Page last updated: 2024-08-07 15:13:28
Non-structural protein 4A
[no definition available]
Synonyms
Research
Bioassay Publications (9)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 8 (88.89) | 24.3611 |
2020's | 1 (11.11) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
[no title available]ACS medicinal chemistry letters, , Feb-08, Volume: 9, Issue:2, 2018
P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 28, Issue:10, 2018
Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.ACS medicinal chemistry letters, , Apr-12, Volume: 3, Issue:4, 2012
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.Journal of medicinal chemistry, , 08-26, Volume: 64, Issue:16, 2021
A review on HCV inhibitors: Significance of non-structural polyproteins.European journal of medicinal chemistry, , Feb-15, Volume: 164, 2019
Design and Synthesis of P2-P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors.ACS medicinal chemistry letters, , Dec-08, Volume: 7, Issue:12, 2016
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.ACS medicinal chemistry letters, , Jan-14, Volume: 7, Issue:1, 2016
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.ACS medicinal chemistry letters, , Apr-12, Volume: 3, Issue:4, 2012