kynurenine has been researched along with Fibrosis in 6 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influence cGVHD severity and manifestation (fibrosing versus gastrointestinal [GI] cGVHD)." | 8.02 | Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease. ( Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T, 2021) |
| "Fibrosis is a pathological form of aberrant tissue repair, the complications of which account for nearly half of all deaths in the industrialized world." | 6.58 | Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis. ( Dolivo, DM; Dominko, T; Larson, SA, 2018) |
| "1 to 10 μM, ITE from 1 to 100 μM or curcumin from 5 to 20 μM had no significant effect on fibrosis markers in TGF-β1-induced CCD-18Co." | 4.12 | Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts. ( Amamou, A; Bôle-Feysot, C; Leboutte, M; Marion-Letellier, R; Savoye, G; Yaker, L, 2022) |
| " A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influence cGVHD severity and manifestation (fibrosing versus gastrointestinal [GI] cGVHD)." | 4.02 | Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease. ( Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T, 2021) |
| "Fibrosis is a pathological form of aberrant tissue repair, the complications of which account for nearly half of all deaths in the industrialized world." | 2.58 | Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis. ( Dolivo, DM; Dominko, T; Larson, SA, 2018) |
| "Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary blistering disorder characterized by skin fragility, chronic inflammation, malnutrition, and fibrosis." | 1.72 | Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa. ( Aala, WJ; Chen, YF; Chen, YL; Hou, PC; Hsu, CK; Lin, YC; Lu, HC; McGrath, JA; Onoufriadis, A, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 4 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Orsatti, L | 1 |
| Stiehl, T | 1 |
| Dischinger, K | 1 |
| Speziale, R | 1 |
| Di Pasquale, P | 1 |
| Monteagudo, E | 1 |
| Müller-Tidow, C | 1 |
| Radujkovic, A | 1 |
| Dreger, P | 1 |
| Luft, T | 1 |
| Chen, YF | 1 |
| Lu, HC | 1 |
| Hou, PC | 1 |
| Lin, YC | 1 |
| Aala, WJ | 1 |
| Onoufriadis, A | 1 |
| McGrath, JA | 1 |
| Chen, YL | 1 |
| Hsu, CK | 1 |
| Amamou, A | 1 |
| Yaker, L | 1 |
| Leboutte, M | 1 |
| Bôle-Feysot, C | 1 |
| Savoye, G | 1 |
| Marion-Letellier, R | 1 |
| Turski, WA | 1 |
| Wnorowski, A | 1 |
| Turski, GN | 1 |
| Turski, CA | 1 |
| Turski, L | 1 |
| Dolivo, DM | 1 |
| Larson, SA | 1 |
| Dominko, T | 1 |
| Osawa, Y | 1 |
| Kanamori, H | 1 |
| Seki, E | 1 |
| Hoshi, M | 1 |
| Ohtaki, H | 1 |
| Yasuda, Y | 1 |
| Ito, H | 1 |
| Suetsugu, A | 1 |
| Nagaki, M | 1 |
| Moriwaki, H | 1 |
| Saito, K | 1 |
| Seishima, M | 1 |
2 reviews available for kynurenine and Fibrosis
| Article | Year |
|---|---|
AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome:" a translational review and therapeutic perspectives.
Topics: Air Pollutants; Betacoronavirus; Calcitriol; Coronavirus Infections; COVID-19; COVID-19 Drug Treatme | 2020 |
Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis.
Topics: Cell Differentiation; Fibroblasts; Fibrosis; Humans; Kynurenine; Receptors, Aryl Hydrocarbon; Seroto | 2018 |
4 other studies available for kynurenine and Fibrosis
| Article | Year |
|---|---|
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
Topics: Adolescent; Adult; Aged; Chemokine CXCL9; Female; Fibrosis; Gene Expression Regulation; Graft vs Hos | 2021 |
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa.
Topics: Chromatography, Liquid; Epidermolysis Bullosa Dystrophica; Fibrosis; Glutamates; Glutamine; Humans; | 2022 |
Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts.
Topics: Curcumin; Fibroblasts; Fibrosis; Humans; Kynurenine; Receptors, Aryl Hydrocarbon; Transforming Growt | 2022 |
L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin.
Topics: Adenoviridae; Animal Feed; Animals; Aromatic-L-Amino-Acid Decarboxylases; Fatty Liver; Fibrosis; Fru | 2011 |