14-deoxy-11,12-didehydroandrographolide profile

## 14-deoxy-11,12-didehydroandrographolide: A Potential Therapeutic Agent

**14-deoxy-11,12-didehydroandrographolide** is a **natural product** derived from the **plant Andrographis paniculata**, commonly known as **King of Bitters**. It is a **diterpenoid lactone**, a class of organic compounds with a complex structure consisting of four isoprene units.

**Importance in Research:**

14-deoxy-11,12-didehydroandrographolide has attracted significant research interest due to its potential **therapeutic properties**. Studies have shown it to possess a wide range of biological activities, including:

* **Anti-inflammatory:** It inhibits the production of inflammatory mediators like TNF-α and IL-6.
* **Antiviral:** It demonstrates activity against various viruses, including dengue virus, influenza virus, and herpes simplex virus.
* **Antibacterial:** It shows potential against a range of bacterial strains, including Staphylococcus aureus and Escherichia coli.
* **Anticancer:** Research suggests it may have anticancer effects by inducing apoptosis in cancer cells and inhibiting tumor growth.
* **Immunomodulatory:** It can modulate immune responses, potentially enhancing the body's ability to fight infections.
* **Hepatoprotective:** It shows potential for protecting the liver from damage.

**Research Focus:**

The research on 14-deoxy-11,12-didehydroandrographolide is primarily focused on:

* **Understanding its mechanisms of action:** Researchers are working to understand the molecular pathways through which this compound exerts its therapeutic effects.
* **Developing new drugs:** Its promising biological activities have led to investigations into its potential as a drug candidate for various diseases.
* **Improving its bioavailability:** Efforts are ongoing to enhance the absorption and effectiveness of this compound in the body.

**Current Status:**

While promising, research on 14-deoxy-11,12-didehydroandrographolide is still in its early stages. Further studies are required to confirm its efficacy and safety in humans before it can be used as a therapeutic agent.

**Conclusion:**

14-deoxy-11,12-didehydroandrographolide is a naturally occurring compound with significant potential in various therapeutic applications. Continued research is crucial to unlock its full potential and pave the way for the development of new and effective treatments.

14-deoxy-11,12-didehydroandrographolide: a diterpenoid from Andrographis paniculata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Andrographis	genus	A plant genus of the family ACANTHACEAE. Members contain andrographolide and other DITERPENES and androechin, a CHALCONE.[MeSH]	Acanthaceae	A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH]

ID Source	ID
PubMed CID	44583846
SCHEMBL ID	20512981
MeSH ID	M0479971

Synonym
14-deoxy-11,12-didehydroandrographolide
SCHEMBL20512981

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (16.67)	29.6817
2010's	18 (75.00)	24.3611
2020's	2 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gentamicin Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	2.25	1
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.98	4	D-glucopyranose	epitope; mouse metabolite
zithromax Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.	2.25	1	macrolide antibiotic	antibacterial drug; environmental contaminant; xenobiotic
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.06	1
andrographolide [no description available]	4.08	14	carbobicyclic compound; gamma-lactone; labdane diterpenoid; primary alcohol; secondary alcohol	anti-HIV agent; anti-inflammatory drug; antineoplastic agent; metabolite
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.11	1	cysteinium	fundamental metabolite
neoandrographolide neoandrographolide: structure in first source; isolated from Andrographis paniculata	2.98	4
14-deoxyandrographolide 14-deoxyandrographolide: from Andrographis paniculata; structure in first source	2.46	2
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.05	1

Condition	Relationship Strength	Studies
Cholangiocellular Carcinoma [description not available]	2.15	1
Bile Duct Cancer [description not available]	2.15	1
Bile Duct Neoplasms Tumors or cancer of the BILE DUCTS.	2.15	1
Cholangiocarcinoma A malignant tumor arising from the epithelium of the BILE DUCTS.	7.15	1
Leucocythaemia [description not available]	2.1	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.1	1
HPV Infection [description not available]	2.11	1
Cancer of Cervix [description not available]	2.11	1
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	2.11	1
Papillomavirus Infections Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.	2.11	1
Breast Cancer [description not available]	2.5	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.5	2
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.13	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.77	3
Infections, Orthomyxoviridae [description not available]	2.13	1
Orthomyxoviridae Infections Virus diseases caused by the ORTHOMYXOVIRIDAE.	2.13	1
Anasarca [description not available]	2.05	1
Delayed Hypersensitivity [description not available]	2.05	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.05	1
Carbon Tetrachloride Poisoning Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.	2.05	1
Diabetic Glomerulosclerosis [description not available]	2.05	1
Cirrhosis [description not available]	2.05	1
Hyperglycemia, Postprandial Abnormally high BLOOD GLUCOSE level after a meal.	2.05	1
Diabetic Nephropathies KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.	2.05	1
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	7.05	1
Hyperglycemia Abnormally high BLOOD GLUCOSE level.	2.05	1
Asthma, Bronchial [description not available]	2.06	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	2.06	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.03	1

14-deoxy-11,12-didehydroandrographolide

Description

Cross-References

Synonyms (2)

Research

Studies (24)

Market Indicators

Research Demand Index: 24.99

Study Types