An NADH-ubiquinone oxidoreductase chain 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P03915]
EC 7.1.1.2;
NADH dehydrogenase subunit 5
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
aurapten | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
marmin | Homo sapiens (human) | IC50 | 30.0000 | 2 | 2 |
This protein enables 2 target(s):
Target | Category | Definition |
---|---|---|
NADH dehydrogenase (ubiquinone) activity | molecular function | Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). [RHEA:29091] |
NADH dehydrogenase activity | molecular function | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. [RHEA:11356] |
This protein is located in 1 target(s):
Target | Category | Definition |
---|---|---|
mitochondrial inner membrane | cellular component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
This protein is part of 1 target(s):
Target | Category | Definition |
---|---|---|
mitochondrial respiratory chain complex I | cellular component | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. [GOC:mtg_sensu, ISBN:0198547684] |
This protein is involved in 8 target(s):
Target | Category | Definition |
---|---|---|
response to hypoxia | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd] |
mitochondrial electron transport, NADH to ubiquinone | biological process | The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. [ISBN:0716731363] |
aerobic respiration | biological process | The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590] |
response to organonitrogen compound | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. [PMID:9869419] |
mitochondrial respiratory chain complex I assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. [GOC:rph] |
response to hydrogen peroxide | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [GOC:jl] |
proton motive force-driven mitochondrial ATP synthesis | biological process | The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. [GOC:mtg_sensu, ISBN:0716731363] |
electron transport coupled proton transport | biological process | The transport of protons against an electrochemical gradient, using energy from electron transport. [GOC:mah] |