gentamicin has been researched along with Fibrosis in 11 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical application of gentamicin has been limited by its nephrotoxicity, which is characterized by kidney injury, interstitial fibrosis and progressive renal impairment." | 3.79 | Plasmid pUDK-HGF encoding human hepatocyte growth factor gene attenuates gentamicin-induced kidney injury in rats. ( Chen, X; Chen, Z; Han, Y; Hu, C; Liu, X; Lu, Y; Wang, H; Wu, Z; Xiong, X; Zhang, Q, 2013) |
| " We investigated whether paricalcitol ameliorates tubular dysfunction and fibrosis in gentamicin (GM)-induced renal injury." | 3.76 | Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats. ( Bae, EH; Choi, C; Kim, IJ; Kim, SW; Lee, J; Ma, SK; Park, JW, 2010) |
| "To investigate the mechanism of fibrosis in peritoneal dialysis, we observed the effects of the hyperosmotic glucose and antibiotics such as gentamicin and cefazolin on rat peritoneal mesothelial cells with cell culture, fibrin-plate lyzing and Northern blotting analysis method." | 3.69 | [Hyperosmotic glucose and antibiotics induce production of plasminogen activator inhibitor and expression of TGF beta mRNA by rat peritoneal mesothelial cells]. ( Chen, X; Dong, K; Fu, B, 1997) |
| "Aliskiren treatment attenuated the decreased creatinine clearance, increased fractional sodium excretion, glomerulosclerosis and tubulointerstitial fibrosis and counteracted the increased ED-1 expression in gentamicin-treated rats." | 1.40 | Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats. ( Bae, EH; Choi, JS; Joo, SY; Kim, CS; Kim, EY; Kim, IJ; Kim, SW; Lee, J; Ma, SK, 2014) |
| "Gentamicin-treated rats presented a transitory increase in plasma creatinine levels." | 1.33 | Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. ( Balbi, AP; Coimbra, TM; Costa, RS; Volpini, RA, 2006) |
| "In 2 patients with severe Meniere's disease (MD), there was histologic evidence of occlusion of the vein of the vestibular aqueduct (VVA)." | 1.31 | Vascular occlusion in the endolymphatic sac in Meniere's disease. ( Friberg, U; Rask-Andersen, H, 2002) |
| " Muscle irritation experiment was carried out with a single dosage of 100 mg HAPA-B, 100 mg amikacin (AMK), saline, 0." | 1.27 | [Local irritation study with isepamicin]. ( Kobayashi, Y; Kohira, T; Yamamoto, H; Yano, J, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Beshay, ON | 1 |
| Ewees, MG | 1 |
| Abdel-Bakky, MS | 1 |
| Hafez, SMNA | 1 |
| Abdelrehim, AB | 1 |
| Bayoumi, AMA | 1 |
| Keser, N | 1 |
| Is, M | 1 |
| Ceman, D | 1 |
| Somay, A | 1 |
| Bae, EH | 2 |
| Kim, IJ | 2 |
| Joo, SY | 1 |
| Kim, EY | 1 |
| Choi, JS | 1 |
| Kim, CS | 1 |
| Ma, SK | 2 |
| Lee, J | 2 |
| Kim, SW | 2 |
| Cianciolo Cosentino, C | 1 |
| Skrypnyk, NI | 1 |
| Brilli, LL | 1 |
| Chiba, T | 1 |
| Novitskaya, T | 1 |
| Woods, C | 1 |
| West, J | 1 |
| Korotchenko, VN | 1 |
| McDermott, L | 1 |
| Day, BW | 1 |
| Davidson, AJ | 1 |
| Harris, RC | 1 |
| de Caestecker, MP | 1 |
| Hukriede, NA | 1 |
| Park, JW | 1 |
| Choi, C | 1 |
| Chen, X | 2 |
| Chen, Z | 1 |
| Wang, H | 1 |
| Xiong, X | 1 |
| Liu, X | 1 |
| Hu, C | 1 |
| Han, Y | 1 |
| Lu, Y | 1 |
| Wu, Z | 1 |
| Zhang, Q | 1 |
| Volpini, RA | 1 |
| Balbi, AP | 1 |
| Costa, RS | 1 |
| Coimbra, TM | 1 |
| Dong, K | 1 |
| Fu, B | 1 |
| Friberg, U | 1 |
| Rask-Andersen, H | 1 |
| Russell, RC | 1 |
| Graham, DR | 1 |
| Feller, AM | 1 |
| Zook, EG | 1 |
| Mathur, A | 1 |
| Kohira, T | 1 |
| Yano, J | 1 |
| Kobayashi, Y | 1 |
| Yamamoto, H | 1 |
11 other studies available for gentamicin and Fibrosis
| Article | Year |
|---|---|
Resveratrol reduces gentamicin-induced EMT in the kidney via inhibition of reactive oxygen species and involving TGF-β/Smad pathway.
Topics: Animals; Biomarkers; Epithelial-Mesenchymal Transition; Fibrosis; Gentamicins; Kidney; Male; Mice; O | 2020 |
Locally Used Antibiotics for Spinal Infection Prophylaxis and Their Effects on Epidural Fibrosis: an Experimental Laminectomy Study in Rats Using Rifamycin and Gentamycin.
Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Epidural Space; Fibroblasts; Fibrosis; Genta | 2019 |
Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats.
Topics: Amides; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Adhesion Molecules; Cytokines; Extracel | 2014 |
Histone deacetylase inhibitor enhances recovery after AKI.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Fibrosis; Gentamicins; Histone Deacetylase 1; | 2013 |
Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats.
Topics: Animals; Aquaporin 1; Bone Density Conservation Agents; Carrier Proteins; Cell Adhesion Molecules; C | 2010 |
Plasmid pUDK-HGF encoding human hepatocyte growth factor gene attenuates gentamicin-induced kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Apoptosis; Fibrosis; Gene Transfer Techniques; | 2013 |
Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Creatinine; Female; Fibrosis; Gentamicins; Immuno | 2006 |
[Hyperosmotic glucose and antibiotics induce production of plasminogen activator inhibitor and expression of TGF beta mRNA by rat peritoneal mesothelial cells].
Topics: Animals; Cefazolin; Cells, Cultured; Epithelium; Fibrosis; Gentamicins; Glucose; Male; Peritoneal Di | 1997 |
Vascular occlusion in the endolymphatic sac in Meniere's disease.
Topics: Adult; Aged; Anti-Bacterial Agents; Audiometry; Biopsy; Calcinosis; Case-Control Studies; Combined M | 2002 |
Experimental evaluation of the antibiotic carrying capacity of a muscle flap into a fibrotic cavity.
Topics: Animals; Anti-Bacterial Agents; Enterobacteriaceae Infections; Fibrosis; Gentamicins; Humans; Male; | 1988 |
[Local irritation study with isepamicin].
Topics: Animals; Atrophy; Blood Vessels; Edema; Fibrosis; Gentamicins; Hemorrhage; Injections, Intramuscular | 1986 |