Page last updated: 2024-11-04

suramin and Fibrosis

suramin has been researched along with Fibrosis in 12 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the efficacy and safety of suramin, genistein and collagen matrix for the prevention of inflammation, the reduction of fibrosis and the delay in adjustment after strabismus surgery on a rabbit model."7.83Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best? ( Akova, YA; Bakar, C; Oktem, C; Oto, S; Ozdemir, H; Toru, S, 2016)
"Topical application of suramin could reduce epidural fibrosis after laminectomy, and the application of suramin could inhibit the proliferation of fibroblasts in rats."7.83The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats. ( Chen, H; Dai, J; He, J; Li, X; Sun, Y; Wang, J; Wang, S; Yan, L, 2016)
"We recently showed that suramin treatment prevents the onset of renal fibrosis in a model of obstructive nephropathy induced by unilateral ureteral obstruction (UUO)."7.77Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. ( Liu, N; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011)
"Suramin- and saline-treated (control) mdx mice performed exercise on a treadmill to worsen disease progression."5.37Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker. ( Marques, MJ; Matsumura, CY; Pertille, A; Santo Neto, H; Taniguti, AP, 2011)
"Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown."5.37Suramin inhibits renal fibrosis in chronic kidney disease. ( Liu, N; Pang, M; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011)
"Suramin was applied with concentrations ranging from 10 mg/ml to 333 mg/ml once during surgery and four times following surgery."5.30Suramin inhibits wound healing following filtering procedures for glaucoma. ( Chévez-Barrios, P; Feldman, RM; Lieberman, MW; Mietz, H, 1998)
"To evaluate the efficacy and safety of suramin, genistein and collagen matrix for the prevention of inflammation, the reduction of fibrosis and the delay in adjustment after strabismus surgery on a rabbit model."3.83Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best? ( Akova, YA; Bakar, C; Oktem, C; Oto, S; Ozdemir, H; Toru, S, 2016)
"Topical application of suramin could reduce epidural fibrosis after laminectomy, and the application of suramin could inhibit the proliferation of fibroblasts in rats."3.83The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats. ( Chen, H; Dai, J; He, J; Li, X; Sun, Y; Wang, J; Wang, S; Yan, L, 2016)
"Suramin treatment initiated at 2 weeks post-injury was observed to promote muscle regeneration and muscle strength, and to decrease fibrosis."3.78Timing of the administration of suramin treatment after muscle injury. ( Fu, FH; Gharaibeh, B; Huard, J; Li, Y; Nozaki, M; Ota, S; Terada, S; Uehara, K, 2012)
" To determine whether suramin, an antagonist of TGF-β, could aid in the prevention of fibrosis, we injected it into the anterior tibialis muscle [12 rabbits received low-dose suramin (50 mg), 12 received high-dose suramin (100 mg), and 12 received sham injections]."3.77Distraction osteogenesis-induced muscle fibrosis may not be associated with TGF-β1. ( Koplin, SA; McCarthy, J; Mitchell, J; Noonan, KJ; Olabisi, R; Salamat, S; Su, L; Torrealba, J, 2011)
"We recently showed that suramin treatment prevents the onset of renal fibrosis in a model of obstructive nephropathy induced by unilateral ureteral obstruction (UUO)."3.77Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. ( Liu, N; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011)
"Suramin enhances muscle healing by both stimulating muscle regeneration and preventing fibrosis in contused skeletal muscle."3.74Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth. ( Ambrosio, F; Fu, FH; Huard, J; Li, Y; Nozaki, M; Uehara, K; Zhu, J, 2008)
"Severe muscle fibrosis is the endpoint of many chronic myopathies."1.39Duchenne muscular dystrophy fibroblast nodules: a cell-based assay for screening anti-fibrotic agents. ( Gibertini, S; Mantegazza, R; Mora, M; Savadori, P; Zanotti, S, 2013)
"Suramin- and saline-treated (control) mdx mice performed exercise on a treadmill to worsen disease progression."1.37Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker. ( Marques, MJ; Matsumura, CY; Pertille, A; Santo Neto, H; Taniguti, AP, 2011)
"Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown."1.37Suramin inhibits renal fibrosis in chronic kidney disease. ( Liu, N; Pang, M; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011)
"Suramin has been found to inhibit transforming growth factor (TGF)-beta1 expression by competitively binding to the growth factor receptor."1.32Antifibrotic effects of suramin in injured skeletal muscle after laceration. ( Chan, YS; Foster, W; Fu, FH; Horaguchi, T; Huard, J; Li, Y; Somogyi, G, 2003)
"Suramin was applied with concentrations ranging from 10 mg/ml to 333 mg/ml once during surgery and four times following surgery."1.30Suramin inhibits wound healing following filtering procedures for glaucoma. ( Chévez-Barrios, P; Feldman, RM; Lieberman, MW; Mietz, H, 1998)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's2 (16.67)29.6817
2010's9 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zanotti, S1
Gibertini, S1
Savadori, P1
Mantegazza, R1
Mora, M1
Oktem, C1
Oto, S1
Toru, S1
Bakar, C1
Ozdemir, H1
Akova, YA1
Dai, J1
Li, X1
Yan, L1
Chen, H1
He, J1
Wang, S1
Wang, J1
Sun, Y1
Nozaki, M2
Li, Y3
Zhu, J1
Ambrosio, F1
Uehara, K2
Fu, FH3
Huard, J3
Taniguti, AP2
Pertille, A1
Matsumura, CY2
Santo Neto, H2
Marques, MJ2
Koplin, SA1
Su, L1
Salamat, S1
Torrealba, J1
McCarthy, J1
Mitchell, J1
Olabisi, R1
Noonan, KJ1
Liu, N2
Tolbert, E2
Pang, M1
Ponnusamy, M2
Yan, H2
Zhuang, S2
Ota, S1
Terada, S1
Gharaibeh, B1
Rodrigues-Simioni, L1
Chan, YS1
Foster, W1
Horaguchi, T1
Somogyi, G1
Mietz, H1
Chévez-Barrios, P1
Feldman, RM1
Lieberman, MW1

Other Studies

12 other studies available for suramin and Fibrosis

ArticleYear
Duchenne muscular dystrophy fibroblast nodules: a cell-based assay for screening anti-fibrotic agents.
    Cell and tissue research, 2013, Volume: 352, Issue:3

    Topics: Biological Assay; Blotting, Western; Collagen; Decorin; Drug Evaluation, Preclinical; Enzyme-Linked

2013
Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best?
    Current eye research, 2016, Volume: 41, Issue:3

    Topics: Animals; Antineoplastic Agents; Biomarkers; Collagen; Conjunctiva; Endoglin; Epithelium; Female; Fib

2016
The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats.
    Journal of orthopaedic surgery and research, 2016, Oct-01, Volume: 11, Issue:1

    Topics: Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Epidu

2016
Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth.
    The American journal of sports medicine, 2008, Volume: 36, Issue:12

    Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Line; Contusions; Down-Regulation; Fibros

2008
Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker.
    Muscle & nerve, 2011, Volume: 43, Issue:1

    Topics: Animals; Creatine Kinase; Disease Models, Animal; Female; Fibrosis; Male; Mice; Mice, Inbred C57BL;

2011
Distraction osteogenesis-induced muscle fibrosis may not be associated with TGF-β1.
    Journal of pediatric orthopedics, 2011, Volume: 31, Issue:4

    Topics: Animals; Ankle Joint; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Immunohist

2011
Suramin inhibits renal fibrosis in chronic kidney disease.
    Journal of the American Society of Nephrology : JASN, 2011, Volume: 22, Issue:6

    Topics: Actins; Animals; Antineoplastic Agents; Cells, Cultured; Chronic Disease; Disease Models, Animal; Di

2011
Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:3

    Topics: Actins; Animals; Blotting, Western; Cells, Cultured; Collagen Type I; Disease Progression; ErbB Rece

2011
Timing of the administration of suramin treatment after muscle injury.
    Muscle & nerve, 2012, Volume: 46, Issue:1

    Topics: Animals; Antineoplastic Agents; Contusions; Drug Administration Schedule; Fibroblasts; Fibrosis; Fol

2012
Suramin affects metalloproteinase-9 activity and increases β-dystroglycan levels in the diaphragm of the dystrophin-deficient mdx mouse.
    Muscle & nerve, 2012, Volume: 46, Issue:5

    Topics: Animals; Diaphragm; Dystroglycans; Dystrophin; Enzyme Activation; Female; Fibrosis; Male; Matrix Met

2012
Antifibrotic effects of suramin in injured skeletal muscle after laceration.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:2

    Topics: 3T3 Cells; Actins; Animals; Blotting, Western; Fibroblasts; Fibrosis; Injections; Intracellular Memb

2003
Suramin inhibits wound healing following filtering procedures for glaucoma.
    The British journal of ophthalmology, 1998, Volume: 82, Issue:7

    Topics: Animals; Electromyography; Female; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pressure; Rabb

1998