Mitochondrial pyruvate carrier 2

A brain protein 44 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95563]

Brain protein 44

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
msdc-0160	Homo sapiens (human)	IC50	1.2000	1	1

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
pyruvate transmembrane transporter activity	molecular function	Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other. [GOC:ai]

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]

This protein is active in 1 target(s):

Target	Category	Definition
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]

This protein is part of 1 target(s):

Target	Category	Definition
inner mitochondrial membrane protein complex	cellular component	Any protein complex that is part of the inner mitochondrial membrane. [GOC:dos]

This protein is involved in 3 target(s):

Target	Category	Definition
acetyl-CoA biosynthetic process from pyruvate	biological process	The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. [GOC:dph, GOC:go_curators, GOC:tb]
mitochondrial pyruvate transmembrane transport	biological process	The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:vw, PMID:22628558]
positive regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]