suramin and Fibrosis
suramin has been researched along with Fibrosis in 12 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy and safety of suramin, genistein and collagen matrix for the prevention of inflammation, the reduction of fibrosis and the delay in adjustment after strabismus surgery on a rabbit model." | 7.83 | Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best? ( Akova, YA; Bakar, C; Oktem, C; Oto, S; Ozdemir, H; Toru, S, 2016) |
| "Topical application of suramin could reduce epidural fibrosis after laminectomy, and the application of suramin could inhibit the proliferation of fibroblasts in rats." | 7.83 | The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats. ( Chen, H; Dai, J; He, J; Li, X; Sun, Y; Wang, J; Wang, S; Yan, L, 2016) |
| "We recently showed that suramin treatment prevents the onset of renal fibrosis in a model of obstructive nephropathy induced by unilateral ureteral obstruction (UUO)." | 7.77 | Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. ( Liu, N; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| "Suramin- and saline-treated (control) mdx mice performed exercise on a treadmill to worsen disease progression." | 5.37 | Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker. ( Marques, MJ; Matsumura, CY; Pertille, A; Santo Neto, H; Taniguti, AP, 2011) |
| "Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown." | 5.37 | Suramin inhibits renal fibrosis in chronic kidney disease. ( Liu, N; Pang, M; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| "Suramin was applied with concentrations ranging from 10 mg/ml to 333 mg/ml once during surgery and four times following surgery." | 5.30 | Suramin inhibits wound healing following filtering procedures for glaucoma. ( Chévez-Barrios, P; Feldman, RM; Lieberman, MW; Mietz, H, 1998) |
| "To evaluate the efficacy and safety of suramin, genistein and collagen matrix for the prevention of inflammation, the reduction of fibrosis and the delay in adjustment after strabismus surgery on a rabbit model." | 3.83 | Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best? ( Akova, YA; Bakar, C; Oktem, C; Oto, S; Ozdemir, H; Toru, S, 2016) |
| "Topical application of suramin could reduce epidural fibrosis after laminectomy, and the application of suramin could inhibit the proliferation of fibroblasts in rats." | 3.83 | The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats. ( Chen, H; Dai, J; He, J; Li, X; Sun, Y; Wang, J; Wang, S; Yan, L, 2016) |
| "Suramin treatment initiated at 2 weeks post-injury was observed to promote muscle regeneration and muscle strength, and to decrease fibrosis." | 3.78 | Timing of the administration of suramin treatment after muscle injury. ( Fu, FH; Gharaibeh, B; Huard, J; Li, Y; Nozaki, M; Ota, S; Terada, S; Uehara, K, 2012) |
| " To determine whether suramin, an antagonist of TGF-β, could aid in the prevention of fibrosis, we injected it into the anterior tibialis muscle [12 rabbits received low-dose suramin (50 mg), 12 received high-dose suramin (100 mg), and 12 received sham injections]." | 3.77 | Distraction osteogenesis-induced muscle fibrosis may not be associated with TGF-β1. ( Koplin, SA; McCarthy, J; Mitchell, J; Noonan, KJ; Olabisi, R; Salamat, S; Su, L; Torrealba, J, 2011) |
| "We recently showed that suramin treatment prevents the onset of renal fibrosis in a model of obstructive nephropathy induced by unilateral ureteral obstruction (UUO)." | 3.77 | Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. ( Liu, N; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| "Suramin enhances muscle healing by both stimulating muscle regeneration and preventing fibrosis in contused skeletal muscle." | 3.74 | Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth. ( Ambrosio, F; Fu, FH; Huard, J; Li, Y; Nozaki, M; Uehara, K; Zhu, J, 2008) |
| "Severe muscle fibrosis is the endpoint of many chronic myopathies." | 1.39 | Duchenne muscular dystrophy fibroblast nodules: a cell-based assay for screening anti-fibrotic agents. ( Gibertini, S; Mantegazza, R; Mora, M; Savadori, P; Zanotti, S, 2013) |
| "Suramin- and saline-treated (control) mdx mice performed exercise on a treadmill to worsen disease progression." | 1.37 | Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker. ( Marques, MJ; Matsumura, CY; Pertille, A; Santo Neto, H; Taniguti, AP, 2011) |
| "Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown." | 1.37 | Suramin inhibits renal fibrosis in chronic kidney disease. ( Liu, N; Pang, M; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| "Suramin has been found to inhibit transforming growth factor (TGF)-beta1 expression by competitively binding to the growth factor receptor." | 1.32 | Antifibrotic effects of suramin in injured skeletal muscle after laceration. ( Chan, YS; Foster, W; Fu, FH; Horaguchi, T; Huard, J; Li, Y; Somogyi, G, 2003) |
| "Suramin was applied with concentrations ranging from 10 mg/ml to 333 mg/ml once during surgery and four times following surgery." | 1.30 | Suramin inhibits wound healing following filtering procedures for glaucoma. ( Chévez-Barrios, P; Feldman, RM; Lieberman, MW; Mietz, H, 1998) |
Research
Studies (12)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Zanotti, S | 1 |
| Gibertini, S | 1 |
| Savadori, P | 1 |
| Mantegazza, R | 1 |
| Mora, M | 1 |
| Oktem, C | 1 |
| Oto, S | 1 |
| Toru, S | 1 |
| Bakar, C | 1 |
| Ozdemir, H | 1 |
| Akova, YA | 1 |
| Dai, J | 1 |
| Li, X | 1 |
| Yan, L | 1 |
| Chen, H | 1 |
| He, J | 1 |
| Wang, S | 1 |
| Wang, J | 1 |
| Sun, Y | 1 |
| Nozaki, M | 2 |
| Li, Y | 3 |
| Zhu, J | 1 |
| Ambrosio, F | 1 |
| Uehara, K | 2 |
| Fu, FH | 3 |
| Huard, J | 3 |
| Taniguti, AP | 2 |
| Pertille, A | 1 |
| Matsumura, CY | 2 |
| Santo Neto, H | 2 |
| Marques, MJ | 2 |
| Koplin, SA | 1 |
| Su, L | 1 |
| Salamat, S | 1 |
| Torrealba, J | 1 |
| McCarthy, J | 1 |
| Mitchell, J | 1 |
| Olabisi, R | 1 |
| Noonan, KJ | 1 |
| Liu, N | 2 |
| Tolbert, E | 2 |
| Pang, M | 1 |
| Ponnusamy, M | 2 |
| Yan, H | 2 |
| Zhuang, S | 2 |
| Ota, S | 1 |
| Terada, S | 1 |
| Gharaibeh, B | 1 |
| Rodrigues-Simioni, L | 1 |
| Chan, YS | 1 |
| Foster, W | 1 |
| Horaguchi, T | 1 |
| Somogyi, G | 1 |
| Mietz, H | 1 |
| Chévez-Barrios, P | 1 |
| Feldman, RM | 1 |
| Lieberman, MW | 1 |
Other Studies
12 other studies available for suramin and Fibrosis
| Article | Year |
|---|---|
Duchenne muscular dystrophy fibroblast nodules: a cell-based assay for screening anti-fibrotic agents.
Topics: Biological Assay; Blotting, Western; Collagen; Decorin; Drug Evaluation, Preclinical; Enzyme-Linked | 2013 |
Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best?
Topics: Animals; Antineoplastic Agents; Biomarkers; Collagen; Conjunctiva; Endoglin; Epithelium; Female; Fib | 2016 |
The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats.
Topics: Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Epidu | 2016 |
Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Line; Contusions; Down-Regulation; Fibros | 2008 |
Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker.
Topics: Animals; Creatine Kinase; Disease Models, Animal; Female; Fibrosis; Male; Mice; Mice, Inbred C57BL; | 2011 |
Distraction osteogenesis-induced muscle fibrosis may not be associated with TGF-β1.
Topics: Animals; Ankle Joint; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Immunohist | 2011 |
Suramin inhibits renal fibrosis in chronic kidney disease.
Topics: Actins; Animals; Antineoplastic Agents; Cells, Cultured; Chronic Disease; Disease Models, Animal; Di | 2011 |
Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy.
Topics: Actins; Animals; Blotting, Western; Cells, Cultured; Collagen Type I; Disease Progression; ErbB Rece | 2011 |
Timing of the administration of suramin treatment after muscle injury.
Topics: Animals; Antineoplastic Agents; Contusions; Drug Administration Schedule; Fibroblasts; Fibrosis; Fol | 2012 |
Suramin affects metalloproteinase-9 activity and increases β-dystroglycan levels in the diaphragm of the dystrophin-deficient mdx mouse.
Topics: Animals; Diaphragm; Dystroglycans; Dystrophin; Enzyme Activation; Female; Fibrosis; Male; Matrix Met | 2012 |
Antifibrotic effects of suramin in injured skeletal muscle after laceration.
Topics: 3T3 Cells; Actins; Animals; Blotting, Western; Fibroblasts; Fibrosis; Injections; Intracellular Memb | 2003 |
Suramin inhibits wound healing following filtering procedures for glaucoma.
Topics: Animals; Electromyography; Female; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pressure; Rabb | 1998 |