Page last updated: 2024-10-18

kynurenine and Fibrosis

kynurenine has been researched along with Fibrosis in 6 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

Research Excerpts

ExcerptRelevanceReference
" A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influence cGVHD severity and manifestation (fibrosing versus gastrointestinal [GI] cGVHD)."8.02Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease. ( Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T, 2021)
"Fibrosis is a pathological form of aberrant tissue repair, the complications of which account for nearly half of all deaths in the industrialized world."6.58Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis. ( Dolivo, DM; Dominko, T; Larson, SA, 2018)
"1 to 10 μM, ITE from 1 to 100 μM or curcumin from 5 to 20 μM had no significant effect on fibrosis markers in TGF-β1-induced CCD-18Co."4.12Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts. ( Amamou, A; Bôle-Feysot, C; Leboutte, M; Marion-Letellier, R; Savoye, G; Yaker, L, 2022)
" A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influence cGVHD severity and manifestation (fibrosing versus gastrointestinal [GI] cGVHD)."4.02Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease. ( Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T, 2021)
"Fibrosis is a pathological form of aberrant tissue repair, the complications of which account for nearly half of all deaths in the industrialized world."2.58Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis. ( Dolivo, DM; Dominko, T; Larson, SA, 2018)
"Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary blistering disorder characterized by skin fragility, chronic inflammation, malnutrition, and fibrosis."1.72Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa. ( Aala, WJ; Chen, YF; Chen, YL; Hou, PC; Hsu, CK; Lin, YC; Lu, HC; McGrath, JA; Onoufriadis, A, 2022)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's4 (66.67)2.80

Authors

AuthorsStudies
Orsatti, L1
Stiehl, T1
Dischinger, K1
Speziale, R1
Di Pasquale, P1
Monteagudo, E1
Müller-Tidow, C1
Radujkovic, A1
Dreger, P1
Luft, T1
Chen, YF1
Lu, HC1
Hou, PC1
Lin, YC1
Aala, WJ1
Onoufriadis, A1
McGrath, JA1
Chen, YL1
Hsu, CK1
Amamou, A1
Yaker, L1
Leboutte, M1
Bôle-Feysot, C1
Savoye, G1
Marion-Letellier, R1
Turski, WA1
Wnorowski, A1
Turski, GN1
Turski, CA1
Turski, L1
Dolivo, DM1
Larson, SA1
Dominko, T1
Osawa, Y1
Kanamori, H1
Seki, E1
Hoshi, M1
Ohtaki, H1
Yasuda, Y1
Ito, H1
Suetsugu, A1
Nagaki, M1
Moriwaki, H1
Saito, K1
Seishima, M1

Reviews

2 reviews available for kynurenine and Fibrosis

ArticleYear
AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome:" a translational review and therapeutic perspectives.
    Restorative neurology and neuroscience, 2020, Volume: 38, Issue:4

    Topics: Air Pollutants; Betacoronavirus; Calcitriol; Coronavirus Infections; COVID-19; COVID-19 Drug Treatme

2020
Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis.
    Cellular and molecular life sciences : CMLS, 2018, Volume: 75, Issue:20

    Topics: Cell Differentiation; Fibroblasts; Fibrosis; Humans; Kynurenine; Receptors, Aryl Hydrocarbon; Seroto

2018

Other Studies

4 other studies available for kynurenine and Fibrosis

ArticleYear
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
    Cell reports. Medicine, 2021, 10-19, Volume: 2, Issue:10

    Topics: Adolescent; Adult; Aged; Chemokine CXCL9; Female; Fibrosis; Gene Expression Regulation; Graft vs Hos

2021
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa.
    Journal of dermatological science, 2022, Volume: 107, Issue:2

    Topics: Chromatography, Liquid; Epidermolysis Bullosa Dystrophica; Fibrosis; Glutamates; Glutamine; Humans;

2022
Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts.
    Nutrients, 2022, Aug-09, Volume: 14, Issue:16

    Topics: Curcumin; Fibroblasts; Fibrosis; Humans; Kynurenine; Receptors, Aryl Hydrocarbon; Transforming Growt

2022
L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin.
    The Journal of biological chemistry, 2011, Oct-07, Volume: 286, Issue:40

    Topics: Adenoviridae; Animal Feed; Animals; Aromatic-L-Amino-Acid Decarboxylases; Fatty Liver; Fibrosis; Fru

2011