
Topics: Actins; Animals; Cell Line; Collagen Type I; Collagenases; Deoxycytosine Nucleotides; Diterpenes, Kaurane; Down-Regulation; Fibrosis; Glucosides; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Lymphokines; Male; MAP Kinase Signaling System; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-myc; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Thioacetamide; Transforming Growth Factor beta1; Up-Regulation | 2019 |
Dapagliflozin Attenuates Cardiac Remodeling in Mice Model of Cardiac Pressure Overload.
Topics: Animals; Benzhydryl Compounds; Blotting, Western; Cardiomyopathies; Disease Models, Animal; Echocardiography; Fibrosis; Glucosides; Heart Ventricles; Hypertrophy, Left Ventricular; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Sodium-Glucose Transport Proteins; Sodium-Glucose Transporter 2 Inhibitors; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling | 2019 |
SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart.
Topics: Animals; Antioxidant Response Elements; Antioxidants; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Glucosides; Mice, Inbred C57BL; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Phosphorylation; Signal Transduction; Smad Proteins; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cardiomyopathies; Cell Line; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Fibrosis; Gene Expression Regulation; Glucosides; Isoproterenol; Male; Mice; NF-kappa B; Smad Proteins; Transforming Growth Factor beta1 | 2019 |
Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways.
Topics: Cadherins; Cell Line; Cytokines; Epithelial-Mesenchymal Transition; Extracellular Matrix; Fibrosis; Gene Expression Regulation; Glucosides; Humans; Kidney; Kidney Diseases; Kidney Tubules, Proximal; MAP Kinase Signaling System; NF-kappa B; Phenols; Rhodiola; Toll-Like Receptor 4 | 2019 |
Fat and Fibrosis: Does Empagliflozin Impair the Progression of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus?
Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Humans; Non-alcoholic Fatty Liver Disease | 2020 |
The sodium-glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats.
Topics: Animals; Atrial Function, Left; Atrial Natriuretic Factor; Benzhydryl Compounds; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fibrosis; Gene Expression Regulation; Glucosides; Heart Failure; Hemodynamics; Hypertension; Male; Myocardium; Natriuretic Peptide, Brain; Rats, Inbred SHR; Rats, Inbred WKY; Recovery of Function; Sodium-Glucose Transporter 2 Inhibitors; Tumor Necrosis Factor-alpha; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Liquiritinapioside - A mineralocorticoid-like substance from liquorice.
Topics: Animals; Cell Line; China; Collagen Type I; Fibrosis; Flavanones; Glucosides; Glycyrrhiza; Humans; MAP Kinase Signaling System; Mineralocorticoids; Myocardium; Plant Extracts; Receptors, Mineralocorticoid; Signal Transduction; Terpenes; Transforming Growth Factor beta1 | 2019 |
Inhibitory Effects of Tofogliflozin on Cardiac Hypertrophy in Dahl Salt-Sensitive and Salt-Resistant Rats Fed a High-Fat Diet.
Topics: Animals; Benzhydryl Compounds; Blood Pressure; Cardiomegaly; Diet, High-Fat; Fibrosis; Glucosides; Interleukin-6; Ketones; Male; Models, Animal; Myocytes, Cardiac; Natriuretic Peptides; Rats; Rats, Inbred Dahl; Sodium-Glucose Transporter 2 Inhibitors | 2019 |
Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice.
Topics: Adipocytes; Adipogenesis; Adipose Tissue; Adiposity; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Fibrosis; Glucosides; Inflammation Mediators; Insulin Resistance; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Obesity; Paracrine Communication; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Vascular Remodeling; Vascular System Injuries | 2019 |
Paeoniflorin attenuates pressure overload-induced cardiac remodeling via inhibition of TGFβ/Smads and NF-κB pathways.
Topics: Animals; Apoptosis; Benzoates; Biomarkers; Bridged-Ring Compounds; Cardiomegaly; Fibrosis; Glucosides; Heart; Inflammation; Male; Mice; Mice, Inbred C57BL; Monoterpenes; Myocytes, Cardiac; NF-kappa B; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Ventricular Function, Left; Ventricular Remodeling | 2013 |
Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice.
Topics: Animals; Benzoates; Bone Morphogenetic Protein 7; Bridged-Ring Compounds; Collagen; Down-Regulation; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression Regulation; Glucosides; Kidney Diseases; Male; Mice; Mice, Inbred ICR; Monoterpenes; Paeonia; Phosphorylation; Plasminogen Activator Inhibitor 1; Smad2 Protein; Transforming Growth Factor beta1; Ureteral Obstruction | 2013 |
Radiation mitigating properties of the lignan component in flaxseed.
Topics: Animal Feed; Animals; Bronchoalveolar Lavage Fluid; Butylene Glycols; Cytokines; Female; Fibrosis; Flax; Glucosides; Kaplan-Meier Estimate; Lignans; Lung; Lung Injury; Malondialdehyde; Mice; Mice, Inbred C57BL; Neutrophils; Oxygen; Phytotherapy; Radiation Injuries, Experimental; Radiation Pneumonitis; Radiation-Protective Agents; Seeds; Survival Rate; Time Factors; Transforming Growth Factor beta1; Tyrosine | 2013 |
The aqueous extract of Lycopus lucidus Turcz ameliorates streptozotocin-induced diabetic renal damage via inhibiting TGF-β1 signaling pathway.
Topics: Animals; Caffeic Acids; Cell Line; Cinnamates; Depsides; Diabetic Nephropathies; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Glucosides; Humans; Luteolin; Lycopus; Male; Mice; Phosphorylation; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Rosmarinic Acid; Signal Transduction; Streptozocin; Transforming Growth Factor beta1 | 2013 |
Effects of Cyanidin-3-O-glucoside on Synthetic and Metabolic Activity of Ethanol Stimulated Human Pancreatic Stellate Cells.
Topics: Anthocyanins; Cells, Cultured; Collagen Type I; Ethanol; Extracellular Matrix Proteins; Fibronectins; Fibrosis; Glucosides; Humans; Pancreatic Stellate Cells | 2015 |
Sodium-Glucose Linked Cotransporter-2 Inhibition Does Not Attenuate Disease Progression in the Rat Remnant Kidney Model of Chronic Kidney Disease.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Disease Progression; Fibrosis; Gene Expression; Glomerular Filtration Rate; Glucosides; Glycosuria; Humans; Hypertension, Renal; Hypoglycemic Agents; Kidney; Male; Nephrectomy; Proteinuria; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; RNA, Messenger; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1; Treatment Failure | 2016 |
Anti-fibrotic effect of wogonin in renal tubular epithelial cells via Smad3-dependent mechanisms.
Topics: Active Transport, Cell Nucleus; Animals; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Epithelial Cells; Fibrosis; Flavanones; Glucosides; Humans; Kidney Tubules, Proximal; Mice; Phosphorylation; Rats; Receptors, Transforming Growth Factor beta; Smad3 Protein; Transforming Growth Factor beta1 | 2016 |
PPAR-γ is involved in the protective effect of 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside against cardiac fibrosis in pressure-overloaded rats.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiotonic Agents; Cell Differentiation; Cell Proliferation; Collagen Type I; Collagen Type III; Fibroblasts; Fibronectins; Fibrosis; Gene Expression Regulation; Glucosides; Heart; Male; Myocardium; Plasminogen Activator Inhibitor 1; PPAR gamma; Pressure; Rats; Stilbenes | 2016 |
The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway.
Topics: Animals; Cell Survival; Collagen; Down-Regulation; Feeding Behavior; Fibrosis; Flavanones; Fructose; Glucosides; Inflammation; Insulin Resistance; Lipid Metabolism; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardium; Myocytes, Cardiac; NF-kappa B; Protective Agents | 2016 |
Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts.
Topics: Animals; Benzhydryl Compounds; Fibrosis; Gene Expression Regulation; Glucosides; Humans; Interleukin-10; Macrophages; Myocardial Infarction; Myocardium; Rats; Reactive Oxygen Species; Signal Transduction; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; STAT3 Transcription Factor | 2017 |
Radiolabeled arginine-glycine-aspartic acid peptides to image angiogenesis in swine model of hibernating myocardium.
Topics: Animals; Capillaries; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Echocardiography; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Glucosides; Humans; Integrin alphaVbeta3; Male; Myocardium; Neovascularization, Physiologic; Oligopeptides; Radiopharmaceuticals; Swine; Time Factors; Tomography, Emission-Computed, Single-Photon; Vascular Endothelial Growth Factor A | 2008 |
Targeted imaging offers advantages over physiological imaging for evaluation of angiogenic therapy.
Topics: Animals; Capillaries; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Echocardiography; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Glucosides; Humans; Integrin alphaVbeta3; Myocardium; Neovascularization, Physiologic; Oligopeptides; Radiopharmaceuticals; Time Factors; Tomography, Emission-Computed, Single-Photon; Vascular Endothelial Growth Factor A | 2008 |
Gastrodin protects against cardiac hypertrophy and fibrosis.
Topics: Animals; Benzyl Alcohols; Cardiomegaly; Collagen; Fibrosis; GATA4 Transcription Factor; Glucosides; Male; MAP Kinase Signaling System; Mice | 2012 |