mitomycin has been researched along with Fibrosis in 116 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors conducted a study to evaluate the effects and the safety of locally applied mitomycin C (MMC) on epidural fibrosis after microendoscopic discectomy (MED)." | 9.17 | Inhibition of epidural fibrosis after microendoscopic discectomy with topical application of mitomycin C: a randomized, controlled, double-blind trial. ( Cao, X; Hong, X; Liu, L; Sui, T; Wu, X, 2013) |
| "In this prospective, randomized clinical study the authors sought to evaluate the effects of locally applied mitomycin C on peridural fibrosis during lumbar microdiscectomy." | 9.13 | Mitomycin protection of peridural fibrosis in lumbar disc surgery. ( Altan, T; Celik, S; Celik, SE; Göksu, K; Ince, I; Kapran, Z, 2008) |
| "To compare the clinical outcome of pterygium surgery combining intraoperative mitomycin C (MMC) with a free conjunctival autograft, with three other methods of pterygium surgery, including intraoperative MMC alone, conjunctival autograft alone, and bare sclera without adjunctive treatment." | 9.12 | Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. ( Frucht-Pery, J; Ilsar, M; Landau, D; Orucov, F; Raiskup, F; Solomon, A, 2006) |
| "This review details the current understanding of the mechanism of action and corneal effects of mitomycin C (MMC) for prophylactic prevention of stromal fibrosis after photorefractive keratectomy (PRK), and includes discussion of available information on dosage and exposure time recommended for MMC during PRK." | 9.05 | Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK. ( Carlos de Oliveira, R; Wilson, SE, 2020) |
| "To investigate the efficacy of nintedanib on preventing postoperative scar in formation following glaucoma filtering surgery (GFC) in rabbits in comparison with Mitomycin-C (MMC)." | 8.31 | The anti-scar effect of tyrosine-kinase inhibitor nintedanib in experimental glaucoma filtration surgery in rabbits. ( Demirci Küçük, K; Furat Rençber, S; Öztürk, A; Yazır, Y; Yüksel, N; Yüksel, R, 2023) |
| "The aim was to evaluate the effectiveness of bacterial cellulose membrane (BCM) in preventing fibrosis in trabeculectomy and the biocompatibility of BCM with conjunctiva and sclera." | 8.02 | Novel Bacterial Cellulose Membrane to Reduce Fibrosis Following Trabeculectomy. ( Akpolat, N; Koc, O; Tekin, IO; Yazgan, S, 2021) |
| " The purpose of this study was to investigate the effect of mitomycin C on reducing endometrial fibrosis for IUA." | 7.96 | The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion. ( Shen, X; Sun, C; Wang, W; Xu, F; Xu, X; Zheng, J, 2020) |
| "To find safer and more effective drugs than mitomycin C to prevent conjunctival fibrosis in a rabbit model." | 7.91 | Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis. ( Han, GS; Jung, HS; Kim, ES; Kim, JY; Suh, LH; Tchah, H; Yoon, SY, 2019) |
| "To investigate the antifibrotic effects of sakuraso-saponin on a primary culture of human pterygium fibroblasts (HPFs) and normal human Tenon fibroblasts (HTFs) as compared to the effects of mitomycin C (MMC)." | 7.91 | Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C. ( Jang, SW; Jeong, H; Kim, JY; Lee, CM; Lee, H; Lee, JH; Park, SY; Shin, JA; Tchah, H, 2019) |
| "We aimed to investigate the prophylactic effect simvastatin of and mitomycin C (MMC) on laryngeal and tracheal stenosis in tracheotomised rats by histopathological evaluation of laryngotracheal segment." | 7.88 | Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. ( Ekinci, A; Erdoğan, AS; Kesici, H; Koc, S, 2018) |
| "Mitomycin C (MMC) is known to reduce epidural fibrosis, but the underlying mechanisms have not yet been elucidated." | 7.81 | Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE. ( Cai, J; Cao, X; Fu, Y; Ge, Y; Lu, C; Shi, K; Sun, Y; Yan, L, 2015) |
| "The aim of this study was to evaluate the anterior corneal surface regularity and light scattering before and after Descemet membrane endothelial keratoplasty (DMEK) with epithelial debridement and application of mitomycin C in Fuchs dystrophy-affected eyes with preoperative subepithelial fibrosis or anterior basement membrane dystrophy." | 7.80 | Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy. ( Chaurasia, S; McKee, Y; Price, FW; Price, MO, 2014) |
| "Topically administration of Tacrolimus and Octreotide effectively reduced the subconjuntival scarring response 2 weeks after experimental glaucoma filtration surgery." | 7.78 | Modulation of postoperative scarring with tacrolimus and octreotide in experimental glaucoma filtration surgery. ( Arslan, S; Aydemir, O; Dağlı, AF; Güler, M, 2012) |
| "Temozolomide was found to be effective in preventing epidural fibrosis." | 7.78 | The effect of temozolomide on the prevention of epidural fibrosis developing after lumbar laminectomy in rats. ( Aydincak, O; Baykaner, K; Emmez, H; Kurt, G; Memis, L; Sepici, A; Yilmaz, MB, 2012) |
| "The authors conducted a study to determine the effectiveness of mitomycin C (MMC) in preventing epidural fibrosis in rats which underwent craniectomy." | 7.75 | The effect of mitomycin C as fibrosis preventive agent during craniectomies. ( Cemil, B; Cevirgen, B; Gurcay, AG; Kaptanoglu, E; Kaymaz, F; Tekdemir, I; Tun, K, 2009) |
| "This study examined the preventive effects of the local application of mitomycin C (MMC), 5-fluorouracil (5-FU), and cyclosporine A (CsA) in minimizing spinal epidural fibrosis in a rat laminectomy model." | 7.74 | Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model. ( Cukur, S; Dosoglu, M; Gezen, F; Is, M; Yildiz, KH, 2007) |
| "The authors conducted a study to determine the effectiveness of mitomycin C in preventing postlaminectomy peridural fibrosis in rabbits." | 7.72 | Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits. ( Baykaner, K; Ceviker, N; Dogulu, F; Emmez, H; Erdem, O; Kurt, G; Memis, L, 2003) |
| "Twenty-one eyes of 21 patients with refractory glaucoma underwent glaucoma surgery involving placement of a modified Molteno implant and intraoperative application of mitomycin C." | 7.69 | Mitomycin C as adjunctive therapy with glaucoma implant surgery. ( Nicolela, MT; Susanna, R; Takahashi, WY, 1994) |
| "The effects of mitomycin-C on intraocular pressure (IOP), facility of outflow (C), and Tenon's capsule fibrosis were studied over 60 days in 10 clinically normal dogs." | 7.69 | Effects of topically applied mitomycin-C on intraocular pressure, facility of outflow, and fibrosis after glaucoma filtration surgery in clinically normal dogs. ( Davidson, MG; Glover, TL; Nasisse, MP, 1995) |
| "Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis." | 6.72 | History, presence, and future of mitomycin C in glaucoma filtration surgery. ( Al Majidi, R; Beckers, HJM; Gorgels, TGMF; Pinchuk, L; van Mechelen, RJS; Webers, CAB; Wolters, JEJ, 2021) |
| "Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery." | 5.72 | Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022) |
| "Excessive fibrosis is the topmost factor for the defeat of surgical glaucoma drainage device (GDD) implantation." | 5.51 | Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis. ( Dong, A; Fan, P; Han, L; Shao, Z; Yuan, H; Zhou, X, 2019) |
| "There was intensive epineural scar formation in the control group." | 5.43 | Prevention of Epidural Fibrosis in Rats by Local Administration of Mitomycin C or Daunorubicin. ( Ilbay, G; Ilbay, K; Vural, E; Yilmaz, M, 2016) |
| "Epidural fibrosis was evaluated histologically." | 5.32 | Mitomycin C in preventing spinal epidural fibrosis in a laminectomy model in rats. ( Ebel, H; Ernestus, RI; Klug, N; Lee, JY; Stenzel, W; Wedekind, C, 2004) |
| "Mitomycin-C was administered to the injured urethra in the form of irrigation for 5 min." | 5.32 | Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture. ( Ayyildiz, A; Caydere, M; Erol, D; Germiyanoglu, C; Gülerkaya, B; Nuhoglu, B; Ustün, H, 2004) |
| "The authors conducted a study to evaluate the effects and the safety of locally applied mitomycin C (MMC) on epidural fibrosis after microendoscopic discectomy (MED)." | 5.17 | Inhibition of epidural fibrosis after microendoscopic discectomy with topical application of mitomycin C: a randomized, controlled, double-blind trial. ( Cao, X; Hong, X; Liu, L; Sui, T; Wu, X, 2013) |
| "Between July 2005 and October 2007, 61 consecutive medically uncontrolled glaucoma patients scheduled for first-time trabeculectomy were randomized to 1 of 3 study topical medication groups: nonsteroidal anti-inflammatory drugs (ketorolac), steroids (fluorometholone), or placebo (artificial tears)." | 5.14 | Preoperative nonsteroidal anti-inflammatory drug or steroid and outcomes after trabeculectomy: a randomized controlled trial. ( Breusegem, C; Fieuws, S; Renier, C; Spielberg, L; Stalmans, I; Van de Veire, S; Van Ginderdeuren, R; Vandewalle, E; Zeyen, T, 2010) |
| "In this prospective, randomized clinical study the authors sought to evaluate the effects of locally applied mitomycin C on peridural fibrosis during lumbar microdiscectomy." | 5.13 | Mitomycin protection of peridural fibrosis in lumbar disc surgery. ( Altan, T; Celik, S; Celik, SE; Göksu, K; Ince, I; Kapran, Z, 2008) |
| "To compare the clinical outcome of pterygium surgery combining intraoperative mitomycin C (MMC) with a free conjunctival autograft, with three other methods of pterygium surgery, including intraoperative MMC alone, conjunctival autograft alone, and bare sclera without adjunctive treatment." | 5.12 | Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. ( Frucht-Pery, J; Ilsar, M; Landau, D; Orucov, F; Raiskup, F; Solomon, A, 2006) |
| "This review details the current understanding of the mechanism of action and corneal effects of mitomycin C (MMC) for prophylactic prevention of stromal fibrosis after photorefractive keratectomy (PRK), and includes discussion of available information on dosage and exposure time recommended for MMC during PRK." | 5.05 | Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK. ( Carlos de Oliveira, R; Wilson, SE, 2020) |
| "With the increased use of intraoperative antifibrotic (eg, mitomycin and fluorouracil) as an adjunct to standard trabeculectomy, an increased incidence is seen of late-onset filtering bleb-related infections." | 4.82 | Glaucoma-filtering bleb infections. ( Mac, I; Soltau, JB, 2003) |
| "The use of antifibrotic agents, namely, 5-fluorouracil and mitomycin C, in conjunction with glaucoma surgery has resulted in lower postoperative intraocular pressures after trabeculectomy or combined cataract and glaucoma surgery." | 4.82 | Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery. ( Singh, K; Yoon, PS, 2004) |
| "To investigate the efficacy of nintedanib on preventing postoperative scar in formation following glaucoma filtering surgery (GFC) in rabbits in comparison with Mitomycin-C (MMC)." | 4.31 | The anti-scar effect of tyrosine-kinase inhibitor nintedanib in experimental glaucoma filtration surgery in rabbits. ( Demirci Küçük, K; Furat Rençber, S; Öztürk, A; Yazır, Y; Yüksel, N; Yüksel, R, 2023) |
| "The purpose of this study was to evaluate the effectiveness and safety of an open bleb revision with mitomycin- C (MMC) for bleb fibrosis after PreserFlo MicroShunt implantation." | 4.31 | Outcomes of Open Bleb Revision After PreserFlo MicroShunt Failure in Patients With Glaucoma. ( Hoffmann, EM; Pfeiffer, N; Schuster, AK; Strzalkowska, A; Strzalkowski, P, 2023) |
| "The aim was to evaluate the effectiveness of bacterial cellulose membrane (BCM) in preventing fibrosis in trabeculectomy and the biocompatibility of BCM with conjunctiva and sclera." | 4.02 | Novel Bacterial Cellulose Membrane to Reduce Fibrosis Following Trabeculectomy. ( Akpolat, N; Koc, O; Tekin, IO; Yazgan, S, 2021) |
| " The purpose of this study was to investigate the effect of mitomycin C on reducing endometrial fibrosis for IUA." | 3.96 | The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion. ( Shen, X; Sun, C; Wang, W; Xu, F; Xu, X; Zheng, J, 2020) |
| "To investigate the antifibrotic effects of sakuraso-saponin on a primary culture of human pterygium fibroblasts (HPFs) and normal human Tenon fibroblasts (HTFs) as compared to the effects of mitomycin C (MMC)." | 3.91 | Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C. ( Jang, SW; Jeong, H; Kim, JY; Lee, CM; Lee, H; Lee, JH; Park, SY; Shin, JA; Tchah, H, 2019) |
| "To find safer and more effective drugs than mitomycin C to prevent conjunctival fibrosis in a rabbit model." | 3.91 | Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis. ( Han, GS; Jung, HS; Kim, ES; Kim, JY; Suh, LH; Tchah, H; Yoon, SY, 2019) |
| "Rabbit model studies suggested better morphology blebs with equal intraocular pressure (IOP) efficacy as a standard mitomycin C (MMC) trabeculectomy using a novel slow-release drug delivery antifibrotic system delivering small quantities of MMC and 5-fluorouracil (5-FU)." | 3.91 | Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model. ( Ayyala, RS; Blake, D; Fullerton, M; Greenberg, E; John, V; Le, C; Mancera, N; Margo, C; Muddasani, N; Satija, C; Singh, S; Swann, FB; Wall, J; Zhang, Z; Zurakowski, D, 2019) |
| "We aimed to investigate the prophylactic effect simvastatin of and mitomycin C (MMC) on laryngeal and tracheal stenosis in tracheotomised rats by histopathological evaluation of laryngotracheal segment." | 3.88 | Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. ( Ekinci, A; Erdoğan, AS; Kesici, H; Koc, S, 2018) |
| "Mitomycin C and 5-fluorouracil have been used in GDD and trabeculectomy to prevent the exaggerated cellular reaction that leads to fibrosis." | 3.83 | A role for antimetabolites in glaucoma tube surgery: current evidence and future directions. ( Amoozgar, B; Han, Y; Kuo, J; Lin, SC, 2016) |
| "Mitomycin C (MMC) is known to reduce epidural fibrosis, but the underlying mechanisms have not yet been elucidated." | 3.81 | Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE. ( Cai, J; Cao, X; Fu, Y; Ge, Y; Lu, C; Shi, K; Sun, Y; Yan, L, 2015) |
| "2 mg/mL mitomycin C may provide initial and transient stimulation of collagen for necessary repair to damaged tissue without the long-term risk of fibrosis." | 3.80 | Dose-dependent effect of mitomycin C on human vocal fold fibroblasts. ( Chen, F; Dikkers, FG; Li, NY; Thibeault, SL, 2014) |
| "The aim of this study was to evaluate the anterior corneal surface regularity and light scattering before and after Descemet membrane endothelial keratoplasty (DMEK) with epithelial debridement and application of mitomycin C in Fuchs dystrophy-affected eyes with preoperative subepithelial fibrosis or anterior basement membrane dystrophy." | 3.80 | Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy. ( Chaurasia, S; McKee, Y; Price, FW; Price, MO, 2014) |
| "This study was undertaken to evaluate the efficacy of co-treatment with suberoylanilide hydroxamic acid (SAHA) and mitomycin-C (MMC) on corneal fibrosis in an in-vivo model." | 3.80 | The efficacy of co-treatment with suberoylanilide hydroxamic acid and mitomycin C on corneal scarring after therapeutic keratectomy: an animal study. ( Kim, SW; Park, WC; Woo, JE; Yoo, YH, 2014) |
| "Temozolomide was found to be effective in preventing epidural fibrosis." | 3.78 | The effect of temozolomide on the prevention of epidural fibrosis developing after lumbar laminectomy in rats. ( Aydincak, O; Baykaner, K; Emmez, H; Kurt, G; Memis, L; Sepici, A; Yilmaz, MB, 2012) |
| "Topically administration of Tacrolimus and Octreotide effectively reduced the subconjuntival scarring response 2 weeks after experimental glaucoma filtration surgery." | 3.78 | Modulation of postoperative scarring with tacrolimus and octreotide in experimental glaucoma filtration surgery. ( Arslan, S; Aydemir, O; Dağlı, AF; Güler, M, 2012) |
| "This study was conducted to evaluate cytotoxicity due to co-treatment with low-dose Mitomycin-C (MMC) and the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA) for glaucoma filtration surgery." | 3.76 | An experimental study of rabbit conjunctival epithelial toxicity using co-treatment with mitomycin-C and a histone deacetylase inhibitor. ( Ahn, HB; Jeung, WJ; Kim, TH; Oh, HC; Park, WC; Rho, JH; Rho, SH; Yoo, YH, 2010) |
| "The authors conducted a study to determine the effectiveness of mitomycin C (MMC) in preventing epidural fibrosis in rats which underwent craniectomy." | 3.75 | The effect of mitomycin C as fibrosis preventive agent during craniectomies. ( Cemil, B; Cevirgen, B; Gurcay, AG; Kaptanoglu, E; Kaymaz, F; Tekdemir, I; Tun, K, 2009) |
| "The protective effects of topical mitomycin-C (MMC) have been well documented for tracheal stenosis; however, to the best of our knowledge, the use of heparin as an anti-inflammatory agent to support wound healing in upper airway surgery was not studied before." | 3.75 | Topical heparin: a promising agent for the prevention of tracheal stenosis in airway surgery. ( Barutca, S; Derincegoz, OO; Derinceoz, OO; Meteoglu, I; Ogurlu, M; Sen, S, 2009) |
| "The aim of the study was to assess the outcomes of surgical revision with reopening of the scleral flap in eyes with failed glaucoma surgery and adjunctive mitomycin C (MMC)." | 3.74 | Surgical revision of failed filtration surgery with mitomycin C augmentation. ( Anand, N; Arora, S, 2007) |
| "To evaluate long-term outcomes after Ahmed valve implantation in patients with glaucoma when using adjunctive intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU)." | 3.74 | Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes. ( Alvarado, JA; Hollander, DA; Juster, RP; Lee, LC, 2008) |
| "This study examined the preventive effects of the local application of mitomycin C (MMC), 5-fluorouracil (5-FU), and cyclosporine A (CsA) in minimizing spinal epidural fibrosis in a rat laminectomy model." | 3.74 | Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model. ( Cukur, S; Dosoglu, M; Gezen, F; Is, M; Yildiz, KH, 2007) |
| "The role of topically applied mitomycin C in preventing postoperative perineural fibrosis was examined by gross anatomical dissection and histological analysis in rats." | 3.73 | Topical application of mitomycin C prevents epineural scar formation in rats. ( Ceylan, S; Etus, V; Ilbay, G; Ilbay, K; Yildiz, K, 2005) |
| "American Glaucoma Society (AGS) members continue to report preference for mitomycin C use in ten clinical settings." | 3.73 | 2002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use. ( Feuer, WF; Joshi, AB; Parrish, RK, 2005) |
| "To evaluate influence of mitomycin C on fibrosis in temporomandibular joints of rabbits with mandibular traction." | 3.73 | Mitomycin C effect on fibrous adhesions of rabbit temporomandibular joint. ( Aydin, E; Ozdemir, BH; Uckan, S; Uyar, P, 2005) |
| "To investigate whether cultured autologous fibroblasts injected into the subconjunctival space of rabbit may be used as a new treatment modality for conjunctival and subconjunctival atrophy caused by mitomycin C (MMC)." | 3.73 | Injection of cultured autologous fibroblasts into the subconjunctival space of rabbits treated with mitomycin C. ( Hwang, JM; Kee, C, 2006) |
| "Mitomycin C in appropriate dose minimizes postoperative fibrosis and granulations, thereby maintaining a bigger postoperative ostium throughout the postoperative observation period." | 3.73 | Effect of mitomycin C on ostium in dacryocystorhinostomy. ( Barua, CK; Bhattacharjee, H; Bhattacharjee, K; Bhuyan, SK; Deka, A; Khaund, G, 2006) |
| "The authors conducted a study to determine the effectiveness of mitomycin C in preventing postlaminectomy peridural fibrosis in rabbits." | 3.72 | Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits. ( Baykaner, K; Ceviker, N; Dogulu, F; Emmez, H; Erdem, O; Kurt, G; Memis, L, 2003) |
| "Mitomycin-C use may lead to lacrimal apparatus fibrosis and symptomatic epiphora when inciting a toxoallergic reaction." | 3.72 | Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia. ( Billing, K; Karagiannis, A; Selva, D, 2003) |
| "Topical mitomycin C delays the healing of surgical wounds in rats up to the fourth week following treatment, but the degree of fibrosis is comparable in both treated and untreated wounds after 12 weeks." | 3.72 | Clinical and histological healing of surgical wounds treated with mitomycin C. ( Borges, Jde P; Eckley, CA; Guaraldo, L; Ribeiro, Fde A; Zacchi, FF, 2004) |
| "The effects of mitomycin-C on intraocular pressure (IOP), facility of outflow (C), and Tenon's capsule fibrosis were studied over 60 days in 10 clinically normal dogs." | 3.69 | Effects of topically applied mitomycin-C on intraocular pressure, facility of outflow, and fibrosis after glaucoma filtration surgery in clinically normal dogs. ( Davidson, MG; Glover, TL; Nasisse, MP, 1995) |
| "Twenty-one eyes of 21 patients with refractory glaucoma underwent glaucoma surgery involving placement of a modified Molteno implant and intraoperative application of mitomycin C." | 3.69 | Mitomycin C as adjunctive therapy with glaucoma implant surgery. ( Nicolela, MT; Susanna, R; Takahashi, WY, 1994) |
| "Presentation of one study on the incidence of fibrino-necrotic ulcers in patients undergoing endovesical chemoprophylaxis with mitomycin C." | 3.69 | [Fibrino-necrotic ulcers in endovesical chemoprophylaxis in superficial bladder carcinoma: our case histories]. ( Arnáiz Esteban, F; Espuela Orgaz, R; Fernández Rosáenz, J; Guinda Sevillano, C; Martínez Pérez, E; Nogueras Gimeno, MA; Pérez Arbej, JA, 1994) |
| "To evaluate intraocular pressure (IOP) control and surgical complications following trabeculectomy with 5-fluorouracil (5-FU) or mitomycin at the inferior limbus." | 3.69 | Trabeculectomy at the inferior limbus. ( Caronia, RM; Cohen, H; Friedman, R; Liebmann, JM; Ritch, R, 1996) |
| "Administration of subconjunctival 5-fluorouracil (5-FU) and topical mitomycin-C (MMC) has been shown to improve the success rate of glaucoma-filtering surgery." | 3.69 | A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies. ( Akata, RF; Gökçe, M; Kiremitçi-Gümüşderelioglu, M, 1996) |
| "Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis." | 2.72 | History, presence, and future of mitomycin C in glaucoma filtration surgery. ( Al Majidi, R; Beckers, HJM; Gorgels, TGMF; Pinchuk, L; van Mechelen, RJS; Webers, CAB; Wolters, JEJ, 2021) |
| "Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery." | 1.72 | Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022) |
| " Suberanilohydroxamic acid (SAHA) however has been proposed to prevent corneal haze without any adverse effects." | 1.62 | Safety and efficacy of combination of suberoylamilide hydroxyamic acid and mitomycin C in reducing pro-fibrotic changes in human corneal epithelial cells. ( Dadachanji, ZV; Das, D; Ghosh, A; Khamar, P; Krishna, L; Kumar, NR; Matalia, H; Mohan, RR; Murugeswari, P; Shetty, R; Subramani, M, 2021) |
| "Treatment of tracheal stenosis is occasionally performed in combination with wound healing modulators to manipulate new extracellular matrix (ECM) formation and prevent fibrosis." | 1.56 | Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. ( Baltazares-Lipp, M; Baltazares-Lipp, ME; Gaxiola-Gaxiola, M; González-González, AI; Hernández-Jiménez, C; Iñiguez-García, MA; Jasso-Victoria, R; Luna-Flores, A; Olmos-Zuñiga, JR; Silva-Martínez, M; Solis-Alanis, N; Vázquez-Minero, JC, 2020) |
| "Excessive fibrosis is the topmost factor for the defeat of surgical glaucoma drainage device (GDD) implantation." | 1.51 | Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis. ( Dong, A; Fan, P; Han, L; Shao, Z; Yuan, H; Zhou, X, 2019) |
| "Epidural scar formation after laminectomy impede surgical outcomes of decompression." | 1.46 | MMC controlled-release membranes attenuate epidural scar formation in rat models after laminectomy. ( Cao, X; Geng, D; Jiang, L; Liu, J; Qin, J; Shen, X; Wang, B; Wu, T; Xie, H; Yu, C; Yuan, T, 2017) |
| "There was intensive epineural scar formation in the control group." | 1.43 | Prevention of Epidural Fibrosis in Rats by Local Administration of Mitomycin C or Daunorubicin. ( Ilbay, G; Ilbay, K; Vural, E; Yilmaz, M, 2016) |
| "The frequency of LT1009 dosage was determined initially using an enzyme-linked immunosorbent assay assay measuring LT1009 eye tissue retention in 6 New Zealand White rabbits." | 1.39 | Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. ( Beattie, AR; Levine, MA; Lukowski, ZL; Meyers, CA; Min, J; Samuelson, DA; Schultz, GS; Sherwood, MB; Stoller, G, 2013) |
| "Mitomycin C-treated HTFs were used for comparison." | 1.38 | In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon's fibroblasts: comparisons with mitomycin C. ( Seet, LF; Su, R; Toh, LZ; Wong, TT, 2012) |
| "Mean intraocular pressure was 28." | 1.37 | Needling augmented with topical application of mitomycin C for management of bleb failure. ( Abd El Hameed, M; Ghoneim, EM, 2011) |
| "The area of epidural scar tissue and degree of epidural adhesion were determined by 7." | 1.36 | Study on the optimal concentration of topical mitomycin-C in preventing postlaminectomy epidural adhesion. ( Cao, X; Lu, S; Su, C; Teng, G; Yao, C; Zang, F; Zhang, A, 2010) |
| "Epidural fibrosis is the scar tissue formed over the dura mater after a laminectomy." | 1.35 | Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model. ( Cemil, B; Cevirgen, B; Comert, A; Kaptanoglu, E; Kaymaz, F; Tekdemir, I; Tun, K, 2009) |
| "Mitomycin may inhibit wound healing by downregulating the gene expression for extracellular matrix proteins." | 1.32 | The effect of mitomycin on extracellular matrix proteins in a rat wound model. ( Gray, SD; Li, W; Tritle, N, 2003) |
| "Epidural fibrosis was evaluated histologically." | 1.32 | Mitomycin C in preventing spinal epidural fibrosis in a laminectomy model in rats. ( Ebel, H; Ernestus, RI; Klug, N; Lee, JY; Stenzel, W; Wedekind, C, 2004) |
| "Mitomycin-C was administered to the injured urethra in the form of irrigation for 5 min." | 1.32 | Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture. ( Ayyildiz, A; Caydere, M; Erol, D; Germiyanoglu, C; Gülerkaya, B; Nuhoglu, B; Ustün, H, 2004) |
| "Intraocular pressures were lower in the group that received MMC compared to the 5-FU group, but not in the group that did not receive antimetabolites, at all time intervals measured (P < ." | 1.30 | Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents. ( Budenz, DL; Gordon, J; Keates, EU; Piltz-Seymour, J; Pyfer, M; Singh, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (11.21) | 18.2507 |
| 2000's | 47 (40.52) | 29.6817 |
| 2010's | 42 (36.21) | 24.3611 |
| 2020's | 14 (12.07) | 2.80 |
| Authors | Studies |
|---|---|
| van Mechelen, RJS | 2 |
| Wolters, JE | 1 |
| Bertens, CJF | 1 |
| Webers, CAB | 2 |
| van den Biggelaar, FJHM | 1 |
| Gorgels, TGMF | 2 |
| Beckers, HJM | 2 |
| Carré, C | 1 |
| Baudin, F | 1 |
| Buteau, B | 1 |
| Martine, L | 1 |
| Grégoire, S | 1 |
| Vasku, G | 1 |
| Berdeaux, O | 1 |
| Béduneau, A | 1 |
| Pellequer, Y | 1 |
| Jamoussi, J | 1 |
| Desrumeaux, C | 1 |
| Aho, S | 1 |
| Bron, AM | 1 |
| Acar, N | 1 |
| Creuzot-Garcher, C | 1 |
| Gabrielle, PH | 1 |
| Vinokurtseva, A | 1 |
| Armstrong, JJ | 1 |
| Liu, H | 1 |
| Hutnik, CML | 1 |
| Yüksel, R | 1 |
| Yüksel, N | 1 |
| Yazır, Y | 1 |
| Öztürk, A | 1 |
| Furat Rençber, S | 1 |
| Demirci Küçük, K | 1 |
| Strzalkowska, A | 1 |
| Strzalkowski, P | 1 |
| Hoffmann, EM | 1 |
| Pfeiffer, N | 2 |
| Schuster, AK | 1 |
| Salimi, A | 1 |
| Kovalyuk, N | 1 |
| Harasymowycz, PJ | 1 |
| Lee, H | 1 |
| Jeong, H | 1 |
| Lee, CM | 1 |
| Shin, JA | 1 |
| Jang, SW | 1 |
| Lee, JH | 1 |
| Park, SY | 1 |
| Kim, JY | 2 |
| Tchah, H | 2 |
| Stahnke, T | 2 |
| Gajda-Derylo, B | 1 |
| Stachs, O | 2 |
| Guthoff, RF | 1 |
| Jünemann, A | 1 |
| Füllen, G | 1 |
| Xu, F | 1 |
| Shen, X | 2 |
| Sun, C | 1 |
| Xu, X | 1 |
| Wang, W | 1 |
| Zheng, J | 1 |
| Lin, LT | 1 |
| Chen, JT | 1 |
| Lu, DW | 1 |
| Tai, MC | 1 |
| Liang, CM | 1 |
| Chen, CL | 1 |
| Pao, SI | 1 |
| Hsu, CK | 1 |
| Chen, YH | 1 |
| Carlos de Oliveira, R | 1 |
| Wilson, SE | 1 |
| Olmos-Zuñiga, JR | 1 |
| Baltazares-Lipp, M | 1 |
| Hernández-Jiménez, C | 1 |
| Jasso-Victoria, R | 1 |
| Gaxiola-Gaxiola, M | 1 |
| Silva-Martínez, M | 1 |
| Iñiguez-García, MA | 1 |
| González-González, AI | 1 |
| Vázquez-Minero, JC | 1 |
| Luna-Flores, A | 1 |
| Solis-Alanis, N | 1 |
| Baltazares-Lipp, ME | 1 |
| Steven, S | 1 |
| Wolters, JEJ | 1 |
| Al Majidi, R | 1 |
| Pinchuk, L | 1 |
| Swogger, J | 1 |
| Conner, IP | 1 |
| Happ-Smith, C | 1 |
| Kemmerer, MC | 1 |
| Julian, DR | 1 |
| Davis, R | 1 |
| Wells, A | 1 |
| Schuman, JS | 1 |
| Yates, CC | 1 |
| Shetty, R | 1 |
| Kumar, NR | 1 |
| Subramani, M | 1 |
| Krishna, L | 1 |
| Murugeswari, P | 1 |
| Matalia, H | 1 |
| Khamar, P | 1 |
| Dadachanji, ZV | 1 |
| Mohan, RR | 1 |
| Ghosh, A | 1 |
| Das, D | 1 |
| Yazgan, S | 1 |
| Tekin, IO | 1 |
| Akpolat, N | 1 |
| Koc, O | 1 |
| Xie, H | 1 |
| Wang, B | 1 |
| Qin, J | 1 |
| Jiang, L | 1 |
| Yu, C | 1 |
| Geng, D | 1 |
| Yuan, T | 1 |
| Wu, T | 1 |
| Cao, X | 5 |
| Liu, J | 1 |
| Chong, RS | 1 |
| Lee, YS | 1 |
| Chu, SWL | 1 |
| Toh, LZ | 2 |
| Wong, TTL | 1 |
| Ekinci, A | 1 |
| Koc, S | 1 |
| Erdoğan, AS | 1 |
| Kesici, H | 1 |
| Szabó, D | 1 |
| Kovács, D | 1 |
| Endrész, V | 1 |
| Igaz, N | 1 |
| Jenovai, K | 1 |
| Spengler, G | 1 |
| Tiszlavicz, L | 1 |
| Molnár, J | 1 |
| Burián, K | 1 |
| Kiricsi, M | 1 |
| Rovó, L | 1 |
| Dong, A | 1 |
| Han, L | 1 |
| Shao, Z | 1 |
| Fan, P | 1 |
| Zhou, X | 1 |
| Yuan, H | 1 |
| Swann, FB | 1 |
| Singh, S | 1 |
| Blake, D | 1 |
| John, V | 1 |
| Le, C | 1 |
| Fullerton, M | 1 |
| Margo, C | 1 |
| Zhang, Z | 2 |
| Muddasani, N | 1 |
| Wall, J | 1 |
| Satija, C | 1 |
| Greenberg, E | 1 |
| Mancera, N | 1 |
| Zurakowski, D | 1 |
| Ayyala, RS | 2 |
| Ali, MJ | 1 |
| Paulsen, F | 1 |
| Yoon, SY | 1 |
| Kim, ES | 1 |
| Han, GS | 1 |
| Suh, LH | 1 |
| Jung, HS | 1 |
| Liu, L | 1 |
| Sui, T | 2 |
| Hong, X | 1 |
| Wu, X | 1 |
| Li, NY | 1 |
| Chen, F | 1 |
| Dikkers, FG | 1 |
| Thibeault, SL | 1 |
| Rao, A | 1 |
| Chatterjee, S | 1 |
| Woo, JE | 1 |
| Park, WC | 3 |
| Yoo, YH | 3 |
| Kim, SW | 2 |
| Chaurasia, S | 1 |
| Price, MO | 1 |
| McKee, Y | 1 |
| Price, FW | 1 |
| Ma, J | 1 |
| Li, X | 2 |
| Zhang, W | 1 |
| Huang, L | 1 |
| Chen, M | 1 |
| Xi, L | 1 |
| Duan, L | 1 |
| Quan, D | 1 |
| Ge, J | 2 |
| Uyeturk, U | 1 |
| Gucuk, A | 1 |
| Firat, T | 1 |
| Kemahli, E | 1 |
| Kukner, A | 1 |
| Ozyalvacli, ME | 1 |
| Sun, Y | 1 |
| Ge, Y | 1 |
| Fu, Y | 1 |
| Yan, L | 1 |
| Cai, J | 1 |
| Shi, K | 1 |
| Lu, C | 1 |
| Matsui, Y | 1 |
| Sunatani, Y | 1 |
| Hayashi, N | 1 |
| Okino, K | 1 |
| Okushi, Y | 1 |
| Mukai, K | 1 |
| Adachi, H | 1 |
| Yamaya, H | 1 |
| Iwabuchi, K | 1 |
| Yokoyama, H | 1 |
| Kinast, RM | 1 |
| Akula, KK | 1 |
| Mansberger, SL | 1 |
| Barker, GT | 1 |
| Gardiner, SK | 1 |
| Whitson, E | 1 |
| DeBarber, AE | 1 |
| Amoozgar, B | 1 |
| Lin, SC | 1 |
| Han, Y | 1 |
| Kuo, J | 1 |
| Vural, E | 1 |
| Yilmaz, M | 1 |
| Ilbay, K | 2 |
| Ilbay, G | 2 |
| Schultheiss, M | 1 |
| Schnichels, S | 1 |
| Konrad, EM | 1 |
| Bartz-Schmidt, KU | 1 |
| Zahn, G | 1 |
| Caldirola, P | 1 |
| Fsadni, MG | 1 |
| Caram-Lelham, N | 1 |
| Spitzer, MS | 1 |
| Alvarado, JA | 1 |
| Hollander, DA | 1 |
| Juster, RP | 1 |
| Lee, LC | 1 |
| Law, SK | 1 |
| Celik, SE | 1 |
| Altan, T | 1 |
| Celik, S | 1 |
| Göksu, K | 1 |
| Ince, I | 1 |
| Kapran, Z | 1 |
| Sahiner, N | 1 |
| Kravitz, DJ | 1 |
| Qadir, R | 1 |
| Blake, DA | 1 |
| Haque, S | 1 |
| John, VT | 1 |
| Margo, CE | 1 |
| Sen, S | 2 |
| Meteoglu, I | 1 |
| Ogurlu, M | 1 |
| Derincegoz, OO | 1 |
| Derinceoz, OO | 1 |
| Barutca, S | 1 |
| Cemil, B | 3 |
| Tun, K | 2 |
| Kaptanoglu, E | 2 |
| Cevirgen, B | 2 |
| Gurcay, AG | 1 |
| Kaymaz, F | 2 |
| Tekdemir, I | 2 |
| Elner, VM | 1 |
| Newman-Casey, PA | 1 |
| Patil, AJ | 1 |
| Flint, A | 1 |
| Biswas, J | 1 |
| Moroi, SE | 1 |
| Pushparaj, V | 1 |
| Edward, DP | 1 |
| Tappeiner, C | 1 |
| Meyenberg, A | 1 |
| Goldblum, D | 1 |
| Mojon, D | 1 |
| Zingg, JM | 1 |
| Nesaretnam, K | 1 |
| Kilchenmann, M | 1 |
| Frueh, BE | 1 |
| Comert, A | 1 |
| Hoehn, R | 1 |
| Lamparter, J | 1 |
| Vossmerbaeumer, U | 1 |
| Breusegem, C | 1 |
| Spielberg, L | 1 |
| Van Ginderdeuren, R | 1 |
| Vandewalle, E | 1 |
| Renier, C | 1 |
| Van de Veire, S | 1 |
| Fieuws, S | 1 |
| Zeyen, T | 1 |
| Stalmans, I | 1 |
| Rabb, CH | 1 |
| Su, C | 2 |
| Yao, C | 1 |
| Lu, S | 1 |
| Zhang, A | 1 |
| Teng, G | 1 |
| Zang, F | 1 |
| Kocaoglu, B | 1 |
| Akgun, U | 1 |
| Nalbantoglu, U | 1 |
| Poyanlı, O | 1 |
| Karahan, M | 1 |
| Kim, TH | 2 |
| Oh, HC | 1 |
| Rho, JH | 2 |
| Ahn, HB | 1 |
| Jeung, WJ | 1 |
| Rho, SH | 2 |
| Knape, RM | 1 |
| Smith, MF | 1 |
| Shao, T | 1 |
| Seet, LF | 1 |
| Su, R | 1 |
| Wong, TT | 1 |
| Ghoneim, EM | 1 |
| Abd El Hameed, M | 1 |
| Lukowski, ZL | 2 |
| Min, J | 2 |
| Beattie, AR | 2 |
| Meyers, CA | 2 |
| Levine, MA | 2 |
| Stoller, G | 1 |
| Schultz, GS | 2 |
| Samuelson, DA | 2 |
| Sherwood, MB | 2 |
| Zhang, X | 1 |
| Zhang, H | 1 |
| Arslan, S | 1 |
| Aydemir, O | 1 |
| Güler, M | 1 |
| Dağlı, AF | 1 |
| Löbler, M | 1 |
| Kastner, C | 1 |
| Wree, A | 1 |
| Sternberg, K | 1 |
| Schmitz, KP | 1 |
| Guthoff, R | 1 |
| Hogewind, BF | 1 |
| Pijl, B | 1 |
| Hoyng, CB | 1 |
| Theelen, T | 1 |
| Aydincak, O | 1 |
| Yilmaz, MB | 1 |
| Emmez, H | 2 |
| Kurt, G | 3 |
| Sepici, A | 1 |
| Memis, L | 2 |
| Baykaner, K | 2 |
| Gray, SD | 1 |
| Tritle, N | 1 |
| Li, W | 1 |
| Mac, I | 1 |
| Soltau, JB | 1 |
| Dogulu, F | 2 |
| Erdem, O | 2 |
| Ceviker, N | 2 |
| Billing, K | 1 |
| Karagiannis, A | 1 |
| Selva, D | 2 |
| Ribeiro, Fde A | 1 |
| Guaraldo, L | 1 |
| Borges, Jde P | 1 |
| Zacchi, FF | 1 |
| Eckley, CA | 1 |
| Hyung, SM | 1 |
| Jung, MS | 1 |
| Higginbotham, EJ | 1 |
| Lee, JY | 3 |
| Stenzel, W | 3 |
| Ebel, H | 2 |
| Wedekind, C | 1 |
| Ernestus, RI | 3 |
| Klug, N | 3 |
| Yoon, KC | 1 |
| Yang, KJ | 1 |
| Seo, JS | 1 |
| Lee, SE | 1 |
| Heo, T | 1 |
| Chun, BJ | 1 |
| Jung, S | 1 |
| Kim, KK | 1 |
| Ahn, KY | 1 |
| Yoon, PS | 1 |
| Singh, K | 2 |
| Sasson, AR | 1 |
| Wetherington, RW | 1 |
| Hoffman, JP | 1 |
| Ross, EA | 1 |
| Cooper, H | 1 |
| Meropol, NJ | 1 |
| Freedman, G | 1 |
| Pingpank, JF | 1 |
| Eisenberg, BL | 1 |
| Etus, V | 1 |
| Yildiz, K | 1 |
| Ceylan, S | 1 |
| Shetty, RK | 1 |
| Wartluft, L | 1 |
| Moster, MR | 1 |
| Ayyildiz, A | 1 |
| Nuhoglu, B | 1 |
| Gülerkaya, B | 1 |
| Caydere, M | 1 |
| Ustün, H | 1 |
| Germiyanoglu, C | 1 |
| Erol, D | 1 |
| Francis, BA | 1 |
| Du, LT | 1 |
| Najafi, K | 1 |
| Murthy, R | 1 |
| Kurumety, U | 1 |
| Rao, N | 1 |
| Minckler, DS | 1 |
| Joshi, AB | 1 |
| Parrish, RK | 1 |
| Feuer, WF | 1 |
| Watson, JC | 1 |
| Kadri, OA | 1 |
| Wilcox, MJ | 1 |
| Cincik, H | 1 |
| Güngör, A | 1 |
| Cekin, E | 1 |
| Saglam, O | 1 |
| Yildirim, S | 1 |
| Poyrazoglu, E | 1 |
| Candan, H | 1 |
| Aydin, E | 1 |
| Uckan, S | 1 |
| Ozdemir, BH | 1 |
| Uyar, P | 1 |
| Battelino, S | 1 |
| Hocevar-Boltezar, I | 1 |
| Zargi, M | 1 |
| Epstein, RJ | 3 |
| Majmudar, PA | 3 |
| Frucht-Pery, J | 1 |
| Raiskup, F | 1 |
| Ilsar, M | 1 |
| Landau, D | 1 |
| Orucov, F | 1 |
| Solomon, A | 1 |
| Mietz, H | 2 |
| Krieglstein, GK | 2 |
| Löhr, M | 2 |
| Stützer, H | 2 |
| Nakamura, T | 1 |
| Inatomi, T | 1 |
| Sekiyama, E | 1 |
| Ang, LP | 1 |
| Yokoi, N | 1 |
| Kinoshita, S | 1 |
| Impekoven, P | 1 |
| Theisohn, M | 1 |
| Reithmeier, T | 1 |
| Hwang, JM | 1 |
| Kee, C | 1 |
| Leibovitch, I | 1 |
| Deka, A | 1 |
| Bhattacharjee, K | 1 |
| Bhuyan, SK | 1 |
| Barua, CK | 1 |
| Bhattacharjee, H | 1 |
| Khaund, G | 1 |
| Goldberg, I | 1 |
| Ritch, R | 2 |
| Yildiz, KH | 1 |
| Gezen, F | 1 |
| Is, M | 1 |
| Cukur, S | 1 |
| Dosoglu, M | 1 |
| Anand, N | 1 |
| Arora, S | 1 |
| Aytar, MH | 1 |
| Baykaner, MK | 1 |
| Woo, JM | 1 |
| Lee, DJ | 1 |
| Park, JM | 1 |
| Jeong, WJ | 1 |
| Farid, M | 1 |
| Morishige, N | 1 |
| Lam, L | 1 |
| Wahlert, A | 1 |
| Steinert, RF | 1 |
| Jester, JV | 1 |
| Glover, TL | 1 |
| Nasisse, MP | 1 |
| Davidson, MG | 1 |
| Lee, DA | 2 |
| Susanna, R | 1 |
| Nicolela, MT | 1 |
| Takahashi, WY | 1 |
| Guinda Sevillano, C | 1 |
| Arnáiz Esteban, F | 1 |
| Fernández Rosáenz, J | 1 |
| Pérez Arbej, JA | 1 |
| Martínez Pérez, E | 1 |
| Nogueras Gimeno, MA | 1 |
| Espuela Orgaz, R | 1 |
| Shields, MB | 1 |
| Scroggs, MW | 1 |
| Sloop, CM | 1 |
| Simmons, RB | 1 |
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| Keates, EU | 1 |
| Forstot, SL | 1 |
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| Damiano, RE | 1 |
| Brenart, R | 1 |
| Kapetansky, FM | 1 |
| Kapetansky, SD | 1 |
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| Jain, S | 1 |
| Raviv, T | 1 |
| Maldonado, MJ | 1 |
| Hefetz, L | 1 |
| Naveh, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open-enrollment, Prospective Study of Endothelial Keratoplasty Outcomes[NCT00800111] | 2,593 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| A Pilot Study Using Neoadjuvant Proton Beam Radiation Therapy and Chemotherapy for Marginally Resectable Carcinoma of the Pancreas[NCT00763516] | 8 participants (Actual) | Interventional | 2009-02-28 | Completed | |||
| Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Primary Open Angle Glaucoma: a Three-year Comparative Study[NCT01633775] | 100 participants (Actual) | Observational | 2007-12-31 | Completed | |||
| Analysis of Effect of Low Level Laser Therapy in Spinal Surgery[NCT02529657] | 48 participants (Actual) | Interventional | 2013-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for mitomycin and Fibrosis
| Article | Year |
|---|---|
Animal models and drug candidates for use in glaucoma filtration surgery: A systematic review.
Topics: Animals; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pressure; Mice; Mitomycin; Models, Anima | 2022 |
Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK.
Topics: Alkylating Agents; Corneal Opacity; Corneal Stroma; Fibrosis; Humans; Lasers, Excimer; Mitomycin; My | 2020 |
History, presence, and future of mitomycin C in glaucoma filtration surgery.
Topics: Alkylating Agents; Drug Delivery Systems; Fibrosis; Filtering Surgery; Glaucoma; History, 20th Centu | 2021 |
Ultrastructure of the lacrimal drainage system in health and disease: A major review.
Topics: Bacteria; Biofilms; Cicatrix; Constriction, Pathologic; Dacryocystorhinostomy; Fibrinolytic Agents; | 2019 |
Glaucoma-filtering bleb infections.
Topics: Anti-Bacterial Agents; Drug Administration Schedule; Endophthalmitis; Fibrosis; Filtering Surgery; F | 2003 |
Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery.
Topics: Antimetabolites, Antineoplastic; Cataract Extraction; Fibrosis; Fluorouracil; Glaucoma; Glaucoma Dra | 2004 |
Antifibrosis agents and glaucoma surgery.
Topics: Animals; Conjunctiva; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomycin | 1994 |
Basic science and clinical aspects of wound healing in glaucoma filtering surgery.
Topics: Culture Techniques; Fibroblasts; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomy | 1998 |
[Use of drugs inhibiting fibrosis after trabeculectomy].
Topics: Adrenal Cortex Hormones; Aminopropionitrile; Fibrosis; Fluorouracil; Humans; Mitomycin; Postoperativ | 1992 |
6 trials available for mitomycin and Fibrosis
| Article | Year |
|---|---|
Inhibition of epidural fibrosis after microendoscopic discectomy with topical application of mitomycin C: a randomized, controlled, double-blind trial.
Topics: Administration, Cutaneous; Adult; Diskectomy; Double-Blind Method; Epidural Space; Fibrosis; Humans; | 2013 |
Mitomycin protection of peridural fibrosis in lumbar disc surgery.
Topics: Adult; Diskectomy; Dura Mater; Female; Fibrosis; Follow-Up Studies; Humans; Lumbar Vertebrae; Magnet | 2008 |
Preoperative nonsteroidal anti-inflammatory drug or steroid and outcomes after trabeculectomy: a randomized controlled trial.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antihyper | 2010 |
Purified triamcinolone acetonide as antifibrotic adjunct in glaucoma filtering surgery.
Topics: Aged; Alkylating Agents; Conjunctiva; Female; Fibrosis; Glaucoma, Angle-Closure; Glaucoma, Open-Angl | 2013 |
Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Combined Modality Therapy; Conjunctiva; Female; Fibrosis; | 2006 |
Postoperative application of mitomycin c improves the complete success rate of primary trabeculectomy: a prospective, randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Female; Fibrosis; Follow-Up Studies; Glaucoma; Hu | 2006 |
101 other studies available for mitomycin and Fibrosis
| Article | Year |
|---|---|
Effects of topical docosahexaenoic acid on postoperative fibrosis in an animal model of glaucoma filtration surgery.
Topics: Animals; Disease Models, Animal; Docosahexaenoic Acids; Fibrosis; Filtering Surgery; Glaucoma; Intra | 2023 |
Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery.
Topics: Aspirin; Cell Transdifferentiation; Cells, Cultured; Chromatography, Liquid; Cicatrix; Collagen; Cyt | 2022 |
The anti-scar effect of tyrosine-kinase inhibitor nintedanib in experimental glaucoma filtration surgery in rabbits.
Topics: Animals; Cicatrix; Conjunctiva; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pressure; Matrix | 2023 |
Outcomes of Open Bleb Revision After PreserFlo MicroShunt Failure in Patients With Glaucoma.
Topics: Fibrosis; Glaucoma; Humans; Infant; Intraocular Pressure; Mitomycin; Retrospective Studies; Tonometr | 2023 |
Tube Shunt Revision With Excision of Fibrotic Capsule Using Mitomycin C With and Without Ologen-a Collagen Matrix Implant: A 3-Year Follow-up Study.
Topics: Adult; Aged; Alkylating Agents; Collagen; Female; Fibrosis; Follow-Up Studies; Glaucoma; Glaucoma Dr | 2019 |
Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C.
Topics: Actins; Alkylating Agents; Blotting, Western; Cell Movement; Cell Survival; Cells, Cultured; Fibrobl | 2019 |
[Systems Biology in Ophthalmology - Innovative Drug Identification for the Specific Prevention of Postoperative Fibrosis].
Topics: Actins; Fibroblasts; Fibrosis; Humans; Mitomycin; Ophthalmologic Surgical Procedures; Ophthalmology; | 2019 |
The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Survival; Collagen Type I; Disease Models, Animal; | 2020 |
Antifibrotic role of low-dose mitomycin-c-induced cellular senescence in trabeculectomy models.
Topics: Animals; Biomarkers; Cell Survival; Cell Transdifferentiation; Cellular Senescence; Dose-Response Re | 2020 |
Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection.
Topics: Anastomosis, Surgical; Animals; Cicatrix; Collagen; Decorin; Disease Models, Animal; Dogs; Extracell | 2020 |
September consultation #2.
Topics: Fibrosis; Humans; Mitomycin; Referral and Consultation; Refractive Errors; Vision Tests | 2020 |
Novel combination therapy reduces subconjunctival fibrosis after glaucoma filtration surgery in the rabbit model.
Topics: Animals; Conjunctiva; Disease Models, Animal; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pre | 2021 |
Safety and efficacy of combination of suberoylamilide hydroxyamic acid and mitomycin C in reducing pro-fibrotic changes in human corneal epithelial cells.
Topics: Adult; Apoptosis; Cells, Cultured; Collagen Type IV; Epithelium, Corneal; Female; Fibrosis; Humans; | 2021 |
Novel Bacterial Cellulose Membrane to Reduce Fibrosis Following Trabeculectomy.
Topics: Animals; Cellulose; Conjunctiva; Fibrosis; Intraocular Pressure; Mitomycin; Rabbits; Sclera; Trabecu | 2021 |
MMC controlled-release membranes attenuate epidural scar formation in rat models after laminectomy.
Topics: Animals; Cicatrix; Delayed-Action Preparations; Disease Models, Animal; Epidural Space; Fibrosis; La | 2017 |
Inhibition of Monocyte Chemoattractant Protein 1 Prevents Conjunctival Fibrosis in an Experimental Model of Glaucoma Filtration Surgery.
Topics: Animals; Antifibrinolytic Agents; Cell Survival; Chemokine CCL2; Collagen; Conjunctiva; Disease Mode | 2017 |
Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats.
Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Female; Fibrosis; Inflammation; Laryngostenosi | 2018 |
Antifibrotic effect of mitomycin-C on human vocal cord fibroblasts.
Topics: Actins; Cell Culture Techniques; Cell Line; Fibroblasts; Fibrosis; Humans; Laryngectomy; Mitomycin; | 2019 |
Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis.
Topics: Adsorption; Cell-Derived Microparticles; Coated Materials, Biocompatible; Drug Liberation; Fibrosis; | 2019 |
Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model.
Topics: Absorbable Implants; Animals; Drug Delivery Systems; Drug Implants; Drug Liberation; Endophthalmitis | 2019 |
Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis.
Topics: Animals; Conjunctiva; Conjunctival Diseases; Cornea; Disease Models, Animal; Fibroblasts; Fibrosis; | 2019 |
Dose-dependent effect of mitomycin C on human vocal fold fibroblasts.
Topics: Alkylating Agents; Blotting, Western; Cicatrix; Dose-Response Relationship, Drug; Fibrosis; Humans; | 2014 |
Epiconjunctival mitomycin-C application for early failing filtering blebs.
Topics: Alkylating Agents; Conjunctiva; Female; Fibrosis; Glaucoma; Humans; Intraocular Pressure; Male; Midd | 2014 |
The efficacy of co-treatment with suberoylanilide hydroxamic acid and mitomycin C on corneal scarring after therapeutic keratectomy: an animal study.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Cicatrix; Corneal Diseases; Cytokin | 2014 |
Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy.
Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Basement Membrane; Corneal Endothelial Cell Loss; | 2014 |
CSM enhances the filtration bleb survival in rabbit model of experimental glaucoma surgery.
Topics: Alkylating Agents; Animals; Chitosan; Conjunctiva; Disease Models, Animal; Drug Carriers; Fibrosis; | 2014 |
Effect of mitomycin, bevacizumab, and 5-Fluorouracil to inhibit urethral fibrosis in a rabbit model.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; Collagen; Disease | 2014 |
Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE.
Topics: Animals; Apoptosis; Cells, Cultured; Cicatrix; Down-Regulation; Epidural Space; Failed Back Surgery | 2015 |
DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts.
Topics: Adult; Aged; Allografts; Capillaries; Cells, Cultured; Collagen; DNA Breaks, Double-Stranded; Female | 2016 |
Concentration Accuracy of Compounded Mitomycin C for Ophthalmic Surgery.
Topics: Alkylating Agents; Chromatography, High Pressure Liquid; Drug Compounding; Drug Storage; Fibrosis; G | 2016 |
A role for antimetabolites in glaucoma tube surgery: current evidence and future directions.
Topics: Animals; Antimetabolites; Fibrosis; Fluorouracil; Glaucoma; Humans; Mitomycin; Trabeculectomy | 2016 |
Prevention of Epidural Fibrosis in Rats by Local Administration of Mitomycin C or Daunorubicin.
Topics: Animals; Antibiotics, Antineoplastic; Cicatrix; Daunorubicin; Disease Models, Animal; Female; Fibros | 2016 |
α5β1-Integrin inhibitor (CLT-28643) effective in rabbit trabeculectomy model.
Topics: Administration, Topical; Alkylating Agents; Aminoquinolines; Animals; Collagen; Conjunctiva; Disease | 2017 |
Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkylating Agents; Cataract Extraction; Combined Modalit | 2008 |
A modified technique of Ahmed glaucoma valve implantation with adjunctive use of antifibrotic agents.
Topics: Alkylating Agents; Combined Modality Therapy; Fibrosis; Fluorouracil; Glaucoma; Glaucoma Drainage Im | 2008 |
Creation of a drug-coated glaucoma drainage device using polymer technology: in vitro and in vivo studies.
Topics: Alkylating Agents; Animals; Conjunctiva; Cornea; Drug Delivery Systems; Fibrosis; Glaucoma Drainage | 2009 |
Topical heparin: a promising agent for the prevention of tracheal stenosis in airway surgery.
Topics: Animals; Disease Models, Animal; Fibrinolytic Agents; Fibrosis; Granulation Tissue; Heparin; Mitomyc | 2009 |
The effect of mitomycin C as fibrosis preventive agent during craniectomies.
Topics: Administration, Topical; Animals; Arachnoid; Bone Regeneration; Craniotomy; Dura Mater; Female; Fibr | 2009 |
Aberrant wound-healing response in mitomycin C-treated leaking blebs: a histopathologic study.
Topics: Antibiotics, Antineoplastic; Conjunctival Diseases; Female; Fibroblasts; Fibrosis; Glaucoma; Humans; | 2009 |
Antifibrotic effects of tocotrienols on human Tenon's fibroblasts.
Topics: Cell Count; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Dose-Response Relationship | 2010 |
Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Dura Mater; Fibrosis; Lam | 2009 |
Seizures following subconjunctival 5-FU therapy.
Topics: Aged; Alkylating Agents; Antimetabolites; Combined Modality Therapy; Conjunctiva; Fibrosis; Fluorour | 2011 |
Failed back syndrome and epidural fibrosis.
Topics: Animals; Drug Delivery Systems; Epidural Space; Fibrosis; Humans; Low Back Pain; Lumbar Vertebrae; M | 2010 |
Study on the optimal concentration of topical mitomycin-C in preventing postlaminectomy epidural adhesion.
Topics: Administration, Topical; Animals; Cicatrix; Dose-Response Relationship, Drug; Epidural Space; Evoked | 2010 |
Adhesion reduction after knee surgery in a rat model by mitomycin C.
Topics: Animals; Cell Proliferation; Cicatrix; Disease Models, Animal; Female; Fibrosis; Foreign-Body Reacti | 2011 |
An experimental study of rabbit conjunctival epithelial toxicity using co-treatment with mitomycin-C and a histone deacetylase inhibitor.
Topics: Alkylating Agents; Animals; Apoptosis; Cells, Cultured; Conjunctiva; Drug Therapy, Combination; Epit | 2010 |
Antimetabolite application technique in trabeculectomy surgery.
Topics: Antimetabolites; Drug Delivery Systems; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraoperative Car | 2011 |
Target drug delivery system as a new scarring modulation after glaucoma filtration surgery.
Topics: Chitosan; Cicatrix; Drug Carriers; Drug Delivery Systems; Fibrinolytic Agents; Fibrosis; Filtering S | 2011 |
In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon's fibroblasts: comparisons with mitomycin C.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Cicatrix; Collagen Ty | 2012 |
Needling augmented with topical application of mitomycin C for management of bleb failure.
Topics: Administration, Topical; Alkylating Agents; Combined Modality Therapy; Conjunctiva; Female; Fibrosis | 2011 |
Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model.
Topics: Alkylating Agents; Animals; Antibodies, Monoclonal, Humanized; Cicatrix; Conjunctiva; Disease Models | 2013 |
Effect of topical application of mitomycin-C on wound healing in a postlaminectomy rat model: an experimental study.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Blood Vessels; Cell Count; Fibroblasts; Fib | 2012 |
Modulation of postoperative scarring with tacrolimus and octreotide in experimental glaucoma filtration surgery.
Topics: Administration, Topical; Alkylating Agents; Animals; Cicatrix; Conjunctival Diseases; Disease Models | 2012 |
Prevention of ocular scarring post glaucoma filtration surgery using the inflammatory cell and platelet binding modulator saratin in a rabbit model.
Topics: Administration, Topical; Animals; Blood Platelets; Cicatrix; Disease Models, Animal; Eye; Fibrosis; | 2012 |
Different fibroblast subpopulations of the eye: a therapeutic target to prevent postoperative fibrosis in glaucoma therapy.
Topics: Adipose Tissue; Cell Culture Techniques; Cell Proliferation; Choroid; Extracellular Matrix Proteins; | 2012 |
The effect of temozolomide on the prevention of epidural fibrosis developing after lumbar laminectomy in rats.
Topics: Animals; Dacarbazine; Dura Mater; Epidural Space; Fibroblasts; Fibrosis; Laminectomy; Lumbar Vertebr | 2012 |
The effect of mitomycin on extracellular matrix proteins in a rat wound model.
Topics: Administration, Topical; Animals; Down-Regulation; Extracellular Matrix Proteins; Fibrosis; Gene Exp | 2003 |
Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits.
Topics: Administration, Topical; Alkylating Agents; Animals; Dura Mater; Female; Fibrosis; Laminectomy; Male | 2003 |
Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia.
Topics: Administration, Topical; Antibiotics, Antineoplastic; Corneal Diseases; Female; Fibrosis; Humans; La | 2003 |
Clinical and histological healing of surgical wounds treated with mitomycin C.
Topics: Administration, Topical; Animals; Antibiotics, Antineoplastic; Dermatologic Surgical Procedures; Fib | 2004 |
Management of hypotony after trabeculectomy with mitomycin C.
Topics: Fibrosis; Humans; Mitomycin; Ocular Hypotension; Retrospective Studies; Trabeculectomy | 2003 |
The case against glaucoma drainage implant surgery in patients with a poor prognosis for standard filtering procedure.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Fibrosis; Fluorouracil; Glaucoma; Glau | 2004 |
Mitomycin C in preventing spinal epidural fibrosis in a laminectomy model in rats.
Topics: Alkylating Agents; Animals; Back Pain; Dose-Response Relationship, Drug; Dura Mater; Epidural Space; | 2004 |
Effect of human RAD50 gene therapy on glaucoma filtering surgery in rabbit eye.
Topics: Animals; Cell Division; Conjunctiva; DNA-Binding Proteins; Fibroblasts; Fibrosis; Genetic Therapy; G | 2004 |
Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: analysis of histopathology and outcome.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Deox | 2003 |
Topical application of mitomycin C prevents epineural scar formation in rats.
Topics: Administration, Topical; Animals; Cicatrix; Dissection; Fibrosis; Male; Mitomycin; Nucleic Acid Synt | 2005 |
Slit-lamp needle revision of failed filtering blebs using high-dose mitomycin C.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Conjunct | 2005 |
Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.
Topics: Animals; Antibiotics, Antineoplastic; Cicatrix; Disease Models, Animal; Dose-Response Relationship, | 2004 |
Histopathologic features of conjunctival filtering blebs.
Topics: Cell Count; Conjunctiva; Epithelial Cells; Fibrosis; Fluorouracil; Glaucoma; Goblet Cells; Humans; M | 2005 |
2002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use.
Topics: Antineoplastic Agents; Drug Utilization; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Glauco | 2005 |
Effects of mitomycin C on glaucoma filtration capsules.
Topics: Animals; Antibiotics, Antineoplastic; Chemotherapy, Adjuvant; Fibrosis; Glaucoma; Glaucoma Drainage | 2005 |
Effects of topical application of mitomycin-C and 5-fluorouracil on myringotomy in rats.
Topics: Administration, Topical; Animals; Antimetabolites; Fibrosis; Fluorouracil; Middle Ear Ventilation; M | 2005 |
Mitomycin C effect on fibrous adhesions of rabbit temporomandibular joint.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrati | 2005 |
Intraoperative use of mitomycin C in fibrous atresia of the external auditory canal.
Topics: Adult; Constriction, Pathologic; Ear Canal; Female; Fibrosis; Follow-Up Studies; Humans; Male; Middl | 2005 |
Alternative approach to the treatment of subepithelial fibrosis following radial keratotomy.
Topics: Antibiotics, Antineoplastic; Corneal Diseases; Epithelium, Corneal; Fibrosis; Humans; Keratotomy, Ra | 2006 |
The role of mitomycin C in reducing recurrence of epidural fibrosis after repeated operation in a laminectomy model in rats.
Topics: Alkylating Agents; Animals; Chi-Square Distribution; Epidural Space; Fibrosis; Laminectomy; Male; Mi | 2006 |
Novel clinical application of sterilized, freeze-dried amniotic membrane to treat patients with pterygium.
Topics: Adult; Aged; Amnion; Conjunctiva; Epithelium; Female; Fibrosis; Freeze Drying; Humans; Male; Middle | 2006 |
The effect of mitomycin C in reducing epidural fibrosis after lumbar laminectomy in rats.
Topics: Alkylating Agents; Animals; Epidural Space; Fibrosis; Laminectomy; Lumbar Vertebrae; Male; Mitomycin | 2006 |
Injection of cultured autologous fibroblasts into the subconjunctival space of rabbits treated with mitomycin C.
Topics: Animals; Antibiotics, Antineoplastic; Atrophy; Cells, Cultured; Conjunctiva; Conjunctival Diseases; | 2006 |
Mitomycin C in dacryocystorhinostomy.
Topics: Alkylating Agents; Cell Proliferation; Combined Modality Therapy; Dacryocystorhinostomy; Fibrosis; H | 2006 |
Effect of mitomycin C on ostium in dacryocystorhinostomy.
Topics: Adolescent; Adult; Alkylating Agents; Cell Proliferation; Child; Child, Preschool; Combined Modality | 2006 |
Mietz H, Krieglstein GK: Postoperative application of mitomycin C improves the complete success rate of primary trabeculectomy: a prospective, randomized trial. Graefes Arch Clin Exp Ophthalmol 2006; 244: 1429-1436.
Topics: Alkylating Agents; Fibrosis; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Mitomycin; P | 2007 |
Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model.
Topics: Animals; Antibiotics, Antineoplastic; Cell Count; Cyclosporine; Epidural Space; Fibroblasts; Fibrosi | 2007 |
Surgical revision of failed filtration surgery with mitomycin C augmentation.
Topics: Aged; Antihypertensive Agents; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; F | 2007 |
A comparison of the local effectiveness of mitomycin C, aprotinin, and Adcon-L in experimental peridural fibrosis.
Topics: Animals; Aprotinin; Dura Mater; Epidural Space; Fibrosis; Laminectomy; Lumbar Vertebrae; Male; Mitom | 2008 |
Co-treatment of suberoylanilide hydroxamic acid and mitomycin-C induces the apoptosis of rabbit tenon's capsule fibroblast and improves the outcome of glaucoma filtration surgery.
Topics: Alkylating Agents; Animals; Apoptosis; bcl-Associated Death Protein; Blotting, Western; Caspase 3; C | 2008 |
Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation.
Topics: Alkylating Agents; Animals; Combined Modality Therapy; Cornea; Corneal Opacity; Fibrillar Collagens; | 2008 |
Effects of topically applied mitomycin-C on intraocular pressure, facility of outflow, and fibrosis after glaucoma filtration surgery in clinically normal dogs.
Topics: Animals; Collagen; Conjunctiva; Connective Tissue; Dogs; Drug Implants; Fibroblasts; Fibrosis; Filte | 1995 |
Mitomycin C as adjunctive therapy with glaucoma implant surgery.
Topics: Adult; Aged; Biocompatible Materials; Chemotherapy, Adjuvant; Female; Fibrosis; Follow-Up Studies; G | 1994 |
[Fibrino-necrotic ulcers in endovesical chemoprophylaxis in superficial bladder carcinoma: our case histories].
Topics: Administration, Intravesical; Aged; Carcinoma; Combined Modality Therapy; Female; Fibrosis; Follow-U | 1994 |
Clinical and histopathologic observations concerning hypotony after trabeculectomy with adjunctive mitomycin C.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Conjunctiva; Female; Fibrosis | 1993 |
Trabeculectomy at the inferior limbus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Chemotherapy, Adjuvant; Child; Chi | 1996 |
Histopathology of episcleral fibrosis after trabeculectomy with and without mitomycin C.
Topics: Actins; Adult; Aged; Antibiotics, Antineoplastic; Cell Division; Child; Connective Tissue; Female; F | 1996 |
A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies.
Topics: Administration, Topical; Animals; Antibiotics, Antineoplastic; Conjunctiva; Cornea; Delayed-Action P | 1996 |
Corneal safety-valve incision in mitomycin filtering surgery.
Topics: Antibiotics, Antineoplastic; Cornea; Fibrosis; Filtering Surgery; Humans; Intraocular Pressure; Intr | 1998 |
Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents.
Topics: Aged; Cataract; Chemotherapy, Adjuvant; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraocular Pressu | 1999 |
Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery.
Topics: Administration, Topical; Adult; Debridement; Epithelium, Corneal; Female; Fibrosis; Humans; Keratoto | 2000 |
Antimetabolite use in revising failing filtering blebs.
Topics: Anterior Eye Segment; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Fibrosis; Glaucoma, O | 1999 |
Topical MMC for subepithelial fibrosis after refractive corneal surgery.
Topics: Administration, Topical; Epithelium, Corneal; Fibrosis; Humans; Lasers, Excimer; Mitomycin; Photoref | 2001 |
Subepithelial fibrosis after RK.
Topics: Alkylating Agents; Corneal Diseases; Debridement; Epithelium, Corneal; Fibrosis; Humans; Keratotomy, | 2000 |
Intraoperative MMC after excimer laser surgery for myopia.
Topics: Administration, Topical; Antibiotics, Antineoplastic; Epithelium, Corneal; Fibrosis; Humans; Intraop | 2002 |