| Assay ID | Title | Year | Journal | Article |
|---|
| AID657686 | Cytotoxicity against human A549 cells by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID620361 | Antimigratory activity against human HUVEC cells assessed as migration rate at 40 uM after 24 hrs by wound-healing assay relative to control | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID196553 | Neurite length after administration (1 uM) in rat cortical neurons | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10
| Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. |
| AID1681589 | Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID620366 | Antiangiogenic activity in fli-1:enhanced GFP expressing transgenic zebrafish embryo assessed as inhibition of neovacularisation at 10 uM after 24 hrs relative to control | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID657663 | Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID620208 | Antiangiogenic activity in fli-1:enhanced GFP expressing transgenic zebrafish embryo assessed as inhibition of neovacularisation at 40 uM after 24 hrs relative to control | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID657664 | Cytotoxicity against human A549 cells after 24 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID427630 | Inhibition of COX2 in sheep placental vesicle by enzyme immunoassay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. |
| AID611429 | Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV at 30 uM by two-microelectrode voltage clamp technique relative to GABA | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship. |
| AID427628 | Inhibition of COX2 in sheep placental vesicle at 8 uM by enzyme immunoassay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. |
| AID611251 | Octanol-water partition coefficient, log P of the compound | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship. |
| AID611340 | Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique relative to GABA | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship. |
| AID731349 | Displacement of [3H]CP55,940 from recombinant human CB2 receptor expressed in CHO cells after 2 hrs by liquid scintillation counting | 2013 | ACS medicinal chemistry letters, Jan-10, Volume: 4, Issue:1
| Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. |
| AID427632 | Inhibition of 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. |
| AID620211 | Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID620209 | Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID620210 | Antiproliferative activity against human A549 cells after 24 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID620365 | Antiangiogenic activity in fli-1:enhanced GFP expressing transgenic zebrafish embryo assessed as inhibition of neovacularisation at 5 uM after 24 hrs relative to control | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID657494 | Inhibition of LPS-induced COX2-mediated PGF1 production in mouse RAW264.7 cells at 100 nM after 24 hrs by EIA | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production. |
| AID1681588 | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1279207 | Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 5 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, Apr-01, Volume: 24, Issue:7
| Anti-inflammatory neolignans from the roots of Magnolia officinalis. |
| AID311630 | Cytotoxicity against human HeLa cells by MTT assay | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10
| Cytotoxic lignans from the stem bark of Magnolia officinalis. |
| AID427629 | Inhibition of COX1 in ram seminal vesicle by enzyme immunoassay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. |
| AID657493 | Inhibition of recombinant human COX2 using arachidonic acid as substrate at 100 nM preincubated for 10 mins prior substrate addition measured after 2 mins by EIA | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production. |
| AID1681591 | Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1279204 | Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, Apr-01, Volume: 24, Issue:7
| Anti-inflammatory neolignans from the roots of Magnolia officinalis. |
| AID657667 | Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID657666 | Cytotoxicity against human HT-29 cells after 24 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID657495 | Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production. |
| AID1297972 | Agonist activity at human CB2 receptor expressed in CHO cell membranes after 90 mins by [35S]GTPgammaS binding assay | 2016 | European journal of medicinal chemistry, Jun-30, Volume: 116 | Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands. |
| AID657665 | Cytotoxicity against human A549 cells after 72 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID657687 | Cytotoxicity against human HT-29 cells by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID1681586 | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID196552 | Neurite length after administration (0.1 uM) in rat cortical neurons | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10
| Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. |
| AID657496 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability by propidium iodide staining based FACS-flow cytometry | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production. |
| AID620364 | Antiangiogenic activity against human HUVEC cells assessed as inhibition of tube formation at 20 uM after 12 hrs by matrigel-based assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID657685 | Cytotoxicity against human UACC-903 cells by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID1647066 | Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and in vitro antitumor evaluation of honokiol derivatives. |
| AID311631 | Cytotoxicity against human A549 cells by MTT assay | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10
| Cytotoxic lignans from the stem bark of Magnolia officinalis. |
| AID1552550 | Partition coefficient, log P of the compound | 2019 | Bioorganic & medicinal chemistry, 08-15, Volume: 27, Issue:16
| Anti-proliferative activity and structure-activity relationship of honokiol derivatives. |
| AID1681590 | Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID657662 | Cytotoxicity against human UACC-903 cells after 24 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. |
| AID611249 | Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship. |
| AID311632 | Cytotoxicity against human K562 cells by MTT assay | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10
| Cytotoxic lignans from the stem bark of Magnolia officinalis. |
| AID620367 | Antiangiogenic activity in fli-1:enhanced GFP expressing transgenic zebrafish embryo assessed as inhibition of neovacularisation at 20 uM after 24 hrs relative to control | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID620213 | Antimigratory activity against human HUVEC cells at 20 uM after 24 hrs by wound-healing assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID427631 | Inhibition of 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes at 8 uM | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. |
| AID620212 | Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. |
| AID1647067 | Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and in vitro antitumor evaluation of honokiol derivatives. |
| AID1515003 | Cytotoxicity against LPS-stimulated mouse BV2 cells assessed as cell viability at 20 uM after 24 hrs by MTT assay relative to control | 2019 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2
| Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol. |
| AID1515002 | Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay | 2019 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2
| Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol. |
| AID1681587 | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1647065 | Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and in vitro antitumor evaluation of honokiol derivatives. |
| AID1681592 | Antiproliferative activity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID427627 | Inhibition of COX1 in ram seminal vesicle at 8 uM by enzyme immunoassay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. |
| AID1799559 | Binding Assay from Article 10.1016/j.chembiol.2011.05.012: \\Mechanisms of Osteoclastogenesis Inhibition by a Novel Class of Biphenyl-Type Cannabinoid CB(2) Receptor Inverse Agonists.\\ | 2011 | Chemistry & biology, Aug-26, Volume: 18, Issue:8
| Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |