isoliensinine

Description

isoliensinine: isolated from the Chinese herbal medicine lotus plumule; structure in first source [MeSH]

Isoliensinine : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	5274591
CHEMBL ID	502370
SCHEMBL ID	12807696
CHEBI ID	185701
MeSH ID	M0483605

Synonyms (20)

Synonym
7-isoquinolinol, 1,2,3,4-tetrahydro-1-[[4-hydroxy-3-[[(1r)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-, (1r)-
(1r)-1-[[4-hydroxy-3-[[(1r)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1h-isoquinolin-7-ol
isoliensinine
CHEMBL502370
6817-41-0
CHEBI:185701
7-isoquinolinol, 1,2,3,4-tetrahydro-1-((4-hydroxy-3-((1,2,3,4-tetrahydro-6-methoxy-1-((4-methoxyphenyl)methyl)-2-methyl-7-isoquinolinyl)oxy)phenyl)methyl)-6-methoxy-2-methyl-, (r-(r,r))-
isoliensinin
S9247
AKOS015902511
SCHEMBL12807696
AC-34956
Q-100768
DTXSID60218346
mfcd11042260
A14687
CCG-270232
HY-N0770
CS-0009795
(r)-1-(4-hydroxy-3-(((r)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)benzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Drug Classes (1)

Class	Description
isoquinolines	A class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives.

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID397128	Inhibition of formyl-methionyl-leucyl-phenylalanine induced superoxide generation in PMNC		Journal of natural products, , Volume: 54, Issue:3 ISSN: 0163-3864	Bisbenzylisoquinoline alkaloids.

Research

Studies (31)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (22.58)	29.6817
2010's	16 (51.61)	24.3611
2020's	8 (25.81)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (6.06%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	31 (93.94%)	84.16%

Substance	Classes	Roles	Relationship Strength
pk 11195	aromatic amide; isoquinolines; monocarboxylic acid amide; monochlorobenzenes	antineoplastic agent	low
5-aminoisoquinolinone	isoquinolines		low
debrisoquin	carboxamidine; isoquinolines	adrenergic agent; antihypertensive agent; human metabolite; sympatholytic agent	low
ethaverine	isoquinolines		low
n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide	isoquinolines; sulfonamide		low
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide	bromobenzenes; isoquinolines; olefinic compound; secondary amino compound; sulfonamide	EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor	low
1-(5-isoquinolinesulfonyl)-2-methylpiperazine	isoquinolines; N-sulfonylpiperazine	EC 2.7.11.13 (protein kinase C) inhibitor	low
1-(5-isoquinolinesulfonyl)piperazine	isoquinolines		low
ha 1004	isoquinolines		low
fasudil	isoquinolines; N-sulfonyldiazepane	antihypertensive agent; calcium channel blocker; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; geroprotector; neuroprotective agent; nootropic agent; vasodilator agent	low
hydrocotarnine	isoquinolines		low
nomifensine	isoquinolines	dopamine uptake inhibitor	low
6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one	isoquinolines		low
papaverine	benzylisoquinoline alkaloid; dimethoxybenzene; isoquinolines	antispasmodic drug; vasodilator agent	low
praziquantel	isoquinolines		low
scriptaid	isoquinolines		low
tilisolol	isoquinolines		low
cotarnine	isoquinolines		low
dimethisoquin	isoquinolines		low
1,2,3,4-tetrahydroisoquinoline	isoquinolines		low
isoquinoline	azaarene; isoquinolines; mancude organic heterobicyclic parent; ortho-fused heteroarene		low
cepharanthine	bisbenzylisoquinoline alkaloid; isoquinolines		low
bicuculline	benzylisoquinoline alkaloid; isoquinoline alkaloid; isoquinolines	agrochemical; central nervous system stimulant; GABA-gated chloride channel antagonist; GABAA receptor antagonist; neurotoxin	low
isocarbostyril	isoquinolines		low
salsolidine	isoquinolines		low
laudanosine	isoquinolines		low
1-methylisoquinoline	isoquinolines		low
heliamine	aromatic ether; diether; isoquinoline alkaloid; isoquinolines	plant metabolite	low
1,2-dehydrosalsolinol	isoquinolines		low
dehydroemetine	aromatic ether; isoquinolines; pyridoisoquinoline	antileishmanial agent; antimalarial; antiprotozoal drug	low
metocurine	isoquinolines		low
thalicarpine	bisbenzylisoquinoline alkaloid; isoquinolines		low
dimoxyline	isoquinolines		low
6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline	isoquinolines		low
coralyne	isoquinolines		low
(3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one	isoquinolines		low
salsoline	isoquinolines		low
isosalsoline	isoquinolines		low
amonafide	isoquinolines		low
daurisoline	isoquinolines		low
magnocurarine	isoquinolines		low
quinapril	dicarboxylic acid monoester; ethyl ester; isoquinolines; tertiary carboxamide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; prodrug	low
tretoquinol	isoquinolines		low
moxaverine	isoquinolines		low
tritoqualine	isoquinolines		low
tubulosine	beta-carbolines; isoquinoline alkaloid; isoquinolines; phenols; secondary amino compound; tertiary amino compound		low
hernandezine	bisbenzylisoquinoline alkaloid; isoquinolines		low
tetrandrine	bisbenzylisoquinoline alkaloid; isoquinolines		low
dauricine	aromatic ether; bisbenzylisoquinoline alkaloid; isoquinolines; phenols; tertiary amino compound	plant metabolite	low
cherylline	isoquinolines		low
gliquidone	isoquinolines		low
1-methyl-1,2,3,4-tetrahydroisoquinoline	isoquinolines		low
laudanosoline	isoquinolines		low
papaveraldine	isoquinolines		low
corydaline	isoquinoline alkaloid; isoquinolines		low
4-hydroxydebrisoquin	carboxamidine; isoquinolines; secondary alcohol	metabolite	low
quinaprilat	dicarboxylic acid; isoquinolines; tertiary carboxamide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; vasodilator agent	low
cycleanine	bisbenzylisoquinoline alkaloid; isoquinolines		low
dihydrotetrabenazine	isoquinolines		low
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline	isoquinolines; organochlorine compound		low
1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline	isoquinolines		low
cki 7	isoquinolines; organochlorine compound; primary amino compound; sulfonamide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	low
pixantrone	isoquinolines		low
isodibut	isoquinolines		low
3,4-dihydro-5-methyl-1(2h)-isoquinolinone	isoquinolines		low
solifenacin	isoquinolines		low
liensinine	isoquinolines		low
trilobine	isoquinolines		low
corynoline	benzophenanthridine alkaloid; cyclic acetal; isoquinolines; organic heterohexacyclic compound; secondary alcohol	antineoplastic agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; hepatoprotective agent; metabolite	low
minalrestat	isoquinolines		low
hydrastine	isoquinolines	metabolite	low
pronuciferine	aromatic ether; cyclic ketone; isoquinoline alkaloid; isoquinolines; organic heterotetracyclic compound	plant metabolite	low
5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine	isoquinolines		low
solifenacin succinate	isoquinolines		low
berbamine	bisbenzylisoquinoline alkaloid; isoquinolines		low
2-(2-oxolanylmethyl)benzo[de]isoquinoline-1,3-dione	isoquinolines		low
guatteguamerine	bisbenzylisoquinoline alkaloid; isoquinolines		low
korupensamine-b	isoquinolines; naphthalenes		low
obamegine	bisbenzylisoquinoline alkaloid; isoquinolines		low
hydrastine hydrochloride, (s-(r,s))-isomer	isoquinolines		low
narcotoline	isoquinolines		low
oxyacanthine	bisbenzylisoquinoline alkaloid; isoquinolines; macrocycle; phenols; tertiary amino compound		low
floxacillin	isoquinolines		low
dioncophylline a	biaryl; isoquinoline alkaloid; isoquinolines; methoxynaphthalene; methylnaphthalenes; naphthalenes	antifungal agent; antimalarial; metabolite; molluscicide	low
dioncophylline c	aromatic ether; biaryl; isoquinoline alkaloid; isoquinolines; methoxynaphthalene; methylnaphthalenes; naphthols	antimalarial; antiplasmodial drug; metabolite	low
h 1152	isoquinolines; N-sulfonyldiazepane	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	low
9,10-dimethoxy-2,4,6,7-tetrahydro-[1,3]oxazino[4,3-a]isoquinoline-1-carbonitrile	isoquinolines		low
hydrastine, (r-(r,s))-isomer	isoquinolines		low
6,7-dimethoxy-N-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-2-carboxamide	isoquinolines		low
5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(2-furanyl)-4-oxazolecarbonitrile	isoquinolines		low
1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-phenyl-1-butanone	isoquinolines		low
methyl isoquinoline-3-carboxylate	isoquinolines		low
1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(2-fluorophenoxy)ethanone	isoquinolines		low
1-spiro[2,4-dihydroisoquinoline-3,1'-cyclohexane]thione	isoquinolines		low
N-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carbothioamide	isoquinolines		low
N-(4-fluorophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide	isoquinolines		low
3-amino-2-(4-methoxyphenyl)-7-nitro-1-oxo-4-isoquinolinecarbonitrile	isoquinolines		low
4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,6-dimethylphenyl)benzamide	isoquinolines		low
LSM-16526	isoquinolines		low
drotaverin	isoquinolines		low
5,5-diethyl-1-[oxo(1-piperidinyl)methyl]-6H-pyrrolo[2,1-a]isoquinoline-2,3-dione	isoquinolines		low
N-(4-fluorophenyl)-2-(5-methoxy-1-oxo-2-isoquinolinyl)acetamide	isoquinolines		low
2-[[1-oxo-2-[2-oxo-2-(1-piperidinyl)ethyl]-5-isoquinolinyl]oxy]acetic acid ethyl ester	isoquinolines		low
2-[[2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]acetic acid ethyl ester	isoquinolines		low
5-[[2-[(3-methylphenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxymethyl]-2-furancarboxylic acid methyl ester	isoquinolines		low
5-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethoxy]-2-[(3-methylphenyl)methyl]-3,4-dihydroisoquinolin-1-one	isoquinolines		low
4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-[4-(1-pyrrolidinylsulfonyl)phenyl]benzamide	isoquinolines		low
4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-[4-(1-piperidinylsulfonyl)phenyl]benzamide	isoquinolines		low
1-(5-isoquinolinyl)-3-(2-phenylethyl)thiourea	isoquinolines		low
1-(4-ethoxyphenyl)-3-(5-isoquinolinyl)thiourea	isoquinolines		low
4-[[5-(difluoromethylthio)-4-methyl-1,2,4-triazol-3-yl]methoxy]-5-methylisoquinoline	isoquinolines		low
2-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]thio]-3-ethyl-5,6-dimethyl-4-thieno[2,3-d]pyrimidinone	isoquinolines		low
N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(2-methoxyethyl)acetamide	isoquinolines		low
2-(Methylamino)-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione	isoquinolines		low
3-[3-(1,3-dioxo-2-benzo[de]isoquinolinyl)propylthio]propanoic acid	isoquinolines		low
4-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-(1,1-dioxo-3-thiolanyl)butanamide	isoquinolines		low
2-[4-(3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyl]benzo[de]isoquinoline-1,3-dione	isoquinolines		low
4-bromobenzenesulfonic acid (1,3-dioxo-2-benzo[de]isoquinolinyl) ester	isoquinolines		low
2-(3-hydroxyphenyl)-6-(1-piperidinyl)benzo[de]isoquinoline-1,3-dione	isoquinolines		low
2-[3-(1H-1,2,4-triazol-5-ylthio)propyl]benzo[de]isoquinoline-1,3-dione	isoquinolines		low
2-[2-[4-[2-hydroxy-3-(2-methylphenoxy)propyl]-1-piperazinyl]ethyl]benzo[de]isoquinoline-1,3-dione	isoquinolines		low
2-benzoyl-N-(6-methoxy-3-pyridinyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide	isoquinolines		low
mcn 5652	isoquinolines		low
3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-N-(6-methyl-2-pyridinyl)-1-oxo-3,4-dihydroisoquinoline-4-carboxamide	isoquinolines		low
4-[(4-cyclohexyl-1-piperazinyl)-oxomethyl]-2-ethyl-6,7-dimethoxy-1-isoquinolinone	isoquinolines		low
1-[[1-(2-methoxyanilino)-4-isoquinolinyl]-oxomethyl]-4-piperidinecarboxamide	isoquinolines		low
3,4-dihydro-1H-isoquinolin-2-yl-(1-ethylsulfonyl-4-piperidinyl)methanone	isoquinolines		low
1-cyclopentyl-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-5-oxo-3-pyrrolidinecarboxamide	isoquinolines		low
3-(3,4-dimethoxyphenyl)-2-methyl-N-[2-(4-morpholinyl)ethyl]-1-oxo-3,4-dihydroisoquinoline-4-carboxamide	isoquinolines		low
1-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-(4-ethylphenyl)urea	isoquinolines		low
6,7-dimethoxy-N-[(5-methyl-2-furanyl)methyl]-2-(2-methylpropyl)-1-oxo-4-isoquinolinecarboxamide	isoquinolines		low
4-[[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine	isoquinolines		low
5-[3,4-dihydro-1H-isoquinolin-2-yl(phenyl)methyl]-6-thiazolo[3,2-b][1,2,4]triazolol	isoquinolines		low
4-chloro-N-[1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-methylpropan-2-yl]benzenesulfonamide	isoquinolines		low
5-[2-[3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethoxy]-2-(phenylmethyl)-3,4-dihydroisoquinolin-1-one	isoquinolines		low
2-[[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester	isoquinolines		low
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(4-fluorophenyl)-2-(2-methoxyethyl)-1-oxo-3,4-dihydroisoquinoline-4-carboxamide	isoquinolines		low
2-[[2-[2-(4-methoxyanilino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester	isoquinolines		low
2-(4-chlorophenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid	isoquinolines		low
4-phenyl-1,2,3,4-tetrahydroisoquinoline	isoquinolines		low
6,7-dimethoxy-N-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamide	isoquinolines		low
8-nitro-5-[3-(trifluoromethyl)-1-piperidinyl]isoquinoline	isoquinolines		low
2-(3-methyl-1-oxo-2-isoquinolinyl)-N-(3,4,5-trimethoxyphenyl)acetamide	isoquinolines		low
8-hydroxymanzamine a	alkaloid; beta-carbolines; isoquinolines	anti-HSV-2 agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; metabolite	low
mivacurium	isoquinolines		low
bw b1090u	isoquinolines		low
3,4-dihydro-1H-isoquinolin-2-yl-(4-ethyl-5-thieno[3,2-b]pyrrolyl)methanone	isoquinolines		low
papaveroline	isoquinolines		low
norbinaltorphimine	isoquinolines		low
naltrindole	isoquinolines		low
manzamine a	alkaloid; beta-carbolines; isoquinolines	animal metabolite; anti-HSV-1 agent; antimalarial; antineoplastic agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; marine metabolite	low
2-(2-phenylethyl)benzo[de]isoquinoline-1,3-dione	isoquinolines		low
ripasudil	isoquinolines		low
ancistroealaine a	aromatic ether; biaryl; isoquinoline alkaloid; isoquinolines; methoxynaphthalene; methylnaphthalenes	antileishmanial agent; antiplasmodial drug; metabolite; trypanocidal drug	low
SIS3 free base	aromatic ether; enamide; isoquinolines; monocarboxylic acid amide; pyrrolopyridine; tertiary carboxamide	Smad3 inhibitor	low
fg-4592	aromatic ether; isoquinolines; N-acylglycine	EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor; EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor	low
sar 1118	1-benzofurans; isoquinolines; L-phenylalanine derivative; N-acyl-L-alpha-amino acid; sulfone	anti-inflammatory drug; lymphocyte function-associated antigen-1 antagonist	low
4-(4-chlorophenyl)sulfonyl-5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-ethylsulfonylthiazole	isoquinolines		low
bebeerine	bisbenzylisoquinoline alkaloid; isoquinolines		low
(1S)-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-2-oxido-3,4-dihydro-1H-isoquinolin-2-ium-7-ol	isoquinolines; tertiary amine oxide		low
dihydrotetrabenazine, (2alpha,3beta,11bbeta)-isomer	isoquinolines		low
jorunnamycin a	isoquinolines		low
1-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-(4-nitrophenyl)urea	isoquinolines		low
2-(1,3-benzodioxol-5-ylmethyl)-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline	isoquinolines		low
N-(3-nitrophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide	isoquinolines		low
2-(5-butoxy-1-oxo-2-isoquinolinyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide	isoquinolines		low
almorexant	isoquinolines		low
ipi-145	isoquinolines		low
nbi 31772	aromatic ketone; benzenediols; hydroxy monocarboxylic acid; isoquinolines; tetrol	insulin-like growth factor-binding protein inhibitor	low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
spermidine	1	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector	2017	2017	7.0	low	0	1	0
ketoconazole	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine		2007	2007	17.0	low	1	0	0
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	1	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector	2021	2021	3.0	low	0	0	1
maprotiline	1	anthracenes		2017	2017	7.0	low	0	1	0
metformin	1	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic	2017	2017	7.0	low	0	1	0
serine	1	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2016	2016	8.0	low	0	1	0
phenylephrine	1	phenols; phenylethanolamines; secondary amino compound	alpha-adrenergic agonist; cardiotonic drug; mydriatic agent; nasal decongestant; protective agent; sympathomimetic agent; vasoconstrictor agent	2005	2005	19.0	low	1	0	0
tert-butylhydroperoxide	1	alkyl hydroperoxide	antibacterial agent; oxidising agent	2013	2013	11.0	low	0	1	0
trehalose	1	trehalose	Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2017	2017	7.0	low	0	1	0
pyrroles	1	pyrrole; secondary amine		2017	2017	7.0	low	0	1	0
cepharanthine	1	bisbenzylisoquinoline alkaloid; isoquinolines		2017	2017	7.0	low	0	1	0
malondialdehyde	1	dialdehyde	biomarker	2013	2013	11.0	low	0	1	0
paclitaxel	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent	2023	2023	1.0	low	0	0	1
dauricine	1	aromatic ether; bisbenzylisoquinoline alkaloid; isoquinolines; phenols; tertiary amino compound	plant metabolite	2017	2017	7.0	low	0	1	0
higenamine	1	norcoclaurine		2015	2015	9.0	low	0	1	0
liensinine	17	isoquinolines		2007	2021	10.7	high	5	10	2
quinidine	1	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker	2007	2007	17.0	low	1	0	0
resveratrol	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger	2017	2017	7.0	low	0	1	0
stilbenes	1	stilbene		2017	2017	7.0	low	0	1	0
1,1-diphenyl-2-picrylhydrazyl	1			2013	2013	11.0	low	0	1	0
cholecalciferol	1	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite	2017	2017	7.0	low	0	1	0
sirolimus	1	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor	2017	2017	7.0	low	0	1	0
mk 2206	1	organic heterotricyclic compound	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	2021	2021	3.0	low	0	0	1
gx 15-070	1			2017	2017	7.0	low	0	1	0
tetracarboxyphenylporphine	1			2021	2021	3.0	low	0	0	1
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	1			2021	2021	3.0	low	0	0	1
neferine	17			2004	2021	11.2	high	6	9	2

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	2010's	post-2020
2019 Novel Coronavirus Disease	1	2021	2021	3.0	low	0	1
Age-Related Osteoporosis	1	2023	2023	1.0	low	0	1
Arrhythmia	1	2021	2021	3.0	low	0	1
Arrhythmias, Cardiac	1	2021	2021	3.0	low	0	1
Autoimmune Disease	1	2017	2017	7.0	low	1	0
Autoimmune Diseases	1	2017	2017	7.0	low	1	0
Benign Neoplasms	1	2017	2017	7.0	low	1	0
Bone Diseases, Metabolic	1	2023	2023	1.0	low	0	1
Bone Loss, Osteoclastic	1	2023	2023	1.0	low	0	1
Cancer of Colon	1	2023	2023	1.0	low	0	1
Cancer of Liver	2	2015	2016	8.5	low	2	0
Cancer of Prostate	1	2021	2021	3.0	low	0	1
Carcinoma, Hepatocellular	2	2015	2016	8.5	low	2	0
Cirrhosis	1	2023	2023	1.0	low	0	1
Colonic Neoplasms	1	2023	2023	1.0	low	0	1
Diabetes Mellitus, Adult-Onset	1	2017	2017	7.0	low	1	0
Diabetes Mellitus, Type 2	1	2017	2017	7.0	low	1	0
Disease Models, Animal	1	2015	2015	9.0	low	1	0
Diseases of Immune System	1	2017	2017	7.0	low	1	0
ER-Negative PR-Negative HER2-Negative Breast Cancer	1	2015	2015	9.0	low	1	0
Fibrosis	1	2023	2023	1.0	low	0	1
Hepatocellular Carcinoma	2	2015	2016	8.5	low	2	0
Immune System Diseases	1	2017	2017	7.0	low	1	0
Infection	1	2017	2017	7.0	low	1	0
Infections	1	2017	2017	7.0	low	1	0
Infections, Plasmodium	1	2023	2023	1.0	low	0	1
Kidney Diseases	1	2023	2023	1.0	low	0	1
Liver Neoplasms	2	2015	2016	8.5	low	2	0
Low Bone Density	1	2023	2023	1.0	low	0	1
Malaria	1	2023	2023	1.0	low	0	1
Malaria, Falciparum	1	2023	2023	1.0	low	0	1
Neoplasms	1	2017	2017	7.0	low	1	0
Osteoporosis	1	2023	2023	1.0	low	0	1
Plasmodium falciparum Malaria	1	2023	2023	1.0	low	0	1
Prostatic Neoplasms	1	2021	2021	3.0	low	0	1
Triple Negative Breast Neoplasms	1	2015	2015	9.0	low	1	0

Pharmacokinetics (2)

Article	Year
Simultaneous determination of liensinine, isoliensinine and neferine in rat plasma by UPLC-MS/MS and application of the technique to pharmacokinetic studies. Journal of ethnopharmacology, , Apr-02, Volume: 163	2015
Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study. Arzneimittel-Forschung, , Volume: 61, Issue:6	2011

isoliensinine

Description

Cross-References

Synonyms (20)

Drug Classes (1)

Bioassays (1)

Research

Studies (31)

Study Types

Related Drugs (193)

Drugs in this Class (169)

Drugs Researched Together (27)

Related Conditions (36)

Pharmacokinetics (2)