Compounds > beta-aminoarteether maleate
Page last updated: 2024-08-03 23:40:38

beta-aminoarteether maleate

Description

beta-aminoarteether maleate: an immunosuppressive agent; structure in first source [MeSH]

beta-aminoarteether maleate : The maleate salt of beta-aminoarteether. Synthetic artemisinin derivative with potent immunosuppressive activity. [CHeBI]

Cross-References

ID SourceID
PubMed CID86289593
CHEBI ID78570
MeSH IDM0547441

Synonyms (9)

Synonym
sm934
CHEBI:78570
10-(beta-aminoethoxy)dihydroartemisinin maleate
beta-aminoarteether maleate
2-[[(3r,5as,6r,8as,9r,10s,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]ethanamine ethanedioate (1:1)
beta-2'-aminoarteether maleate
2-{[(1r,4s,5r,8s,9r,10s,12r,13r)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0(4,13).0(8,13)]hexadec-10-yl]oxy}ethanamine ethanedioate (1:1)
2-(10beta-dihydroartemisinoxy)ethylamine maleate
Q27147854

Roles (1)

RoleDescription
allergenA chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.

Drug Classes (1)

ClassDescription
maleate saltSalts from maleic acid.

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's9 (69.23)24.3611
2020's3 (23.08)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (15.38%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (84.62%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
prochlorperazine maleate
0
maleate salt00low000000
clothiapine
0
maleate salt00low000000
timolol maleate
0
maleate saltanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist		00low000000
brompheniramine maleate
0
maleate saltanti-allergic agent00low000000
trimipramine maleate
0
maleate saltantidepressant00low000000
carbinoxamine maleate
0
maleate saltanti-allergic agent;
antiparkinson drug;
H1-receptor antagonist;
muscarinic antagonist		00low000000
enalapril maleate
0
maleate saltantihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
prodrug		00low000000
dizocilpine maleate
0
maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist		00low000000
paroxetine maleate
0
maleate saltantidepressant;
anxiolytic drug;
hepatotoxic agent;
P450 inhibitor;
serotonin uptake inhibitor		00low000000
ergonovine maleate
0
maleate saltdiagnostic agent;
oxytocic		00low000000
trifluoperazine dimaleate
0
maleate salt00low000000
cgs 12066b
0
maleate saltprodrug;
serotonergic agonist		00low000000
tegaserod maleate
0
maleate saltserotonergic agonist00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
dinitrochlorobenzene
0
C-nitro compound;
monochlorobenzenes		allergen;
epitope;
sensitiser		00low000000
choline
0
cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite		00low000000
4-aminophenol
0
aminophenolallergen;
metabolite		00low000000
formaldehyde
0
aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite		00low000000
4-aminobenzoic acid
0
aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite		00low000000
phenylacetic acid
0
benzenes;
monocarboxylic acid;
phenylacetic acids		allergen;
Aspergillus metabolite;
auxin;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
Escherichia coli metabolite;
human metabolite;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite;
toxin		00low000000
phosphorylcholine
0
phosphocholinesallergen;
epitope;
hapten;
human metabolite;
mouse metabolite		00low000000
propylene glycol
0
glycol;
propane-1,2-diols		allergen;
human xenobiotic metabolite;
mouse metabolite;
protic solvent		00low000000
uracil
0
pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite		00low000000
2,4-dinitrophenol
0
dinitrophenolallergen;
antiseptic drug;
bacterial xenobiotic metabolite;
geroprotector;
oxidative phosphorylation inhibitor		00low000000
benzocaine
0
benzoate ester;
substituted aniline		allergen;
antipruritic drug;
sensitiser;
topical anaesthetic		00low000000
carbamazepine epoxide
0
dibenzoazepine;
epoxide;
ureas		allergen;
drug metabolite;
marine xenobiotic metabolite		00low000000
n-methyl-4-aminophenol
0
phenolsallergen00low000000
barbituric acid
0
barbituratesallergen;
xenobiotic		00low000000
mannitol
0
mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent		00low000000
dinitrofluorobenzene
0
C-nitro compound;
organofluorine compound		agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent		00low000000
ethylene oxide
0
gas molecular entity;
oxacycle;
saturated organic heteromonocyclic parent		allergen;
mouse metabolite;
mutagen		00low000000
methylmethacrylate
0
enoate ester;
methyl ester		allergen;
polymerisation monomer		00low000000
phthalic anhydride
0
2-benzofurans;
cyclic dicarboxylic anhydride		allergen00low000000
picryl chloride
0
C-nitro compound;
monochlorobenzenes		allergen;
epitope;
explosive;
hapten		00low000000
2,6-diisocyanatotoluene
0
toluene meta-diisocyanateallergen;
hapten		00low000000
6-methylcoumarin
0
coumarinsallergen;
fragrance		00low000000
veratric acid
0
benzoic acidsallergen;
plant metabolite		00low000000
2,5-diaminotoluene
0
diamineallergen00low000000
ethylene dimethacrylate
0
enoate esterallergen;
cross-linking reagent;
polymerisation monomer		00low000000
butylphen
0
phenolsallergen00low000000
carvone
0
botanical anti-fungal agent;
carvones		allergen00low000000
benzylamine
0
aralkylamine;
primary amine		allergen;
EC 3.5.5.1 (nitrilase) inhibitor;
plant metabolite		00low000000
4-aminodiphenylamine
0
aromatic amine;
secondary amino compound		allergen00low000000
4,4'-diphenylmethane diisocyanate
0
diisocyanateallergen;
hapten		00low000000
n-isopropyl-n-phenyl-4-phenylenediamine
0
N-substituted diamineallergen;
antioxidant		00low000000
4,4'-diaminodiphenylmethane
0
aromatic amineallergen;
carcinogenic agent		00low000000
diphenylguanidine
0
guanidinesallergen00low000000
monobenzone
0
benzyl etherallergen;
dermatologic drug;
melanin synthesis inhibitor		00low000000
phenyl isocyanate
0
benzenes;
isocyanates		allergen;
hapten		00low000000
phenylisothiocyanate
0
isothiocyanateallergen;
reagent		00low000000
4-phenylenediamine
0
phenylenediamineallergen;
dye;
hapten;
reagent		00low000000
glyoxal
0
dialdehydeagrochemical;
allergen;
pesticide;
plant growth regulator		00low000000
hydroxycitronellal
0
tertiary alcoholallergen;
fragrance		00low000000
maleic anhydride
0
cyclic dicarboxylic anhydride;
furans		allergen00low000000
butyl isocyanate
0
isocyanatesallergen00low000000
tetrachlorophthalic anhydride
0
cyclic dicarboxylic anhydride;
tetrachlorobenzene		allergen;
cross-linking reagent		00low000000
framycetin
0
aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite		00low000000
dimethoxyphenylethylamine
0
alkaloid;
aromatic ether;
phenylethylamine		allergen;
plant metabolite		00low000000
dibenzothiazyl disulfide
0
benzothiazoles;
organic disulfide		allergen00low000000
4-sulfanilic acid
0
aminobenzenesulfonic acidallergen;
environmental contaminant;
xenobiotic metabolite;
xenobiotic		00low000000
resorcinol monobenzoate
0
benzoate esterallergen00low000000
ethyl isothiocyanate
0
isothiocyanateallergen00low000000
aminopenicillanic acid
0
amino acid zwitterion;
penicillanic acids		allergen00low000000
trimellitic anhydride
0
2-benzofurans;
cyclic dicarboxylic anhydride;
dioxo monocarboxylic acid		allergen;
epitope;
hapten		00low000000
anthrarobin
0
anthracenetriolallergen00low000000
toluene 2,4-diisocyanate
0
toluene meta-diisocyanateallergen;
hapten		00low000000
methyl isocyanate
0
isocyanatesallergen;
apoptosis inducer		00low000000
disperse orange 3
0
azobenzenes;
primary arylamine		allergen;
dye		00low000000
1,6-hexamethylene diisocyanate
0
diisocyanateallergen;
hapten		00low000000
hydroxyethyl methacrylate
0
enoate esterallergen;
polymerisation monomer		00low000000
cyclohexylisocyanate
0
isocyanatesallergen00low000000
phenoxyacetic acid
0
aromatic ether;
monocarboxylic acid		allergen;
Aspergillus metabolite;
human xenobiotic metabolite;
plant growth retardant		00low000000
methylene bis(4-cyclohexylisocyanate)
0
diisocyanateallergen00low000000
potassium dichromate
0
potassium saltallergen;
oxidising agent;
sensitiser		00low000000
nickel sulfate
0
metal sulfateallergen00low000000
beryllium sulfate
0
metal sulfateallergen00low000000
triforine
0
amide fungicide;
formamides;
N-alkylpiperazine;
organochlorine compound		allergen;
antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor		00low000000
lamivudine
0
monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug		00low000000
1,2-dibromo-2,4-dicyanobutane
0
aliphatic nitrile;
organobromine compound		allergen;
sensitiser		00low000000
squaric acid dibutyl ester
0
cyclic ketone;
diether		allergen;
immunological adjuvant		00low000000
4-nitrobenzyl bromide
0
benzyl bromides;
C-nitro compound		allergen;
sensitiser		00low000000
n-phenylglycine
0
non-proteinogenic alpha-amino acidallergen00low000000
3-pentadecacatechol
0
catecholsallergen00low000000
4-tolyl isocyanate
0
isocyanates;
toluenes		allergen;
hapten		00low000000
bis(diphenylphosphine)ethane
0
diphosphanes;
tertiary phosphine		allergen00low000000
primin
0
1,4-benzoquinonesallergen;
antifeedant;
antimicrobial agent;
hapten;
metabolite		00low000000
disperse blue 124
0
1,3-thiazoles;
monoazo compound;
tertiary amine		allergen;
dye;
hapten		00low000000
fluazinam
0
(trifluoromethyl)benzenes;
aminopyridine;
C-nitro compound;
chloropyridine;
monochlorobenzenes;
secondary amino compound		allergen;
antifungal agrochemical;
apoptosis inducer;
environmental contaminant;
xenobiotic		00low000000
dehydroabietic acid
0
abietane diterpenoid;
carbotricyclic compound;
monocarboxylic acid		allergen;
metabolite		00low000000
sulfamethoxazole hydroxylamine
0
isoxazoles;
sulfonamide		allergen;
metabolite		00low000000
4'-hydroxydiclofenac
0
dichlorobenzene;
monocarboxylic acid;
phenols;
secondary amino compound		allergen;
drug metabolite		00low000000
4-nitrososulfamethoxazole
0
isoxazoles;
nitroso compound;
sulfonamide		allergen;
metabolite		00low000000
geraniol
0
3,7-dimethylocta-2,6-dien-1-ol;
monoterpenoid;
primary alcohol		allergen;
fragrance;
plant metabolite;
volatile oil component		00low000000
diphenylthiourea
0
thioureasallergen00low000000
pyrimidine-2-thiol
0
aryl thiol;
pyrimidines		allergen;
corrosion inhibitor		00low000000
1,3-dibutyl-2-thiourea
0
thioureasallergen00low000000
thiobarbituric acid
0
barbituratesallergen;
reagent		00low000000
2-thiopyridine
0
aryl thiol;
pyridines		allergen;
fluorescence quencher		00low000000
krn 7000
0
glycophytoceramide;
N-acyl-beta-D-galactosylphytosphingosine		allergen;
antigen;
antineoplastic agent;
epitope;
immunological adjuvant		00low000000
cobaltous chloride
0
cobalt salt;
inorganic chloride		allergen;
calcium channel blocker;
sensitiser;
two-colour indicator		00low000000
glyceryl monothioglycolate
0
thioglycolate esterallergen00low000000
5-hydroxydiclofenac
0
dichlorobenzene;
monocarboxylic acid;
phenols;
secondary amino compound		allergen;
drug metabolite		00low000000
chloramine-t
0
organic sodium saltallergen;
antifouling biocide;
disinfectant		00low000000
tylosin
0
aldehyde;
disaccharide derivative;
enone;
leucomycin;
macrolide antibiotic;
monosaccharide derivative		allergen;
bacterial metabolite;
environmental contaminant;
xenobiotic		00low000000
1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-butenone
0
enoneallergen;
fragrance		00low000000
tixocortol pivalate
0
corticosteroid;
pivalate ester;
tertiary alpha-hydroxy ketone;
thioester		allergen;
anti-allergic agent;
glucocorticoid receptor agonist		00low000000
6-tuliposide a
0
6-O-acyl-D-glucose;
homoallylic alcohol		allergen;
metabolite		00low000000
sodium bisulfite
0
inorganic sodium salt;
sulfite salt		allergen;
food antioxidant;
food colour retention agent;
mutagen;
reducing agent		00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
artemisinin
5
organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite		201520226.6high000041
artesunic acid
1
201820186.0medium000010
ovalbumin
1
2009200915.0medium000100
scopolamine hydrobromide
1
202120213.0medium000001
myelin oligodendrocyte glycoprotein (35-55)
1
2013201311.0medium000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Adenopathy0
1
201620168.0low000010
Adjuvant Arthritis0
1
201620168.0low000010
Allergic Encephalomyelitis0
1
2013201311.0low000010
Anti-Phospholipid Antibody Syndrome0
1
202120213.0low000001
Antiphospholipid Syndrome0
1
202120213.0low000001
Arthritis, Rheumatoid0
1
201620168.0low000010
Autoimmune Disease0
1
202220222.0low000001
Autoimmune Diseases0
1
202220222.0low000001
Breast Cancer0
1
201920195.0low000010
Breast Neoplasms0
1
201920195.0low000010
Bright Disease0
1
2012201212.0low000010
Cirrhosis0
1
201520159.0low000010
Colitis Gravis0
1
201820186.0low000010
Colitis, Ulcerative0
1
201820186.0low000010
Disease Exacerbation0
1
201620168.0low000010
Disease Models, Animal0
5
201120226.4medium000032
Dry Eye0
1
202120213.0low000001
Dry Eye Syndromes0
1
202120213.0low000001
Enlarged Spleen0
1
201620168.0low000010
Extramembranous Glomerulopathy0
1
201520159.0low000010
Fibrosis0
1
201520159.0low000010
Glomerulonephritis0
1
2012201212.0low000010
Glomerulonephritis, Lupus0
2
201620215.5low000011
Glomerulonephritis, Membranous0
1
201520159.0low000010
Inflammation0
2
202120213.0low000002
Innate Inflammatory Response0
2
202120213.0low000002
Kidney Diseases0
1
201520159.0low000010
Libman-Sacks Disease0
4
201120218.5low000031
Lupus Erythematosus, Systemic0
4
201120218.5low000031
Lupus Nephritis0
2
201620215.5low000011
Metastase0
1
201920195.0low000010
Neoplasm Metastasis0
1
201920195.0low000010
Proteinuria0
1
201520159.0low000010
Rheumatoid Arthritis0
1
201620168.0low000010

Bioavailability (1)

ArticleYear
Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms.
Acta pharmacologica Sinica, , Volume: 43, Issue:12		2022

Dosage (2)

ArticleYear
Artemisinins-a Promising New Treatment for Systemic Lupus Erythematosus: a Descriptive Review.
Current rheumatology reports, , 07-28, Volume: 20, Issue:9		2018
Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation.
Cellular & molecular immunology, , Volume: 13, Issue:3		2016