acetovanillone has been researched along with Fibrosis in 18 studies
apocynin : An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased bioavailability of reactive oxygen species (ROS) has been implicated in the pathogenesis of mineralocorticoid hypertension." | 5.32 | NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats. ( Park, JB; Park, MY; Park, YM; Suh, YL, 2004) |
| "In rats with diabetic nephropathy, apocynin (1) reduced renal injury and improved renal function; (2) downregulated the expression of NLRP3 in renal cortex; (3) downregulated the expression of XIAP in renal cortex; and (4) attenuated renal fibrosis." | 1.48 | Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy. ( Du, P; Hou, Y; Jiang, W; Li, X; Sun, W; Sun, X; Wang, L; Wang, Z; Xiang, Y; Xin, R; Yuan, W; Zhang, H, 2018) |
| "Myocardial fibrosis is the endpoint pathology common to many cardiovascular disorders." | 1.43 | Changes in interconnected pathways implicating microRNAs are associated with the activity of apocynin in attenuating myocardial fibrogenesis. ( Chen, Y; Cui, J; Du, X; Wang, P; Wang, W; Yang, Q; Zhang, T, 2016) |
| "Type 4 cardiorenal syndrome (CRS) refers to the cardiac injury induced by chronic kidney disease." | 1.42 | Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition. ( Chen, J; Huang, F; Huang, H; Liu, X; Liu, Y; Tang, W; Wang, JF; Zhang, K, 2015) |
| "Kidney fibrosis is a typical feature of chronic kidney disease and is characterized as an expansion of the interstitium due to increases in extracellular matrix molecules and interstitial cells caused by accumulations of extrarenal cells and by the proliferation or differentiation of intrarenal cells." | 1.40 | Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis. ( Han, SJ; Jang, HS; Kim, JI; Park, KM, 2014) |
| "Increased bioavailability of reactive oxygen species (ROS) has been implicated in the pathogenesis of mineralocorticoid hypertension." | 1.32 | NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats. ( Park, JB; Park, MY; Park, YM; Suh, YL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 13 (72.22) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 2 |
| Lai, F | 1 |
| Cheng, X | 2 |
| Wang, Y | 2 |
| Yang, Q | 3 |
| Chen, HY | 1 |
| Wang, JN | 1 |
| Han, HQ | 1 |
| Jiang, L | 1 |
| Wu, WF | 1 |
| Wei, B | 1 |
| Gao, L | 1 |
| Ma, QY | 1 |
| Liu, XQ | 1 |
| Chen, Q | 1 |
| Wen, JG | 1 |
| Jin, J | 1 |
| Huang, Y | 1 |
| Ni, WJ | 1 |
| Ma, TT | 1 |
| Li, J | 1 |
| Meng, XM | 1 |
| Zhang, S | 1 |
| Tan, X | 1 |
| Chen, Y | 3 |
| Zhang, X | 1 |
| Huang, L | 1 |
| Zhu, J | 1 |
| Zheng, M | 1 |
| Zou, R | 1 |
| Zhou, Y | 1 |
| Zhu, M | 1 |
| Xin, R | 1 |
| Sun, X | 1 |
| Wang, Z | 1 |
| Yuan, W | 1 |
| Jiang, W | 1 |
| Wang, L | 1 |
| Xiang, Y | 1 |
| Li, X | 1 |
| Hou, Y | 1 |
| Sun, W | 1 |
| Du, P | 1 |
| Jang, HS | 2 |
| Kim, JI | 2 |
| Jung, KJ | 1 |
| Kim, J | 1 |
| Han, KH | 1 |
| Park, KM | 2 |
| Han, SJ | 1 |
| Liu, L | 1 |
| Cui, J | 2 |
| Jia, C | 1 |
| Xiong, M | 1 |
| Ning, B | 1 |
| Du, X | 2 |
| Wang, P | 2 |
| Yu, X | 1 |
| Li, L | 1 |
| Wang, W | 2 |
| Zhang, T | 2 |
| Qi, W | 1 |
| Niu, J | 1 |
| Qin, Q | 1 |
| Qiao, Z | 1 |
| Gu, Y | 1 |
| Liu, Y | 3 |
| Liu, X | 2 |
| Chen, J | 2 |
| Zhang, K | 2 |
| Huang, F | 1 |
| Wang, JF | 1 |
| Tang, W | 1 |
| Huang, H | 2 |
| Cai, Q | 1 |
| Wang, J | 1 |
| Zheng, X | 1 |
| Song, Y | 1 |
| Qu, L | 1 |
| Tang, J | 1 |
| Meng, L | 1 |
| Liu, F | 1 |
| Wei, CC | 1 |
| Wu, SJ | 1 |
| Chenier, I | 1 |
| Zhang, SL | 1 |
| Filep, JG | 1 |
| Ingelfinger, JR | 1 |
| Chan, JS | 1 |
| Dendooven, A | 1 |
| Ishola, DA | 1 |
| Nguyen, TQ | 1 |
| Van der Giezen, DM | 1 |
| Kok, RJ | 1 |
| Goldschmeding, R | 1 |
| Joles, JA | 1 |
| Basile, DP | 1 |
| Leonard, EC | 1 |
| Beal, AG | 1 |
| Schleuter, D | 1 |
| Friedrich, J | 1 |
| Park, YM | 1 |
| Park, MY | 1 |
| Suh, YL | 1 |
| Park, JB | 1 |
| Masamune, A | 1 |
| Watanabe, T | 1 |
| Kikuta, K | 1 |
| Satoh, K | 1 |
| Shimosegawa, T | 1 |
1 review available for acetovanillone and Fibrosis
| Article | Year |
|---|---|
Oxidative stress in obstructive nephropathy.
Topics: Acetophenones; Animals; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Kidney; Mice; NADPH Oxi | 2011 |
17 other studies available for acetovanillone and Fibrosis
| Article | Year |
|---|---|
Involvement of NADPH oxidases in the Na/K‑ATPase/Src/ROS oxidant amplification loop in renal fibrosis.
Topics: Adenosine Triphosphatases; Animals; Fibrosis; Kidney Diseases; Mice; NADPH Oxidase 4; NADPH Oxidases | 2023 |
Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7.
Topics: Acetophenones; Animals; Cell Line; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DN | 2020 |
Postconditioning protects renal fibrosis by attenuating oxidative stress-induced mitochondrial injury.
Topics: Acetophenones; Animals; Antioxidants; Cell Line; DNA Damage; DNA, Mitochondrial; Epithelial-Mesenchy | 2017 |
Tanshinone IIA protects against subclinical lipopolysaccharide induced cardiac fibrosis in mice through inhibition of NADPH oxidase.
Topics: Abietanes; Acetophenones; Animals; Cardiomyopathies; Fibrosis; Lipopolysaccharides; Male; Mice, Inbr | 2018 |
Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Antioxidants; Cytoprotection; Diabetes Mellitus, E | 2018 |
Bone marrow-derived cells play a major role in kidney fibrosis via proliferation and differentiation in the infiltrated site.
Topics: Acetophenones; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell L | 2013 |
Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis.
Topics: Acetophenones; Acute Kidney Injury; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Pr | 2014 |
Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis.
Topics: Acetophenones; Animals; Antioxidants; Cardiomyopathies; Female; Fibrosis; Humans; Isoproterenol; Mal | 2014 |
Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells.
Topics: Acetophenones; Animals; Apoptosis; Cell Line; Fibronectins; Fibrosis; Gene Expression; Glycated Seru | 2015 |
Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition.
Topics: Acetophenones; Aged; Aged, 80 and over; Animals; Antioxidants; Cardio-Renal Syndrome; Cardiomegaly; | 2015 |
Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Acetophenones; Aged; Angiotensin II; Animals; Cardio-Renal Syndrome; Ca | 2015 |
Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Fibrosis; Kidney; Lipid Peroxidatio | 2016 |
Changes in interconnected pathways implicating microRNAs are associated with the activity of apocynin in attenuating myocardial fibrogenesis.
Topics: Acetophenones; Animals; Cardiotonic Agents; Fibrosis; Gene Expression Profiling; Gene Regulatory Net | 2016 |
Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension.
Topics: Acetophenones; Animals; Apoptosis; Fibrosis; Hypertension; Kidney Tubules; Mice; Mice, Transgenic; N | 2009 |
Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity.
Topics: Acetophenones; Acute Kidney Injury; Angiotensin II; Animals; Blood Pressure; Creatinine; Disease Pro | 2012 |
NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats.
Topics: Acetophenones; Aldosterone; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Collagen; Fibro | 2004 |
NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells.
Topics: Acetophenones; Actins; Angiotensin II; Animals; Becaplermin; Cell Line, Tumor; Cell Proliferation; C | 2008 |