Page last updated: 2024-12-07

statine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

statine: amine component of pepstatin; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID123915
SCHEMBL ID8594
MeSH IDM0060721

Synonyms (21)

Synonym
heptanoic acid, 4-amino-3-hydroxy-6-methyl-, (3s,4s)-
inchi=1/c8h17no3/c1-5(2)3-6(9)7(10)4-8(11)12/h5-7,10h,3-4,9h2,1-2h3,(h,11,12)/t6-,7-/m0/s
(3s,4s)-4-amino-3-hydroxy-6-methylheptanoic acid
statine
49642-07-1
unii-ytc77xr1ek
ytc77xr1ek ,
DFVFTMTWCUHJBL-BQBZGAKWSA-N
SCHEMBL8594
(3s,4s)-statine
statine [mi]
statine, (-)-
HY-101877
CS-7998
(3s,4s)-(-)-statine
AKOS028114708
mfcd00037277
(3s,4s)-4-amino-3-hydroxy-6-methylheptanoic acid hydrochloride
Q7604197
DTXSID00964315
(3s,4s)-4-amino-3-hydroxy-6-methyl-heptanoic acid

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
" Consistent with recent clinical trial data, MP demonstrated an excellent safety profile but produced no significant effects on major lipoproteins when used as monotherapy or when given with concomitant statin therapy."( Modified-policosanol does not reduce plasma lipoproteins in hyperlipidemic patients when used alone or in combination with statin therapy.
Backes, JM; Gibson, CA; Moriarty, PM; Ruisinger, JF, 2011
)
0.37

Bioavailability

ExcerptReferenceRelevance
" Progress has also been slow in efforts to understand the principles required in the synthesis of potent renin inhibitors with significant bioavailability after oral administration."( Why renin inhibitors?
Haber, E, 1989
)
0.28
" Benzimidazole containing compounds like VII were not orally bioavailable to a significant extent, neither in mice nor in rats."( HIV proteinase inhibitors containing 2-aminobenzylstatine as a novel scissile bond replacement: biochemical and pharmacological characterization.
Billich, A; Charpiot, B; Fricker, G; Gstach, H; Lehr, P; Peichl, P; Rosenwirth, B; Scholz, D, 1994
)
0.54
"Policosanol is a poorly absorbed nutritional supplement used primarily for cholesterol management."( Modified-policosanol does not reduce plasma lipoproteins in hyperlipidemic patients when used alone or in combination with statin therapy.
Backes, JM; Gibson, CA; Moriarty, PM; Ruisinger, JF, 2011
)
0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (120)

TimeframeStudies, This Drug (%)All Drugs %
pre-199027 (22.50)18.7374
1990's24 (20.00)18.2507
2000's27 (22.50)29.6817
2010's41 (34.17)24.3611
2020's1 (0.83)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 144.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index144.21 (24.57)
Research Supply Index4.91 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index269.03 (26.88)
Search Engine Supply Index2.01 (0.95)

This Compound (144.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials6 (4.69%)5.53%
Reviews8 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other114 (89.06%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]