| Assay ID | Title | Year | Journal | Article |
|---|
| AID61010 | Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. |
| AID40548 | Binding affinity against Beta-1 adrenergic receptor | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID272398 | Activity at human dopamine D4.4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production | 2006 | Journal of medicinal chemistry, Nov-16, Volume: 49, Issue:23
| trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
| AID36321 | Binding affinity against Alpha-1 adrenergic receptor | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID64778 | Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. |
| AID272394 | Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production | 2006 | Journal of medicinal chemistry, Nov-16, Volume: 49, Issue:23
| trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
| AID232940 | Binding selectivity against alpha-2/D1 receptor. | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID61347 | Binding affinity of compound towards dopamine receptor D1 was determined in rat striatal homogenate using [3H]SCH-23390 as radioligand | 1996 | Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
| 9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore. |
| AID183955 | Effect on cAMP synthesis in rat striatal membranes as increase above basal value at a concentration of 10 uM in the presence of 1 uM of SCH 23390. | 1995 | Journal of medicinal chemistry, Jan-20, Volume: 38, Issue:2
| Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands. |
| AID61196 | Tested for its affinity towards Dopamine receptor D1 in rat striatal membrane | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
| AID63211 | Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1 | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID34588 | Intrinsic activity measured as ability to stimulate dopamine sensitive Adenylate cyclase activity was measured in rat striatum. | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. |
| AID64784 | Binding affinity towards Dopamine receptor D2 by displacing [3H]spiperone radio-ligand in rat striatal membranes by using radioligand competition assay. | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13
| Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H- benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy- 1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10- dihydro-1,2-dihydroxyanthracene as conformationa |
| AID452083 | Displacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation counting | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID64779 | Affinity towards Dopamine receptor D2 was evaluated in rat striatal membrane using [3H]spiperone as radioligand | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. |
| AID637502 | Selectivity ratio of Ki for dopamine D1 receptor to Ki for dopamine D2 receptor | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. |
| AID63348 | Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID61352 | Tested for binding affinity towards Dopamine receptor D1 labelled by [3H]- SCH 23390 as radioligand | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
| AID61862 | In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID63344 | Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID272399 | Intrinsic activity at human dopamine D4.4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production relative to dopamine | 2006 | Journal of medicinal chemistry, Nov-16, Volume: 49, Issue:23
| trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
| AID617955 | Displacement of [3H]-N-methylspiperone from dopamine D2-like receptor in pig striatal tissue homogenates after 30 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. |
| AID61330 | Affinity on C6 glioma cells transfected with Dopamine receptor D2L | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. |
| AID695381 | Displacement of [3H]-SCH-23390 from dopamine D1 like receptor in pig striatal homogenates after 30 mins by scintillation counting | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. |
| AID64925 | In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes. | 2000 | Journal of medicinal chemistry, Aug-10, Volume: 43, Issue:16
| CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
| AID64785 | The compound is evaluated for the affinity towards Dopamine receptor D2, using [3H]-spiperone as ligand on rat striatal membranes. | 1997 | Journal of medicinal chemistry, Jul-04, Volume: 40, Issue:14
| Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine. |
| AID233475 | Hill slope was determined for the compound in D2 receptor binding assay | 1996 | Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
| 9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore. |
| AID63066 | Binding affinity to human Dopamine receptor D2 by using radioligand [3H]spiperone in LTK cells | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID61858 | Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID64301 | In vitro binding affinity against Dopamine receptor D2 like from rat caudate membrane using [3H]-spiperone as radioligand | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID34584 | Effective concentration as Adenylate cyclase activity was measured in rat homogenate | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. |
| AID272397 | Intrinsic activity at rat dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production relative to dopamine | 2006 | Journal of medicinal chemistry, Nov-16, Volume: 49, Issue:23
| trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
| AID272396 | Activity at rat dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production | 2006 | Journal of medicinal chemistry, Nov-16, Volume: 49, Issue:23
| trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
| AID34596 | Effective concentration against adenylate cyclase | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
| AID62748 | Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D2 | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID63040 | Affinity towards Dopamine receptor D1 | 1998 | Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22
| CoMFA-based prediction of agonist affinities at recombinant D1 vs D2 dopamine receptors. |
| AID1593409 | Bias factor, transduction co-efficient for agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation to agonist activity at recombinant C-terminal RLuc8-fused huma | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7
| Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D |
| AID64781 | Binding affinity of compound towards Dopamine receptor D2 was determined in rat striatal homogenate using [3H]- spiperone as radioligand | 1996 | Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
| 9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore. |
| AID64607 | Tested for its affinity towards D2 receptor in rat striatal membrane | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
| AID272393 | Displacement of [3H]spiperone from dopamine D2-like receptor in porcine striata homogenate | 2006 | Journal of medicinal chemistry, Nov-16, Volume: 49, Issue:23
| trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
| AID34315 | Stimulation of Adenylate cyclase from rat striatal membranes | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. |
| AID611559 | Selectivity ratio Ki for dopamine D2 like receptor in porcine striatal membranes to Ki for dopamine D1 like receptor in porcine striatal membranes | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. |
| AID64282 | Displacement of [3H]- -spiperone from Dopamine receptor D2 in rat striatum | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. |
| AID64917 | In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes. | 2000 | Journal of medicinal chemistry, Aug-10, Volume: 43, Issue:16
| CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
| AID183956 | Effect on cAMP synthesis in rat striatal membranes as increase above basal value at a concentration of 10 uM | 1995 | Journal of medicinal chemistry, Jan-20, Volume: 38, Issue:2
| Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands. |
| AID611558 | Displacement of [3H]spiperone from dopamine D2 like receptor in porcine striatal membranes after 30 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. |
| AID62000 | log(1/Kd) value against recombinant Dopamine receptor D1A expressed in COS7 cell | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors. |
| AID232939 | Binding selectivity against D2/D1 receptor. | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID61350 | Binding affinity to the Dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay. | 1995 | Journal of medicinal chemistry, Jun-23, Volume: 38, Issue:13
| Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H- benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy- 1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10- dihydro-1,2-dihydroxyanthracene as conformationa |
| AID272392 | Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate | 2006 | Journal of medicinal chemistry, Nov-16, Volume: 49, Issue:23
| trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
| AID208183 | Tested effective dose for maximal stimulation of adenylate cyclase in rat striatal membrane | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
| AID64783 | Binding affinity for Dopamine receptor D2 of rat striatal homogenate | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. |
| AID61414 | Binding affinity for Dopamine receptor D2 was assessed in vitro in rat striatal membranes using [3H]-SCH- 23390 radioligand | 1995 | Journal of medicinal chemistry, Jan-20, Volume: 38, Issue:2
| Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands. |
| AID64135 | Tested for binding affinity towards D2 receptor labelled by [3H]- spiperone as radioligand | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
| AID452082 | Displacement of [3H]spiperone from rat dopamine D4 receptor expressed in CHO cells by scintillation counting | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID63212 | Potency in adenylate cyclase functional assay against Dopamine receptor D1 | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID233473 | Hill slope was determined for the compound in D1 receptor binding assay | 1996 | Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
| 9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore. |
| AID208184 | Tested effective dose for maximal stimulation of adenylate cyclase in rat striatal membrane | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
| AID695379 | Displacement of [3H]-N-methylspiperone from dopamine D2 like receptor in pig striatal homogenates after 30 mins by scintillation counting | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. |
| AID617957 | Intrinsic activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins relative to dopamine | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. |
| AID62764 | Intrinsic activity relative to dopamine for human Dopamine receptor D2 | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID637501 | Binding affinity to dopamine D2 receptor | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. |
| AID61349 | Binding affinity for dopamine receptor D1 in rat striatal homogenate | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. |
| AID695380 | Selectivity ratio of Ki for dopamine D2 like receptor in pig striatal homogenates to Ki for dopamine D1 like receptor in pig striatal homogenates | 2012 | Bioorganic & medicinal chemistry, Nov-01, Volume: 20, Issue:21
| Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. |
| AID272395 | Intrinsic activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production relative to dopamine | 2006 | Journal of medicinal chemistry, Nov-16, Volume: 49, Issue:23
| trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. |
| AID62918 | Binding affinity against cloned human Dopamine receptor D2 using [3H]spiperone as radioligand transfected in HEK cells | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID61343 | Inhibition of [3H]SCH-23390 binding to rat striatal membrane Dopamine receptor D1 | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. |
| AID61998 | Low-affinity agonist dissociation constant against striatal Dopamine receptor D1A | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors. |
| AID35782 | Binding affinity against Alpha-2 adrenergic receptor | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID230016 | Ratio of Ki for human dopamine-2(D-2) and dopamine-1(D-1) receptors | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID61345 | Affinity towards Dopamine receptor D1 was evaluated in rat striatal membrane using [3H]SCH-23,390 as radioligand | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. |
| AID41499 | Binding affinity against Beta-2 adrenergic receptor | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID64790 | In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes. | 2000 | Journal of medicinal chemistry, Aug-10, Volume: 43, Issue:16
| CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
| AID34316 | Percentage maximum stimulation adenylate cyclase was measured versus DA | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. |
| AID4466 | Binding affinity against serotonergic 5-HT1a receptor | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID61859 | Intrinsic activity is the magnitude of response for stimulation of Dopamine receptor D1 like expressed as percent relative to the dopamine | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID617954 | Displacement of [3H]SCH23390 from dopamine D1-like receptor in pig striatal tissue homogenates after 30 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. |
| AID177567 | Ability to produce robust rotation in the lesioned rat after subcutaneous administration | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID63227 | Affinity towards Dopamine receptor D2 | 1998 | Journal of medicinal chemistry, Oct-22, Volume: 41, Issue:22
| CoMFA-based prediction of agonist affinities at recombinant D1 vs D2 dopamine receptors. |
| AID452079 | Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as intracellular calcium by fluorescence microplate reader | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID63341 | Intrinsic activity relative against Dopamine receptor D1. | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10
| trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists. |
| AID63338 | Intrinsic activity relative to dopamine for human Dopamine receptor D1 | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID452073 | Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells by scintillation counting | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID233819 | Relative binding affinity for dopamine receptors D1 and D2 in rat striatal homogenates | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. |
| AID452081 | Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in CHO cells by scintillation counting | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID61683 | Affinity on C6 glioma cells transfected with Dopamine receptor D3 | 1999 | Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5
| Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. |
| AID452072 | Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID63370 | Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. |
| AID61353 | The compound is evaluated for the affinity towards Dopamine receptor D1, using [3H]- SCH 23390 as ligand on rat striatal membranes. | 1997 | Journal of medicinal chemistry, Jul-04, Volume: 40, Issue:14
| Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine. |
| AID452078 | Antagonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as quinpirole-induced intracellular calcium by fluorescence microplate reader | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID637500 | Binding affinity to dopamine D1 receptor | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. |
| AID4776 | Binding affinity against serotonergic 5-HT1c receptor | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID196584 | Evaluated for the maximum stimulation of adenylate cyclase in rat striatal tissue with respect to the maximum stimulation caused by dopamine | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. |
| AID611557 | Displacement of [3H]SCH-23390 from dopamine D1 like receptor in porcine striatal membranes after 30 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. |
| AID37373 | In vitro binding affinity against adrenergic Alpha-2 adrenergic receptor from rat cortical membrane using [3H]rauwolscine as radioligand | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo. |
| AID34600 | Tested for effective dose agonist activity against adenylate cyclase in rat striatal membrane | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. |
| AID5139 | Binding affinity against serotonergic 5-HT2 receptor | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
| (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac |
| AID452077 | Antagonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as SKF-38393-induced intracellular calcium by fluorescence microplate reader | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID617956 | Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. |
| AID64919 | In vitro affinity at mutant D2 receptor (S197A) in C6 (glioma) cell membranes. | 2000 | Journal of medicinal chemistry, Aug-10, Volume: 43, Issue:16
| CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
| AID61197 | Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand | 1995 | Journal of medicinal chemistry, Jan-20, Volume: 38, Issue:2
| Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands. |
| AID452080 | Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as intracellular calcium by fluorescence microplate reader | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities? |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |