Page last updated: 2024-11-06

mitomycin and Fibrosis

mitomycin has been researched along with Fibrosis in 116 studies

Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.

Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

Research Excerpts

ExcerptRelevanceReference
"The authors conducted a study to evaluate the effects and the safety of locally applied mitomycin C (MMC) on epidural fibrosis after microendoscopic discectomy (MED)."9.17Inhibition of epidural fibrosis after microendoscopic discectomy with topical application of mitomycin C: a randomized, controlled, double-blind trial. ( Cao, X; Hong, X; Liu, L; Sui, T; Wu, X, 2013)
"In this prospective, randomized clinical study the authors sought to evaluate the effects of locally applied mitomycin C on peridural fibrosis during lumbar microdiscectomy."9.13Mitomycin protection of peridural fibrosis in lumbar disc surgery. ( Altan, T; Celik, S; Celik, SE; Göksu, K; Ince, I; Kapran, Z, 2008)
"To compare the clinical outcome of pterygium surgery combining intraoperative mitomycin C (MMC) with a free conjunctival autograft, with three other methods of pterygium surgery, including intraoperative MMC alone, conjunctival autograft alone, and bare sclera without adjunctive treatment."9.12Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. ( Frucht-Pery, J; Ilsar, M; Landau, D; Orucov, F; Raiskup, F; Solomon, A, 2006)
"This review details the current understanding of the mechanism of action and corneal effects of mitomycin C (MMC) for prophylactic prevention of stromal fibrosis after photorefractive keratectomy (PRK), and includes discussion of available information on dosage and exposure time recommended for MMC during PRK."9.05Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK. ( Carlos de Oliveira, R; Wilson, SE, 2020)
"To investigate the efficacy of nintedanib on preventing postoperative scar in formation following glaucoma filtering surgery (GFC) in rabbits in comparison with Mitomycin-C (MMC)."8.31The anti-scar effect of tyrosine-kinase inhibitor nintedanib in experimental glaucoma filtration surgery in rabbits. ( Demirci Küçük, K; Furat Rençber, S; Öztürk, A; Yazır, Y; Yüksel, N; Yüksel, R, 2023)
"The aim was to evaluate the effectiveness of bacterial cellulose membrane (BCM) in preventing fibrosis in trabeculectomy and the biocompatibility of BCM with conjunctiva and sclera."8.02Novel Bacterial Cellulose Membrane to Reduce Fibrosis Following Trabeculectomy. ( Akpolat, N; Koc, O; Tekin, IO; Yazgan, S, 2021)
" The purpose of this study was to investigate the effect of mitomycin C on reducing endometrial fibrosis for IUA."7.96The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion. ( Shen, X; Sun, C; Wang, W; Xu, F; Xu, X; Zheng, J, 2020)
"To find safer and more effective drugs than mitomycin C to prevent conjunctival fibrosis in a rabbit model."7.91Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis. ( Han, GS; Jung, HS; Kim, ES; Kim, JY; Suh, LH; Tchah, H; Yoon, SY, 2019)
"To investigate the antifibrotic effects of sakuraso-saponin on a primary culture of human pterygium fibroblasts (HPFs) and normal human Tenon fibroblasts (HTFs) as compared to the effects of mitomycin C (MMC)."7.91Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C. ( Jang, SW; Jeong, H; Kim, JY; Lee, CM; Lee, H; Lee, JH; Park, SY; Shin, JA; Tchah, H, 2019)
"We aimed to investigate the prophylactic effect simvastatin of and mitomycin C (MMC) on laryngeal and tracheal stenosis in tracheotomised rats by histopathological evaluation of laryngotracheal segment."7.88Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. ( Ekinci, A; Erdoğan, AS; Kesici, H; Koc, S, 2018)
"Mitomycin C (MMC) is known to reduce epidural fibrosis, but the underlying mechanisms have not yet been elucidated."7.81Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE. ( Cai, J; Cao, X; Fu, Y; Ge, Y; Lu, C; Shi, K; Sun, Y; Yan, L, 2015)
"The aim of this study was to evaluate the anterior corneal surface regularity and light scattering before and after Descemet membrane endothelial keratoplasty (DMEK) with epithelial debridement and application of mitomycin C in Fuchs dystrophy-affected eyes with preoperative subepithelial fibrosis or anterior basement membrane dystrophy."7.80Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy. ( Chaurasia, S; McKee, Y; Price, FW; Price, MO, 2014)
"Topically administration of Tacrolimus and Octreotide effectively reduced the subconjuntival scarring response 2 weeks after experimental glaucoma filtration surgery."7.78Modulation of postoperative scarring with tacrolimus and octreotide in experimental glaucoma filtration surgery. ( Arslan, S; Aydemir, O; Dağlı, AF; Güler, M, 2012)
"Temozolomide was found to be effective in preventing epidural fibrosis."7.78The effect of temozolomide on the prevention of epidural fibrosis developing after lumbar laminectomy in rats. ( Aydincak, O; Baykaner, K; Emmez, H; Kurt, G; Memis, L; Sepici, A; Yilmaz, MB, 2012)
"The authors conducted a study to determine the effectiveness of mitomycin C (MMC) in preventing epidural fibrosis in rats which underwent craniectomy."7.75The effect of mitomycin C as fibrosis preventive agent during craniectomies. ( Cemil, B; Cevirgen, B; Gurcay, AG; Kaptanoglu, E; Kaymaz, F; Tekdemir, I; Tun, K, 2009)
"This study examined the preventive effects of the local application of mitomycin C (MMC), 5-fluorouracil (5-FU), and cyclosporine A (CsA) in minimizing spinal epidural fibrosis in a rat laminectomy model."7.74Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model. ( Cukur, S; Dosoglu, M; Gezen, F; Is, M; Yildiz, KH, 2007)
"The authors conducted a study to determine the effectiveness of mitomycin C in preventing postlaminectomy peridural fibrosis in rabbits."7.72Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits. ( Baykaner, K; Ceviker, N; Dogulu, F; Emmez, H; Erdem, O; Kurt, G; Memis, L, 2003)
"Twenty-one eyes of 21 patients with refractory glaucoma underwent glaucoma surgery involving placement of a modified Molteno implant and intraoperative application of mitomycin C."7.69Mitomycin C as adjunctive therapy with glaucoma implant surgery. ( Nicolela, MT; Susanna, R; Takahashi, WY, 1994)
"The effects of mitomycin-C on intraocular pressure (IOP), facility of outflow (C), and Tenon's capsule fibrosis were studied over 60 days in 10 clinically normal dogs."7.69Effects of topically applied mitomycin-C on intraocular pressure, facility of outflow, and fibrosis after glaucoma filtration surgery in clinically normal dogs. ( Davidson, MG; Glover, TL; Nasisse, MP, 1995)
"Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis."6.72History, presence, and future of mitomycin C in glaucoma filtration surgery. ( Al Majidi, R; Beckers, HJM; Gorgels, TGMF; Pinchuk, L; van Mechelen, RJS; Webers, CAB; Wolters, JEJ, 2021)
"Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery."5.72Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022)
"Excessive fibrosis is the topmost factor for the defeat of surgical glaucoma drainage device (GDD) implantation."5.51Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis. ( Dong, A; Fan, P; Han, L; Shao, Z; Yuan, H; Zhou, X, 2019)
"There was intensive epineural scar formation in the control group."5.43Prevention of Epidural Fibrosis in Rats by Local Administration of Mitomycin C or Daunorubicin. ( Ilbay, G; Ilbay, K; Vural, E; Yilmaz, M, 2016)
"Epidural fibrosis was evaluated histologically."5.32Mitomycin C in preventing spinal epidural fibrosis in a laminectomy model in rats. ( Ebel, H; Ernestus, RI; Klug, N; Lee, JY; Stenzel, W; Wedekind, C, 2004)
"Mitomycin-C was administered to the injured urethra in the form of irrigation for 5 min."5.32Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture. ( Ayyildiz, A; Caydere, M; Erol, D; Germiyanoglu, C; Gülerkaya, B; Nuhoglu, B; Ustün, H, 2004)
"The authors conducted a study to evaluate the effects and the safety of locally applied mitomycin C (MMC) on epidural fibrosis after microendoscopic discectomy (MED)."5.17Inhibition of epidural fibrosis after microendoscopic discectomy with topical application of mitomycin C: a randomized, controlled, double-blind trial. ( Cao, X; Hong, X; Liu, L; Sui, T; Wu, X, 2013)
"Between July 2005 and October 2007, 61 consecutive medically uncontrolled glaucoma patients scheduled for first-time trabeculectomy were randomized to 1 of 3 study topical medication groups: nonsteroidal anti-inflammatory drugs (ketorolac), steroids (fluorometholone), or placebo (artificial tears)."5.14Preoperative nonsteroidal anti-inflammatory drug or steroid and outcomes after trabeculectomy: a randomized controlled trial. ( Breusegem, C; Fieuws, S; Renier, C; Spielberg, L; Stalmans, I; Van de Veire, S; Van Ginderdeuren, R; Vandewalle, E; Zeyen, T, 2010)
"In this prospective, randomized clinical study the authors sought to evaluate the effects of locally applied mitomycin C on peridural fibrosis during lumbar microdiscectomy."5.13Mitomycin protection of peridural fibrosis in lumbar disc surgery. ( Altan, T; Celik, S; Celik, SE; Göksu, K; Ince, I; Kapran, Z, 2008)
"To compare the clinical outcome of pterygium surgery combining intraoperative mitomycin C (MMC) with a free conjunctival autograft, with three other methods of pterygium surgery, including intraoperative MMC alone, conjunctival autograft alone, and bare sclera without adjunctive treatment."5.12Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. ( Frucht-Pery, J; Ilsar, M; Landau, D; Orucov, F; Raiskup, F; Solomon, A, 2006)
"This review details the current understanding of the mechanism of action and corneal effects of mitomycin C (MMC) for prophylactic prevention of stromal fibrosis after photorefractive keratectomy (PRK), and includes discussion of available information on dosage and exposure time recommended for MMC during PRK."5.05Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK. ( Carlos de Oliveira, R; Wilson, SE, 2020)
"With the increased use of intraoperative antifibrotic (eg, mitomycin and fluorouracil) as an adjunct to standard trabeculectomy, an increased incidence is seen of late-onset filtering bleb-related infections."4.82Glaucoma-filtering bleb infections. ( Mac, I; Soltau, JB, 2003)
"The use of antifibrotic agents, namely, 5-fluorouracil and mitomycin C, in conjunction with glaucoma surgery has resulted in lower postoperative intraocular pressures after trabeculectomy or combined cataract and glaucoma surgery."4.82Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery. ( Singh, K; Yoon, PS, 2004)
"To investigate the efficacy of nintedanib on preventing postoperative scar in formation following glaucoma filtering surgery (GFC) in rabbits in comparison with Mitomycin-C (MMC)."4.31The anti-scar effect of tyrosine-kinase inhibitor nintedanib in experimental glaucoma filtration surgery in rabbits. ( Demirci Küçük, K; Furat Rençber, S; Öztürk, A; Yazır, Y; Yüksel, N; Yüksel, R, 2023)
"The purpose of this study was to evaluate the effectiveness and safety of an open bleb revision with mitomycin- C (MMC) for bleb fibrosis after PreserFlo MicroShunt implantation."4.31Outcomes of Open Bleb Revision After PreserFlo MicroShunt Failure in Patients With Glaucoma. ( Hoffmann, EM; Pfeiffer, N; Schuster, AK; Strzalkowska, A; Strzalkowski, P, 2023)
"The aim was to evaluate the effectiveness of bacterial cellulose membrane (BCM) in preventing fibrosis in trabeculectomy and the biocompatibility of BCM with conjunctiva and sclera."4.02Novel Bacterial Cellulose Membrane to Reduce Fibrosis Following Trabeculectomy. ( Akpolat, N; Koc, O; Tekin, IO; Yazgan, S, 2021)
" The purpose of this study was to investigate the effect of mitomycin C on reducing endometrial fibrosis for IUA."3.96The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion. ( Shen, X; Sun, C; Wang, W; Xu, F; Xu, X; Zheng, J, 2020)
"To investigate the antifibrotic effects of sakuraso-saponin on a primary culture of human pterygium fibroblasts (HPFs) and normal human Tenon fibroblasts (HTFs) as compared to the effects of mitomycin C (MMC)."3.91Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C. ( Jang, SW; Jeong, H; Kim, JY; Lee, CM; Lee, H; Lee, JH; Park, SY; Shin, JA; Tchah, H, 2019)
"To find safer and more effective drugs than mitomycin C to prevent conjunctival fibrosis in a rabbit model."3.91Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis. ( Han, GS; Jung, HS; Kim, ES; Kim, JY; Suh, LH; Tchah, H; Yoon, SY, 2019)
"Rabbit model studies suggested better morphology blebs with equal intraocular pressure (IOP) efficacy as a standard mitomycin C (MMC) trabeculectomy using a novel slow-release drug delivery antifibrotic system delivering small quantities of MMC and 5-fluorouracil (5-FU)."3.91Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model. ( Ayyala, RS; Blake, D; Fullerton, M; Greenberg, E; John, V; Le, C; Mancera, N; Margo, C; Muddasani, N; Satija, C; Singh, S; Swann, FB; Wall, J; Zhang, Z; Zurakowski, D, 2019)
"We aimed to investigate the prophylactic effect simvastatin of and mitomycin C (MMC) on laryngeal and tracheal stenosis in tracheotomised rats by histopathological evaluation of laryngotracheal segment."3.88Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. ( Ekinci, A; Erdoğan, AS; Kesici, H; Koc, S, 2018)
"Mitomycin C and 5-fluorouracil have been used in GDD and trabeculectomy to prevent the exaggerated cellular reaction that leads to fibrosis."3.83A role for antimetabolites in glaucoma tube surgery: current evidence and future directions. ( Amoozgar, B; Han, Y; Kuo, J; Lin, SC, 2016)
"Mitomycin C (MMC) is known to reduce epidural fibrosis, but the underlying mechanisms have not yet been elucidated."3.81Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE. ( Cai, J; Cao, X; Fu, Y; Ge, Y; Lu, C; Shi, K; Sun, Y; Yan, L, 2015)
"2 mg/mL mitomycin C may provide initial and transient stimulation of collagen for necessary repair to damaged tissue without the long-term risk of fibrosis."3.80Dose-dependent effect of mitomycin C on human vocal fold fibroblasts. ( Chen, F; Dikkers, FG; Li, NY; Thibeault, SL, 2014)
"The aim of this study was to evaluate the anterior corneal surface regularity and light scattering before and after Descemet membrane endothelial keratoplasty (DMEK) with epithelial debridement and application of mitomycin C in Fuchs dystrophy-affected eyes with preoperative subepithelial fibrosis or anterior basement membrane dystrophy."3.80Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy. ( Chaurasia, S; McKee, Y; Price, FW; Price, MO, 2014)
"This study was undertaken to evaluate the efficacy of co-treatment with suberoylanilide hydroxamic acid (SAHA) and mitomycin-C (MMC) on corneal fibrosis in an in-vivo model."3.80The efficacy of co-treatment with suberoylanilide hydroxamic acid and mitomycin C on corneal scarring after therapeutic keratectomy: an animal study. ( Kim, SW; Park, WC; Woo, JE; Yoo, YH, 2014)
"Temozolomide was found to be effective in preventing epidural fibrosis."3.78The effect of temozolomide on the prevention of epidural fibrosis developing after lumbar laminectomy in rats. ( Aydincak, O; Baykaner, K; Emmez, H; Kurt, G; Memis, L; Sepici, A; Yilmaz, MB, 2012)
"Topically administration of Tacrolimus and Octreotide effectively reduced the subconjuntival scarring response 2 weeks after experimental glaucoma filtration surgery."3.78Modulation of postoperative scarring with tacrolimus and octreotide in experimental glaucoma filtration surgery. ( Arslan, S; Aydemir, O; Dağlı, AF; Güler, M, 2012)
"This study was conducted to evaluate cytotoxicity due to co-treatment with low-dose Mitomycin-C (MMC) and the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA) for glaucoma filtration surgery."3.76An experimental study of rabbit conjunctival epithelial toxicity using co-treatment with mitomycin-C and a histone deacetylase inhibitor. ( Ahn, HB; Jeung, WJ; Kim, TH; Oh, HC; Park, WC; Rho, JH; Rho, SH; Yoo, YH, 2010)
"The authors conducted a study to determine the effectiveness of mitomycin C (MMC) in preventing epidural fibrosis in rats which underwent craniectomy."3.75The effect of mitomycin C as fibrosis preventive agent during craniectomies. ( Cemil, B; Cevirgen, B; Gurcay, AG; Kaptanoglu, E; Kaymaz, F; Tekdemir, I; Tun, K, 2009)
"The protective effects of topical mitomycin-C (MMC) have been well documented for tracheal stenosis; however, to the best of our knowledge, the use of heparin as an anti-inflammatory agent to support wound healing in upper airway surgery was not studied before."3.75Topical heparin: a promising agent for the prevention of tracheal stenosis in airway surgery. ( Barutca, S; Derincegoz, OO; Derinceoz, OO; Meteoglu, I; Ogurlu, M; Sen, S, 2009)
"The aim of the study was to assess the outcomes of surgical revision with reopening of the scleral flap in eyes with failed glaucoma surgery and adjunctive mitomycin C (MMC)."3.74Surgical revision of failed filtration surgery with mitomycin C augmentation. ( Anand, N; Arora, S, 2007)
"To evaluate long-term outcomes after Ahmed valve implantation in patients with glaucoma when using adjunctive intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU)."3.74Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes. ( Alvarado, JA; Hollander, DA; Juster, RP; Lee, LC, 2008)
"This study examined the preventive effects of the local application of mitomycin C (MMC), 5-fluorouracil (5-FU), and cyclosporine A (CsA) in minimizing spinal epidural fibrosis in a rat laminectomy model."3.74Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model. ( Cukur, S; Dosoglu, M; Gezen, F; Is, M; Yildiz, KH, 2007)
"The role of topically applied mitomycin C in preventing postoperative perineural fibrosis was examined by gross anatomical dissection and histological analysis in rats."3.73Topical application of mitomycin C prevents epineural scar formation in rats. ( Ceylan, S; Etus, V; Ilbay, G; Ilbay, K; Yildiz, K, 2005)
"American Glaucoma Society (AGS) members continue to report preference for mitomycin C use in ten clinical settings."3.732002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use. ( Feuer, WF; Joshi, AB; Parrish, RK, 2005)
"To evaluate influence of mitomycin C on fibrosis in temporomandibular joints of rabbits with mandibular traction."3.73Mitomycin C effect on fibrous adhesions of rabbit temporomandibular joint. ( Aydin, E; Ozdemir, BH; Uckan, S; Uyar, P, 2005)
"To investigate whether cultured autologous fibroblasts injected into the subconjunctival space of rabbit may be used as a new treatment modality for conjunctival and subconjunctival atrophy caused by mitomycin C (MMC)."3.73Injection of cultured autologous fibroblasts into the subconjunctival space of rabbits treated with mitomycin C. ( Hwang, JM; Kee, C, 2006)
"Mitomycin C in appropriate dose minimizes postoperative fibrosis and granulations, thereby maintaining a bigger postoperative ostium throughout the postoperative observation period."3.73Effect of mitomycin C on ostium in dacryocystorhinostomy. ( Barua, CK; Bhattacharjee, H; Bhattacharjee, K; Bhuyan, SK; Deka, A; Khaund, G, 2006)
"The authors conducted a study to determine the effectiveness of mitomycin C in preventing postlaminectomy peridural fibrosis in rabbits."3.72Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits. ( Baykaner, K; Ceviker, N; Dogulu, F; Emmez, H; Erdem, O; Kurt, G; Memis, L, 2003)
"Mitomycin-C use may lead to lacrimal apparatus fibrosis and symptomatic epiphora when inciting a toxoallergic reaction."3.72Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia. ( Billing, K; Karagiannis, A; Selva, D, 2003)
"Topical mitomycin C delays the healing of surgical wounds in rats up to the fourth week following treatment, but the degree of fibrosis is comparable in both treated and untreated wounds after 12 weeks."3.72Clinical and histological healing of surgical wounds treated with mitomycin C. ( Borges, Jde P; Eckley, CA; Guaraldo, L; Ribeiro, Fde A; Zacchi, FF, 2004)
"The effects of mitomycin-C on intraocular pressure (IOP), facility of outflow (C), and Tenon's capsule fibrosis were studied over 60 days in 10 clinically normal dogs."3.69Effects of topically applied mitomycin-C on intraocular pressure, facility of outflow, and fibrosis after glaucoma filtration surgery in clinically normal dogs. ( Davidson, MG; Glover, TL; Nasisse, MP, 1995)
"Twenty-one eyes of 21 patients with refractory glaucoma underwent glaucoma surgery involving placement of a modified Molteno implant and intraoperative application of mitomycin C."3.69Mitomycin C as adjunctive therapy with glaucoma implant surgery. ( Nicolela, MT; Susanna, R; Takahashi, WY, 1994)
"Presentation of one study on the incidence of fibrino-necrotic ulcers in patients undergoing endovesical chemoprophylaxis with mitomycin C."3.69[Fibrino-necrotic ulcers in endovesical chemoprophylaxis in superficial bladder carcinoma: our case histories]. ( Arnáiz Esteban, F; Espuela Orgaz, R; Fernández Rosáenz, J; Guinda Sevillano, C; Martínez Pérez, E; Nogueras Gimeno, MA; Pérez Arbej, JA, 1994)
"To evaluate intraocular pressure (IOP) control and surgical complications following trabeculectomy with 5-fluorouracil (5-FU) or mitomycin at the inferior limbus."3.69Trabeculectomy at the inferior limbus. ( Caronia, RM; Cohen, H; Friedman, R; Liebmann, JM; Ritch, R, 1996)
"Administration of subconjunctival 5-fluorouracil (5-FU) and topical mitomycin-C (MMC) has been shown to improve the success rate of glaucoma-filtering surgery."3.69A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies. ( Akata, RF; Gökçe, M; Kiremitçi-Gümüşderelioglu, M, 1996)
"Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis."2.72History, presence, and future of mitomycin C in glaucoma filtration surgery. ( Al Majidi, R; Beckers, HJM; Gorgels, TGMF; Pinchuk, L; van Mechelen, RJS; Webers, CAB; Wolters, JEJ, 2021)
"Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery."1.72Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022)
" Suberanilohydroxamic acid (SAHA) however has been proposed to prevent corneal haze without any adverse effects."1.62Safety and efficacy of combination of suberoylamilide hydroxyamic acid and mitomycin C in reducing pro-fibrotic changes in human corneal epithelial cells. ( Dadachanji, ZV; Das, D; Ghosh, A; Khamar, P; Krishna, L; Kumar, NR; Matalia, H; Mohan, RR; Murugeswari, P; Shetty, R; Subramani, M, 2021)
"Treatment of tracheal stenosis is occasionally performed in combination with wound healing modulators to manipulate new extracellular matrix (ECM) formation and prevent fibrosis."1.56Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. ( Baltazares-Lipp, M; Baltazares-Lipp, ME; Gaxiola-Gaxiola, M; González-González, AI; Hernández-Jiménez, C; Iñiguez-García, MA; Jasso-Victoria, R; Luna-Flores, A; Olmos-Zuñiga, JR; Silva-Martínez, M; Solis-Alanis, N; Vázquez-Minero, JC, 2020)
"Excessive fibrosis is the topmost factor for the defeat of surgical glaucoma drainage device (GDD) implantation."1.51Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis. ( Dong, A; Fan, P; Han, L; Shao, Z; Yuan, H; Zhou, X, 2019)
"Epidural scar formation after laminectomy impede surgical outcomes of decompression."1.46MMC controlled-release membranes attenuate epidural scar formation in rat models after laminectomy. ( Cao, X; Geng, D; Jiang, L; Liu, J; Qin, J; Shen, X; Wang, B; Wu, T; Xie, H; Yu, C; Yuan, T, 2017)
"There was intensive epineural scar formation in the control group."1.43Prevention of Epidural Fibrosis in Rats by Local Administration of Mitomycin C or Daunorubicin. ( Ilbay, G; Ilbay, K; Vural, E; Yilmaz, M, 2016)
"The frequency of LT1009 dosage was determined initially using an enzyme-linked immunosorbent assay assay measuring LT1009 eye tissue retention in 6 New Zealand White rabbits."1.39Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. ( Beattie, AR; Levine, MA; Lukowski, ZL; Meyers, CA; Min, J; Samuelson, DA; Schultz, GS; Sherwood, MB; Stoller, G, 2013)
"Mitomycin C-treated HTFs were used for comparison."1.38In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon's fibroblasts: comparisons with mitomycin C. ( Seet, LF; Su, R; Toh, LZ; Wong, TT, 2012)
"Mean intraocular pressure was 28."1.37Needling augmented with topical application of mitomycin C for management of bleb failure. ( Abd El Hameed, M; Ghoneim, EM, 2011)
"The area of epidural scar tissue and degree of epidural adhesion were determined by 7."1.36Study on the optimal concentration of topical mitomycin-C in preventing postlaminectomy epidural adhesion. ( Cao, X; Lu, S; Su, C; Teng, G; Yao, C; Zang, F; Zhang, A, 2010)
"Epidural fibrosis is the scar tissue formed over the dura mater after a laminectomy."1.35Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model. ( Cemil, B; Cevirgen, B; Comert, A; Kaptanoglu, E; Kaymaz, F; Tekdemir, I; Tun, K, 2009)
"Mitomycin may inhibit wound healing by downregulating the gene expression for extracellular matrix proteins."1.32The effect of mitomycin on extracellular matrix proteins in a rat wound model. ( Gray, SD; Li, W; Tritle, N, 2003)
"Epidural fibrosis was evaluated histologically."1.32Mitomycin C in preventing spinal epidural fibrosis in a laminectomy model in rats. ( Ebel, H; Ernestus, RI; Klug, N; Lee, JY; Stenzel, W; Wedekind, C, 2004)
"Mitomycin-C was administered to the injured urethra in the form of irrigation for 5 min."1.32Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture. ( Ayyildiz, A; Caydere, M; Erol, D; Germiyanoglu, C; Gülerkaya, B; Nuhoglu, B; Ustün, H, 2004)
"Intraocular pressures were lower in the group that received MMC compared to the 5-FU group, but not in the group that did not receive antimetabolites, at all time intervals measured (P < ."1.30Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents. ( Budenz, DL; Gordon, J; Keates, EU; Piltz-Seymour, J; Pyfer, M; Singh, K, 1999)

Research

Studies (116)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (11.21)18.2507
2000's47 (40.52)29.6817
2010's42 (36.21)24.3611
2020's14 (12.07)2.80

Authors

AuthorsStudies
van Mechelen, RJS2
Wolters, JE1
Bertens, CJF1
Webers, CAB2
van den Biggelaar, FJHM1
Gorgels, TGMF2
Beckers, HJM2
Carré, C1
Baudin, F1
Buteau, B1
Martine, L1
Grégoire, S1
Vasku, G1
Berdeaux, O1
Béduneau, A1
Pellequer, Y1
Jamoussi, J1
Desrumeaux, C1
Aho, S1
Bron, AM1
Acar, N1
Creuzot-Garcher, C1
Gabrielle, PH1
Vinokurtseva, A1
Armstrong, JJ1
Liu, H1
Hutnik, CML1
Yüksel, R1
Yüksel, N1
Yazır, Y1
Öztürk, A1
Furat Rençber, S1
Demirci Küçük, K1
Strzalkowska, A1
Strzalkowski, P1
Hoffmann, EM1
Pfeiffer, N2
Schuster, AK1
Salimi, A1
Kovalyuk, N1
Harasymowycz, PJ1
Lee, H1
Jeong, H1
Lee, CM1
Shin, JA1
Jang, SW1
Lee, JH1
Park, SY1
Kim, JY2
Tchah, H2
Stahnke, T2
Gajda-Derylo, B1
Stachs, O2
Guthoff, RF1
Jünemann, A1
Füllen, G1
Xu, F1
Shen, X2
Sun, C1
Xu, X1
Wang, W1
Zheng, J1
Lin, LT1
Chen, JT1
Lu, DW1
Tai, MC1
Liang, CM1
Chen, CL1
Pao, SI1
Hsu, CK1
Chen, YH1
Carlos de Oliveira, R1
Wilson, SE1
Olmos-Zuñiga, JR1
Baltazares-Lipp, M1
Hernández-Jiménez, C1
Jasso-Victoria, R1
Gaxiola-Gaxiola, M1
Silva-Martínez, M1
Iñiguez-García, MA1
González-González, AI1
Vázquez-Minero, JC1
Luna-Flores, A1
Solis-Alanis, N1
Baltazares-Lipp, ME1
Steven, S1
Wolters, JEJ1
Al Majidi, R1
Pinchuk, L1
Swogger, J1
Conner, IP1
Happ-Smith, C1
Kemmerer, MC1
Julian, DR1
Davis, R1
Wells, A1
Schuman, JS1
Yates, CC1
Shetty, R1
Kumar, NR1
Subramani, M1
Krishna, L1
Murugeswari, P1
Matalia, H1
Khamar, P1
Dadachanji, ZV1
Mohan, RR1
Ghosh, A1
Das, D1
Yazgan, S1
Tekin, IO1
Akpolat, N1
Koc, O1
Xie, H1
Wang, B1
Qin, J1
Jiang, L1
Yu, C1
Geng, D1
Yuan, T1
Wu, T1
Cao, X5
Liu, J1
Chong, RS1
Lee, YS1
Chu, SWL1
Toh, LZ2
Wong, TTL1
Ekinci, A1
Koc, S1
Erdoğan, AS1
Kesici, H1
Szabó, D1
Kovács, D1
Endrész, V1
Igaz, N1
Jenovai, K1
Spengler, G1
Tiszlavicz, L1
Molnár, J1
Burián, K1
Kiricsi, M1
Rovó, L1
Dong, A1
Han, L1
Shao, Z1
Fan, P1
Zhou, X1
Yuan, H1
Swann, FB1
Singh, S1
Blake, D1
John, V1
Le, C1
Fullerton, M1
Margo, C1
Zhang, Z2
Muddasani, N1
Wall, J1
Satija, C1
Greenberg, E1
Mancera, N1
Zurakowski, D1
Ayyala, RS2
Ali, MJ1
Paulsen, F1
Yoon, SY1
Kim, ES1
Han, GS1
Suh, LH1
Jung, HS1
Liu, L1
Sui, T2
Hong, X1
Wu, X1
Li, NY1
Chen, F1
Dikkers, FG1
Thibeault, SL1
Rao, A1
Chatterjee, S1
Woo, JE1
Park, WC3
Yoo, YH3
Kim, SW2
Chaurasia, S1
Price, MO1
McKee, Y1
Price, FW1
Ma, J1
Li, X2
Zhang, W1
Huang, L1
Chen, M1
Xi, L1
Duan, L1
Quan, D1
Ge, J2
Uyeturk, U1
Gucuk, A1
Firat, T1
Kemahli, E1
Kukner, A1
Ozyalvacli, ME1
Sun, Y1
Ge, Y1
Fu, Y1
Yan, L1
Cai, J1
Shi, K1
Lu, C1
Matsui, Y1
Sunatani, Y1
Hayashi, N1
Okino, K1
Okushi, Y1
Mukai, K1
Adachi, H1
Yamaya, H1
Iwabuchi, K1
Yokoyama, H1
Kinast, RM1
Akula, KK1
Mansberger, SL1
Barker, GT1
Gardiner, SK1
Whitson, E1
DeBarber, AE1
Amoozgar, B1
Lin, SC1
Han, Y1
Kuo, J1
Vural, E1
Yilmaz, M1
Ilbay, K2
Ilbay, G2
Schultheiss, M1
Schnichels, S1
Konrad, EM1
Bartz-Schmidt, KU1
Zahn, G1
Caldirola, P1
Fsadni, MG1
Caram-Lelham, N1
Spitzer, MS1
Alvarado, JA1
Hollander, DA1
Juster, RP1
Lee, LC1
Law, SK1
Celik, SE1
Altan, T1
Celik, S1
Göksu, K1
Ince, I1
Kapran, Z1
Sahiner, N1
Kravitz, DJ1
Qadir, R1
Blake, DA1
Haque, S1
John, VT1
Margo, CE1
Sen, S2
Meteoglu, I1
Ogurlu, M1
Derincegoz, OO1
Derinceoz, OO1
Barutca, S1
Cemil, B3
Tun, K2
Kaptanoglu, E2
Cevirgen, B2
Gurcay, AG1
Kaymaz, F2
Tekdemir, I2
Elner, VM1
Newman-Casey, PA1
Patil, AJ1
Flint, A1
Biswas, J1
Moroi, SE1
Pushparaj, V1
Edward, DP1
Tappeiner, C1
Meyenberg, A1
Goldblum, D1
Mojon, D1
Zingg, JM1
Nesaretnam, K1
Kilchenmann, M1
Frueh, BE1
Comert, A1
Hoehn, R1
Lamparter, J1
Vossmerbaeumer, U1
Breusegem, C1
Spielberg, L1
Van Ginderdeuren, R1
Vandewalle, E1
Renier, C1
Van de Veire, S1
Fieuws, S1
Zeyen, T1
Stalmans, I1
Rabb, CH1
Su, C2
Yao, C1
Lu, S1
Zhang, A1
Teng, G1
Zang, F1
Kocaoglu, B1
Akgun, U1
Nalbantoglu, U1
Poyanlı, O1
Karahan, M1
Kim, TH2
Oh, HC1
Rho, JH2
Ahn, HB1
Jeung, WJ1
Rho, SH2
Knape, RM1
Smith, MF1
Shao, T1
Seet, LF1
Su, R1
Wong, TT1
Ghoneim, EM1
Abd El Hameed, M1
Lukowski, ZL2
Min, J2
Beattie, AR2
Meyers, CA2
Levine, MA2
Stoller, G1
Schultz, GS2
Samuelson, DA2
Sherwood, MB2
Zhang, X1
Zhang, H1
Arslan, S1
Aydemir, O1
Güler, M1
Dağlı, AF1
Löbler, M1
Kastner, C1
Wree, A1
Sternberg, K1
Schmitz, KP1
Guthoff, R1
Hogewind, BF1
Pijl, B1
Hoyng, CB1
Theelen, T1
Aydincak, O1
Yilmaz, MB1
Emmez, H2
Kurt, G3
Sepici, A1
Memis, L2
Baykaner, K2
Gray, SD1
Tritle, N1
Li, W1
Mac, I1
Soltau, JB1
Dogulu, F2
Erdem, O2
Ceviker, N2
Billing, K1
Karagiannis, A1
Selva, D2
Ribeiro, Fde A1
Guaraldo, L1
Borges, Jde P1
Zacchi, FF1
Eckley, CA1
Hyung, SM1
Jung, MS1
Higginbotham, EJ1
Lee, JY3
Stenzel, W3
Ebel, H2
Wedekind, C1
Ernestus, RI3
Klug, N3
Yoon, KC1
Yang, KJ1
Seo, JS1
Lee, SE1
Heo, T1
Chun, BJ1
Jung, S1
Kim, KK1
Ahn, KY1
Yoon, PS1
Singh, K2
Sasson, AR1
Wetherington, RW1
Hoffman, JP1
Ross, EA1
Cooper, H1
Meropol, NJ1
Freedman, G1
Pingpank, JF1
Eisenberg, BL1
Etus, V1
Yildiz, K1
Ceylan, S1
Shetty, RK1
Wartluft, L1
Moster, MR1
Ayyildiz, A1
Nuhoglu, B1
Gülerkaya, B1
Caydere, M1
Ustün, H1
Germiyanoglu, C1
Erol, D1
Francis, BA1
Du, LT1
Najafi, K1
Murthy, R1
Kurumety, U1
Rao, N1
Minckler, DS1
Joshi, AB1
Parrish, RK1
Feuer, WF1
Watson, JC1
Kadri, OA1
Wilcox, MJ1
Cincik, H1
Güngör, A1
Cekin, E1
Saglam, O1
Yildirim, S1
Poyrazoglu, E1
Candan, H1
Aydin, E1
Uckan, S1
Ozdemir, BH1
Uyar, P1
Battelino, S1
Hocevar-Boltezar, I1
Zargi, M1
Epstein, RJ3
Majmudar, PA3
Frucht-Pery, J1
Raiskup, F1
Ilsar, M1
Landau, D1
Orucov, F1
Solomon, A1
Mietz, H2
Krieglstein, GK2
Löhr, M2
Stützer, H2
Nakamura, T1
Inatomi, T1
Sekiyama, E1
Ang, LP1
Yokoi, N1
Kinoshita, S1
Impekoven, P1
Theisohn, M1
Reithmeier, T1
Hwang, JM1
Kee, C1
Leibovitch, I1
Deka, A1
Bhattacharjee, K1
Bhuyan, SK1
Barua, CK1
Bhattacharjee, H1
Khaund, G1
Goldberg, I1
Ritch, R2
Yildiz, KH1
Gezen, F1
Is, M1
Cukur, S1
Dosoglu, M1
Anand, N1
Arora, S1
Aytar, MH1
Baykaner, MK1
Woo, JM1
Lee, DJ1
Park, JM1
Jeong, WJ1
Farid, M1
Morishige, N1
Lam, L1
Wahlert, A1
Steinert, RF1
Jester, JV1
Glover, TL1
Nasisse, MP1
Davidson, MG1
Lee, DA2
Susanna, R1
Nicolela, MT1
Takahashi, WY1
Guinda Sevillano, C1
Arnáiz Esteban, F1
Fernández Rosáenz, J1
Pérez Arbej, JA1
Martínez Pérez, E1
Nogueras Gimeno, MA1
Espuela Orgaz, R1
Shields, MB1
Scroggs, MW1
Sloop, CM1
Simmons, RB1
Caronia, RM1
Liebmann, JM1
Friedman, R1
Cohen, H1
Arnold, G1
Kirchhof, B1
Diestelhorst, M1
Kiremitçi-Gümüşderelioglu, M1
Gökçe, M1
Akata, RF1
MacLeod, JD1
Chang, MR1
Cheng, Q1
Budenz, DL1
Pyfer, M1
Gordon, J1
Piltz-Seymour, J1
Keates, EU1
Forstot, SL1
Dennis, RF2
Nirankari, VS1
Damiano, RE1
Brenart, R1
Kapetansky, FM1
Kapetansky, SD1
Azar, DT1
Jain, S1
Raviv, T1
Maldonado, MJ1
Hefetz, L1
Naveh, N1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Open-enrollment, Prospective Study of Endothelial Keratoplasty Outcomes[NCT00800111]2,593 participants (Actual)Interventional2008-02-29Completed
A Pilot Study Using Neoadjuvant Proton Beam Radiation Therapy and Chemotherapy for Marginally Resectable Carcinoma of the Pancreas[NCT00763516]8 participants (Actual)Interventional2009-02-28Completed
Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Primary Open Angle Glaucoma: a Three-year Comparative Study[NCT01633775]100 participants (Actual)Observational2007-12-31Completed
Analysis of Effect of Low Level Laser Therapy in Spinal Surgery[NCT02529657]48 participants (Actual)Interventional2013-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for mitomycin and Fibrosis

ArticleYear
Animal models and drug candidates for use in glaucoma filtration surgery: A systematic review.
    Experimental eye research, 2022, Volume: 217

    Topics: Animals; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pressure; Mice; Mitomycin; Models, Anima

2022
Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK.
    Experimental eye research, 2020, Volume: 200

    Topics: Alkylating Agents; Corneal Opacity; Corneal Stroma; Fibrosis; Humans; Lasers, Excimer; Mitomycin; My

2020
History, presence, and future of mitomycin C in glaucoma filtration surgery.
    Current opinion in ophthalmology, 2021, Mar-01, Volume: 32, Issue:2

    Topics: Alkylating Agents; Drug Delivery Systems; Fibrosis; Filtering Surgery; Glaucoma; History, 20th Centu

2021
Ultrastructure of the lacrimal drainage system in health and disease: A major review.
    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2019, Volume: 224

    Topics: Bacteria; Biofilms; Cicatrix; Constriction, Pathologic; Dacryocystorhinostomy; Fibrinolytic Agents;

2019
Glaucoma-filtering bleb infections.
    Current opinion in ophthalmology, 2003, Volume: 14, Issue:2

    Topics: Anti-Bacterial Agents; Drug Administration Schedule; Endophthalmitis; Fibrosis; Filtering Surgery; F

2003
Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery.
    Current opinion in ophthalmology, 2004, Volume: 15, Issue:2

    Topics: Antimetabolites, Antineoplastic; Cataract Extraction; Fibrosis; Fluorouracil; Glaucoma; Glaucoma Dra

2004
Antifibrosis agents and glaucoma surgery.
    Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:11

    Topics: Animals; Conjunctiva; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomycin

1994
Basic science and clinical aspects of wound healing in glaucoma filtering surgery.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1998, Volume: 14, Issue:1

    Topics: Culture Techniques; Fibroblasts; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomy

1998
[Use of drugs inhibiting fibrosis after trabeculectomy].
    Harefuah, 1992, Nov-15, Volume: 123, Issue:10

    Topics: Adrenal Cortex Hormones; Aminopropionitrile; Fibrosis; Fluorouracil; Humans; Mitomycin; Postoperativ

1992

Trials

6 trials available for mitomycin and Fibrosis

ArticleYear
Inhibition of epidural fibrosis after microendoscopic discectomy with topical application of mitomycin C: a randomized, controlled, double-blind trial.
    Journal of neurosurgery. Spine, 2013, Volume: 18, Issue:5

    Topics: Administration, Cutaneous; Adult; Diskectomy; Double-Blind Method; Epidural Space; Fibrosis; Humans;

2013
Mitomycin protection of peridural fibrosis in lumbar disc surgery.
    Journal of neurosurgery. Spine, 2008, Volume: 9, Issue:3

    Topics: Adult; Diskectomy; Dura Mater; Female; Fibrosis; Follow-Up Studies; Humans; Lumbar Vertebrae; Magnet

2008
Preoperative nonsteroidal anti-inflammatory drug or steroid and outcomes after trabeculectomy: a randomized controlled trial.
    Ophthalmology, 2010, Volume: 117, Issue:7

    Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antihyper

2010
Purified triamcinolone acetonide as antifibrotic adjunct in glaucoma filtering surgery.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2013, Volume: 251, Issue:4

    Topics: Aged; Alkylating Agents; Conjunctiva; Female; Fibrosis; Glaucoma, Angle-Closure; Glaucoma, Open-Angl

2013
Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence.
    American journal of ophthalmology, 2006, Volume: 141, Issue:6

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Combined Modality Therapy; Conjunctiva; Female; Fibrosis;

2006
Postoperative application of mitomycin c improves the complete success rate of primary trabeculectomy: a prospective, randomized trial.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2006, Volume: 244, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Female; Fibrosis; Follow-Up Studies; Glaucoma; Hu

2006

Other Studies

101 other studies available for mitomycin and Fibrosis

ArticleYear
Effects of topical docosahexaenoic acid on postoperative fibrosis in an animal model of glaucoma filtration surgery.
    Acta ophthalmologica, 2023, Volume: 101, Issue:1

    Topics: Animals; Disease Models, Animal; Docosahexaenoic Acids; Fibrosis; Filtering Surgery; Glaucoma; Intra

2023
Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery.
    Experimental eye research, 2022, Volume: 225

    Topics: Aspirin; Cell Transdifferentiation; Cells, Cultured; Chromatography, Liquid; Cicatrix; Collagen; Cyt

2022
The anti-scar effect of tyrosine-kinase inhibitor nintedanib in experimental glaucoma filtration surgery in rabbits.
    Experimental eye research, 2023, Volume: 229

    Topics: Animals; Cicatrix; Conjunctiva; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pressure; Matrix

2023
Outcomes of Open Bleb Revision After PreserFlo MicroShunt Failure in Patients With Glaucoma.
    Journal of glaucoma, 2023, 08-01, Volume: 32, Issue:8

    Topics: Fibrosis; Glaucoma; Humans; Infant; Intraocular Pressure; Mitomycin; Retrospective Studies; Tonometr

2023
Tube Shunt Revision With Excision of Fibrotic Capsule Using Mitomycin C With and Without Ologen-a Collagen Matrix Implant: A 3-Year Follow-up Study.
    Journal of glaucoma, 2019, Volume: 28, Issue:11

    Topics: Adult; Aged; Alkylating Agents; Collagen; Female; Fibrosis; Follow-Up Studies; Glaucoma; Glaucoma Dr

2019
Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C.
    Investigative ophthalmology & visual science, 2019, 11-01, Volume: 60, Issue:14

    Topics: Actins; Alkylating Agents; Blotting, Western; Cell Movement; Cell Survival; Cells, Cultured; Fibrobl

2019
[Systems Biology in Ophthalmology - Innovative Drug Identification for the Specific Prevention of Postoperative Fibrosis].
    Klinische Monatsblatter fur Augenheilkunde, 2019, Volume: 236, Issue:12

    Topics: Actins; Fibroblasts; Fibrosis; Humans; Mitomycin; Ophthalmologic Surgical Procedures; Ophthalmology;

2019
The Effect of Mitomycin C on Reducing Endometrial Fibrosis for Intrauterine Adhesion.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, Jan-02, Volume: 26

    Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Survival; Collagen Type I; Disease Models, Animal;

2020
Antifibrotic role of low-dose mitomycin-c-induced cellular senescence in trabeculectomy models.
    PloS one, 2020, Volume: 15, Issue:6

    Topics: Animals; Biomarkers; Cell Survival; Cell Transdifferentiation; Cellular Senescence; Dose-Response Re

2020
Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection.
    BioMed research international, 2020, Volume: 2020

    Topics: Anastomosis, Surgical; Animals; Cicatrix; Collagen; Decorin; Disease Models, Animal; Dogs; Extracell

2020
September consultation #2.
    Journal of cataract and refractive surgery, 2020, Volume: 46, Issue:10

    Topics: Fibrosis; Humans; Mitomycin; Referral and Consultation; Refractive Errors; Vision Tests

2020
Novel combination therapy reduces subconjunctival fibrosis after glaucoma filtration surgery in the rabbit model.
    Clinical & experimental ophthalmology, 2021, Volume: 49, Issue:1

    Topics: Animals; Conjunctiva; Disease Models, Animal; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pre

2021
Safety and efficacy of combination of suberoylamilide hydroxyamic acid and mitomycin C in reducing pro-fibrotic changes in human corneal epithelial cells.
    Scientific reports, 2021, 02-23, Volume: 11, Issue:1

    Topics: Adult; Apoptosis; Cells, Cultured; Collagen Type IV; Epithelium, Corneal; Female; Fibrosis; Humans;

2021
Novel Bacterial Cellulose Membrane to Reduce Fibrosis Following Trabeculectomy.
    Journal of glaucoma, 2021, 11-01, Volume: 30, Issue:11

    Topics: Animals; Cellulose; Conjunctiva; Fibrosis; Intraocular Pressure; Mitomycin; Rabbits; Sclera; Trabecu

2021
MMC controlled-release membranes attenuate epidural scar formation in rat models after laminectomy.
    Molecular medicine reports, 2017, Volume: 15, Issue:6

    Topics: Animals; Cicatrix; Delayed-Action Preparations; Disease Models, Animal; Epidural Space; Fibrosis; La

2017
Inhibition of Monocyte Chemoattractant Protein 1 Prevents Conjunctival Fibrosis in an Experimental Model of Glaucoma Filtration Surgery.
    Investigative ophthalmology & visual science, 2017, 07-01, Volume: 58, Issue:9

    Topics: Animals; Antifibrinolytic Agents; Cell Survival; Chemokine CCL2; Collagen; Conjunctiva; Disease Mode

2017
Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats.
    International journal of pediatric otorhinolaryngology, 2018, Volume: 105

    Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Female; Fibrosis; Inflammation; Laryngostenosi

2018
Antifibrotic effect of mitomycin-C on human vocal cord fibroblasts.
    The Laryngoscope, 2019, Volume: 129, Issue:7

    Topics: Actins; Cell Culture Techniques; Cell Line; Fibroblasts; Fibrosis; Humans; Laryngectomy; Mitomycin;

2019
Glaucoma Drainage Device Coated with Mitomycin C Loaded Opal Shale Microparticles to Inhibit Bleb Fibrosis.
    ACS applied materials & interfaces, 2019, Mar-13, Volume: 11, Issue:10

    Topics: Adsorption; Cell-Derived Microparticles; Coated Materials, Biocompatible; Drug Liberation; Fibrosis;

2019
Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model.
    Journal of glaucoma, 2019, Volume: 28, Issue:6

    Topics: Absorbable Implants; Animals; Drug Delivery Systems; Drug Implants; Drug Liberation; Endophthalmitis

2019
Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis.
    PloS one, 2019, Volume: 14, Issue:7

    Topics: Animals; Conjunctiva; Conjunctival Diseases; Cornea; Disease Models, Animal; Fibroblasts; Fibrosis;

2019
Dose-dependent effect of mitomycin C on human vocal fold fibroblasts.
    Head & neck, 2014, Volume: 36, Issue:3

    Topics: Alkylating Agents; Blotting, Western; Cicatrix; Dose-Response Relationship, Drug; Fibrosis; Humans;

2014
Epiconjunctival mitomycin-C application for early failing filtering blebs.
    Seminars in ophthalmology, 2014, Volume: 29, Issue:1

    Topics: Alkylating Agents; Conjunctiva; Female; Fibrosis; Glaucoma; Humans; Intraocular Pressure; Male; Midd

2014
The efficacy of co-treatment with suberoylanilide hydroxamic acid and mitomycin C on corneal scarring after therapeutic keratectomy: an animal study.
    Current eye research, 2014, Volume: 39, Issue:4

    Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Cicatrix; Corneal Diseases; Cytokin

2014
Descemet membrane endothelial keratoplasty combined with epithelial debridement and mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy.
    Cornea, 2014, Volume: 33, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Basement Membrane; Corneal Endothelial Cell Loss;

2014
CSM enhances the filtration bleb survival in rabbit model of experimental glaucoma surgery.
    Current eye research, 2014, Volume: 39, Issue:10

    Topics: Alkylating Agents; Animals; Chitosan; Conjunctiva; Disease Models, Animal; Drug Carriers; Fibrosis;

2014
Effect of mitomycin, bevacizumab, and 5-Fluorouracil to inhibit urethral fibrosis in a rabbit model.
    Journal of endourology, 2014, Volume: 28, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; Collagen; Disease

2014
Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE.
    European journal of pharmacology, 2015, Oct-15, Volume: 765

    Topics: Animals; Apoptosis; Cells, Cultured; Cicatrix; Down-Regulation; Epidural Space; Failed Back Surgery

2015
DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts.
    Clinical and experimental nephrology, 2016, Volume: 20, Issue:3

    Topics: Adult; Aged; Allografts; Capillaries; Cells, Cultured; Collagen; DNA Breaks, Double-Stranded; Female

2016
Concentration Accuracy of Compounded Mitomycin C for Ophthalmic Surgery.
    JAMA ophthalmology, 2016, Volume: 134, Issue:2

    Topics: Alkylating Agents; Chromatography, High Pressure Liquid; Drug Compounding; Drug Storage; Fibrosis; G

2016
A role for antimetabolites in glaucoma tube surgery: current evidence and future directions.
    Current opinion in ophthalmology, 2016, Volume: 27, Issue:2

    Topics: Animals; Antimetabolites; Fibrosis; Fluorouracil; Glaucoma; Humans; Mitomycin; Trabeculectomy

2016
Prevention of Epidural Fibrosis in Rats by Local Administration of Mitomycin C or Daunorubicin.
    Turkish neurosurgery, 2016, Volume: 26, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Cicatrix; Daunorubicin; Disease Models, Animal; Female; Fibros

2016
α5β1-Integrin inhibitor (CLT-28643) effective in rabbit trabeculectomy model.
    Acta ophthalmologica, 2017, Volume: 95, Issue:1

    Topics: Administration, Topical; Alkylating Agents; Aminoquinolines; Animals; Collagen; Conjunctiva; Disease

2017
Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes.
    American journal of ophthalmology, 2008, Volume: 146, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkylating Agents; Cataract Extraction; Combined Modalit

2008
A modified technique of Ahmed glaucoma valve implantation with adjunctive use of antifibrotic agents.
    American journal of ophthalmology, 2008, Volume: 146, Issue:2

    Topics: Alkylating Agents; Combined Modality Therapy; Fibrosis; Fluorouracil; Glaucoma; Glaucoma Drainage Im

2008
Creation of a drug-coated glaucoma drainage device using polymer technology: in vitro and in vivo studies.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2009, Volume: 127, Issue:4

    Topics: Alkylating Agents; Animals; Conjunctiva; Cornea; Drug Delivery Systems; Fibrosis; Glaucoma Drainage

2009
Topical heparin: a promising agent for the prevention of tracheal stenosis in airway surgery.
    The Journal of surgical research, 2009, Volume: 157, Issue:1

    Topics: Animals; Disease Models, Animal; Fibrinolytic Agents; Fibrosis; Granulation Tissue; Heparin; Mitomyc

2009
The effect of mitomycin C as fibrosis preventive agent during craniectomies.
    British journal of neurosurgery, 2009, Volume: 23, Issue:3

    Topics: Administration, Topical; Animals; Arachnoid; Bone Regeneration; Craniotomy; Dura Mater; Female; Fibr

2009
Aberrant wound-healing response in mitomycin C-treated leaking blebs: a histopathologic study.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2009, Volume: 127, Issue:8

    Topics: Antibiotics, Antineoplastic; Conjunctival Diseases; Female; Fibroblasts; Fibrosis; Glaucoma; Humans;

2009
Antifibrotic effects of tocotrienols on human Tenon's fibroblasts.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2010, Volume: 248, Issue:1

    Topics: Cell Count; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Dose-Response Relationship

2010
Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model.
    Journal of neurosurgery. Spine, 2009, Volume: 11, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Dura Mater; Fibrosis; Lam

2009
Seizures following subconjunctival 5-FU therapy.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2011, Volume: 249, Issue:1

    Topics: Aged; Alkylating Agents; Antimetabolites; Combined Modality Therapy; Conjunctiva; Fibrosis; Fluorour

2011
Failed back syndrome and epidural fibrosis.
    The spine journal : official journal of the North American Spine Society, 2010, Volume: 10, Issue:5

    Topics: Animals; Drug Delivery Systems; Epidural Space; Fibrosis; Humans; Low Back Pain; Lumbar Vertebrae; M

2010
Study on the optimal concentration of topical mitomycin-C in preventing postlaminectomy epidural adhesion.
    European journal of pharmacology, 2010, Aug-25, Volume: 640, Issue:1-3

    Topics: Administration, Topical; Animals; Cicatrix; Dose-Response Relationship, Drug; Epidural Space; Evoked

2010
Adhesion reduction after knee surgery in a rat model by mitomycin C.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2011, Volume: 19, Issue:1

    Topics: Animals; Cell Proliferation; Cicatrix; Disease Models, Animal; Female; Fibrosis; Foreign-Body Reacti

2011
An experimental study of rabbit conjunctival epithelial toxicity using co-treatment with mitomycin-C and a histone deacetylase inhibitor.
    Archives of pharmacal research, 2010, Volume: 33, Issue:8

    Topics: Alkylating Agents; Animals; Apoptosis; Cells, Cultured; Conjunctiva; Drug Therapy, Combination; Epit

2010
Antimetabolite application technique in trabeculectomy surgery.
    Clinical & experimental ophthalmology, 2011, Volume: 39, Issue:6

    Topics: Antimetabolites; Drug Delivery Systems; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraoperative Car

2011
Target drug delivery system as a new scarring modulation after glaucoma filtration surgery.
    Diagnostic pathology, 2011, Jul-08, Volume: 6

    Topics: Chitosan; Cicatrix; Drug Carriers; Drug Delivery Systems; Fibrinolytic Agents; Fibrosis; Filtering S

2011
In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon's fibroblasts: comparisons with mitomycin C.
    Journal of cellular and molecular medicine, 2012, Volume: 16, Issue:6

    Topics: Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Cicatrix; Collagen Ty

2012
Needling augmented with topical application of mitomycin C for management of bleb failure.
    Journal of glaucoma, 2011, Volume: 20, Issue:8

    Topics: Administration, Topical; Alkylating Agents; Combined Modality Therapy; Conjunctiva; Female; Fibrosis

2011
Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model.
    Journal of glaucoma, 2013, Volume: 22, Issue:2

    Topics: Alkylating Agents; Animals; Antibodies, Monoclonal, Humanized; Cicatrix; Conjunctiva; Disease Models

2013
Effect of topical application of mitomycin-C on wound healing in a postlaminectomy rat model: an experimental study.
    European journal of pharmacology, 2012, Jan-05, Volume: 674, Issue:1

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Blood Vessels; Cell Count; Fibroblasts; Fib

2012
Modulation of postoperative scarring with tacrolimus and octreotide in experimental glaucoma filtration surgery.
    Current eye research, 2012, Volume: 37, Issue:3

    Topics: Administration, Topical; Alkylating Agents; Animals; Cicatrix; Conjunctival Diseases; Disease Models

2012
Prevention of ocular scarring post glaucoma filtration surgery using the inflammatory cell and platelet binding modulator saratin in a rabbit model.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Administration, Topical; Animals; Blood Platelets; Cicatrix; Disease Models, Animal; Eye; Fibrosis;

2012
Different fibroblast subpopulations of the eye: a therapeutic target to prevent postoperative fibrosis in glaucoma therapy.
    Experimental eye research, 2012, Volume: 100

    Topics: Adipose Tissue; Cell Culture Techniques; Cell Proliferation; Choroid; Extracellular Matrix Proteins;

2012
The effect of temozolomide on the prevention of epidural fibrosis developing after lumbar laminectomy in rats.
    Turkish neurosurgery, 2012, Volume: 22, Issue:6

    Topics: Animals; Dacarbazine; Dura Mater; Epidural Space; Fibroblasts; Fibrosis; Laminectomy; Lumbar Vertebr

2012
The effect of mitomycin on extracellular matrix proteins in a rat wound model.
    The Laryngoscope, 2003, Volume: 113, Issue:2

    Topics: Administration, Topical; Animals; Down-Regulation; Extracellular Matrix Proteins; Fibrosis; Gene Exp

2003
Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits.
    Journal of neurosurgery, 2003, Volume: 99, Issue:1 Suppl

    Topics: Administration, Topical; Alkylating Agents; Animals; Dura Mater; Female; Fibrosis; Laminectomy; Male

2003
Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia.
    American journal of ophthalmology, 2003, Volume: 136, Issue:4

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Corneal Diseases; Female; Fibrosis; Humans; La

2003
Clinical and histological healing of surgical wounds treated with mitomycin C.
    The Laryngoscope, 2004, Volume: 114, Issue:1

    Topics: Administration, Topical; Animals; Antibiotics, Antineoplastic; Dermatologic Surgical Procedures; Fib

2004
Management of hypotony after trabeculectomy with mitomycin C.
    Korean journal of ophthalmology : KJO, 2003, Volume: 17, Issue:2

    Topics: Fibrosis; Humans; Mitomycin; Ocular Hypotension; Retrospective Studies; Trabeculectomy

2003
The case against glaucoma drainage implant surgery in patients with a poor prognosis for standard filtering procedure.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2004, Volume: 122, Issue:1

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Fibrosis; Fluorouracil; Glaucoma; Glau

2004
Mitomycin C in preventing spinal epidural fibrosis in a laminectomy model in rats.
    Journal of neurosurgery, 2004, Volume: 100, Issue:1 Suppl Sp

    Topics: Alkylating Agents; Animals; Back Pain; Dose-Response Relationship, Drug; Dura Mater; Epidural Space;

2004
Effect of human RAD50 gene therapy on glaucoma filtering surgery in rabbit eye.
    Current eye research, 2004, Volume: 28, Issue:3

    Topics: Animals; Cell Division; Conjunctiva; DNA-Binding Proteins; Fibroblasts; Fibrosis; Genetic Therapy; G

2004
Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: analysis of histopathology and outcome.
    International journal of gastrointestinal cancer, 2003, Volume: 34, Issue:2-3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Deox

2003
Topical application of mitomycin C prevents epineural scar formation in rats.
    Neurosurgical review, 2005, Volume: 28, Issue:2

    Topics: Administration, Topical; Animals; Cicatrix; Dissection; Fibrosis; Male; Mitomycin; Nucleic Acid Synt

2005
Slit-lamp needle revision of failed filtering blebs using high-dose mitomycin C.
    Journal of glaucoma, 2005, Volume: 14, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Conjunct

2005
Effect of intraurethral Mitomycin-C on healing and fibrosis in rats with experimentally induced urethral stricture.
    International journal of urology : official journal of the Japanese Urological Association, 2004, Volume: 11, Issue:12

    Topics: Animals; Antibiotics, Antineoplastic; Cicatrix; Disease Models, Animal; Dose-Response Relationship,

2004
Histopathologic features of conjunctival filtering blebs.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2005, Volume: 123, Issue:2

    Topics: Cell Count; Conjunctiva; Epithelial Cells; Fibrosis; Fluorouracil; Glaucoma; Goblet Cells; Humans; M

2005
2002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use.
    Journal of glaucoma, 2005, Volume: 14, Issue:2

    Topics: Antineoplastic Agents; Drug Utilization; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Glauco

2005
Effects of mitomycin C on glaucoma filtration capsules.
    Biomedical sciences instrumentation, 2005, Volume: 41

    Topics: Animals; Antibiotics, Antineoplastic; Chemotherapy, Adjuvant; Fibrosis; Glaucoma; Glaucoma Drainage

2005
Effects of topical application of mitomycin-C and 5-fluorouracil on myringotomy in rats.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2005, Volume: 26, Issue:3

    Topics: Administration, Topical; Animals; Antimetabolites; Fibrosis; Fluorouracil; Middle Ear Ventilation; M

2005
Mitomycin C effect on fibrous adhesions of rabbit temporomandibular joint.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2005, Volume: 133, Issue:5

    Topics: Animals; Biopsy, Needle; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrati

2005
Intraoperative use of mitomycin C in fibrous atresia of the external auditory canal.
    Ear, nose, & throat journal, 2005, Volume: 84, Issue:12

    Topics: Adult; Constriction, Pathologic; Ear Canal; Female; Fibrosis; Follow-Up Studies; Humans; Male; Middl

2005
Alternative approach to the treatment of subepithelial fibrosis following radial keratotomy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2006, Volume: 124, Issue:2

    Topics: Antibiotics, Antineoplastic; Corneal Diseases; Epithelium, Corneal; Fibrosis; Humans; Keratotomy, Ra

2006
The role of mitomycin C in reducing recurrence of epidural fibrosis after repeated operation in a laminectomy model in rats.
    Journal of neurosurgery. Spine, 2006, Volume: 4, Issue:4

    Topics: Alkylating Agents; Animals; Chi-Square Distribution; Epidural Space; Fibrosis; Laminectomy; Male; Mi

2006
Novel clinical application of sterilized, freeze-dried amniotic membrane to treat patients with pterygium.
    Acta ophthalmologica Scandinavica, 2006, Volume: 84, Issue:3

    Topics: Adult; Aged; Amnion; Conjunctiva; Epithelium; Female; Fibrosis; Freeze Drying; Humans; Male; Middle

2006
The effect of mitomycin C in reducing epidural fibrosis after lumbar laminectomy in rats.
    Journal of neurosurgery. Spine, 2006, Volume: 5, Issue:1

    Topics: Alkylating Agents; Animals; Epidural Space; Fibrosis; Laminectomy; Lumbar Vertebrae; Male; Mitomycin

2006
Injection of cultured autologous fibroblasts into the subconjunctival space of rabbits treated with mitomycin C.
    American journal of ophthalmology, 2006, Volume: 142, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Atrophy; Cells, Cultured; Conjunctiva; Conjunctival Diseases;

2006
Mitomycin C in dacryocystorhinostomy.
    Clinical & experimental ophthalmology, 2006, Volume: 34, Issue:6

    Topics: Alkylating Agents; Cell Proliferation; Combined Modality Therapy; Dacryocystorhinostomy; Fibrosis; H

2006
Effect of mitomycin C on ostium in dacryocystorhinostomy.
    Clinical & experimental ophthalmology, 2006, Volume: 34, Issue:6

    Topics: Adolescent; Adult; Alkylating Agents; Cell Proliferation; Child; Child, Preschool; Combined Modality

2006
Mietz H, Krieglstein GK: Postoperative application of mitomycin C improves the complete success rate of primary trabeculectomy: a prospective, randomized trial. Graefes Arch Clin Exp Ophthalmol 2006; 244: 1429-1436.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007, Volume: 245, Issue:8

    Topics: Alkylating Agents; Fibrosis; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Mitomycin; P

2007
Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2007, Volume: 16, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Cell Count; Cyclosporine; Epidural Space; Fibroblasts; Fibrosi

2007
Surgical revision of failed filtration surgery with mitomycin C augmentation.
    Journal of glaucoma, 2007, Volume: 16, Issue:5

    Topics: Aged; Antihypertensive Agents; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; F

2007
A comparison of the local effectiveness of mitomycin C, aprotinin, and Adcon-L in experimental peridural fibrosis.
    Surgical neurology, 2008, Volume: 70, Issue:6

    Topics: Animals; Aprotinin; Dura Mater; Epidural Space; Fibrosis; Laminectomy; Lumbar Vertebrae; Male; Mitom

2008
Co-treatment of suberoylanilide hydroxamic acid and mitomycin-C induces the apoptosis of rabbit tenon's capsule fibroblast and improves the outcome of glaucoma filtration surgery.
    Current eye research, 2008, Volume: 33, Issue:3

    Topics: Alkylating Agents; Animals; Apoptosis; bcl-Associated Death Protein; Blotting, Western; Caspase 3; C

2008
Detection of corneal fibrosis by imaging second harmonic-generated signals in rabbit corneas treated with mitomycin C after excimer laser surface ablation.
    Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:10

    Topics: Alkylating Agents; Animals; Combined Modality Therapy; Cornea; Corneal Opacity; Fibrillar Collagens;

2008
Effects of topically applied mitomycin-C on intraocular pressure, facility of outflow, and fibrosis after glaucoma filtration surgery in clinically normal dogs.
    American journal of veterinary research, 1995, Volume: 56, Issue:7

    Topics: Animals; Collagen; Conjunctiva; Connective Tissue; Dogs; Drug Implants; Fibroblasts; Fibrosis; Filte

1995
Mitomycin C as adjunctive therapy with glaucoma implant surgery.
    Ophthalmic surgery, 1994, Volume: 25, Issue:7

    Topics: Adult; Aged; Biocompatible Materials; Chemotherapy, Adjuvant; Female; Fibrosis; Follow-Up Studies; G

1994
[Fibrino-necrotic ulcers in endovesical chemoprophylaxis in superficial bladder carcinoma: our case histories].
    Actas urologicas espanolas, 1994, Volume: 18, Issue:5

    Topics: Administration, Intravesical; Aged; Carcinoma; Combined Modality Therapy; Female; Fibrosis; Follow-U

1994
Clinical and histopathologic observations concerning hypotony after trabeculectomy with adjunctive mitomycin C.
    American journal of ophthalmology, 1993, Dec-15, Volume: 116, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Conjunctiva; Female; Fibrosis

1993
Trabeculectomy at the inferior limbus.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Chemotherapy, Adjuvant; Child; Chi

1996
Histopathology of episcleral fibrosis after trabeculectomy with and without mitomycin C.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1996, Volume: 234, Issue:6

    Topics: Actins; Adult; Aged; Antibiotics, Antineoplastic; Cell Division; Child; Connective Tissue; Female; F

1996
A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies.
    Journal of biomaterials science. Polymer edition, 1996, Volume: 7, Issue:10

    Topics: Administration, Topical; Animals; Antibiotics, Antineoplastic; Conjunctiva; Cornea; Delayed-Action P

1996
Corneal safety-valve incision in mitomycin filtering surgery.
    Ophthalmology, 1998, Volume: 105, Issue:1

    Topics: Antibiotics, Antineoplastic; Cornea; Fibrosis; Filtering Surgery; Humans; Intraocular Pressure; Intr

1998
Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents.
    Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:5

    Topics: Aged; Cataract; Chemotherapy, Adjuvant; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraocular Pressu

1999
Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery.
    Ophthalmology, 2000, Volume: 107, Issue:1

    Topics: Administration, Topical; Adult; Debridement; Epithelium, Corneal; Female; Fibrosis; Humans; Keratoto

2000
Antimetabolite use in revising failing filtering blebs.
    Seminars in ophthalmology, 1999, Volume: 14, Issue:3

    Topics: Anterior Eye Segment; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Fibrosis; Glaucoma, O

1999
Topical MMC for subepithelial fibrosis after refractive corneal surgery.
    Ophthalmology, 2001, Volume: 108, Issue:2

    Topics: Administration, Topical; Epithelium, Corneal; Fibrosis; Humans; Lasers, Excimer; Mitomycin; Photoref

2001
Subepithelial fibrosis after RK.
    Journal of cataract and refractive surgery, 2000, Volume: 26, Issue:10

    Topics: Alkylating Agents; Corneal Diseases; Debridement; Epithelium, Corneal; Fibrosis; Humans; Keratotomy,

2000
Intraoperative MMC after excimer laser surgery for myopia.
    Ophthalmology, 2002, Volume: 109, Issue:5

    Topics: Administration, Topical; Antibiotics, Antineoplastic; Epithelium, Corneal; Fibrosis; Humans; Intraop

2002