deferoxamine has been researched along with Fibrosis in 14 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The iron chelator, deferoxamine (DFO), has been shown to potentially improve dermal radiation-induced fibrosis (RIF) in mice through increased angiogenesis and reduced oxidative damage." | 8.02 | A comparative analysis of deferoxamine treatment modalities for dermal radiation-induced fibrosis. ( Abbas, DB; Chen, K; Diaz Deleon, NM; Fahy, EJ; Griffin, M; Gurtner, GC; Lavin, CV; Lee, DK; Longaker, MT; Mascharak, S; Momeni, A; Wan, DC, 2021) |
| "The iron chelator, deferoxamine (DFO), has been shown to potentially improve dermal radiation-induced fibrosis (RIF) in mice through increased angiogenesis and reduced oxidative damage." | 4.02 | A comparative analysis of deferoxamine treatment modalities for dermal radiation-induced fibrosis. ( Abbas, DB; Chen, K; Diaz Deleon, NM; Fahy, EJ; Griffin, M; Gurtner, GC; Lavin, CV; Lee, DK; Longaker, MT; Mascharak, S; Momeni, A; Wan, DC, 2021) |
| "Long-term administration of angiotensin II causes myocardial loss and cardiac fibrosis." | 3.73 | Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart. ( Aizawa, T; Ishizaka, N; Iso-o, N; Mori, I; Nagai, R; Noiri, E; Ohno, M; Saito, K; Sata, M, 2005) |
| "Pulmonary iron overload was induced in heterozygous β-globin knockout mice (muβth-3/+, BKO)." | 1.42 | Effects of Iron Chelators on Pulmonary Iron Overload and Oxidative Stress in β-Thalassemic Mice. ( Chaisri, U; Fucharoen, S; Hemstapat, W; Morales, NP; Srichairatanakool, S; Svasti, S; Wichaiyo, S; Yatmark, P, 2015) |
| "Iron overload is associated with long-term cardiac iron accumulation and tissue changes such as fibrosis." | 1.31 | Changes in gene expression with iron loading and chelation in cardiac myocytes and non-myocytic fibroblasts. ( Liu, Y; Parkes, JG; Sirna, JB; Templeton, DM, 2000) |
| "Idiopathic hemochromatosis is frequently associated with various malignancies including hepatic carcinoma." | 1.28 | [A case of idiopathic hemochromatosis associated with gastric cancer]. ( Akagi, K; Fujishima, M; Ishitsuka, T; Nomiyama, K; Okamura, T; Shibuya, T; Sugie, Y; Tsuji, H, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Lavin, CV | 1 |
| Abbas, DB | 1 |
| Fahy, EJ | 1 |
| Lee, DK | 1 |
| Griffin, M | 1 |
| Diaz Deleon, NM | 1 |
| Mascharak, S | 1 |
| Chen, K | 1 |
| Momeni, A | 1 |
| Gurtner, GC | 1 |
| Longaker, MT | 2 |
| Wan, DC | 2 |
| Cheon, YI | 1 |
| Kim, JM | 1 |
| Shin, SC | 1 |
| Kim, HS | 1 |
| Lee, JC | 1 |
| Park, GC | 1 |
| Sung, ES | 1 |
| Lee, M | 1 |
| Lee, BJ | 1 |
| Feng, Y | 1 |
| Jia, L | 1 |
| Ma, W | 1 |
| Tian, C | 1 |
| Du, H | 1 |
| Pepe, A | 1 |
| Meloni, A | 1 |
| Filosa, A | 1 |
| Pistoia, L | 1 |
| Borsellino, Z | 1 |
| D'Ascola, DG | 1 |
| Lisi, R | 1 |
| Putti, MC | 1 |
| Allò, M | 1 |
| Gamberini, MR | 1 |
| Quarta, A | 1 |
| Fidone, C | 1 |
| Casini, T | 1 |
| Restaino, G | 1 |
| Midiri, M | 1 |
| Mangione, M | 1 |
| Positano, V | 1 |
| Casale, M | 1 |
| Tevlin, R | 1 |
| Ikeda, Y | 1 |
| Ozono, I | 1 |
| Tajima, S | 1 |
| Imao, M | 1 |
| Horinouchi, Y | 1 |
| Izawa-Ishizawa, Y | 1 |
| Kihira, Y | 1 |
| Miyamoto, L | 1 |
| Ishizawa, K | 1 |
| Tsuchiya, K | 1 |
| Tamaki, T | 1 |
| Shvedova, AA | 1 |
| Kisin, ER | 1 |
| Murray, AR | 1 |
| Mouithys-Mickalad, A | 1 |
| Stadler, K | 1 |
| Mason, RP | 1 |
| Kadiiska, M | 1 |
| Yatmark, P | 1 |
| Morales, NP | 1 |
| Chaisri, U | 1 |
| Wichaiyo, S | 1 |
| Hemstapat, W | 1 |
| Srichairatanakool, S | 1 |
| Svasti, S | 1 |
| Fucharoen, S | 1 |
| Dai, J | 1 |
| Xie, C | 1 |
| Vincent, R | 1 |
| Churg, A | 1 |
| Saito, K | 1 |
| Ishizaka, N | 1 |
| Aizawa, T | 1 |
| Sata, M | 1 |
| Iso-o, N | 1 |
| Noiri, E | 1 |
| Mori, I | 1 |
| Ohno, M | 1 |
| Nagai, R | 1 |
| Teixeira, KC | 1 |
| Soares, FS | 1 |
| Rocha, LG | 1 |
| Silveira, PC | 1 |
| Silva, LA | 1 |
| Valença, SS | 1 |
| Dal Pizzol, F | 1 |
| Streck, EL | 1 |
| Pinho, RA | 1 |
| Panchenko, MV | 1 |
| Farber, HW | 1 |
| Korn, JH | 1 |
| Parkes, JG | 1 |
| Liu, Y | 1 |
| Sirna, JB | 1 |
| Templeton, DM | 1 |
| Sugie, Y | 1 |
| Tsuji, H | 1 |
| Nomiyama, K | 1 |
| Ishitsuka, T | 1 |
| Akagi, K | 1 |
| Fujishima, M | 1 |
| Shibuya, T | 1 |
| Okamura, T | 1 |
14 other studies available for deferoxamine and Fibrosis
| Article | Year |
|---|---|
A comparative analysis of deferoxamine treatment modalities for dermal radiation-induced fibrosis.
Topics: Animals; Biomarkers; Deferoxamine; Dermis; Disease Susceptibility; Female; Fibrosis; Mice; Microvess | 2021 |
Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats.
Topics: Animals; Deferoxamine; Female; Fibrosis; Iron; Rats; Rats, Sprague-Dawley; Salivary Glands; Transfor | 2023 |
Iron Chelator Deferoxamine Alleviates Progression of Diabetic Nephropathy by Relieving Inflammation and Fibrosis in Rats.
Topics: Animals; Deferoxamine; Diabetes Mellitus; Diabetic Nephropathies; Fibrosis; Inflammation; Iron; Iron | 2023 |
Prospective CMR Survey in Children With Thalassemia Major: Insights From a National Network.
Topics: Adolescent; Age Factors; beta-Thalassemia; Cardiomyopathies; Child; Deferiprone; Deferoxamine; Femal | 2020 |
Deferoxamine to Minimize Fibrosis During Radiation Therapy.
Topics: Administration, Cutaneous; Administration, Topical; Chelating Agents; Deferoxamine; Fibrosis; Humans | 2022 |
Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.
Topics: Animals; Blotting, Western; Chelation Therapy; Deferoxamine; Fibrosis; Immunohistochemistry; Iron Ch | 2014 |
ESR evidence for in vivo formation of free radicals in tissue of mice exposed to single-walled carbon nanotubes.
Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cytokines; Deferoxamine; Electron Spin Resonanc | 2014 |
Effects of Iron Chelators on Pulmonary Iron Overload and Oxidative Stress in β-Thalassemic Mice.
Topics: Animals; Antidotes; beta-Globins; beta-Thalassemia; Deferiprone; Deferoxamine; Dextrans; Female; Fib | 2015 |
Air pollution particles produce airway wall remodeling in rat tracheal explants.
Topics: Air Pollution; alpha-Fetoproteins; Animals; Cells, Cultured; Chelating Agents; Collagen; Deferoxamin | 2003 |
Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart.
Topics: Aldosterone; Angiotensin II; Animals; Chemokine CCL2; Deferoxamine; Enzyme Inhibitors; Ferritins; Fi | 2005 |
Attenuation of bleomycin-induced lung injury and oxidative stress by N-acetylcysteine plus deferoxamine.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Bleomycin; Catalase; Deferoxamine; Dru | 2008 |
Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts.
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Hypoxia; Cells, Cultured; Chelating Agents; Deferoxa | 2000 |
Changes in gene expression with iron loading and chelation in cardiac myocytes and non-myocytic fibroblasts.
Topics: Animals; Animals, Newborn; Cells, Cultured; Chelation Therapy; Collagen; Culture Media, Conditioned; | 2000 |
[A case of idiopathic hemochromatosis associated with gastric cancer].
Topics: Adenocarcinoma; Aged; Deferoxamine; Fibrosis; Hemochromatosis; Humans; Liver; Male; Stomach Neoplasm | 1992 |