cytosporone b profile

cytosporone B: a Nur77 agonist; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	10687292
CHEMBL ID	1221517
CHEBI ID	95039
SCHEMBL ID	14900697
MeSH ID	M0524914

Synonym
CHEMBL1221517
cytosporone b
ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate
bdbm50378798
321661-62-5
3,5-dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester
csn-b
benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester
dothiorelone g
gtpl5424
BRD-K86191271-001-01-9
SCHEMBL14900697
DTXSID80443557
cytosporone b, >=98% (hplc)
CHEBI:95039
CS-6882
HY-N2148
ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
AKOS027470187
J-018662
BCP18389
cytosporone-b; csn-b; dothiorelone g; dothiorelone-g
(3,5-dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester
mfcd12912406
Q27076966
EX-A4029
AS-16748
HMS3740I13
csn-b;dothiorelone g
e4l ,
ethyl 2-[2-octanoyl-3,5-bis(oxidanyl)phenyl]ethanoate
W16910
S6674
WMA66162
3,5-dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester, csn-b
3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester, csn-b
A935069
AC-36470

Excerpt	Reference	Relevance
"Cytosporone B (Csn-B) is a naturally occurring agonist of Nr4A1, and the role of Csn-B in the physiological process of cardiac rejection is poorly defined."	( Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+T cells. Chen, J; Chen, S; Ding, X; Le, S; Su, Y; Wang, K; Wu, C; Xia, J; Zhang, A, 2022)	2.89

Class	Description
aromatic ketone	A ketone in which the carbonyl group is attached to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)	EC50 (µMol)	0.0002	0.0001	0.0002	0.0003	AID500598; AID500599
Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)	Kd	0.9900	0.2900	0.7233	1.5100	AID500587; AID500644; AID500645
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
positive regulation of transcription by RNA polymerase II	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
response to amphetamine	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
cell migration involved in sprouting angiogenesis	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
transcription by RNA polymerase II	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
apoptotic process	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
inflammatory response	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
signal transduction	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
neurotransmitter secretion involved in regulation of skeletal muscle contraction	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
intracellular receptor signaling pathway	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
detection of lipopolysaccharide	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
endothelial cell chemotaxis	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
skeletal muscle cell differentiation	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
positive regulation of apoptotic process	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
cellular response to fibroblast growth factor stimulus	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
fat cell differentiation	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
negative regulation of cell cycle	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
response to electrical stimulus	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
regulation of type B pancreatic cell proliferation	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
cellular response to corticotropin-releasing hormone stimulus	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
non-canonical inflammasome complex assembly	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
lipopolysaccharide binding	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
DNA binding	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
nuclear receptor activity	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
protein binding	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
zinc ion binding	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
identical protein binding	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
protein heterodimerization activity	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
nuclear glucocorticoid receptor binding	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
nucleoplasm	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
mitochondrion	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
cytosol	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
nuclear membrane	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
presynapse	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
chromatin	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
transcription regulator complex	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
nucleus	Nuclear receptor subfamily 4 group A member 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (132)

Assay ID	Title	Year	Journal	Article
AID500604	Increase in blood glucose level in wild-type mouse C57BL/6 at 50 mg/kg, ip within 30 mins	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808293	Modulation of Gal4-fused VP16 expressed in PC12 cells co-transfected with UAS repoter gene assessed as decrease in luciferase activity at 5 to 100 uM incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808467	Modulation of full length human NOR1 expressed in SK-N-BE(2) cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500662	Agonist activity at Nur77 expressed in human BGC823 cells assessed as Nr4a1mRNA expression by real-time PCR	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121081	Induction of apoptosis in human BGC823 cells assessed as procaspase9 cleavage at 15.5 uM after 48 hrs	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500607	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as glucose-6-phosphatase mRNA at 50 mg/kg, ip within 30 mins by real-time PCR analysis relative to control	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500597	Binding affinity to nuclear orphan receptor Nur77 by sedimentation equilibrium assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500592	Binding affinity to GST-tagged nuclear orphan receptor Nur77 at 25 degC by fluorescence quenching analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500659	Agonist activity at Nur77 in Nr4A1 deficient mouse assessed as transcriptional activation of luciferase reporter gene relative to control	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500620	Agonist activity at Nur77 in insulin treated mouse C57BL/6 assessed as glucose-6-phosphatase mRNA after 60 mins by real-time PCR relative to control	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500588	Agonist activity at nuclear orphan receptor Nur77 in human BGC823 cells bearing beta-galactosidase expression vector assessed as transcriptional activation of NurRE reporter gene after 12 hrs by luciferase assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500601	Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-Y453A assessed as transactivation after 12 hrs by luciferase reporter gene assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808468	Modulation of full length human Nur77 expressed in SK-N-BE(2) cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assa	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1121083	Induction of apoptosis in human BGC823 cells assessed as nuclear DNA condensation at 15.5 uM after 48 hrs	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500599	Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-LBD assessed as transactivation after 12 hrs by luciferase reporter gene assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808450	Modulation of full length human Nur77 expressed in SK-N-BE(2) cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500640	Antitumor activity against human BGC823 cells expressing Nur77-WT xenografted in athymic nude mouse BALB/c assessed as tumor weight 13 mg/kg, ip twice a week after 4 weeks	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808283	Cytotoxicity against rat PC-12 cells assessed as reduction in cell viability at 5 to 100 uM incubated for 18 hrs by Cell titer-glo assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808274	Modulation of full length human Nurr1 expressed in SKNBE(2) cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500653	Induction of SRC1 recruitment to NurRE in human BGC823 cells after 12 hrs by luciferase/beta-galactosidase reporter assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808463	Modulation of full length human NOR1 expressed in HEK293T cells co-transfected with RXRalpha luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500628	Induction of mitochondrial translocation of Nur77 from nucleus in human BGC823 cells transfected with GFP-Nur77 at 5 ug/ml after 12 hrs using immunostained with anti-Hsp60 by confocal microscopy	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500624	Induction of Nur77 mediated apoptosis in human BGC823 cells assessed as nuclear DNA condensation by flow cytometry assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500611	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as pyruvate kinase mRNA at 50 mg/kg, ip within 30 mins by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808470	Modulation of full length human Nur77 expressed in SK-N-BE(2) cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500630	Antiproliferative activity against human BGC823 cells assessed as number of viable cells after 72 hrs by MTT assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500618	Agonist activity at Nur77 in Nr4a1 deficient mouse C57BL/6 assessed as fructose-1,6-bisphosphatase mRNA at 50 mg/kg, ip by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808469	Modulation of full length human Nur77 expressed in SK-N-BE(2) cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808276	Modulation of full length human Nurr1 expressed in PC12 cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500621	Agonist activity at Nur77 in insulin treated mouse C57BL/6 assessed as fructose-1,6-bisphosphatase mRNA after 60 mins by real-time PCR relative to control	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500660	Agonist activity at Nur77 in wild-type mouse transfected withGAL4-Y453A assessed as transcriptional activation of luciferase reporter gene	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808275	Modulation of full length human Nurr1 expressed in PC12 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500612	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as glucose-6-phosphatase mRNA at 50 mg/kg, ip after 300 mins by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808474	Modulation of full length human Nur77 expressed in PC12 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500616	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as pyruvate kinase mRNA at 50 mg/kg, ip after 300 mins by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500658	Agonist activity at Nur77 in wild-type mouse assessed as transcriptional activation of luciferase reporter gene relative to control	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500595	Binding affinity to nuclear orphan receptor Nur77 Y453A mutant at 5 uM by fluorescence quenching analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500625	Induction of Nur77 mediated apoptosis in human BGC823 cells assessed as cytochrome C release from cytosol at 5 uM after 24 hrs by Western blotting analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500626	Induction of Nur77 mediated apoptosis in human BGC823 cells assessed as cytochrome C release from mitochondria at 5 uM after 24 hrs by Western blotting analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500642	Antitumor activity against human BGC823 cells expressing Nur77-WT xenografted in athymic nude mouse BALB/c assessed as increase in Nur77 level by TUNEL assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808458	Modulation of full length human NOR1 expressed in SK-N-BE(2) cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500613	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as fructose-1,6-bisphosphatase mRNA at 50 mg/kg, ip after 300 mins by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500615	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as phosphofructokinase mRNA at 50 mg/kg, ip after 300 mins by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808462	Modulation of full length human Nur77 expressed in HEK293 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter gene assa	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500608	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as fructose-1,6-bisphosphatase mRNA at 50 mg/kg, ip within 30 mins by real-time PCR analysis relative to control	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500657	Agonist activity at Nur77 expressed in human gastric cancer BGC823 assessed as transactivation in presence of siRNA against Nur77	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808471	Modulation of full length human Nur77 expressed in PC12 cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808292	Modulation of Gal4-fused VP16 expressed in SKNBE2 cells co-transfected with UAS repoter gene assessed as decrease in luciferase activity at 5 to 100 uM incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500632	Antiproliferative activity against human H1299 cells assessed as number of viable cells after 72 hrs by MTT assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808295	Modulation of Gal4-fused VP16 expressed in HEK293T cells co-transfected with UAS repoter gene assessed as decrease in luciferase activity at 5 to 100 uM incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808477	Modulation of full length human NOR1 expressed in PC12 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808456	Modulation of full length human NOR1 expressed in SK-N-BE(2) cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500606	Increase in blood glucose level in Nr4a1 deficient mouse C57BL/6 at 50 mg/kg, ip within 30 mins	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500638	Antimicrobial activity against Staphylococcus aureus	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500622	Induction of Nur77 mediated apoptosis in human BGC823 cells at 5 uM after 48 hrs by flow cytometry assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121080	Induction of apoptosis in human H460 cells assessed as DNA fragmentation at 10 uM after 8 hrs by DAPI staining-based confocal microscopy relative to control	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500591	Agonist activity at nuclear orphan receptor Nur77 in human BGC823 cells bearing beta-galactosidase expression vector assessed as transcriptional activation of thyroid receptor reporter gene after 12 hrs by luciferase assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808478	Modulation of full length human NOR1 expressed in PC12 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500617	Agonist activity at Nur77 in Nr4a1 deficient mouse C57BL/6 assessed as glucose-6-phosphatase mRNA at 50 mg/kg, ip by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808278	Modulation of full length human Nurr1 expressed in PC12 cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500661	Agonist activity at Nur77 in Nr4a1 deficient mouse transfected withGAL4-Y453A assessed as transcriptional activation of luciferase reporter gene	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500596	Binding affinity to nuclear orphan receptor Nur77 assessed as conformational change in receptor by CD spectroscopic	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500598	Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-Nur77 assessed as transactivation after 12 hrs by luciferase reporter gene assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500652	Induction of SRC2 recruitment to NurRE in human BGC823 cells after 12 hrs by luciferase/beta-galactosidase reporter assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808277	Modulation of full length human Nurr1 expressed in PC12 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500848	Antitumor activity against human BGC823 cells expressing si-Nur77 xenografted in athymic nude mouse BALB/c assessed as apoptotic cells by TUNEL assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500649	Induction of Nur77-SRC1 interaction in human 293T cells by GST-pull-down assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121084	Induction of translocation of NR4A1 from nucleus to cytoplasm in human H460 cells at 10 uM after 8 hrs by DAPI staining-based confocal microscopy relative to control	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500589	Agonist activity at nuclear orphan receptor Nur77 in human BGC823 cells bearing beta-galactosidase expression vector assessed as transcriptional activation of retinoic acid receptor response element after 12 hrs by luciferase assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121089	Binding affinity to NR4A1 (unknown origin) at 0.1 uM by luciferase reporter gene assay relative to control	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500637	Antimicrobial activity against Mycobacterium tuberculosis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121091	Cytotoxicity against human H460 cells at 20 uM after 72 hrs by MTT assay	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID1808466	Modulation of full length human NOR1 expressed in HEK293T cells co-transfected with with RXRalpha luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter gene assa	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500636	Antiproliferative activity against mouse ME-Hep4 cells assessed as number of viable cells after 72 hrs by MTT assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121087	Induction of apoptosis in human H460 cells assessed as chromatin condensation at 10 uM after 8 hrs by relative to control	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID1808455	Binding affinity to recombinant full length N-terminal His-tagged Nurr1 LBD (353 to 598 residue) expressed in Escherichia coli BL21 by NMR spectroscopy analysis	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500631	Antiproliferative activity against human SW620 cells assessed as number of viable cells after 72 hrs by MTT assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808465	Modulation of full length human NOR1 expressed in HEK293 cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808285	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability at 5 to 100 uM incubated for 18 hrs by Cell titer-glo assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500634	Antiproliferative activity against mouse NIH/3T3 cells assessed as number of viable cells after 72 hrs by MTT assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500635	Antiproliferative activity against human HL7702 cells assessed as number of viable cells after 72 hrs by MTT assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500609	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as hexokinase gene at 50 mg/kg, ip within 30 to 300 mins by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121079	Induction of apoptosis in human H460 cells assessed as PARP cleavage at 10 uM after 8 hrs by SDS-PAGE	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID1121093	Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500655	Induction of SRC2-enhanced Nur77 transactivational activity in human BGC823 cells after 12 hrs by luciferase/beta-galactosidase reporter assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808273	Modulation of full length human Nurr1 expressed in SKNBE(2) cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500629	Induction of mitochondria translocation of Nur77 from nucleus in human BGC823 cells transfected with GFP-Nur77 pretreated with 1 ng/ml leptomycin B at 5 ug/ml after 12 hrs using DPAI by confocal microscope	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808461	Modulation of full length human Nur77 expressed in HEK293 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500614	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as hexokinase mRNA at 50 mg/kg, ip after 300 mins by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500623	Induction of Nur77 mediated apoptosis in human BGC823 cells transfected with si-Nur77 at 5 uM after 48 hrs by flow cytometry assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500594	Binding affinity to nuclear orphan receptor Nur77-DNA binding domain at 5 uM by fluorescence quenching analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500647	Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with pLuc-3500 containing Nr4a1 promoter assessed as transcriptional activity	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808460	Modulation of full length human Nur77 expressed in HEK293 cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1121082	Induction of apoptosis in human BGC823 cells assessed as mitochondrial cytochrome c release at 15.5 uM after 48 hrs	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID1808475	Modulation of full length human NOR1 expressed in PC12 cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808472	Modulation of full length human Nur77 expressed in PC12 cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500648	Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with pLuc-500 containing Nr4a1 promoter assessed as transcriptional activity	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500603	Agonist activity at nuclear orphan receptor NOR1 expressed in human BGC823 cells co-transfected with fused GAL4-NOR1(LBD) assessed as transactivation after 12 hrs by transactivation assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500587	Binding affinity to Nur77 receptor expressed in human BGC823 cells	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500610	Agonist activity at Nur77 in wild-type mouse C57BL/6 assessed as phosphofructokinase mRNA at 50 mg/kg, ip within 30 to 300 mins by real-time PCR analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500602	Agonist activity at nuclear orphan receptor Nurr1 expressed in human BGC823 cells co-transfected with fused GAL4-Nurr1(LBD) assessed as transactivation after 12 hrs by transactivation assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808279	Modulation of full length human Nurr1 expressed in HEK293T cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene ass	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808473	Modulation of full length human Nur77 expressed in PC12 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808464	Modulation of full length human NOR1 expressed in HEK293 cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500605	Increase in blood glucose level in wild-type mouse C57BL/6 at 50 mg/kg, ip after 300 mins	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500593	Binding affinity to nuclear orphan receptor Nur77-ligand binding domain at 5 Um by fluorescence quenching analysis	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808282	Modulation of full length human Nurr1 expressed in HEK293T cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assa	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1121078	Binding affinity to human recombinant N-terminal His6-tagged NR4A1 LBD expressed in Escherichia coli BL21 at 100 uM by NMR spectroscopy	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID1808284	Cytotoxicity against human SKNBE2 cells assessed as reduction in cell viability at 5 to 100 uM incubated for 18 hrs by Cell titer-glo assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500590	Agonist activity at nuclear orphan receptor Nur77 in human BGC823 cells bearing beta-galactosidase expression vector assessed as transcriptional activation of estrogen receptor reporter gene after 12 hrs by luciferase assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808459	Modulation of full length human Nur77 expressed in HEK293 cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500600	Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-DBD assessed as transactivation after 12 hrs by luciferase reporter gene assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121090	Cytotoxicity against human H460 cells after 72 hrs by MTT assay	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500645	Binding affinity to Nur77 Y453A mutant expressed in human BGC823 cells	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500641	Antitumor activity against human BGC823 cells expressing si-Nur77 xenografted in athymic nude mouse BALB/c assessed as tumor weight 13 mg/kg, ip twice a week after 4 weeks	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500646	Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with pLuc-2900 containing Nr4a1 promoter assessed as transcriptional activity	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500656	Induction of SRC1-enhanced Nur77 transactivational activity in human BGC823 cells after 12 hrs by luciferase/beta-galactosidase reporter assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808457	Modulation of full length human NOR1 expressed in SK-N-BE(2) cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808272	Modulation of full length human Nurr1 expressed in SKNBE(2) cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene as	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808281	Modulation of full length human Nurr1 expressed in HEK293T cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808280	Modulation of full length human Nurr1 expressed in SKNBE(2) cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene ass	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500633	Antiproliferative activity against human HepG2 cells assessed as number of viable cells after 72 hrs by MTT assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121092	Cytotoxicity against human H460 cells assessed as cell viability at 10 uM after 72 hrs by MTT assay	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500650	Induction of Nur77-SRC2 interaction in HEK293T cells by GST-pull-down assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500654	Induction of SRC3 recruitment to NurRE in human BGC823 cells after 12 hrs by luciferase/beta-galactosidase reporter assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500619	Reduction in blood glucose level in insulin treated mouse C57BL/6 within 30 mins	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1121088	Cytotoxicity against human LNCAP cells at 20 uM after 72 hrs by MTT assay	2013	MedChemComm, Feb-01, Volume: 4, Issue:2	Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
AID500639	Antimicrobial activity against Saccharomyces cerevisiae	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID1808300	Modulation of full length human Nurr1 expressed in HEK293T cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID1808476	Modulation of full length human NOR1 expressed in PC12 cells co-transfected with luciferase reporter plasmid harboring NurRE response element assessed as increase in luciferase activity incubated for 18 by luciferase reporter gene assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.
AID500651	Induction of Nur77-SRC3 interaction in HEK293T cells by GST-pull-down assay	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
AID500644	Binding affinity to NuR77-LBD receptor expressed in human BGC823 cells	2008	Nature chemical biology, Sep, Volume: 4, Issue:9	Cytosporone B is an agonist for nuclear orphan receptor Nur77.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (4.00)	29.6817
2010's	16 (64.00)	24.3611
2020's	8 (32.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.85%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (96.15%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
amodiaquine Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.. amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.	2.25	1	aminoquinoline; organochlorine compound; phenols; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; drug allergen; EC 2.1.1.8 (histamine N-methyltransferase) inhibitor; non-steroidal anti-inflammatory drug; prodrug
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2.25	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
thiazoles [no description available]	2.21	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.25	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
isoalantolactone isoalantolactone: RN given refers to (3aR-(3aalpha,4aalpha,8abeta,9aalpha))-isomer; structure. isoalantolactone : A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.	2.25	1	eudesmane sesquiterpenoid; sesquiterpene lactone	antifungal agent; apoptosis inducer; plant metabolite
celastrol [no description available]	2.25	1	monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite
cd 437 CD 437: selective for retinoic acid receptors gamma. CD437 : A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)gamma and induces cell cycle arrest and apoptosis in various cancer cells.	2.21	1	adamantanes; monocarboxylic acid; naphthoic acid; phenols	apoptosis inducer; retinoic acid receptor gamma agonist
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.07	1
cocaine Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.	2.25	1	benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid	adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic
alitretinoin Alitretinoin: A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA.	2.04	1	retinoic acid	antineoplastic agent; keratolytic drug; metabolite; retinoid X receptor agonist
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane [no description available]	3.16	1
cgp 52608 CGP 52608: structure given in first source	2.21	1	thiazolidinone
endothelin-1 Endothelin-1: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)	2.13	1
mk 2206 MK 2206: a protein kinase inhibitor and antineoplastic agent	2.17	1	organic heterotricyclic compound	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.17	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	3.37	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.37	2
Innate Inflammatory Response [description not available]	3.42	6
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	3.42	6
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	2.6	1
Adjuvant Arthritis [description not available]	2.21	1
Rheumatoid Arthritis [description not available]	2.21	1
Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	2.21	1
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	2.25	1
Hepatocellular Carcinoma [description not available]	2.25	1
Cancer of Liver [description not available]	2.25	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.25	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.25	1
Disease Exacerbation [description not available]	2.55	2
Breast Cancer [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.08	4
Breast Neoplasms Tumors or cancer of the human BREAST.	2.25	1
Colorectal Cancer [description not available]	7.31	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.31	1
Grippe [description not available]	2.15	1
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	2.15	1
Endometrioma An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst.	2.17	1
Cirrhosis [description not available]	2.58	2
Endometriosis A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.	2.17	1
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	2.58	2
Bladder Cancer [description not available]	2.08	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.08	1
Atherogenesis [description not available]	2.1	1
Atheroma [description not available]	2.1	1
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	2.1	1
Elevated Cholesterol [description not available]	2.11	1
Hypercholesterolemia A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.	2.11	1
Genetic Predisposition [description not available]	2.13	1
Colitis Gravis [description not available]	2.13	1
Colitis, Granulomatous [description not available]	2.13	1
Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.	2.13	1
Crohn Disease A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.	2.13	1
Polyarthritis [description not available]	2.13	1
Arthritis Acute or chronic inflammation of JOINTS.	2.13	1
Acute Respiratory Distress Syndrome [description not available]	2.13	1
Respiratory Distress Syndrome A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.	2.13	1
Cancer of Stomach [description not available]	2.05	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.05	1

cytosporone b

Description

Cross-References

Synonyms (38)

Research Excerpts

Overview

Drug Classes (1)

Protein Targets (1)

Activation Measurements

Biological Processes (23)

Molecular Functions (12)

Ceullar Components (8)

Bioassays (132)

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cytosporone b

Description

Cross-References

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Overview

Drug Classes (1)

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Activation Measurements

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Ceullar Components (8)

Bioassays (132)

Research

Studies (25)

Market Indicators

Research Demand Index: 29.07

Study Types

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