C-C chemokine receptor type 7

A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248]

Synonyms

C-C CKR-7;
CC-CKR-7;
CCR-7;
BLR2;
CDw197;
Epstein-Barr virus-induced G-protein coupled receptor 1;
EBI1;
EBV-induced G-protein coupled receptor 1;
MIP-3 beta receptor

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tak 779	Homo sapiens (human)	IC50	0.0014	1	1
cenicriviroc	Homo sapiens (human)	IC50	0.0031	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
C-C chemokine receptor activity	molecular function	Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:signaling, PMID:8662823]
chemokine (C-C motif) ligand 19 binding	molecular function	Binding to chemokine (C-C motif) ligand 19. [GOC:BHF]
chemokine (C-C motif) ligand 21 binding	molecular function	Binding to chemokine (C-C motif) ligand 21. [GOC:BHF]
C-C motif chemokine 19 receptor activity	molecular function	Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, PMID:15059845]
C-C motif chemokine 21 receptor activity	molecular function	Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, PMID:15059845]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

Involved In

This protein is involved in 46 target(s):

Target	Category	Definition
establishment of T cell polarity	biological process	The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. [GOC:mgi_curators, PMID:11244041, PMID:12615889]
positive regulation of cell-matrix adhesion	biological process	Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. [GOC:hjd]
dendritic cell chemotaxis	biological process	The movement of a dendritic cell in response to an external stimulus. [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
myeloid dendritic cell chemotaxis	biological process	The movement of a myeloid dendritic cell in response to an external stimulus. [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
positive regulation of dendritic cell antigen processing and presentation	biological process	Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. [GOC:add]
positive regulation of hypersensitivity	biological process	Any process that activates or increases the frequency, rate, or extent of hypersensitivity. [GOC:add]
positive regulation of humoral immune response	biological process	Any process that activates or increases the frequency, rate, or extent of a humoral immune response. [GOC:add]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
positive regulation of actin filament polymerization	biological process	Any process that activates or increases the frequency, rate or extent of actin polymerization. [GOC:mah]
positive regulation of pseudopodium assembly	biological process	Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. [GOC:pg]
ruffle organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. [GOC:mah, PMID:10036235]
response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
regulation of type II interferon production	biological process	Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
regulation of interleukin-1 beta production	biological process	Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah]
positive regulation of interleukin-12 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. [GOC:mah]
response to prostaglandin E	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. [GOC:BHF, GOC:vk]
chemokine (C-C motif) ligand 19 signaling pathway	biological process	The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:15059845]
chemokine (C-C motif) ligand 21 signaling pathway	biological process	The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:nhn, GOC:signaling, PMID:15059845]
positive regulation of canonical NF-kappaB signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
negative thymic T cell selection	biological process	The process of elimination of immature T cells in the thymus which react strongly with self-antigens. [ISBN:0781735149, PMID:12414722]
positive regulation of cell adhesion	biological process	Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators]
positive regulation of protein kinase activity	biological process	Any process that activates or increases the frequency, rate or extent of protein kinase activity. [GOC:go_curators]
positive regulation of JNK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
homeostasis of number of cells	biological process	Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. [GOC:isa_complete]
positive regulation of T cell receptor signaling pathway	biological process	Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai]
release of sequestered calcium ion into cytosol	biological process	The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]
positive regulation of filopodium assembly	biological process	Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. [GOC:ai, GOC:dph, GOC:tb]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
cellular response to cytokine stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:mah]
response to nitric oxide	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. [GOC:mah, GOC:yaf]
positive regulation of neutrophil chemotaxis	biological process	Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:dph, GOC:tb]
lymphocyte migration into lymph node	biological process	The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. [GOC:BHF, GOC:pr, PMID:18379575]
mature conventional dendritic cell differentiation	biological process	The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells. [GOC:BHF, http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx, PMID:15845453]
positive regulation of cell motility	biological process	Any process that activates or increases the frequency, rate or extent of cell motility. [GOC:mah]
positive regulation of dendritic cell chemotaxis	biological process	Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis. [GOC:obol]
positive regulation of immunological synapse formation	biological process	Any process that activates or increases the frequency, rate or extent of immunological synapse formation. [GOC:obol]
positive regulation of T cell costimulation	biological process	Any process that activates or increases the frequency, rate or extent of T cell costimulation. [GOC:obol]
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	biological process	Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation. [GOC:obol]
regulation of dendritic cell dendrite assembly	biological process	Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly. [GOC:obol]
negative regulation of dendritic cell apoptotic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. [GOC:mtg_apoptosis, GOC:obol]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
calcium-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
cell chemotaxis	biological process	The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]