Page last updated: 2024-08-24

glucose, (beta-d)-isomer and Fibrosis

glucose, (beta-d)-isomer has been researched along with Fibrosis in 78 studies

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (2.56)29.6817
2010's31 (39.74)24.3611
2020's45 (57.69)2.80

Authors

AuthorsStudies
Droebner, K; Eitner, F; Goea, L; Grundmann, M; Hartmann, E; Klar, J; Kolkhof, P; Nordlohne, J; Pavkovic, M1
Chen, X; Jin, R; Kan, M; Liu, Q; Meng, X; Pu, T; Xing, T; Yang, J; Yang, Y; Zang, H1
Guo, H; Jiao, X; Li, H; Li, X; Liu, J; Liu, Q; Qi, C; Wan, Z; Wang, R; Wang, Z; Wu, X; Zhang, H; Zhao, H1
Jiang, L; Ke, Q; Luo, J; Lv, Y; Shi, C; Wang, L; Yang, J; Zhou, Y1
Cao, Y; Chen, X; Chu, C; Delic, D; Frankenreiter, S; Gaballa, MMS; Hasan, AA; Hocher, B; Klein, T; Krämer, BK; Luo, T; Stadermann, K; Xiong, Y; Xue, Y; Yin, L; Zeng, S1
Huang, H; Shen, W; Xie, ML; Xue, J1
Bhardwaj, N; Sharma, A; Tirpude, NV1
Inzucchi, SE; Kahl, S; Ofstad, AP; Roden, M; Sattar, N; Schüler, E; Wanner, C; Zinman, B1
Chen, J; Huang, Y; Li, T; Lin, X; Lin, Y; Lu, H; Xian, J; Yang, Z; Zhang, Q1
Arai, K; Goto, H; Harada, K; Honda, M; Iida, N; Kaneko, S; Kita, Y; Mizukoshi, E; Nakamura, H; Nakano, Y; Takamura, T; Takata, N; Takeshita, Y; Tanaka, T; Tsujiguchi, H; Yamashita, T1
Alam, MJ; Arava, S; Banerjee, SK; Bugga, P; Katare, P; Maulik, SK; Meghwani, H; Mohammed, SA1
Algara-Suarez, P; Amissi, S; Auger, C; Belcastro, E; Bruckert, C; Chaker, AB; Houngue, U; Jesel, L; Matsushita, K; Morel, O; Mroueh, A; Ohlmann, P; Park, SH; Remila, L; Schini-Kerth, VB1
Ding, L; Liao, L; Tian, L; Tian, Y; Wang, H; Zhao, J1
Choi, D; Hong, GR; Jeon, OH; Kim, C; Kim, D; Kim, JS; Lee, CJ; Lee, HJ; Lee, JJ; Lee, OH; Lee, SG; Lee, SJ; Lee, YH; Lee, YJ; Moon, RK; Oh, J; Park, S1
Chan, SH; Cheng, HC; Chou, WC; Chu, PM; Hsieh, PL; Huang, YT; Tsai, KL1
Aly, RG; Alzaim, I; El-Mallah, A; El-Yazbi, AF; Shaaban, HH; Wahid, A1
Chen, K; Liu, J; Qin, S; Qin, Y; Wang, C; Wu, X; Xiao, W; Yang, Y; Zhang, X1
Liang, Y; Liu, X; Lu, L; Qu, B; Zhang, C; Zheng, K1
Cheng, W; Li, W; Pei, T; Wang, L; Xiao, W; Yan, S; Yang, S; Zeng, Y1
Ding, Y; Liu, Y; Peng, Y; Wang, H; Wang, Y; Zhang, X; Zhang, Y1
Feng, B; Ma, X; Sun, K; Xu, G; Zhang, N; Zhou, Y1
Hashimoto, K; Hashimoto, T; Kariya, T; Koyano, T; Kumrungsee, T; Matsuyama, M; Sakurai, H; Sanada, Y; Sotomaru, Y; van de Loo, FAJ; Yanaka, N; Yazawa, N1
Hsu, JC; Lin, LY; Su, MM; Wang, CY; Yang, WS1
Han, H; Kim, SR; Lee, JH; Oh, EY; Park, HJ; Park, JW; Park, KH1
Ferrannini, E; Gastaldelli, A; Guja, C; Han, J; Hardy, E; Jabbour, SA; Repetto, E1
Hirose, M; Ibi, M; Ishida, N; Matsushita, N; Morino, Y; Saito, M; Sawa, Y; Taira, E1
Chen, P; Han, B; Liu, J; Ruan, H; Wu, P; Yimei, D; Zhang, M1
Barzaghi, F; Carletti, R; Castoldi, G; Colzani, M; di Gioia, CRT; Ippolito, S; Perseghin, G; Stella, A; Zerbini, G1
Abraham, NG; Arad, M; Aravot, D; Arow, M; Freimark, D; Hochhauser, E; Kornowski, R; Nudelman, V; Shainberg, A; Waldman, M; Yadin, D1
Al-Omran, M; Bhatt, DL; Chowdhury, B; Connelly, KA; Hess, DA; Kabir, MG; Luu, AZ; Luu, VZ; Mazer, CD; Pan, Y; Quan, A; Sabongui, S; Teoh, H; Verma, S1
Balogh, DB; Besztercei, B; Fekete, A; Genovese, F; Hodrea, J; Hosszu, A; Koszegi, S; Lenart, L; Sparding, N; Szabo, AJ; Wagner, LJ1
Birnbaum, Y; Chen, H; Nylander, S; Tran, D; Yang, HC; Ye, Y1
Ai, J; Du, Q; Feng, J; Liu, M; Lv, Z1
Liu, CM; Ma, JQ; Ming, QL; Sun, YZ; Tian, ZK; Zhang, YJ1
Amorosi, A; De Rosa, S; Iaconetti, C; Indolfi, C; Mignogna, C; Polimeni, A; Sabatino, J; Sorrentino, S; Spaccarotella, C; Tammè, L; Yasuda, M1
Li, J; Tan, R; Wang, L; Zhao, S; Zhong, X1
Chen, ZQ; Huang, HQ; Li, XJ; Lin, ZY; Quan, SJ; Sun, XH; Xiao, HM; Xu, ZC; Yang, Y; Zhang, M1
Boogerd, CJ; de Boer, RA; Dokter, MM; Lam, CSP; Markousis-Mavrogenis, G; Meems, LMG; Schouten, EM; Silljé, HHW; Voors, AA; Westenbrink, BD; Withaar, C1
Fan, K; Shen, W; Xie, M; Zhang, J; Zhao, Y1
Cai, S; Connelly, K1
Badimon, JJ; Flores-Umanzor, EJ; Fuster, V; Garcia-Ropero, A; Ishikawa, K; Picatoste, B; Requena-Ibanez, JA; San Antonio, R; Santos-Gallego, CG; Sanz, J; Vargas-Delgado, AP; Watanabe, S1
Chen, YJ; Cheng, WL; Chung, CC; Huang, SY; Kao, YH; Lee, TI; Lee, TW; Trang, NN1
El Fayoumi, HM; Elkazzaz, SK; Khodeer, DM; Moustafa, YM1
Barzaghi, F; Carletti, R; Castoldi, G; Colzani, M; di Gioia, CRT; Ippolito, S; Perseghin, G; Stella, A; Zatti, G; Zerbini, G1
Baines, DL; Dockrell, MEC; Pan, X; Phanish, MK1
Chai, D; Chen, X; Chu, Y; Du, H; Lin, J; Lin, X; Liu, J; Ma, K; Ruan, Q; Xie, H; Xu, C; Zeng, J; Zhang, H; Zhang, Y1
An, F; Jin, T; Liu, D; Liu, M; Pan, J; Suo, M; Tian, J; Wang, X; Zhang, M1
Atar, S; Bandel, N; Daud, E; Ertracht, O; Moady, G; Reuveni, T; Shehadeh, M1
Altucci, L; Barbieri, A; Botti, G; Canale, ML; Carbone, A; Conte, M; De Laurentiis, M; Maurea, N; Monti, MG; Paccone, A; Quagliariello, V; Rea, D1
Bajaj, M; Birnbaum, Y; Perez-Polo, JR; Yang, HC; Ye, Y1
Li, J; Ren, J; Tang, QZ; Wan, CX; Xu, CR; Xu, SC; Yuan, YP; Zeng, XF; Zhang, N1
Cao, M; Li, Y; Qin, Y; Wang, T; Xu, Y; Zhai, Q; Zhao, K1
Abbas, NAT; Awad, MM; El Salem, A1
Angayarkanni, N; Shanmuganathan, S1
Ma, X; Ma, Y; Pan, X; Wu, Z1
Alvarez-Suarez, D; Camacho, J; Casas-Grajales, S; Dayana Buendía-Montaño, L; Lakshman, MR; Muriel, P; Ramos-Tovar, E; Reyes-Gordillo, K; Tsutsumi, V1
Jiang, A; Li, F; Shi, L; Wang, S; Zhu, D1
Chen, L; Cheng, Y; Han, F; Li, C; Li, T; Li, X; Liu, X; Lu, Y; Sun, B; Xu, L; Xue, M; Yu, X; Zhang, J1
Jia, CH; Shen, W; Wang, J; Xie, ML; Zhang, JY1
Guo, Y; Li, R; Yan, T; Zhang, X; Zhang, Y; Zhu, L1
Khan, RS; Newsome, PN1
Chang, CY; Chen, WY; Chen, YF; Dai, ZK; Jhuang, WJ; Jhuo, SJ; Lee, AS; Lee, HC; Liu, PL; Shiou, YL1
Fan, S; Gu, K; Li, Y; Luo, H; Wang, X; Wang, Y; Wu, Y; Zhang, T; Zhang, Y1
Akagi, S; Akazawa, K; Ito, H; Kimura, T; Kondo, M; Miura, D; Miyoshi, T; Nakamura, K; Ohno, Y; Saito, Y; Wada, J; Yoshida, M1
Kitamura, K; Miyachi, Y; Mori, K; Nakamura, S; Ogawa, Y; Shiba, K; Tsuchiya, K1
Bian, ZY; Dai, J; Deng, W; Tang, QZ; Yang, HX; Yuan, Y; Zhang, JY; Zhou, H; Zong, J1
Dai, Y; Dou, Y; Guo, J; Wu, X; Zeng, J1
Arguiri, E; Busch, TM; Cengel, KA; Christofidou-Solomidou, M; Dukes, F; Gallagher-Colombo, SM; Pietrofesa, R; Solomides, CC; Turowski, J; Tyagi, S1
Cai, X; Cao, P; Gu, Z; Guan, X; Hu, C; Lu, W; Qian, S; Wang, D; Yang, J; Yao, Y; Zhou, F1
Baniene, R; Barauskas, G; Cesna, V; Gulbinas, A; Kmieliute, K; Maziukiene, A; Trumbeckaite, S; Venclauskas, L1
Gilbert, RE; Kepecs, DM; Thai, K; Zhang, Y1
Gao, L; Huang, C; Huang, Y; Li, HD; Li, J; Li, XF; Li, Z; Lv, XW; Ma, TT; Meng, XM; Ren, GL; Wang, XF; Wu, WF; Xu, T; Zhang, L1
Huang, XL; Peng, Y; Xu, J; Xu, XL; Zeng, Y; Zhang, W1
Li, SZ; Sun, LL; Xu, JJ; Zhang, L; Zhang, Y1
Chang, NC; Lee, TM; Lin, SZ1
Bouchard, M; Donahay, T; Haubner, R; Johnson, LL; Poppas, A; Schofield, L1
Sinusas, AJ1
Bian, Z; Chen, C; Dai, J; Dong, X; Guo, H; Shu, C; Tang, Q; Zhang, DP; Zhang, Y; Zhou, H; Zong, J1

Reviews

2 review(s) available for glucose, (beta-d)-isomer and Fibrosis

ArticleYear
Empagliflozin reduces diffuse myocardial fibrosis by extracellular volume mapping: A meta-analysis of clinical studies.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Benzhydryl Compounds; Cardiomyopathies; Fibrosis; Glucosides; Humans; Myocardium

2022
Salidroside in the Treatment of NAFLD/NASH.
    Chemistry & biodiversity, 2022, Volume: 19, Issue:12

    Topics: Fibrosis; Glucosides; Humans; Liver; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease

2022

Trials

3 trial(s) available for glucose, (beta-d)-isomer and Fibrosis

ArticleYear
Effects of empagliflozin on markers of liver steatosis and fibrosis and their relationship to cardiorenal outcomes.
    Diabetes, obesity & metabolism, 2022, Volume: 24, Issue:6

    Topics: Benzhydryl Compounds; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Humans; Non-alcoholic Fatty Liver Disease; Treatment Outcome

2022
Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial.
    Diabetes care, 2022, 09-01, Volume: 45, Issue:9

    Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Humans; Inflammation; Liver; Non-alcoholic Fatty Liver Disease; Sulfonylurea Compounds

2022
Exenatide and dapagliflozin combination improves markers of liver steatosis and fibrosis in patients with type 2 diabetes.
    Diabetes, obesity & metabolism, 2020, Volume: 22, Issue:3

    Topics: Benzhydryl Compounds; Biomarkers; Diabetes Mellitus, Type 2; Exenatide; Fibrosis; Glucosides; Humans; Hypoglycemic Agents; Non-alcoholic Fatty Liver Disease; Prospective Studies

2020

Other Studies

73 other study(ies) available for glucose, (beta-d)-isomer and Fibrosis

ArticleYear
Direct Blood Pressure-Independent Anti-Fibrotic Effects by the Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone in Progressive Models of Kidney Fibrosis.
    American journal of nephrology, 2021, Volume: 52, Issue:7

    Topics: Actins; Adaptor Proteins, Signal Transducing; Albuminuria; Animals; Benzhydryl Compounds; Blood Pressure; Calcium-Binding Proteins; Collagen; Creatinine; Disease Models, Animal; Fibrosis; Gene Expression; Glucosides; Kidney; Kidney Diseases; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Monocytes; Myofibroblasts; Naphthyridines; Reperfusion Injury; RNA, Messenger; Serpin E2; Sodium-Glucose Transporter 2 Inhibitors; Ureteral Obstruction

2021
Eleutheroside B-loaded poly (lactic-co-glycolic acid) nanoparticles protect against renal fibrosis via Smad3-dependent mechanism.
    Phytotherapy research : PTR, 2021, Volume: 35, Issue:11

    Topics: Animals; Fibrosis; Glucosides; Glycolates; Kidney Diseases; Mice; Molecular Docking Simulation; Nanoparticles; Phenylpropionates; Polylactic Acid-Polyglycolic Acid Copolymer; Smad3 Protein

2021
The combination of ursolic acid and empagliflozin relieves diabetic nephropathy by reducing inflammation, oxidative stress and renal fibrosis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 144

    Topics: Animals; Anti-Inflammatory Agents; Antifibrotic Agents; Antioxidants; Apoptosis; Benzhydryl Compounds; Cell Line; Cell Proliferation; Diabetic Nephropathies; Drug Therapy, Combination; Fibrosis; Glucosides; Inflammation Mediators; Kidney; Male; Nephritis; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Triterpenes; Ursolic Acid

2021
SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022, Volume: 36, Issue:1

    Topics: Animals; Benzhydryl Compounds; Citric Acid Cycle; Fibrosis; Glucosides; Inflammasomes; Kidney Diseases; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Succinates

2022
Antifibrotic effects of low dose SGLT2 Inhibition with empagliflozin in comparison to Ang II receptor blockade with telmisartan in 5/6 nephrectomised rats on high salt diet.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 146

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzhydryl Compounds; Dose-Response Relationship, Drug; Fibrosis; Glucosides; Glycosuria; Heart Diseases; Iron; Kidney Diseases; Male; Nephrectomy; Rats; Rats, Wistar; Sequence Analysis, RNA; Sodium-Glucose Transporter 2 Inhibitors; Sodium, Dietary; Telmisartan

2022
Stevioside inhibits lipopolysaccharide-induced epithelial-to-mesenchymal transition of NRK-52E cells by PPARγ activation.
    Immunopharmacology and immunotoxicology, 2022, Volume: 44, Issue:2

    Topics: Cell Line; Diterpenes, Kaurane; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Glucosides; Humans; Lipopolysaccharides; PPAR gamma; Transforming Growth Factor beta1

2022
Agnuside mitigates OVA-LPS induced perturbed lung homeostasis via modulating inflammatory, autophagy, apoptosis-fibrosis response and myeloid lineages in mice model of allergic asthma.
    International immunopharmacology, 2022, Volume: 106

    Topics: Animals; Apoptosis; Asthma; Autophagy; Bronchoalveolar Lavage Fluid; Cell Lineage; Cytokines; Disease Models, Animal; Fibrosis; Glucosides; Homeostasis; Lung; Mice; Mice, Inbred BALB C; Ovalbumin

2022
SGLT2 inhibitor dapagliflozin attenuates cardiac fibrosis and inflammation by reverting the HIF-2α signaling pathway in arrhythmogenic cardiomyopathy.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022, Volume: 36, Issue:7

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Benzhydryl Compounds; Cardiomyopathies; Collagen; Diabetes Mellitus, Type 2; Fibrosis; Glucose; Glucosides; Heart Diseases; Inflammation; Mice; NF-kappa B; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors

2022
Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress.
    Life sciences, 2022, Oct-15, Volume: 307

    Topics: Animals; Benzhydryl Compounds; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Fibrosis; Fructose; Glucose; Glucosides; Heart Diseases; Insulin Resistance; Mitochondria; Oxidative Stress; Palmitates; Palmitic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2022
Empagliflozin prevents angiotensin II-induced hypertension related micro and macrovascular endothelial cell activation and diastolic dysfunction in rats despite persistent hypertension: Role of endothelial SGLT1 and 2.
    Vascular pharmacology, 2022, Volume: 146

    Topics: Angiotensin II; Animals; Benzhydryl Compounds; Blood Pressure; Collagen; Endothelial Cells; Fibrosis; Glucosides; Hypertension; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats; Rats, Wistar; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Vascular Cell Adhesion Molecule-1

2022
Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling.
    BMC medicine, 2022, 09-07, Volume: 20, Issue:1

    Topics: Animals; Benzhydryl Compounds; Diabetes Mellitus; Fibrosis; Glucosides; Male; Rabbits; Sodium-Glucose Transporter 2 Inhibitors

2022
Dapagliflozin Mitigates Doxorubicin-Caused Myocardium Damage by Regulating AKT-Mediated Oxidative Stress, Cardiac Remodeling, and Inflammation.
    International journal of molecular sciences, 2022, Sep-04, Volume: 23, Issue:17

    Topics: Animals; Apoptosis; Benzhydryl Compounds; Cardiotoxicity; Doxorubicin; Fibrosis; Glucosides; Hypertrophy; Inflammation; Myocardium; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Ventricular Remodeling

2022
Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms.
    Life sciences, 2022, Nov-01, Volume: 308

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzhydryl Compounds; Biomarkers; Cholesterol; Cholic Acid; Diet, High-Fat; Fibrosis; Glucosides; Inflammation; Insulin Resistance; Liver; Metformin; Non-alcoholic Fatty Liver Disease; Pioglitazone; Rats

2022
Effect of Dapagliflozin on Indicators of Myocardial Fibrosis and Levels of Inflammatory Factors in Heart Failure Patients.
    Disease markers, 2022, Volume: 2022

    Topics: Benzhydryl Compounds; C-Reactive Protein; Cardiomyopathies; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Heart Failure; Humans; Interleukin-6; Tumor Necrosis Factor-alpha

2022
Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis.
    Molecules (Basel, Switzerland), 2022, Nov-19, Volume: 27, Issue:22

    Topics: Animals; Ferroptosis; Fibrosis; Glucosides; Kidney Diseases; Mice

2022
Diosmetin-7-O-β-D-glucopyranoside suppresses endothelial-mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis.
    Clinical and experimental pharmacology & physiology, 2023, Volume: 50, Issue:10

    Topics: Animals; Cardiomyopathies; Cardiovascular Diseases; Collagen; Endoplasmic Reticulum Stress; Endothelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Flavonoids; Glucosides; Mice; Molecular Docking Simulation

2023
Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction.
    Cardiovascular diabetology, 2019, 08-20, Volume: 18, Issue:1

    Topics: Animals; Aorta; Benzhydryl Compounds; Biomarkers; Blood Pressure; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytokines; Disease Models, Animal; Female; Fibrosis; Glucosides; Heart Failure; Hypertension; Inflammation Mediators; Lipids; Nitric Oxide; Norepinephrine; Sodium-Glucose Transporter 2 Inhibitors; Sus scrofa; Sympathetic Nervous System; Ventricular Function, Left; Ventricular Remodeling

2019
The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.
    Scientific reports, 2019, 10-01, Volume: 9, Issue:1

    Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Fibrosis; Flavonoids; Glucosides; Hesperidin; Humans; Kidney; Kidney Diseases; Luciferases; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Serum Amyloid A Protein; Transcriptional Activation; Tumor Necrosis Factor-alpha

2019
Effect of Empagliflozin on Cardiac Function, Adiposity, and Diffuse Fibrosis in Patients with Type 2 Diabetes Mellitus.
    Scientific reports, 2019, 10-25, Volume: 9, Issue:1

    Topics: Adiposity; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Female; Fibrosis; Glucosides; Heart Function Tests; Heart Ventricles; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Myocardium; Triglycerides

2019
Empagliflozin and Dulaglutide are Effective against Obesity-induced Airway Hyperresponsiveness and Fibrosis in A Murine Model.
    Scientific reports, 2019, Oct-30, Volume: 9, Issue:1

    Topics: Animals; Benzhydryl Compounds; Cell Differentiation; Cytokines; Diet, High-Fat; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Glucagon-Like Peptides; Glucosides; Immunoglobulin Fc Fragments; Mice; Obesity; Recombinant Fusion Proteins; Respiratory Hypersensitivity; RNA, Messenger; Th1 Cells; Th17 Cells

2019
Pretreatment with KGA-2727, a selective SGLT1 inhibitor, is protective against myocardial infarction-induced ventricular remodeling and heart failure in mice.
    Journal of pharmacological sciences, 2020, Volume: 142, Issue:1

    Topics: Animals; Fibrosis; Gene Expression Regulation; Glucosides; Heart Failure; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Pyrazoles; RNA, Messenger; Sodium-Glucose Transporter 1; Ventricular Remodeling

2020
Protective effects of Salidroside on cardiac function in mice with myocardial infarction.
    Scientific reports, 2019, 12-02, Volume: 9, Issue:1

    Topics: Animals; Apoptosis; Cardiotonic Agents; Coronary Vessels; Cytokines; Disease Models, Animal; Fibrosis; Glucosides; Heart; Ligation; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Phenols; Ventricular Remodeling

2019
Renal Anti-Fibrotic Effect of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension.
    American journal of nephrology, 2020, Volume: 51, Issue:2

    Topics: Angiotensin II; Animals; Benzhydryl Compounds; Fibrosis; Glucosides; Hypertension; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors

2020
Sodium-glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy.
    Cardiovascular diabetology, 2020, 01-10, Volume: 19, Issue:1

    Topics: Angiotensin II; Animals; Benzhydryl Compounds; Biomarkers; Blood Glucose; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Diabetes Mellitus; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Glucosides; Inflammation Mediators; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Sodium-Glucose Transporter 2 Inhibitors; Sodium-Hydrogen Exchanger 1; Ventricular Function, Left

2020
The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension.
    Biochemical and biophysical research communications, 2020, 03-26, Volume: 524, Issue:1

    Topics: Animals; Benzhydryl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Lung; Male; Models, Animal; Monocrotaline; Mortality; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Risk Assessment; Sodium-Glucose Transporter 2 Inhibitors; Vascular Remodeling

2020
Reduced
    American journal of physiology. Renal physiology, 2020, 04-01, Volume: 318, Issue:4

    Topics: Animals; Benzhydryl Compounds; Blood Glucose; Cell Hypoxia; Cell Line; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Fibronectins; Fibrosis; Glucosides; Glycosylation; Humans; Kidney Tubules, Proximal; Male; Rats, Wistar; Sodium-Glucose Transporter 2 Inhibitors; Streptozocin

2020
Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK-mTOR Interplay.
    Cardiovascular drugs and therapy, 2020, Volume: 34, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Disease Progression; Enzyme Activation; Fibrosis; Glucosides; Inflammasomes; Male; Mechanistic Target of Rapamycin Complex 2; Mice, Inbred C57BL; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Purinergic P2Y Receptor Antagonists; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Stroke Volume; Ticagrelor; TOR Serine-Threonine Kinases; Ventricular Function, Left; Ventricular Remodeling

2020
Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats via Inhibiting P38 MAPK Pathway.
    Current medical science, 2020, Volume: 40, Issue:2

    Topics: Animals; Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fibrosis; Gene Expression Regulation; Glucosides; Heart Function Tests; Isoproterenol; Male; MAP Kinase Signaling System; Monoterpenes; Rats; Transforming Growth Factor beta1

2020
Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway.
    Food & function, 2020, May-01, Volume: 11, Issue:5

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Benzyl Alcohols; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Glucosides; HMGB1 Protein; Inflammation; Kidney Diseases; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Phytotherapy; Protein Kinases

2020
Empagliflozin prevents doxorubicin-induced myocardial dysfunction.
    Cardiovascular diabetology, 2020, 05-15, Volume: 19, Issue:1

    Topics: Animals; Benzhydryl Compounds; Cardiomyopathies; Cardiotoxicity; Diastole; Disease Models, Animal; Doxorubicin; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Glucosides; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Sodium-Glucose Transporter 2 Inhibitors; Systole; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2020
Nodakenin alleviated obstructive nephropathy through blunting Snail1 induced fibrosis.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:17

    Topics: Angelica; Animals; Anti-Inflammatory Agents; Coumarins; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Glucosides; Humans; Kidney; Kidney Failure, Chronic; Macrophages; Mice; NF-kappa B; Phosphorylation; Plant Roots; Signal Transduction; Smad3 Protein; Snail Family Transcription Factors; Transforming Growth Factor beta1; Ureteral Obstruction

2020
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
    Acta pharmacologica Sinica, 2020, Volume: 41, Issue:12

    Topics: Animals; Connexins; Diabetes Mellitus, Experimental; Fibronectins; Fibrosis; Gap Junction beta-1 Protein; Glucosides; Intercellular Adhesion Molecule-1; Kidney; Male; Mice, Inbred C57BL; NADPH Oxidase 4; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Stilbenes; Ubiquitination

2020
The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction.
    Cardiovascular research, 2021, 07-27, Volume: 117, Issue:9

    Topics: Angiotensin II; Animals; Benzhydryl Compounds; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Female; Fibrosis; Gene Expression Regulation; Glucagon-Like Peptide-1 Receptor; Glucosides; Heart Failure, Diastolic; Hypertrophy, Left Ventricular; Incretins; Liraglutide; Mice, Inbred C57BL; Myocardium; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Ventricular Function, Left; Ventricular Remodeling

2021
Stevioside inhibits unilateral ureteral obstruction-induced kidney fibrosis and upregulates renal PPARγ expression in mice.
    Journal of food biochemistry, 2020, Volume: 44, Issue:12

    Topics: Animals; Diterpenes, Kaurane; Fibrosis; Glucosides; Kidney; Mice; PPAR gamma; Ureteral Obstruction

2020
Softening the Stiff Heart: SGLT2 Inhibition and Diastolic Function.
    JACC. Cardiovascular imaging, 2021, Volume: 14, Issue:2

    Topics: Benzhydryl Compounds; Fibrosis; Glucosides; Heart Failure; Humans; Predictive Value of Tests; Sodium-Glucose Transporter 2

2021
Empagliflozin Ameliorates Diastolic Dysfunction and Left Ventricular Fibrosis/Stiffness in Nondiabetic Heart Failure: A Multimodality Study.
    JACC. Cardiovascular imaging, 2021, Volume: 14, Issue:2

    Topics: Animals; Benzhydryl Compounds; Diastole; Fibrosis; Glucosides; Heart Failure; Heart Ventricles; Predictive Value of Tests; Stroke Volume; Swine; Ventricular Dysfunction, Left; Ventricular Function, Left

2021
Empagliflozin and Liraglutide Differentially Modulate Cardiac Metabolism in Diabetic Cardiomyopathy in Rats.
    International journal of molecular sciences, 2021, Jan-25, Volume: 22, Issue:3

    Topics: Animals; Apoptosis; Benzhydryl Compounds; Biomarkers; Cytokines; Diabetic Cardiomyopathies; Disease Models, Animal; Echocardiography; Energy Metabolism; Fatty Acids; Fibrosis; Glucose; Glucosides; Heart Function Tests; Hypoglycemic Agents; Immunohistochemistry; Inflammation Mediators; Liraglutide; Myocardium; Rats; Sodium-Glucose Transporter 2 Inhibitors

2021
Role of sodium glucose cotransporter type 2 inhibitors dapagliflozin on diabetic nephropathy in rats; Inflammation, angiogenesis and apoptosis.
    Life sciences, 2021, Sep-01, Volume: 280

    Topics: Animals; Apoptosis; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fibrosis; Glucosides; Inflammation; Kidney; Male; Rats; Sodium-Glucose Transporter 2 Inhibitors; Vascular Endothelial Growth Factor A

2021
Sodium-glucose cotransporter 2 inhibition prevents renal fibrosis in cyclosporine nephropathy.
    Acta diabetologica, 2021, Volume: 58, Issue:8

    Topics: Animals; Benzhydryl Compounds; Blood Pressure; Cyclosporine; Fibrosis; Glucosides; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

2021
High glucose-induced Smad3 linker phosphorylation and CCN2 expression are inhibited by dapagliflozin in a diabetic tubule epithelial cell model.
    Bioscience reports, 2021, 06-25, Volume: 41, Issue:6

    Topics: Benzhydryl Compounds; Cells, Cultured; Connective Tissue Growth Factor; Diabetic Nephropathies; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Glucose; Glucosides; Humans; Kidney Tubules, Proximal; Phosphorylation; Signal Transduction; Smad2 Protein; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1

2021
Dapagliflozin: a sodium-glucose cotransporter 2 inhibitor, attenuates angiotensin II-induced cardiac fibrotic remodeling by regulating TGFβ1/Smad signaling.
    Cardiovascular diabetology, 2021, 06-11, Volume: 20, Issue:1

    Topics: Angiotensin II; Animals; Antifibrotic Agents; Benzhydryl Compounds; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Glucosides; Hypertrophy, Left Ventricular; Male; Myocardium; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2021
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF-β/Smad signalling in type 2 diabetic rats.
    Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:16

    Topics: AMP-Activated Protein Kinases; Animals; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Diet, High-Fat; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Glucosides; Male; Mesoderm; Rats; Signal Transduction; Smad4 Protein; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta

2021
The impact of empagliflozin on cardiac physiology and fibrosis early after myocardial infarction in non-diabetic rats.
    Cardiovascular diabetology, 2021, 07-02, Volume: 20, Issue:1

    Topics: Animals; Benzhydryl Compounds; Collagen; Disease Models, Animal; Fibrosis; Glucosides; Hydroxyproline; Male; Myocardial Infarction; Myocardium; Rats, Sprague-Dawley; Smad3 Protein; Sodium-Glucose Transporter 2 Inhibitors; Stroke Volume; Time Factors; Transforming Growth Factor beta1; Ventricular Function, Left

2021
The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin.
    Cardiovascular diabetology, 2021, 07-23, Volume: 20, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antifibrotic Agents; Apoptosis; Benzhydryl Compounds; Cardiotoxicity; Cell Line; Cytokines; Disease Models, Animal; Doxorubicin; Female; Ferroptosis; Fibrosis; Glucosides; Heart Diseases; Inflammasomes; Inflammation Mediators; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Ventricular Function, Left

2021
SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.
    Cardiovascular drugs and therapy, 2017, Volume: 31, Issue:2

    Topics: Adamantane; AMP-Activated Protein Kinases; Animals; Apoptosis; Benzhydryl Compounds; CARD Signaling Adaptor Proteins; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fibroblasts; Fibrosis; Glucosides; Hypoglycemic Agents; Inflammasomes; Inflammation Mediators; Kidney Tubules, Proximal; Male; Mice, Inbred C57BL; Mice, Obese; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stroke Volume; Time Factors; Ventricular Function, Left

2017
Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.
    Journal of pharmacological sciences, 2017, Volume: 135, Issue:3

    Topics: Administration, Oral; Animals; Arctium; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibrosis; Furans; Glucosides; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocytes, Cardiac; Phytotherapy; Proto-Oncogene Proteins c-akt; Signal Transduction

2017
Cyanidin-3-O-glucoside ameliorates diabetic nephropathy through regulation of glutathione pool.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103

    Topics: Animals; Anthocyanins; Buthionine Sulfoximine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Glucose; Glucosides; Glutathione; Inflammation; Kidney; Lipid Metabolism; Male; Mice, Inbred C57BL; Obesity; Protective Agents

2018
Empagliflozin, SGLT
    Naunyn-Schmiedeberg's archives of pharmacology, 2018, Volume: 391, Issue:12

    Topics: Animals; Benzhydryl Compounds; Fibrosis; Glucosides; Glucuronidase; Kidney; Kidney Diseases; Klotho Proteins; Male; Rats, Wistar; Sodium-Glucose Transporter 2 Inhibitors; Ureteral Obstruction

2018
Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation.
    Microvascular research, 2019, Volume: 121

    Topics: Animals; Benzopyrans; Binding Sites; Cell Movement; Cell Proliferation; Cells, Cultured; Choroid; Diabetic Retinopathy; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Glucosides; Hydrolyzable Tannins; Macaca mulatta; Molecular Docking Simulation; Neovascularization, Pathologic; Phosphorylation; Plant Extracts; Protein Binding; Receptors, Transforming Growth Factor beta; Retinal Vessels; Signal Transduction; Transforming Growth Factor beta1

2019
[Polydatin ameliorates myocardial fibrosis in rats by up-regulating SIRT3 and SDF-1].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2018, Volume: 34, Issue:9

    Topics: Animals; Chemokine CXCL12; Fibrosis; Glucosides; Heart Diseases; Male; Rats; Rats, Sprague-Dawley; Sirtuin 1; Sirtuin 3; Stilbenes; Superoxide Dismutase

2018
Stevioside inhibits experimental fibrosis by down-regulating profibrotic Smad pathways and blocking hepatic stellate cell activation.
    Basic & clinical pharmacology & toxicology, 2019, Volume: 124, Issue:6

    Topics: Actins; Animals; Cell Line; Collagen Type I; Collagenases; Deoxycytosine Nucleotides; Diterpenes, Kaurane; Down-Regulation; Fibrosis; Glucosides; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Lymphokines; Male; MAP Kinase Signaling System; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-myc; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Thioacetamide; Transforming Growth Factor beta1; Up-Regulation

2019
Dapagliflozin Attenuates Cardiac Remodeling in Mice Model of Cardiac Pressure Overload.
    American journal of hypertension, 2019, 04-22, Volume: 32, Issue:5

    Topics: Animals; Benzhydryl Compounds; Blotting, Western; Cardiomyopathies; Disease Models, Animal; Echocardiography; Fibrosis; Glucosides; Heart Ventricles; Hypertrophy, Left Ventricular; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Sodium-Glucose Transport Proteins; Sodium-Glucose Transporter 2 Inhibitors; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling

2019
SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart.
    Cardiovascular diabetology, 2019, 02-02, Volume: 18, Issue:1

    Topics: Animals; Antioxidant Response Elements; Antioxidants; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Glucosides; Mice, Inbred C57BL; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Phosphorylation; Signal Transduction; Smad Proteins; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1; Ventricular Function, Left; Ventricular Remodeling

2019
Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway.
    Food & function, 2019, Feb-20, Volume: 10, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cardiomyopathies; Cell Line; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Fibrosis; Gene Expression Regulation; Glucosides; Isoproterenol; Male; Mice; NF-kappa B; Smad Proteins; Transforming Growth Factor beta1

2019
Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways.
    International journal of molecular sciences, 2019, Mar-04, Volume: 20, Issue:5

    Topics: Cadherins; Cell Line; Cytokines; Epithelial-Mesenchymal Transition; Extracellular Matrix; Fibrosis; Gene Expression Regulation; Glucosides; Humans; Kidney; Kidney Diseases; Kidney Tubules, Proximal; MAP Kinase Signaling System; NF-kappa B; Phenols; Rhodiola; Toll-Like Receptor 4

2019
Fat and Fibrosis: Does Empagliflozin Impair the Progression of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus?
    Digestive diseases and sciences, 2020, Volume: 65, Issue:2

    Topics: Benzhydryl Compounds; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Humans; Non-alcoholic Fatty Liver Disease

2020
The sodium-glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats.
    Cardiovascular diabetology, 2019, 04-01, Volume: 18, Issue:1

    Topics: Animals; Atrial Function, Left; Atrial Natriuretic Factor; Benzhydryl Compounds; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fibrosis; Gene Expression Regulation; Glucosides; Heart Failure; Hemodynamics; Hypertension; Male; Myocardium; Natriuretic Peptide, Brain; Rats, Inbred SHR; Rats, Inbred WKY; Recovery of Function; Sodium-Glucose Transporter 2 Inhibitors; Tumor Necrosis Factor-alpha; Ventricular Function, Left; Ventricular Remodeling

2019
Liquiritinapioside - A mineralocorticoid-like substance from liquorice.
    Food chemistry, 2019, Aug-15, Volume: 289

    Topics: Animals; Cell Line; China; Collagen Type I; Fibrosis; Flavanones; Glucosides; Glycyrrhiza; Humans; MAP Kinase Signaling System; Mineralocorticoids; Myocardium; Plant Extracts; Receptors, Mineralocorticoid; Signal Transduction; Terpenes; Transforming Growth Factor beta1

2019
Inhibitory Effects of Tofogliflozin on Cardiac Hypertrophy in Dahl Salt-Sensitive and Salt-Resistant Rats Fed a High-Fat Diet.
    International heart journal, 2019, May-30, Volume: 60, Issue:3

    Topics: Animals; Benzhydryl Compounds; Blood Pressure; Cardiomegaly; Diet, High-Fat; Fibrosis; Glucosides; Interleukin-6; Ketones; Male; Models, Animal; Myocytes, Cardiac; Natriuretic Peptides; Rats; Rats, Inbred Dahl; Sodium-Glucose Transporter 2 Inhibitors

2019
Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice.
    Cardiovascular diabetology, 2019, 06-24, Volume: 18, Issue:1

    Topics: Adipocytes; Adipogenesis; Adipose Tissue; Adiposity; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Fibrosis; Glucosides; Inflammation Mediators; Insulin Resistance; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Obesity; Paracrine Communication; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Vascular Remodeling; Vascular System Injuries

2019
Paeoniflorin attenuates pressure overload-induced cardiac remodeling via inhibition of TGFβ/Smads and NF-κB pathways.
    Journal of molecular histology, 2013, Volume: 44, Issue:3

    Topics: Animals; Apoptosis; Benzoates; Biomarkers; Bridged-Ring Compounds; Cardiomegaly; Fibrosis; Glucosides; Heart; Inflammation; Male; Mice; Mice, Inbred C57BL; Monoterpenes; Myocytes, Cardiac; NF-kappa B; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Ventricular Function, Left; Ventricular Remodeling

2013
Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Jun-15, Volume: 20, Issue:8-9

    Topics: Animals; Benzoates; Bone Morphogenetic Protein 7; Bridged-Ring Compounds; Collagen; Down-Regulation; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression Regulation; Glucosides; Kidney Diseases; Male; Mice; Mice, Inbred ICR; Monoterpenes; Paeonia; Phosphorylation; Plasminogen Activator Inhibitor 1; Smad2 Protein; Transforming Growth Factor beta1; Ureteral Obstruction

2013
Radiation mitigating properties of the lignan component in flaxseed.
    BMC cancer, 2013, Apr-04, Volume: 13

    Topics: Animal Feed; Animals; Bronchoalveolar Lavage Fluid; Butylene Glycols; Cytokines; Female; Fibrosis; Flax; Glucosides; Kaplan-Meier Estimate; Lignans; Lung; Lung Injury; Malondialdehyde; Mice; Mice, Inbred C57BL; Neutrophils; Oxygen; Phytotherapy; Radiation Injuries, Experimental; Radiation Pneumonitis; Radiation-Protective Agents; Seeds; Survival Rate; Time Factors; Transforming Growth Factor beta1; Tyrosine

2013
The aqueous extract of Lycopus lucidus Turcz ameliorates streptozotocin-induced diabetic renal damage via inhibiting TGF-β1 signaling pathway.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Oct-15, Volume: 20, Issue:13

    Topics: Animals; Caffeic Acids; Cell Line; Cinnamates; Depsides; Diabetic Nephropathies; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Glucosides; Humans; Luteolin; Lycopus; Male; Mice; Phosphorylation; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Rosmarinic Acid; Signal Transduction; Streptozocin; Transforming Growth Factor beta1

2013
Effects of Cyanidin-3-O-glucoside on Synthetic and Metabolic Activity of Ethanol Stimulated Human Pancreatic Stellate Cells.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:12

    Topics: Anthocyanins; Cells, Cultured; Collagen Type I; Ethanol; Extracellular Matrix Proteins; Fibronectins; Fibrosis; Glucosides; Humans; Pancreatic Stellate Cells

2015
Sodium-Glucose Linked Cotransporter-2 Inhibition Does Not Attenuate Disease Progression in the Rat Remnant Kidney Model of Chronic Kidney Disease.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Disease Progression; Fibrosis; Gene Expression; Glomerular Filtration Rate; Glucosides; Glycosuria; Humans; Hypertension, Renal; Hypoglycemic Agents; Kidney; Male; Nephrectomy; Proteinuria; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; RNA, Messenger; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1; Treatment Failure

2016
Anti-fibrotic effect of wogonin in renal tubular epithelial cells via Smad3-dependent mechanisms.
    European journal of pharmacology, 2016, Oct-15, Volume: 789

    Topics: Active Transport, Cell Nucleus; Animals; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Epithelial Cells; Fibrosis; Flavanones; Glucosides; Humans; Kidney Tubules, Proximal; Mice; Phosphorylation; Rats; Receptors, Transforming Growth Factor beta; Smad3 Protein; Transforming Growth Factor beta1

2016
PPAR-γ is involved in the protective effect of 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside against cardiac fibrosis in pressure-overloaded rats.
    European journal of pharmacology, 2016, Nov-15, Volume: 791

    Topics: Angiotensin II; Animals; Blood Pressure; Cardiotonic Agents; Cell Differentiation; Cell Proliferation; Collagen Type I; Collagen Type III; Fibroblasts; Fibronectins; Fibrosis; Gene Expression Regulation; Glucosides; Heart; Male; Myocardium; Plasminogen Activator Inhibitor 1; PPAR gamma; Pressure; Rats; Stilbenes

2016
The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Animals; Cell Survival; Collagen; Down-Regulation; Feeding Behavior; Fibrosis; Flavanones; Fructose; Glucosides; Inflammation; Insulin Resistance; Lipid Metabolism; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardium; Myocytes, Cardiac; NF-kappa B; Protective Agents

2016
Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts.
    Free radical biology & medicine, 2017, Volume: 104

    Topics: Animals; Benzhydryl Compounds; Fibrosis; Gene Expression Regulation; Glucosides; Humans; Interleukin-10; Macrophages; Myocardial Infarction; Myocardium; Rats; Reactive Oxygen Species; Signal Transduction; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; STAT3 Transcription Factor

2017
Radiolabeled arginine-glycine-aspartic acid peptides to image angiogenesis in swine model of hibernating myocardium.
    JACC. Cardiovascular imaging, 2008, Volume: 1, Issue:4

    Topics: Animals; Capillaries; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Echocardiography; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Glucosides; Humans; Integrin alphaVbeta3; Male; Myocardium; Neovascularization, Physiologic; Oligopeptides; Radiopharmaceuticals; Swine; Time Factors; Tomography, Emission-Computed, Single-Photon; Vascular Endothelial Growth Factor A

2008
Targeted imaging offers advantages over physiological imaging for evaluation of angiogenic therapy.
    JACC. Cardiovascular imaging, 2008, Volume: 1, Issue:4

    Topics: Animals; Capillaries; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Echocardiography; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Glucosides; Humans; Integrin alphaVbeta3; Myocardium; Neovascularization, Physiologic; Oligopeptides; Radiopharmaceuticals; Time Factors; Tomography, Emission-Computed, Single-Photon; Vascular Endothelial Growth Factor A

2008
Gastrodin protects against cardiac hypertrophy and fibrosis.
    Molecular and cellular biochemistry, 2012, Volume: 359, Issue:1-2

    Topics: Animals; Benzyl Alcohols; Cardiomegaly; Collagen; Fibrosis; GATA4 Transcription Factor; Glucosides; Male; MAP Kinase Signaling System; Mice

2012