Proteins > NADH-ubiquinone oxidoreductase chain 4L
Page last updated: 2024-08-07 23:11:44

NADH-ubiquinone oxidoreductase chain 4L

An NADH-ubiquinone oxidoreductase chain 4L that is encoded in the genome of human. [PRO:DNx, UniProtKB:P03901]

Synonyms

EC 7.1.1.2;
NADH dehydrogenase subunit 4L

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (2)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
auraptenHomo sapiens (human)IC5014.500022
marminHomo sapiens (human)IC5030.000022

Enables

This protein enables 1 target(s):

TargetCategoryDefinition
NADH dehydrogenase (ubiquinone) activitymolecular functionCatalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). [RHEA:29091]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
mitochondrial inner membranecellular componentThe inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
mitochondrial respiratory chain complex Icellular componentA protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. [GOC:mtg_sensu, ISBN:0198547684]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
mitochondrial electron transport, NADH to ubiquinonebiological processThe transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. [ISBN:0716731363]
aerobic respirationbiological processThe enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590]
proton motive force-driven mitochondrial ATP synthesisbiological processThe transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. [GOC:mtg_sensu, ISBN:0716731363]
transmembrane transportbiological processThe process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]