trimethyloxamine has been researched along with Fibrosis in 12 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 7.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "2% adenine diet for 14 weeks developed CKD with elevated plasma levels of TMAO, provision of a non-lethal inhibitor of gut microbial trimethylamine (TMA) production, iodomethylcholine (IMC), significantly reduced multiple markers of renal injury (plasma creatinine, cystatin C, FGF23, and TMAO), reduced histopathologic evidence of fibrosis, and markedly attenuated development of microalbuminuria." | 4.02 | Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice. ( Charugundla, S; Guo, F; Hazen, SL; Jia, X; Kaczor-Urbanowicz, KE; Lusis, AJ; Magyar, C; Miikeda, A; Nicholas, SB; Pellegrini, M; Shih, DM; Wang, Z; Zhang, W; Zhou, Z; Zuckerman, J, 2021) |
| "Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet, produces trimethylamine (TMA) and the atherothrombosis- and fibrosis-promoting metabolite TMA-N-oxide (TMAO)." | 3.96 | Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease. ( Buffa, JA; DiDonato, JA; Gupta, N; Hazen, SL; Ho, KJ; Li, L; Roberts, AB; Sangwan, N; Skye, SM; Tang, WHW; Varga, J, 2020) |
| "Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine." | 3.96 | Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure. ( Goodchild, TT; Gupta, N; Hazen, SL; Lefer, DJ; Li, Z; Organ, CL; Polhemus, DJ; Sharp, TE; Tang, WHW, 2020) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 3.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide but still lacks specific treatment modalities." | 1.91 | Gut microbiota metabolite TMAO promoted lipid deposition and fibrosis process via KRT17 in fatty liver cells in vitro. ( Jin, N; Lu, X; Nian, F; Wu, L; Xia, Q; Zhu, C, 2023) |
| "Additionally, TMAO treatment induced cardiac hypertrophy and cardiac fibrosis in SD rats." | 1.51 | Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis. ( Chen, M; Deng, Y; Li, Z; Liu, H; Liu, Q; Ou, C; Wu, Z; Yan, J, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 8 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kapetanaki, S | 1 |
| Kumawat, AK | 1 |
| Persson, K | 1 |
| Demirel, I | 1 |
| Zhou, X | 1 |
| Zhang, B | 1 |
| Zhao, X | 1 |
| Lin, Y | 1 |
| Zhuang, Y | 1 |
| Guo, J | 1 |
| Wang, S | 1 |
| Nian, F | 1 |
| Zhu, C | 1 |
| Jin, N | 1 |
| Xia, Q | 1 |
| Wu, L | 1 |
| Lu, X | 1 |
| Gupta, N | 2 |
| Buffa, JA | 1 |
| Roberts, AB | 1 |
| Sangwan, N | 1 |
| Skye, SM | 1 |
| Li, L | 1 |
| Ho, KJ | 1 |
| Varga, J | 1 |
| DiDonato, JA | 1 |
| Tang, WHW | 2 |
| Hazen, SL | 4 |
| Organ, CL | 2 |
| Li, Z | 2 |
| Sharp, TE | 1 |
| Polhemus, DJ | 2 |
| Goodchild, TT | 1 |
| Lefer, DJ | 2 |
| Lu, D | 1 |
| Wang, J | 1 |
| Zhang, H | 1 |
| Shan, Q | 1 |
| Zhou, B | 1 |
| Zhang, W | 1 |
| Miikeda, A | 1 |
| Zuckerman, J | 1 |
| Jia, X | 1 |
| Charugundla, S | 1 |
| Zhou, Z | 1 |
| Kaczor-Urbanowicz, KE | 1 |
| Magyar, C | 1 |
| Guo, F | 1 |
| Wang, Z | 2 |
| Pellegrini, M | 1 |
| Nicholas, SB | 1 |
| Lusis, AJ | 1 |
| Shih, DM | 1 |
| Shi, W | 1 |
| Huang, Y | 1 |
| Yang, Z | 1 |
| Zhu, L | 1 |
| Yu, B | 1 |
| Wu, Z | 1 |
| Yan, J | 1 |
| Liu, H | 1 |
| Liu, Q | 1 |
| Deng, Y | 1 |
| Ou, C | 1 |
| Chen, M | 1 |
| Huc, T | 1 |
| Drapala, A | 1 |
| Gawrys, M | 1 |
| Konop, M | 1 |
| Bielinska, K | 1 |
| Zaorska, E | 1 |
| Samborowska, E | 1 |
| Wyczalkowska-Tomasik, A | 1 |
| Pączek, L | 1 |
| Dadlez, M | 1 |
| Ufnal, M | 1 |
| Yang, W | 1 |
| Zhang, S | 1 |
| Zhu, J | 1 |
| Jiang, H | 1 |
| Jia, D | 1 |
| Ou, T | 1 |
| Qi, Z | 1 |
| Zou, Y | 1 |
| Qian, J | 1 |
| Sun, A | 1 |
| Ge, J | 1 |
| Otsuka, H | 1 |
| Bhushan, S | 1 |
| Bradley, J | 1 |
| Trivedi, R | 1 |
| Tang, WH | 1 |
| Wu, Y | 1 |
12 other studies available for trimethyloxamine and Fibrosis
| Article | Year |
|---|---|
The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway.
Topics: Caspase 1; Cell Line; Cell Proliferation; Collagen; eIF-2 Kinase; Fibroblasts; Fibrosis; Gene Expres | 2021 |
Chlorogenic Acid Prevents Hyperuricemia Nephropathy via Regulating TMAO-Related Gut Microbes and Inhibiting the PI3K/AKT/mTOR Pathway.
Topics: Animals; Chlorogenic Acid; Fibrosis; Gastrointestinal Microbiome; Hyperuricemia; Mammals; Methylamin | 2022 |
Gut microbiota metabolite TMAO promoted lipid deposition and fibrosis process via KRT17 in fatty liver cells in vitro.
Topics: Fibrosis; Gastrointestinal Microbiome; Humans; Lipids; Liver Cirrhosis; Methylamines; Non-alcoholic | 2023 |
Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.
Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; | 2020 |
Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.
Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Down-Regulation; Enzyme Inhi | 2020 |
Renal denervation improves chronic intermittent hypoxia induced hypertension and cardiac fibrosis and balances gut microbiota.
Topics: Animals; Blood Pressure; Cardiomyopathies; Denervation; Disease Models, Animal; Fibrosis; Gastrointe | 2020 |
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.
Topics: Adenine; Albuminuria; Animals; Cardiomegaly; Choline; Disease Models, Animal; Female; Fibroblast Gro | 2021 |
Reduction of TMAO level enhances the stability of carotid atherosclerotic plaque through promoting macrophage M2 polarization and efferocytosis.
Topics: Animals; Carotid Arteries; Carotid Artery Diseases; Disease Models, Animal; Down-Regulation; Enzyme | 2021 |
Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis.
Topics: Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibrosis; Gastrointestinal Microbiom | 2019 |
Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Fibrosis; Hypertension; Male; Methylamines; Myocar | 2018 |
Gut microbe-derived metabolite trimethylamine N-oxide accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis.
Topics: Animals; Cell Differentiation; Collagen Type I; Disease Models, Animal; Fibroblasts; Fibrosis; Gastr | 2019 |
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi | 2016 |