carbon tetrachloride has been researched along with Fibrosis in 125 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (CysLTR1) that protects against inflammation and oxidative stress." | 8.31 | Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation. ( Cao, F; Pu, S; Ren, C; Wang, Y; Wu, Y; Yang, S; Zhang, J; Zhou, H, 2023) |
| "We studied the impact of IFC-305 on a carbon tetrachloride-induced liver fibrosis model in Wistar male rats at 4, 6, and 8 weeks." | 8.31 | Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound. ( de Sánchez, VC; de Vaca, RP; Domínguez-López, M; Guerrero-Celis, N; Rodríguez-Aguilera, JR; Velasco-Loyden, G, 2023) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 8.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| " This study aimed to use a mouse model of carbon tetrachloride (CCL₄)-induced liver fibrosis to investigate the effects of BM-MSCs during liver hypoxia and the involvement of the transforming growth factor beta 1 (TGF-ß1) and SMADs pathway." | 7.91 | Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis. ( Chen, T; Li, J; Xiao, P; Xie, X; Yan, X; Zhang, L; Zhou, D; Zhu, J, 2019) |
| "Oxymatrine (OMT) is able to effectively protect against hepatic fibrosis because of its anti-inflammatory property, while the underlying mechanism remains incompletely understood." | 7.83 | Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways. ( Bai, ZF; Chai, X; Cui, HR; Li, GQ; Li, RS; Liu, HM; Meng, YK; Wang, HB; Wang, JB; Xiao, XH; Zhang, ZF; Zhao, HW, 2016) |
| " Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 7.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
| "Carbon tetrachloride (CCl(4)) was used to induce liver fibrosis in the rat." | 7.74 | Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. ( Clarke, CJ; Dare, T; Munday, MR; Smyth, R; Turton, JA; York, MJ, 2007) |
| "The present study was undertaken to determine whether there is any alteration in the activities of lysosomal enzymes in the liver and sera of rats during the course of carbon tetrachloride (CCl4) induced cirrhosis in rats." | 7.72 | Lysosomal enzyme activity during development of carbon tetrachloride induced cirrhosis in rats. ( Abraham, P, 2004) |
| "Adenosine administration was tested in rats with carbon tetrachloride-induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin." | 7.68 | Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats. ( Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R; Suárez, J, 1990) |
| "Hepatic fibrosis is a late stage process of many chronic liver diseases." | 5.91 | Mangiferin relieves CCl4-induced liver fibrosis in mice. ( Fan, S; Huang, C; Liu, C; Yin, L; Zhang, L, 2023) |
| "Liver fibrosis is a prevalent liver disease that requires rapid and effective treatment prior to its progression to cirrhosis and liver damage." | 5.72 | Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats. ( Albogami, SM; Alotaibi, SS; Batiha, GE; Elewa, YHA; Makled, S; Mostafa-Hedeab, G; Yassin, F; Zein, N, 2022) |
| "Metformin is a hypoglycaemic agent used to treat type 2 diabetes mellitus (DM2) patients, with a broad safety profile." | 5.51 | Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019) |
| "Fibrosis is a common pathologic outcome of chronic disease resulting in the replacement of normal tissue parenchyma with a collagen-rich extracellular matrix produced by myofibroblasts." | 5.51 | Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis. ( Beckett, JD; Bedja, D; Butcher, JT; Chen, Y; Creamer, TJ; Dietz, HC; Gould, RA; Hata, S; Kim, DH; MacFarlane, EG; Mitzner, W; Nagpal, V; Rouf, R; Seman-Senderos, MA; Warren, DS, 2019) |
| "Fibrosis is an inherent response to chronic damage upon immense apoptosis or necrosis." | 5.42 | EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling. ( Kim, DK; Kim, JS; Kim, MJ; Lee, SJ; Nam, JS; Park, SA; Park, SY; Sheen, YY; Woo, HA, 2015) |
| "Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis." | 5.40 | FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. ( Kong, Y; Tang, N; Wang, H; Wang, S, 2014) |
| "However, liver fibrosis is a prolonged change both in gene expression and histopathological alterations." | 5.32 | Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice. ( Jiang, Y; Kang, YJ; Liu, J; Waalkes, M, 2004) |
| "Fibrosis was induced by treatment of rats with drinking water containing 5% ethanol and CCl(4) (2 x weekly, 0." | 5.32 | Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication. ( Balkan, J; Cevikbaş, U; Erman, F; Koçak-Toker, N; Uysal, M, 2004) |
| "Hepatocyte-specific Brg1 knockout mice were generated and injected with carbon tetrachloride (CCl4) for 4, 6, 8, and 12 weeks to induce liver fibrosis." | 4.31 | Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice. ( Cheng, Z; Friess, H; Hartmann, D; Hüser, N; Kaufmann, B; Mogler, C; Schmid, RM; von Figura, G; Wang, B; Yin, Y; Zhong, S, 2023) |
| " Fibrotic mice received a specific FAP inhibitor (FAPi) at 2 doses orally for 2 weeks during parenchymal fibrosis progression (6 weeks of carbon tetrachloride) and regression (2 weeks off carbon tetrachloride), and with biliary fibrosis (Mdr2-/-)." | 4.31 | Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis. ( Abe, H; Aslam, M; Jia, JD; Kim, YO; Klein, T; Park, KS; Schuppan, D; Yan, XZ; Yang, AT; You, H; Zhao, XY, 2023) |
| " Therefore, this study aimed to investigate the role of FRFRD, rich in quercetin and kaempferol, in liver fibrosis induced by CCl4." | 4.31 | Evaluation of the flavonol-rich fraction of Rosa damascena in an animal model of liver fibrosis by targeting the expression of fibrotic cytokines, antioxidant/oxidant ratio and collagen cross-linking. ( Aghaei, M; Ghanadian, M; Hashemnia, M; Moezzi, ND; Mohammadalipour, A; Rostami, M, 2023) |
| "We studied the impact of IFC-305 on a carbon tetrachloride-induced liver fibrosis model in Wistar male rats at 4, 6, and 8 weeks." | 4.31 | Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound. ( de Sánchez, VC; de Vaca, RP; Domínguez-López, M; Guerrero-Celis, N; Rodríguez-Aguilera, JR; Velasco-Loyden, G, 2023) |
| "Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (CysLTR1) that protects against inflammation and oxidative stress." | 4.31 | Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation. ( Cao, F; Pu, S; Ren, C; Wang, Y; Wu, Y; Yang, S; Zhang, J; Zhou, H, 2023) |
| "These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease." | 4.12 | ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022) |
| " This study aimed to use a mouse model of carbon tetrachloride (CCL₄)-induced liver fibrosis to investigate the effects of BM-MSCs during liver hypoxia and the involvement of the transforming growth factor beta 1 (TGF-ß1) and SMADs pathway." | 3.91 | Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis. ( Chen, T; Li, J; Xiao, P; Xie, X; Yan, X; Zhang, L; Zhou, D; Zhu, J, 2019) |
| "Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ function." | 3.91 | The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis. ( Buson, A; Deodhar, M; Findlay, AD; Foot, JS; Greco, A; Jarolimek, W; Joshi, A; Moses, J; Perryman, L; Rayner, B; Schilter, H; Townsend, S; Turner, CI; Yow, TT; Zahoor, A; Zhou, W, 2019) |
| "The effect of systemic treatment with adipose tissue-derived MSCs, pre-differentiated into hepatocytic cells, was investigated in a rat model of liver cirrhosis induced by chronic inhalation of carbon tetrachloride." | 3.85 | Improvement of portal venous pressure in cirrhotic rat livers by systemic treatment with adipose tissue-derived mesenchymal stromal cells. ( Brückner, S; Christ, B; Hempel, M; Roderfeld, M; Roeb, E; Schwill, F; Thonig, A; Zipprich, A, 2017) |
| "Liver fibrosis/cirrhosis was induced in wild type and TGFβ overproducing transgenic mice by carbon tetrachloride and thioacetamide administration." | 3.85 | Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models. ( Bugyik, E; Dezső, K; Mózes, M; Nagy, P; Paku, S; Rókusz, A; Szücs, A; Veres, D, 2017) |
| "We therefore examined the biochemical, histopathological and molecular effects of the 5-HT7 receptor agonist and antagonist on inflammatory liver fibrogenesis in animal models of progressive cirrhosis: a mouse model induced by carbon tetrachloride (CCl4) and in Hep3b cells." | 3.85 | Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro. ( Albayrak, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Polat, B; Unal, D, 2017) |
| "Oxymatrine (OMT) is able to effectively protect against hepatic fibrosis because of its anti-inflammatory property, while the underlying mechanism remains incompletely understood." | 3.83 | Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways. ( Bai, ZF; Chai, X; Cui, HR; Li, GQ; Li, RS; Liu, HM; Meng, YK; Wang, HB; Wang, JB; Xiao, XH; Zhang, ZF; Zhao, HW, 2016) |
| "The role of Physalis peruviana (golden berry) as functional food against hepato-renal fibrosis induced by carbon tetrachloride (CCl4) was evaluated." | 3.83 | Chemical Composition of Golden Berry Leaves Against Hepato-renal Fibrosis. ( El-Gengaihi, SE; Hamed, MA; Khalaf-Allah, Ael-R; Mohammed, MA; Zahran, HG, 2016) |
| "Liver fibrosis in model rats (n = 50) was produced by carbon tetrachloride (CCl4 ) injection." | 3.83 | Assessment of liver fibrosis in rats by MRI with apparent diffusion coefficient and T1 relaxation time in the rotating frame. ( Chan, Q; Hu, G; Li, Y; Liang, W; Lin, T; Lin, X; Quan, X; Zhang, X; Zhong, X, 2016) |
| " Hepatic fibrosis was induced in CD248(-/-) and wild-type controls with carbon tetrachloride (CCl4) treatment." | 3.83 | CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism. ( Aldridge, V; Buckley, CD; Croft, AP; Fear, J; Garg, A; Haldar, D; Hedegaard, D; Henderson, NC; Naylor, AJ; Newsome, PN; Reynolds, GM; Weston, CJ; Wilhelm, A, 2016) |
| "Previously we found carbon tetrachloride (CCl₄) induced cirrhosis associated cardiac hypertrophy and apoptosis." | 3.80 | Herbal supplement attenuation of cardiac fibrosis in rats with CCl₄-induced liver cirrhosis. ( Chang, HC; Chen, RJ; Chiu, YW; Huang, CY; Kuo, YC; Lin, JA; Lin, YM; Liu, JY; Tsai, CH; Tsai, FJ, 2014) |
| "The aim of the present work is to investigate the potential of Physalis peruviana fruits as a hepatorenal protective agent against carbon tetrachloride (CCl4)-induced hepatic and renal fibrosis." | 3.79 | Golden berry juice attenuates the severity of hepatorenal injury. ( El-Gengaihi, SE; Hamed, MA; Khalaf-Allah, Ael-R; Mohammed, MA, 2013) |
| " C57BL/6N mice were fed a high-fat diet (HFD) to develop obesity and were either administered carbon tetrachloride (CCl4 ) eight times (0." | 3.79 | A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice. ( Ishikawa, F; Kado, S; Kano, M; Kobayashi, T; Kubota, N; Masuoka, N; Miyazaki, K; Nagata, Y, 2013) |
| " In this study, the diethylnitrosamine (DEN)-induced liver tumor model and the chronic carbon tetrachloride (CCl(4))-induced liver fibrosis model were both used to investigate the role of STAT3 in liver tumorigenesis." | 3.77 | Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis. ( Gao, B; Lafdil, F; Miller, AM; Niu, J; Park, O; Sun, Z; Wang, H; Wang, L; Yin, S, 2011) |
| "The aim of this study was to investigate the hepatoprotective effects of anthocyanidin delphinidin in carbon tetrachloride (CCl(4))-induced liver fibrosis in mice." | 3.76 | Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice. ( Domitrović, R; Jakovac, H, 2010) |
| "Rat models of experimental hepatic fibrosis were established by injection with CCl(4); the treated rats received emodin via oral administration at a dosage of 20 mg/kg twice a week at the same time." | 3.75 | Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. ( Dong, MX; Geng, YT; Jia, Y; Li, CC; Li, XY; Liu, JC; Niu, YC; Zhang, YB; Zhou, L, 2009) |
| "We investigated the effect of human umbilical mesenchymal stem cells (HUMSCs) from Wharton's jelly on carbon tetrachloride (CCl4)-induced liver fibrosis in rats." | 3.75 | The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis. ( Chen, TH; Chen, YM; Fu, TW; Fu, YS; Hung, SC; Ko, TL; Shih, YH; Tsai, PC, 2009) |
| " Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 3.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
| "MR elastography of the liver was performed in 10 rats with hepatic fibrosis induced by intraperitoneal carbon tetrachloride (CCl(4)) injections and five normal rats." | 3.74 | Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat. ( Abarca-Quinones, J; Annet, L; Leclercq, I; Peeters, F; Salameh, N; Sinkus, R; Ter Beek, LC; Van Beers, BE, 2007) |
| " As model toxic compounds lipopolysaccharide (LPS, inducing inflammation), paracetamol (necrosis), carbon tetrachloride (CCl(4), fibrosis and necrosis) and gliotoxin (apoptosis) were used." | 3.74 | Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity. ( Bauerschmidt, S; Draaisma, AL; Elferink, MG; Groothuis, GM; Merema, MT; Olinga, P; Polman, J; Schoonen, WG, 2008) |
| "Carbon tetrachloride (CCl(4)) was used to induce liver fibrosis in the rat." | 3.74 | Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. ( Clarke, CJ; Dare, T; Munday, MR; Smyth, R; Turton, JA; York, MJ, 2007) |
| "To study the anti-fibrogenic mechanisms of S-adenosylmethionine (AdoMet), transgenic mice harboring the -17 kb to +54 bp of the collagen alpha2 (I) promoter (COL1A2) cloned upstream from the beta-gal reporter gene were injected with carbon tetrachloride (CCl4) to induce fibrosis and coadministered either AdoMet or saline." | 3.73 | S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. ( Cederbaum, AI; Nieto, N, 2005) |
| "Carbon tetrachloride (CCl4)-induced hepatic fibrosis has been considered to be linked to oxidative stress and mediated by aldehydic lipid peroxidation products." | 3.73 | F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis? ( Arezzini, B; Comporti, M; Gardi, C; Monaco, B; Sgherri, C; Signorini, C, 2005) |
| " Mice with liver cirrhosis induced by carbon tetrachloride were injected with 1 x 10(5) non-treated green fluorescent protein (GFP)-positive BMCs via the tail vein." | 3.72 | An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. ( Katada, T; Miyamoto, K; Nishina, H; Ohata, S; Okita, K; Omori, K; Sakaida, I; Shinoda, K; Terai, S; Watanabe, T; Yamamoto, N, 2003) |
| "The present study was undertaken to determine whether there is any alteration in the activities of lysosomal enzymes in the liver and sera of rats during the course of carbon tetrachloride (CCl4) induced cirrhosis in rats." | 3.72 | Lysosomal enzyme activity during development of carbon tetrachloride induced cirrhosis in rats. ( Abraham, P, 2004) |
| "Compared with the fibrosis in rats of the model group, rats treated with either enalapril or losartan, or a combination of two drugs, showed a limited expansion of the interstitium (P < 0." | 3.71 | The expression of AT1 receptor on hepatic stellate cells in rat fibrosis induced by CCl4. ( Huang, X; Li, D; Lu, H; Wang, Z; Wei, H; Zhan, Y, 2001) |
| "Adenosine administration was tested in rats with carbon tetrachloride-induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin." | 3.68 | Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats. ( Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R; Suárez, J, 1990) |
| "Hepatic fibrosis is a late stage process of many chronic liver diseases." | 1.91 | Mangiferin relieves CCl4-induced liver fibrosis in mice. ( Fan, S; Huang, C; Liu, C; Yin, L; Zhang, L, 2023) |
| "Saffron can attenuate liver fibrosis by inhibiting the JAK/STAT3 pathway and the activation of hepatic stellate cell, providing a theoretical basis for the development of new anti-fibrotic drugs." | 1.91 | Saffron reduces the liver fibrosis in mice by inhibiting the JAK/STAT3 pathway. ( Han, Y; Huang, L; Qiu, Q; Su, W; Wang, Z; Yan, J; Yue, S; Zhou, Q, 2023) |
| "Non-alcoholic fatty liver disease (NAFLD)-related liver fibrosis results in the encapsulation of injured liver parenchyma by a collagenous scar mainly imputable to hepatic stellate cells' activation." | 1.72 | Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis. ( Alisi, A; Bianchi, M; Braghini, MR; Comparcola, D; Condorelli, AG; Conti, LA; Crudele, A; De Stefanis, C; Gurrado, F; Lioci, G; Mosca, A; Nobili, R; Panera, N; Sartorelli, MR; Scoppola, V; Smeriglio, A; Svegliati-Baroni, G; Trombetta, D, 2022) |
| "Liver fibrosis is a prevalent liver disease that requires rapid and effective treatment prior to its progression to cirrhosis and liver damage." | 1.72 | Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats. ( Albogami, SM; Alotaibi, SS; Batiha, GE; Elewa, YHA; Makled, S; Mostafa-Hedeab, G; Yassin, F; Zein, N, 2022) |
| "Patients with liver fibrosis who have pain in the liver region may have changed nerve factors." | 1.72 | Neurotrophic factors stimulate the activation of hepatic stellate cells in liver fibrosis. ( Li, Q; Liu, C; Liu, XL; Ma, WT; Sun, TT; Tao, L; Wu, L; Yang, GY; Zhang, W, 2022) |
| "Hepatic fibrosis is the final pathway of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), which eventually develop into cirrhosis and liver cancer." | 1.62 | Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling. ( Chen, Y; Li, Y; Lin, L; Que, R; Zhang, N; Zhou, M, 2021) |
| "Fibrosis is a common pathologic outcome of chronic disease resulting in the replacement of normal tissue parenchyma with a collagen-rich extracellular matrix produced by myofibroblasts." | 1.51 | Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis. ( Beckett, JD; Bedja, D; Butcher, JT; Chen, Y; Creamer, TJ; Dietz, HC; Gould, RA; Hata, S; Kim, DH; MacFarlane, EG; Mitzner, W; Nagpal, V; Rouf, R; Seman-Senderos, MA; Warren, DS, 2019) |
| "In the present study we assessed whether liver fibrosis and cirrhosis can be reversed by treatment with MSCs or fibroblasts concomitant to partial hepatectomy (pHx)-induced liver regeneration." | 1.51 | Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers. ( Barnhoorn, MC; Coenraad, MJ; de Jonge-Muller, ESM; Hawinkels, LJAC; Molendijk, I; van der Helm, D; van Hoek, B; Verspaget, HW, 2019) |
| "Metformin is a hypoglycaemic agent used to treat type 2 diabetes mellitus (DM2) patients, with a broad safety profile." | 1.51 | Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. ( Callegari, E; Gramantieri, L; Guerriero, P; Negrini, M; Pinton, P; Rimessi, A; Sabbioni, S; Shankaraiah, RC; Silini, EM, 2019) |
| " We studied the functional contribution of lysyl oxidase (LOX) to collagen stabilization and hepatic fibrosis progression/reversalin vivousing chronic administration of irreversible LOX inhibitor β-aminopropionitrile (BAPN, or vehicle as control) in C57Bl/6J mice with carbon tetrachloride (CCl4)-induced fibrosis." | 1.43 | Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice. ( Greenstein, A; Ikenaga, N; Liu, SB; Peng, ZW; Popov, Y; Schuppan, D; Smith, V; Sverdlov, DY, 2016) |
| "Fibrosis is an inherent response to chronic damage upon immense apoptosis or necrosis." | 1.42 | EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling. ( Kim, DK; Kim, JS; Kim, MJ; Lee, SJ; Nam, JS; Park, SA; Park, SY; Sheen, YY; Woo, HA, 2015) |
| "Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis." | 1.40 | FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. ( Kong, Y; Tang, N; Wang, H; Wang, S, 2014) |
| "Extent of fibrosis was examined by Masson's stain and measuring hydroxyproline levels." | 1.39 | Multimechanistic antifibrotic effect of biochanin a in rats: implications of proinflammatory and profibrogenic mediators. ( Abdel-Naim, AB; Algandaby, MM; Breikaa, RM; El-Demerdash, E, 2013) |
| " Moreover, a reduction in COX-1 expression and TXB(2) production in rats receiving fenofibrate and a significant increase in NO bioavailability in HEC with fenofibrate were observed." | 1.38 | PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats. ( Bosch, J; García-Calderó, H; García-Pagán, JC; Laviña, B; Rodríguez-Vilarrupla, A; Roglans, N; Rosado, E; Russo, L, 2012) |
| "Hepatic fibrosis was induced in rats by dimethylnitrosamine (DMN) or carbon tetrachloride (CCl4) treatment." | 1.36 | Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. ( Hu, Y; Jian, P; Liu, C; Liu, P; Peng, J; Sun, M; Tao, Q; Wu, JZ; Yang, W, 2010) |
| "Fibrosis was quantified by densitometry on Sirius red-stained histological sections." | 1.34 | Assessment of diffusion-weighted MR imaging in liver fibrosis. ( Abarca-Quinones, J; Annet, L; Leclercq, I; Moulin, P; Peeters, F; Van Beers, BE, 2007) |
| " With repetitive dosing CCl(4) can be used to induce bridging hepatic fibrosis (4 wk of twice-weekly dosing), cirrhosis (8 wk of twice-weekly dosing) and advanced micronodular cirrhosis (12 wk of twice-weekly dosing)." | 1.33 | Modeling liver fibrosis in rodents. ( Constandinou, C; Henderson, N; Iredale, JP, 2005) |
| "However, liver fibrosis is a prolonged change both in gene expression and histopathological alterations." | 1.32 | Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice. ( Jiang, Y; Kang, YJ; Liu, J; Waalkes, M, 2004) |
| "Fibrosis was induced by treatment of rats with drinking water containing 5% ethanol and CCl(4) (2 x weekly, 0." | 1.32 | Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication. ( Balkan, J; Cevikbaş, U; Erman, F; Koçak-Toker, N; Uysal, M, 2004) |
| "Liver cirrhosis was induced by CCl(4) inhalation and phenobarbital in Wistar rats." | 1.31 | Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats. ( Castilla-Cortázar, I; García, M; Muguerza, B; Prieto, J; Quiroga, J; Santidrián, S, 2001) |
| "Hepatic encephalopathy was induced in Wistar rats by administration of CCl4 at a dose of 1 mL/kg orally in liquid paraffin (1:1) twice a week for 90 days." | 1.31 | The protective effect of HD-03 in CCl4-induced hepatic encephalopathy in rats. ( Anturlikar, SD; Gopumadhavan, S; Mitra, SK; Seshadri, SJ; Venkataranganna, MV; Venkatesha Udupa, U, 2001) |
| " Treatment with CCl4 after AFB1 dosing lowered hepatic GSH levels by 20% and increased lipid peroxidation by 40%." | 1.30 | Enhancement of aflatoxin B1-induced enzyme altered hepatic foci in rats by treatment with carbon tetrachloride. ( Lotlikar, PD; Ning, Y; Qin, G; Shinozuka, H; Su, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.20) | 18.7374 |
| 1990's | 7 (5.60) | 18.2507 |
| 2000's | 33 (26.40) | 29.6817 |
| 2010's | 47 (37.60) | 24.3611 |
| 2020's | 34 (27.20) | 2.80 |
| Authors | Studies |
|---|---|
| Bartalis, J | 1 |
| Halaweish, FT | 1 |
| Chen, Y | 4 |
| Que, R | 1 |
| Zhang, N | 2 |
| Lin, L | 1 |
| Zhou, M | 1 |
| Li, Y | 2 |
| Wu, B | 2 |
| Zheng, X | 1 |
| Li, X | 3 |
| Wang, C | 1 |
| Li, L | 1 |
| Tang, Z | 2 |
| Cui, H | 1 |
| Li, Z | 2 |
| Chen, L | 1 |
| Ma, X | 2 |
| Hung, CT | 1 |
| Su, TH | 1 |
| Chen, YT | 2 |
| Wu, YF | 1 |
| Lin, SJ | 1 |
| Lin, SL | 1 |
| Yang, KC | 1 |
| Song, Z | 1 |
| Liu, X | 1 |
| Zhang, W | 2 |
| Luo, Y | 2 |
| Xiao, H | 1 |
| Liu, Y | 2 |
| Dai, G | 1 |
| Hong, J | 1 |
| Li, A | 1 |
| Zein, N | 1 |
| Yassin, F | 1 |
| Makled, S | 1 |
| Alotaibi, SS | 1 |
| Albogami, SM | 1 |
| Mostafa-Hedeab, G | 1 |
| Batiha, GE | 1 |
| Elewa, YHA | 1 |
| Kim, SM | 1 |
| Song, GY | 1 |
| Shim, A | 1 |
| Lee, JH | 1 |
| Eom, CB | 1 |
| Liu, C | 5 |
| Yang, YM | 1 |
| Seki, E | 1 |
| Xue, L | 1 |
| Zhu, X | 1 |
| Zhang, J | 2 |
| Zhou, S | 1 |
| Tang, W | 1 |
| Chen, D | 1 |
| Dai, J | 1 |
| Wu, M | 2 |
| Wang, S | 3 |
| Fan, J | 1 |
| Tong, G | 1 |
| Chen, X | 1 |
| Li, S | 1 |
| Yu, Y | 2 |
| Zhu, S | 1 |
| Zhu, K | 2 |
| Hu, Z | 2 |
| Dong, Y | 1 |
| Chen, R | 1 |
| Zhu, J | 2 |
| Gong, W | 1 |
| Zhou, B | 1 |
| Jin, L | 1 |
| Cong, W | 1 |
| Wang, P | 1 |
| Fang, Y | 1 |
| Qiu, J | 1 |
| Zhou, Y | 1 |
| Wang, Z | 3 |
| Jiang, C | 1 |
| Panera, N | 1 |
| Braghini, MR | 1 |
| Crudele, A | 1 |
| Smeriglio, A | 1 |
| Bianchi, M | 1 |
| Condorelli, AG | 1 |
| Nobili, R | 1 |
| Conti, LA | 1 |
| De Stefanis, C | 1 |
| Lioci, G | 1 |
| Gurrado, F | 1 |
| Comparcola, D | 1 |
| Mosca, A | 1 |
| Sartorelli, MR | 1 |
| Scoppola, V | 1 |
| Svegliati-Baroni, G | 1 |
| Trombetta, D | 1 |
| Alisi, A | 1 |
| Zetterberg, FR | 1 |
| MacKinnon, A | 1 |
| Brimert, T | 1 |
| Gravelle, L | 1 |
| Johnsson, RE | 1 |
| Kahl-Knutson, B | 1 |
| Leffler, H | 1 |
| Nilsson, UJ | 1 |
| Pedersen, A | 1 |
| Peterson, K | 1 |
| Roper, JA | 1 |
| Schambye, H | 1 |
| Slack, RJ | 1 |
| Tantawi, S | 1 |
| Sun, TT | 1 |
| Liu, XL | 1 |
| Yang, GY | 1 |
| Tao, L | 1 |
| Ma, WT | 1 |
| Wu, L | 1 |
| Li, Q | 1 |
| Feng, J | 1 |
| Guo, J | 2 |
| Wang, J | 1 |
| Xiu, G | 1 |
| Xu, J | 3 |
| Ning, K | 1 |
| Ling, B | 1 |
| Fu, Q | 1 |
| Shaban, NZ | 3 |
| Awad, OM | 3 |
| Fouad, GM | 3 |
| Hafez, AM | 3 |
| Abdul-Aziz, AA | 3 |
| El-Kot, SM | 3 |
| Rampa, DR | 2 |
| Feng, H | 2 |
| Allur-Subramaniyan, S | 2 |
| Shim, K | 2 |
| Pekcec, A | 2 |
| Lee, D | 2 |
| Doods, H | 2 |
| Wu, D | 2 |
| Yang, AT | 2 |
| Kim, YO | 2 |
| Yan, XZ | 2 |
| Abe, H | 2 |
| Aslam, M | 2 |
| Park, KS | 2 |
| Zhao, XY | 2 |
| Jia, JD | 2 |
| Klein, T | 2 |
| You, H | 2 |
| Schuppan, D | 4 |
| Zhang, L | 3 |
| Yin, L | 1 |
| Huang, C | 1 |
| Fan, S | 1 |
| Zheng, W | 1 |
| Guan, F | 1 |
| Xu, G | 1 |
| Xiao, J | 1 |
| Huang, X | 3 |
| Guo, F | 1 |
| Song, Y | 1 |
| Pu, S | 1 |
| Ren, C | 1 |
| Zhou, H | 3 |
| Wang, Y | 1 |
| Wu, Y | 1 |
| Yang, S | 1 |
| Cao, F | 1 |
| Domínguez-López, M | 1 |
| de Vaca, RP | 1 |
| Rodríguez-Aguilera, JR | 1 |
| Guerrero-Celis, N | 1 |
| Velasco-Loyden, G | 1 |
| de Sánchez, VC | 1 |
| Lin, W | 1 |
| Cai, Y | 1 |
| Huang, Z | 1 |
| Zhao, R | 1 |
| Yan, T | 1 |
| Xu, H | 2 |
| Liu, Z | 2 |
| Qiuling, L | 1 |
| Qilin, Y | 1 |
| Cheng, Y | 1 |
| Minping, Z | 1 |
| Kangning, W | 1 |
| Enhua, X | 1 |
| Geervliet, E | 1 |
| Terstappen, LWMM | 1 |
| Bansal, R | 1 |
| Rostami, M | 1 |
| Aghaei, M | 1 |
| Ghanadian, M | 1 |
| Hashemnia, M | 1 |
| Moezzi, ND | 1 |
| Mohammadalipour, A | 1 |
| Wang, B | 1 |
| Kaufmann, B | 1 |
| Mogler, C | 1 |
| Zhong, S | 1 |
| Yin, Y | 1 |
| Cheng, Z | 1 |
| Schmid, RM | 1 |
| Friess, H | 1 |
| Hüser, N | 1 |
| von Figura, G | 1 |
| Hartmann, D | 1 |
| Huang, L | 1 |
| Han, Y | 2 |
| Qiu, Q | 1 |
| Yue, S | 1 |
| Zhou, Q | 1 |
| Su, W | 1 |
| Yan, J | 1 |
| Shankaraiah, RC | 1 |
| Callegari, E | 1 |
| Guerriero, P | 1 |
| Rimessi, A | 1 |
| Pinton, P | 1 |
| Gramantieri, L | 1 |
| Silini, EM | 1 |
| Sabbioni, S | 1 |
| Negrini, M | 1 |
| Zhou, D | 1 |
| Li, J | 2 |
| Yan, X | 1 |
| Xiao, P | 1 |
| Chen, T | 1 |
| Xie, X | 1 |
| Xu, L | 2 |
| Zheng, R | 1 |
| Xie, P | 1 |
| Guo, Q | 1 |
| Ji, H | 1 |
| Li, T | 1 |
| Ma, JQ | 2 |
| Sun, YZ | 1 |
| Ming, QL | 1 |
| Tian, ZK | 2 |
| Zhang, YJ | 2 |
| Liu, CM | 2 |
| Naz, I | 1 |
| Khan, MR | 2 |
| Zai, JA | 1 |
| Batool, R | 1 |
| Zahra, Z | 1 |
| Tahir, A | 1 |
| Zhao, Q | 1 |
| Song, N | 1 |
| Yan, Z | 1 |
| Lin, R | 1 |
| Wu, S | 1 |
| Jiang, L | 1 |
| Hong, S | 1 |
| Xie, J | 1 |
| Wang, R | 1 |
| Jiang, X | 1 |
| Hanafy, NAN | 1 |
| Morsy, BM | 1 |
| Hamed, MA | 4 |
| Abd-Alla, HI | 1 |
| Aziz, WM | 1 |
| Kamel, SN | 1 |
| Rókusz, A | 1 |
| Veres, D | 1 |
| Szücs, A | 1 |
| Bugyik, E | 1 |
| Mózes, M | 1 |
| Paku, S | 1 |
| Nagy, P | 1 |
| Dezső, K | 1 |
| Dufton, NP | 1 |
| Peghaire, CR | 1 |
| Osuna-Almagro, L | 1 |
| Raimondi, C | 1 |
| Kalna, V | 1 |
| Chauhan, A | 1 |
| Webb, G | 1 |
| Yang, Y | 1 |
| Birdsey, GM | 1 |
| Lalor, P | 1 |
| Mason, JC | 1 |
| Adams, DH | 1 |
| Randi, AM | 1 |
| Brückner, S | 1 |
| Zipprich, A | 1 |
| Hempel, M | 1 |
| Thonig, A | 1 |
| Schwill, F | 1 |
| Roderfeld, M | 1 |
| Roeb, E | 1 |
| Christ, B | 1 |
| Zhang, GZ | 1 |
| Sun, HC | 1 |
| Zheng, LB | 1 |
| Guo, JB | 1 |
| Zhang, XL | 1 |
| Totoki, T | 1 |
| D' Alessandro-Gabazza, CN | 1 |
| Toda, M | 1 |
| Tonto, PB | 1 |
| Takeshita, A | 1 |
| Yasuma, T | 1 |
| Nishihama, K | 1 |
| Iwasa, M | 1 |
| Horiki, N | 1 |
| Takei, Y | 2 |
| Gabazza, EC | 1 |
| Wang, YH | 1 |
| Li, RK | 1 |
| Fu, Y | 1 |
| Yang, XM | 1 |
| Zhang, YL | 1 |
| Zhu, L | 1 |
| Yang, Q | 1 |
| Gu, JR | 1 |
| Xing, X | 1 |
| Zhang, ZG | 1 |
| Schilter, H | 1 |
| Findlay, AD | 1 |
| Perryman, L | 1 |
| Yow, TT | 1 |
| Moses, J | 1 |
| Zahoor, A | 1 |
| Turner, CI | 1 |
| Deodhar, M | 1 |
| Foot, JS | 1 |
| Zhou, W | 1 |
| Greco, A | 1 |
| Joshi, A | 1 |
| Rayner, B | 1 |
| Townsend, S | 1 |
| Buson, A | 1 |
| Jarolimek, W | 1 |
| Yin, F | 1 |
| Huo, X | 1 |
| Niu, G | 1 |
| Song, M | 1 |
| Chen, S | 1 |
| Zhang, X | 2 |
| van der Helm, D | 1 |
| Barnhoorn, MC | 1 |
| de Jonge-Muller, ESM | 1 |
| Molendijk, I | 1 |
| Hawinkels, LJAC | 1 |
| Coenraad, MJ | 1 |
| van Hoek, B | 1 |
| Verspaget, HW | 1 |
| Kim, DH | 1 |
| Beckett, JD | 1 |
| Nagpal, V | 1 |
| Seman-Senderos, MA | 1 |
| Gould, RA | 1 |
| Creamer, TJ | 1 |
| MacFarlane, EG | 1 |
| Bedja, D | 1 |
| Butcher, JT | 1 |
| Mitzner, W | 1 |
| Rouf, R | 1 |
| Hata, S | 1 |
| Warren, DS | 1 |
| Dietz, HC | 1 |
| El-Gengaihi, SE | 3 |
| Hassan, EE | 1 |
| Zahran, HG | 2 |
| Mohammed, MA | 3 |
| Kubota, N | 1 |
| Kado, S | 1 |
| Kano, M | 1 |
| Masuoka, N | 1 |
| Nagata, Y | 1 |
| Kobayashi, T | 1 |
| Miyazaki, K | 1 |
| Ishikawa, F | 1 |
| Breikaa, RM | 1 |
| Algandaby, MM | 1 |
| El-Demerdash, E | 1 |
| Abdel-Naim, AB | 1 |
| Zhong, Y | 1 |
| Xu, R | 1 |
| Lin, N | 1 |
| Deng, M | 1 |
| Fang, H | 1 |
| Lin, J | 1 |
| Kang, Z | 1 |
| Van Rossen, E | 1 |
| Blijweert, D | 1 |
| Eysackers, N | 1 |
| Mannaerts, I | 1 |
| Schroyen, B | 1 |
| El Taghdouini, A | 1 |
| Edwards, B | 1 |
| Davies, KE | 1 |
| Sokal, E | 1 |
| Najimi, M | 1 |
| Reynaert, H | 1 |
| van Grunsven, LA | 1 |
| Mathison, A | 1 |
| Grzenda, A | 1 |
| Lomberk, G | 1 |
| Velez, G | 1 |
| Buttar, N | 1 |
| Tietz, P | 1 |
| Hendrickson, H | 1 |
| Liebl, A | 1 |
| Xiong, YY | 1 |
| Gores, G | 1 |
| Fernandez-Zapico, M | 1 |
| Larusso, NF | 1 |
| Faubion, W | 1 |
| Shah, VH | 1 |
| Urrutia, R | 1 |
| Khalaf-Allah, Ael-R | 2 |
| Cuenca, S | 1 |
| Sanchez, E | 1 |
| Santiago, A | 1 |
| El Khader, I | 1 |
| Panda, S | 1 |
| Vidal, S | 1 |
| Camilo Nieto, J | 1 |
| Juárez, C | 1 |
| Sancho, F | 1 |
| Guarner, F | 1 |
| Soriano, G | 1 |
| Guarner, C | 1 |
| Manichanh, C | 1 |
| Sahreen, S | 1 |
| Khan, RA | 1 |
| Chang, HC | 1 |
| Chiu, YW | 1 |
| Lin, YM | 1 |
| Chen, RJ | 1 |
| Lin, JA | 1 |
| Tsai, FJ | 1 |
| Tsai, CH | 1 |
| Kuo, YC | 1 |
| Liu, JY | 1 |
| Huang, CY | 1 |
| Kong, Y | 1 |
| Wang, H | 3 |
| Tang, N | 1 |
| O'Brien, AJ | 1 |
| Fullerton, JN | 1 |
| Massey, KA | 1 |
| Auld, G | 1 |
| Sewell, G | 1 |
| James, S | 1 |
| Newson, J | 1 |
| Karra, E | 1 |
| Winstanley, A | 1 |
| Alazawi, W | 1 |
| Garcia-Martinez, R | 1 |
| Cordoba, J | 1 |
| Nicolaou, A | 1 |
| Gilroy, DW | 1 |
| Tsolaki, E | 1 |
| Athanasiou, E | 1 |
| Gounari, E | 1 |
| Zogas, N | 1 |
| Siotou, E | 1 |
| Yiangou, M | 1 |
| Anagnostopoulos, A | 1 |
| Yannaki, E | 1 |
| Park, SA | 1 |
| Kim, MJ | 1 |
| Park, SY | 1 |
| Kim, JS | 1 |
| Lee, SJ | 1 |
| Woo, HA | 1 |
| Kim, DK | 1 |
| Nam, JS | 1 |
| Sheen, YY | 1 |
| Wilhelm, A | 1 |
| Aldridge, V | 1 |
| Haldar, D | 1 |
| Naylor, AJ | 1 |
| Weston, CJ | 1 |
| Hedegaard, D | 1 |
| Garg, A | 1 |
| Fear, J | 1 |
| Reynolds, GM | 1 |
| Croft, AP | 1 |
| Henderson, NC | 1 |
| Buckley, CD | 1 |
| Newsome, PN | 1 |
| Hu, G | 1 |
| Liang, W | 1 |
| Zhong, X | 1 |
| Chan, Q | 1 |
| Lin, X | 1 |
| Lin, T | 1 |
| Quan, X | 1 |
| Liu, SB | 1 |
| Ikenaga, N | 1 |
| Peng, ZW | 1 |
| Sverdlov, DY | 1 |
| Greenstein, A | 1 |
| Smith, V | 1 |
| Popov, Y | 1 |
| Zakaria, S | 1 |
| El-Sisi, A | 1 |
| Zhao, HW | 1 |
| Zhang, ZF | 1 |
| Chai, X | 1 |
| Li, GQ | 1 |
| Cui, HR | 1 |
| Wang, HB | 1 |
| Meng, YK | 1 |
| Liu, HM | 1 |
| Wang, JB | 1 |
| Li, RS | 1 |
| Bai, ZF | 1 |
| Xiao, XH | 1 |
| Wang, MJ | 1 |
| Ling, WW | 1 |
| Meng, LW | 1 |
| Cai, H | 1 |
| Peng, B | 1 |
| Polat, B | 1 |
| Halici, Z | 1 |
| Cadirci, E | 1 |
| Karakus, E | 1 |
| Bayir, Y | 1 |
| Albayrak, A | 1 |
| Unal, D | 1 |
| Yamamotoya, T | 1 |
| Nakatsu, Y | 1 |
| Matsunaga, Y | 1 |
| Fukushima, T | 1 |
| Yamazaki, H | 1 |
| Kaneko, S | 1 |
| Fujishiro, M | 1 |
| Kikuchi, T | 1 |
| Kushiyama, A | 1 |
| Tokunaga, F | 1 |
| Asano, T | 1 |
| Sakoda, H | 1 |
| Jodynis-Liebert, J | 1 |
| Adamska, T | 1 |
| Ewertowska, M | 1 |
| Bylka, W | 1 |
| Matławska, I | 1 |
| Tsai, PC | 1 |
| Fu, TW | 1 |
| Chen, YM | 1 |
| Ko, TL | 1 |
| Chen, TH | 1 |
| Shih, YH | 1 |
| Hung, SC | 1 |
| Fu, YS | 1 |
| Renga, B | 1 |
| Mencarelli, A | 1 |
| Migliorati, M | 1 |
| Distrutti, E | 1 |
| Fiorucci, S | 1 |
| Chen, H | 1 |
| Ning, G | 1 |
| Mitchell, C | 1 |
| Robin, MA | 1 |
| Mayeuf, A | 1 |
| Mahrouf-Yorgov, M | 1 |
| Mansouri, A | 1 |
| Hamard, M | 1 |
| Couton, D | 1 |
| Fromenty, B | 1 |
| Gilgenkrantz, H | 1 |
| Dong, MX | 1 |
| Jia, Y | 1 |
| Zhang, YB | 1 |
| Li, CC | 1 |
| Geng, YT | 1 |
| Zhou, L | 1 |
| Li, XY | 1 |
| Liu, JC | 1 |
| Niu, YC | 1 |
| Wu, SJ | 2 |
| Tam, KW | 1 |
| Tsai, YH | 2 |
| Chang, CC | 1 |
| Chao, JC | 2 |
| Domitrović, R | 1 |
| Jakovac, H | 1 |
| Tao, Q | 1 |
| Sun, M | 1 |
| Wu, JZ | 1 |
| Yang, W | 1 |
| Jian, P | 1 |
| Peng, J | 1 |
| Hu, Y | 1 |
| Liu, P | 1 |
| Wang, QB | 1 |
| Jiang, TT | 1 |
| Chai, WM | 1 |
| Chen, KM | 1 |
| Liu, BY | 1 |
| Wang, LF | 1 |
| Zhang, C | 1 |
| Wang, DB | 1 |
| Jung, J | 1 |
| Lee, HJ | 1 |
| Lee, JM | 1 |
| Na, KH | 1 |
| Hwang, SG | 1 |
| Kim, GJ | 1 |
| Lafdil, F | 1 |
| Wang, L | 1 |
| Park, O | 1 |
| Yin, S | 1 |
| Niu, J | 1 |
| Miller, AM | 1 |
| Sun, Z | 1 |
| Gao, B | 1 |
| Wu, PS | 1 |
| Lin, YH | 1 |
| Rodríguez-Vilarrupla, A | 1 |
| Laviña, B | 1 |
| García-Calderó, H | 1 |
| Russo, L | 1 |
| Rosado, E | 1 |
| Roglans, N | 1 |
| Bosch, J | 1 |
| García-Pagán, JC | 1 |
| Chen, ZZ | 1 |
| Wang, ZL | 1 |
| Deng, CY | 1 |
| Zheng, H | 1 |
| Wang, XH | 1 |
| Ma, L | 1 |
| Ye, X | 1 |
| Ma, YH | 1 |
| Xie, CF | 1 |
| Chen, LJ | 1 |
| Wei, YQ | 1 |
| Bravo, E | 1 |
| D'Amore, E | 1 |
| Ciaffoni, F | 1 |
| Mammola, CL | 1 |
| Puche, JE | 1 |
| Lee, YA | 1 |
| Jiao, J | 1 |
| Aloman, C | 1 |
| Fiel, MI | 1 |
| Muñoz, U | 1 |
| Kraus, T | 1 |
| Lee, T | 1 |
| Yee, HF | 1 |
| Friedman, SL | 1 |
| DIENGOTT, D | 1 |
| UNGAR, H | 1 |
| BARTOK, I | 1 |
| HORVATH, E | 1 |
| DOMJAN, G | 1 |
| Terai, S | 2 |
| Sakaida, I | 2 |
| Yamamoto, N | 1 |
| Omori, K | 2 |
| Watanabe, T | 1 |
| Ohata, S | 1 |
| Katada, T | 1 |
| Miyamoto, K | 1 |
| Shinoda, K | 2 |
| Nishina, H | 2 |
| Okita, K | 2 |
| Jiang, Y | 1 |
| Liu, J | 1 |
| Waalkes, M | 1 |
| Kang, YJ | 1 |
| Liu, QH | 1 |
| Li, DG | 1 |
| Zong, CH | 1 |
| Xu, QF | 1 |
| Lu, HM | 1 |
| Erman, F | 1 |
| Balkan, J | 1 |
| Cevikbaş, U | 1 |
| Koçak-Toker, N | 1 |
| Uysal, M | 1 |
| Fallowfield, JA | 1 |
| Iredale, JP | 3 |
| Abraham, P | 1 |
| Ishikawa, T | 1 |
| Aoyama, K | 1 |
| Uchimura, S | 1 |
| Hamamoto, Y | 1 |
| Oakley, F | 1 |
| Mann, J | 1 |
| Nailard, S | 1 |
| Smart, DE | 1 |
| Mungalsingh, N | 1 |
| Constandinou, C | 2 |
| Ali, S | 1 |
| Wilson, SJ | 1 |
| Millward-Sadler, H | 1 |
| Mann, DA | 1 |
| Nieto, N | 1 |
| Cederbaum, AI | 1 |
| Henderson, N | 1 |
| Comporti, M | 1 |
| Arezzini, B | 1 |
| Signorini, C | 1 |
| Sgherri, C | 1 |
| Monaco, B | 1 |
| Gardi, C | 1 |
| Busch, R | 1 |
| Kim, YK | 1 |
| Neese, RA | 1 |
| Schade-Serin, V | 1 |
| Collins, M | 1 |
| Awada, M | 1 |
| Gardner, JL | 1 |
| Beysen, C | 1 |
| Marino, ME | 1 |
| Misell, LM | 1 |
| Hellerstein, MK | 1 |
| Do, SH | 1 |
| Yun, HS | 1 |
| Jeong, WI | 1 |
| Jeong, DH | 1 |
| Ki, MR | 1 |
| Chung, JY | 1 |
| Park, SJ | 1 |
| Kim, SB | 1 |
| Jeong, KS | 1 |
| Da Silva Morais, A | 1 |
| Abarca-Quinones, J | 3 |
| Horsmans, Y | 1 |
| Stärkel, P | 1 |
| Leclercq, IA | 1 |
| Annet, L | 2 |
| Peeters, F | 2 |
| Leclercq, I | 2 |
| Moulin, P | 1 |
| Van Beers, BE | 2 |
| Abe, W | 1 |
| Ikejima, K | 1 |
| Lang, T | 1 |
| Okumura, K | 1 |
| Enomoto, N | 1 |
| Kitamura, T | 1 |
| Sato, N | 1 |
| Amatucci, A | 1 |
| Novobrantseva, T | 1 |
| Gilbride, K | 1 |
| Brickelmaier, M | 1 |
| Hochman, P | 1 |
| Ibraghimov, A | 1 |
| Smyth, R | 1 |
| Munday, MR | 1 |
| York, MJ | 1 |
| Clarke, CJ | 1 |
| Dare, T | 1 |
| Turton, JA | 1 |
| Salameh, N | 1 |
| Sinkus, R | 1 |
| Ter Beek, LC | 1 |
| Marsillach, J | 1 |
| Ferré, N | 1 |
| Camps, J | 1 |
| Rull, A | 1 |
| Beltran, R | 1 |
| Joven, J | 1 |
| Hamzavi, J | 1 |
| Ehnert, S | 1 |
| Godoy, P | 1 |
| Ciuclan, L | 1 |
| Weng, H | 1 |
| Mertens, PR | 1 |
| Heuchel, R | 1 |
| Dooley, S | 1 |
| Elferink, MG | 1 |
| Olinga, P | 1 |
| Draaisma, AL | 1 |
| Merema, MT | 1 |
| Bauerschmidt, S | 1 |
| Polman, J | 1 |
| Schoonen, WG | 1 |
| Groothuis, GM | 1 |
| Day, CP | 1 |
| Burt, AD | 1 |
| Brown, AS | 1 |
| Bennett, MK | 1 |
| Farrell, DJ | 1 |
| James, OF | 1 |
| Yeaman, SJ | 1 |
| Vollmar, B | 1 |
| Wolf, B | 1 |
| Siegmund, S | 1 |
| Katsen, AD | 1 |
| Menger, MD | 1 |
| Qin, G | 2 |
| Ning, Y | 2 |
| Su, J | 1 |
| Shinozuka, H | 1 |
| Lotlikar, PD | 2 |
| Bolaños, L | 1 |
| Colina, I | 1 |
| Purroy, A | 1 |
| Yamazaki, K | 1 |
| Kawai, A | 1 |
| Kawaguchi, M | 1 |
| Hibino, Y | 1 |
| Li, F | 1 |
| Sasahara, M | 1 |
| Tsukada, K | 1 |
| Hiraga, K | 1 |
| Muguerza, B | 1 |
| Castilla-Cortázar, I | 1 |
| García, M | 1 |
| Quiroga, J | 1 |
| Santidrián, S | 1 |
| Prieto, J | 1 |
| Mitra, SK | 1 |
| Venkataranganna, MV | 1 |
| Gopumadhavan, S | 1 |
| Anturlikar, SD | 1 |
| Seshadri, SJ | 1 |
| Venkatesha Udupa, U | 1 |
| Wei, H | 1 |
| Lu, H | 1 |
| Li, D | 1 |
| Zhan, Y | 1 |
| Herbst, H | 1 |
| Heinrichs, O | 1 |
| Milani, S | 1 |
| Stein, H | 1 |
| Tomaszewski, KE | 1 |
| Harries, GC | 1 |
| Jeffrey, P | 1 |
| Hernández-Muñoz, R | 1 |
| Díaz-Muñoz, M | 1 |
| Suárez, J | 1 |
| Chagoya de Sánchez, V | 1 |
| Xiao, JC | 1 |
| Liu, HJ | 1 |
| Han, D | 1 |
| Jiang, JX | 1 |
| Qing, C | 1 |
| Myara, I | 1 |
| Miech, G | 1 |
| Fabre, M | 1 |
| Mangeot, M | 1 |
| Lemonnier, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quantitative Diagnosis of Liver Fibrosis on Multiparametric MRI[NCT03176797] | 300 participants (Anticipated) | Interventional | 2017-05-03 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for carbon tetrachloride and Fibrosis
| Article | Year |
|---|---|
Targeted treatments for cirrhosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Carbon Tetrachloride; Cell Differentiati | 2004 |
124 other studies available for carbon tetrachloride and Fibrosis
| Article | Year |
|---|---|
In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines.
Topics: Animals; Cell Line; Cell Proliferation; Cucurbitacins; Fibrosis; Hep G2 Cells; Hepatic Stellate Cell | 2011 |
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cells, Cultured; China; Fibrosis; Hepatic Stellate Cells; | 2021 |
Design, synthesis and activity evaluation of prodrug form JBP485 and Vitamin E for alleviation of NASH.
Topics: Animals; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Drug Design; Fibrosis; | 2022 |
Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Hepatocytes; Humans; Liver; Liver C | 2022 |
Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Fibrosis; Hepatic Stellate Cells; Humans; | 2022 |
Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Caspase 3; Cytokines; Dietary Supplements; | 2022 |
Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4.
Topics: Animals; Carbon Tetrachloride; Chemokine CCL3; Chemokine CCL4; Fibrosis; Hepatic Stellate Cells; Hya | 2022 |
Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytokines; Fibr | 2022 |
CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway.
Topics: Animals; Carbon Tetrachloride; Casein Kinase II; Fibrosis; Hedgehog Proteins; Hepatic Stellate Cells | 2023 |
miR-345-5p curbs hepatic stellate cell activation and liver fibrosis progression by suppressing hypoxia-inducible factor-1alpha expression.
Topics: 3' Untranslated Regions; Animals; Carbon Tetrachloride; Cell Proliferation; Fibrosis; Hepatic Stella | 2022 |
Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Liver; Liver Cirrhosis; Mice; Non-alcoholic Fatty Liver Dis | 2022 |
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.
Topics: Animals; Bleomycin; Carbon Tetrachloride; Fibrosis; Galectin 3; Idiopathic Pulmonary Fibrosis; Liver | 2022 |
Neurotrophic factors stimulate the activation of hepatic stellate cells in liver fibrosis.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbon Tetrachloride; Cytokines; Fibrosis; Glial Fibrill | 2022 |
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib | 2022 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Carica; Chemical and Drug Induced Liver Injury; Fibrosi | 2023 |
Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Hypertension, Portal; Kinin | 2022 |
Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Hypertension, Portal; Kinin | 2022 |
Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Hypertension, Portal; Kinin | 2022 |
Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Hypertension, Portal; Kinin | 2022 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibroblasts; Fibrosis; Hepatitis; Humans; Inflammation; Liv | 2023 |
Mangiferin relieves CCl4-induced liver fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Collagen; Fibrosis; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred | 2023 |
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Sirtuin 1; | 2023 |
HOXC8/TGF-β1 positive feedback loop promotes liver fibrosis and hepatic stellate cell activation via activating Smad2/Smad3 signaling.
Topics: Animals; Carbon Tetrachloride; Feedback; Fibrosis; Hepatic Stellate Cells; Homeodomain Proteins; Hum | 2023 |
Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation.
Topics: Animals; Carbon Tetrachloride; Diet; Fibrosis; Hepatic Stellate Cells; Humans; Inflammation; Liver; | 2023 |
Liver fibrotic development is reduced through inflammation prevention by an adenosine derivative compound.
Topics: Adenosine; Animals; Carbon Tetrachloride; Cytokines; Fibrosis; Inflammation; Liver; Liver Cirrhosis; | 2023 |
Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Fibrosis; Glutamate-Cysteine Ligase; Glutat | 2023 |
The application of a novel platform of multiparametric magnetic resonance imaging in a bioenvironmental toxic carbon tetrachloride-induced mouse model of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Inflammation; Liver; Liver Cirrhosi | 2023 |
Hepatocyte survival and proliferation by fibroblast growth factor 7 attenuates liver inflammation, and fibrogenesis during acute liver injury via paracrine mechanisms.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Collagen; Culture Media, Conditioned; Fibroblast | 2023 |
Evaluation of the flavonol-rich fraction of Rosa damascena in an animal model of liver fibrosis by targeting the expression of fibrotic cytokines, antioxidant/oxidant ratio and collagen cross-linking.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Collagen; Cytokines; Fibrosis; Flavonoids; Flavonols; K | 2023 |
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Extracellular Matrix; Fibrosis; Hepatitis; | 2023 |
Saffron reduces the liver fibrosis in mice by inhibiting the JAK/STAT3 pathway.
Topics: Animals; Carbon Tetrachloride; Crocus; Fibrosis; Hepatic Stellate Cells; Inflammation; Liver; Liver | 2023 |
Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Disease M | 2019 |
Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Marrow; Carbon Tetrachloride; Cell | 2019 |
Dysregulation of UDP-glucuronosyltransferases in CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis; Gene Expression Reg | 2020 |
Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Benzyl Alcohols; Carbon Tetrachloride; Disease Models | 2020 |
Pilea umbrosa ameliorate CCl
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; | 2020 |
Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Carotenoids; Disease Models, | 2021 |
AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis.
Topics: Adenylate Kinase; Alanine Transaminase; Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Model | 2020 |
Starch based hydrogel NPs loaded by anthocyanins might treat glycogen storage at cardiomyopathy in animal fibrotic model.
Topics: Animals; Anthocyanins; Carbon Tetrachloride; Cardiomyopathies; Cardiotoxicity; Disease Models, Anima | 2021 |
Downregulation of fibrosis and inflammatory signalling pathways in rats liver
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2021 |
Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Erlotinib Hydrochloride; | 2017 |
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Down-Regulation; End Stage Liver Disease; Endothelia | 2017 |
Improvement of portal venous pressure in cirrhotic rat livers by systemic treatment with adipose tissue-derived mesenchymal stromal cells.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cell Differentiation; Collagen; Disease Models, Anima | 2017 |
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Extrac | 2017 |
Protein S Exacerbates Chronic Liver Injury and Fibrosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; End Stage Liver Disease; Fibrosis; Hepatic Stellate Cells; | 2018 |
Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10.
Topics: Actins; Androstadienes; Animals; Anti-Inflammatory Agents; Aromatase Inhibitors; Bile Ducts; Carbon | 2017 |
The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis.
Topics: Amino Acid Oxidoreductases; Animals; Carbon Tetrachloride; Collagen; Cross-Linking Reagents; Elastin | 2019 |
Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice.
Topics: Animals; Apoptosis; Becaplermin; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Fibr | 2019 |
Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers.
Topics: Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Hepatic Stel | 2019 |
Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis.
Topics: Angiotensin II; Animals; Bleomycin; Calcium-Binding Proteins; Calpain; Carbon Tetrachloride; Cell Li | 2019 |
Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent.
Topics: Acetone; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis | 2013 |
A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Anim | 2013 |
Multimechanistic antifibrotic effect of biochanin a in rats: implications of proinflammatory and profibrogenic mediators.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2013 |
Effect of transplantation route on stem cell migration to fibrotic liver of rats via cellular magnetic resonance imaging.
Topics: Animals; Carbon Tetrachloride; Cell Differentiation; Cell Movement; Cells, Cultured; Ferric Compound | 2013 |
Syncoilin is an intermediate filament protein in activated hepatic stellate cells.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Line; Desmin; Fibrosis; HEK293 Cel | 2014 |
Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis.
Topics: Animals; Apoptosis Regulatory Proteins; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced L | 2013 |
Golden berry juice attenuates the severity of hepatorenal injury.
Topics: Alkaloids; Animals; Antioxidants; Beverages; Bilirubin; Biomarkers; Carbon Tetrachloride; Chemical a | 2013 |
Microbiome composition by pyrosequencing in mesenteric lymph nodes of rats with CCl4-induced cirrhosis.
Topics: Animals; Bifidobacterium; Biodiversity; Carbon Tetrachloride; Cells, Cultured; Disease Models, Anima | 2014 |
Effects of Carissa opaca fruits extracts on oxidative pulmonary damages and fibrosis in rats.
Topics: Animals; Antioxidants; Apocynaceae; Carbon Tetrachloride; DNA Fragmentation; Fibrosis; Fruit; Glutat | 2014 |
Herbal supplement attenuation of cardiac fibrosis in rats with CCl₄-induced liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Connective Tissue Growth Factor; Fibrosis; Liver Cirrhosis, Experimen | 2014 |
FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells.
Topics: Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Movement; Disease Models, Animal; Fibrosis; F | 2014 |
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
Topics: Albumins; Animals; Carbon Tetrachloride; Cyclooxygenase 2; Cytokines; Dinoprostone; Fibrosis; Gene E | 2014 |
Hematopoietic stem cells and liver regeneration: differentially acting hematopoietic stem cell mobilization agents reverse induced chronic liver injury.
Topics: Animals; Benzylamines; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chr | 2014 |
EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling.
Topics: Aniline Compounds; Animals; Bleomycin; Blotting, Western; Carbon Tetrachloride; Cell Line; Chromatin | 2015 |
CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.
Topics: Actins; Angiogenesis Inducing Agents; Animals; Antigens, CD; Antigens, Neoplasm; Becaplermin; Carbon | 2016 |
Assessment of liver fibrosis in rats by MRI with apparent diffusion coefficient and T1 relaxation time in the rotating frame.
Topics: Animals; Area Under Curve; Carbon Tetrachloride; Contrast Media; Diffusion Magnetic Resonance Imagin | 2016 |
Chemical Composition of Golden Berry Leaves Against Hepato-renal Fibrosis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bili | 2016 |
Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice.
Topics: Aminopropionitrile; Animals; Carbon Tetrachloride; Collagen; Collagen Type I; Collagen Type I, alpha | 2016 |
Rebamipide retards CCl4-induced hepatic fibrosis in rats: Possible role for PGE2.
Topics: Alanine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbo | 2016 |
Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways.
Topics: Alanine Transaminase; Alkaloids; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cell Line; | 2016 |
Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl
Topics: Animals; Biopsy; Carbon Tetrachloride; Disease Progression; Elasticity Imaging Techniques; Fibrosis; | 2016 |
Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line; Fibrosis; Humans; Inflammation; | 2017 |
Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Carrier Proteins; Cell Line, Tumor; Disease | 2017 |
Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Aquilegia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis; Glutathi | 2009 |
The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Differentiati | 2009 |
Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation.
Topics: Adrenergic alpha-Agonists; Animals; Base Sequence; Bile Acids and Salts; Carbon Tetrachloride; Cell | 2009 |
Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferati | 2009 |
Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice.
Topics: Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; Caspases; Disease Progression; Fibrosis; Hepat | 2009 |
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2009 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2010 |
Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice.
Topics: Animals; Anthocyanins; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Down-Regulation; Drug-R | 2010 |
Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Collagen Type I; Dimethylnitrosamine; Fibrosis; Hepatic St | 2010 |
MR Imaging of activated hepatic stellate cells in liver injured by CCl4 of rats with integrin-targeted ultrasmall superparamagnetic iron oxide.
Topics: Animals; Carbon Tetrachloride; Ferric Compounds; Ferrocyanides; Fibrosis; Hepatic Stellate Cells; In | 2011 |
Placenta extract promote liver regeneration in CCl4-injured liver rat model.
Topics: Actins; Albumins; Alkyl and Aryl Transferases; Animals; ATP-Binding Cassette Transporters; Carbon Te | 2011 |
Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis.
Topics: Animals; Carbon Tetrachloride; DNA Damage; Fibrosis; Gene Deletion; Gene Expression Regulation, Neop | 2011 |
Hot water extracted Lycium barbarum and Rehmannia glutinosa inhibit liver inflammation and fibrosis in rats.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Down-Regulation; Fibrosis; Humans; Interleuki | 2011 |
PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Cyclooxygenase 1; Disease Models, Animal; Endothelium | 2012 |
(Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione protects rats from carbon tetrachloride-induced liver injury and fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Female; Fibrosis; Liver; Molecular Structure; Random Allocation; Rats | 2012 |
Evaluation of the spontaneous reversibility of carbon tetrachloride-induced liver cirrhosis in rabbits.
Topics: Animals; Body Weight; Carbon Tetrachloride; Fibrosis; Image Processing, Computer-Assisted; Liver; Li | 2012 |
A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Cytokin | 2013 |
Effect of cortisone on carbon tetrachloride cirrhosis in rats.
Topics: Animals; Carbon Tetrachloride; Cortisone; Fibrosis; Liver Cirrhosis; Liver Cirrhosis, Experimental; | 1954 |
[Changes in the activity of individual enzymes in the liver in cirrhosis produced by carbon tetrachloride in rats].
Topics: Animals; Carbon Tetrachloride; Enzymes; Fibrosis; Liver Cirrhosis; Liver Diseases; Rats | 1961 |
An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes.
Topics: Albumins; Animals; Bone Marrow Cells; Carbon Tetrachloride; Cell Culture Techniques; Cell Differenti | 2003 |
Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Fibrosis; Gene Expression Regulation; | 2004 |
Suppressive effects of 17beta-estradiol on hepatic fibrosis in CCl4-induced rat model.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Estradiol; Female; Fibrosis; Hepatocytes; Liver; Liv | 2004 |
Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; beta-Alanine; Betaine; Carbon Tetrachlor | 2004 |
Lysosomal enzyme activity during development of carbon tetrachloride induced cirrhosis in rats.
Topics: Acetylglucosaminidase; Acid Phosphatase; Animals; Carbon Tetrachloride; Fibrosis; Glucuronidase; Lys | 2004 |
Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride; Female; Fibrosis; Gen | 2004 |
Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury.
Topics: Animals; Carbon Tetrachloride; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assa | 2005 |
S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter.
Topics: Animals; Base Sequence; Carbon Tetrachloride; Cells, Cultured; Collagen; Collagen Type I; Cytochrome | 2005 |
Modeling liver fibrosis in rodents.
Topics: Actins; Animals; Animals, Genetically Modified; Apoptosis; Azo Compounds; Carbon Tetrachloride; Colo | 2005 |
F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis?
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen; DNA; Dose-Response Rel | 2005 |
Measurement of protein turnover rates by heavy water labeling of nonessential amino acids.
Topics: Amino Acids; Animals; Blood Proteins; Brain; Brain Chemistry; Carbon Tetrachloride; Collagen; Deuter | 2006 |
Up-regulation of Metabotropic glutamate receptor 3 (mGluR3) in rat fibrosis and cirrhosis model of persistent hypoxic condition.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Fibrosis; Hypoxia; Immunohistochemistry; Live | 2007 |
Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Extracellula | 2007 |
Assessment of diffusion-weighted MR imaging in liver fibrosis.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Diffusion Magnetic Resonance Imaging; Echo-Plan | 2007 |
Low molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type I; Collagen Type I, alpha 1 Chain; Dalteparin; | 2007 |
Recombinant ST2 boosts hepatic Th2 response in vivo.
Topics: Animals; Carbon Tetrachloride; CD4-Positive T-Lymphocytes; Cytokines; Fibrosis; Immunoglobulin Fc Fr | 2007 |
Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemic | 2007 |
Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat.
Topics: Animals; Automation; Carbon Tetrachloride; Elasticity; Elasticity Imaging Techniques; Fibrosis; Hydr | 2007 |
Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats.
Topics: Animals; Apoptosis; Body Weight; Carbon Tetrachloride; Fibrosis; Gene Expression Profiling; Gene Exp | 2008 |
Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Collagen; Disease Models, Animal; Fibrosis; Genes, | 2008 |
Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Down-Regulation; Fibrosis; Forecasting; Gli | 2008 |
Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Membrane; Disease Models, Animal; Fatty Liver, Alcoholic; Fibros | 1993 |
Lymph vessel expansion and function in the development of hepatic fibrosis and cirrhosis.
Topics: Animals; Carbon Tetrachloride; Fibrosis; Kinetics; Liver; Liver Cirrhosis, Experimental; Lymphatic S | 1997 |
Enhancement of aflatoxin B1-induced enzyme altered hepatic foci in rats by treatment with carbon tetrachloride.
Topics: Aflatoxin B1; Animals; Carbon Tetrachloride; Drug Synergism; Fibrosis; gamma-Glutamyltransferase; Gl | 1998 |
Intracerebroventricular infusion of hypertonic NaCl increases urinary CGMP in healthy and cirrhotic rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Brain; Carbon Tetrachloride; Cyclic GMP; Endothe | 1999 |
Simultaneous induction of galectin-3 phosphorylated on tyrosine residue, p21(WAF1/Cip1/Sdi1), and the proliferating cell nuclear antigen at a distinctive period of repair of hepatocytes injured by CCl4.
Topics: Animals; Antigens, Differentiation; Blotting, Northern; Carbon Tetrachloride; Cloning, Molecular; Cy | 2001 |
Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Chemoprevention of aflatoxin B1-initiated and carbon tetrachloride-promoted hepatocarcinogenesis in the rat by green tea.
Topics: Aflatoxin B1; Animals; Carbon Tetrachloride; Cell Division; Cell Transformation, Neoplastic; Fibrosi | 2000 |
The protective effect of HD-03 in CCl4-induced hepatic encephalopathy in rats.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Astrocytes; Carbon Tetrachlorid | 2001 |
The expression of AT1 receptor on hepatic stellate cells in rat fibrosis induced by CCl4.
Topics: Alanine Transaminase; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartate A | 2001 |
Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Induction; Extracellul | 1991 |
The production of hepatic cirrhosis in rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Fibrosis; Hyperplasia; Hypertrophy; Liver; Liver Cirrhos | 1991 |
Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats.
Topics: Adenine Nucleotides; Adenosine; Animals; Carbon Tetrachloride; Collagen; Fibrosis; Liver; Liver Cirr | 1990 |
[Protective effects of the pollen of Codonopsis pilosula (Franch.) Nannf. on liver lesions at the ultrastructural level].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fibrosis; Liver; Male | 1989 |
Changes in prolinase and prolidase activity during CCl4 administration inducing liver cytolysis and fibrosis in rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Dipeptidases; Fibr | 1987 |