prednisolone has been researched along with Insulin Resistance in 53 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arterial stiffness is not affected by low dose prednisolone per se, but is negatively associated with peripheral insulin sensitivity." | 7.85 | Low dose prednisolone and insulin sensitivity differentially affect arterial stiffness and endothelial function: An open interventional and cross-sectional study. ( Burt, MG; Greenfield, JR; Mangelsdorf, BL; Petersons, CJ; Poljak, A; Smith, MD; Thompson, CH, 2017) |
| " The present studies were conducted to characterize consequences of chronic treatment with the synthetic glucocorticoid prednisolone on insulin sensitivity and blood glucose kinetics in mice." | 7.76 | Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice. ( Bloks, VW; Dokter, WH; Grefhorst, A; Groen, AK; Kuipers, F; Laskewitz, AJ; Reijngoud, DJ; van Dijk, TH; van Lierop, MJ, 2010) |
| "Treatment with prednisolone at both dosages reduced CRP levels significantly." | 6.77 | Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction. ( Bijlsma, JW; den Uyl, D; Diamant, M; Dijkmans, BA; Hoes, JN; Lems, WF; Nurmohamed, MT; van Raalte, DH, 2012) |
| "Pioglitazone was effective in decreasing serum HCV RNA at day-14 (n = 10; difference of means = 205,618 IU/ml; 95% CI 26,600 to 384,600; P<0." | 6.77 | Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. ( Buck, M; Chojkier, M; Donohue, M; Elkhayat, H; Sabry, D, 2012) |
| "Treatment with prednisolone (PSL), mycophenolate mofetil (MMF), and tacrolimus (TAC) resulted in improved SLE activity and glucose intolerance with the reduction of anti-insulin receptor autoantibodies." | 5.72 | Effect of a multitarget therapy with prednisolone, mycophenolate mofetil, and tacrolimus in a patient with type B insulin resistance syndrome complicated by lupus nephritis. ( Asano, T; Fujita, Y; Furuya-Yashiro, M; Kiko, Y; Kobayashi, H; Matsumoto, H; Matsuoka, N; Migita, K; Oda, A; Saito, K; Sasajima, T; Sato, S; Shimabukuro, M; Shio-Yano, K; Tanabe, H; Temmoku, J; Watanabe, H, 2022) |
| "Prednisolone treatment aggravated fasting hyperglycemia and hyperinsulinemia caused by high-fat feeding, resulting in a higher homeostatic assessment model of insulin resistance." | 5.38 | Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance. ( Bloks, VW; Dokter, WH; Grefhorst, A; Groen, AK; Kuipers, F; Laskewitz, AJ; Reijngoud, DJ; Schreurs, M; van Dijk, TH; van Lierop, MJ, 2012) |
| "Prednisolone-induced insulin resistance is not associated with postprandial vascular dysfunction in patients with rheumatoid arthritis." | 5.22 | Effect of acute and chronic glucocorticoid therapy on insulin sensitivity and postprandial vascular function. ( Burt, MG; Drake, SM; Heilbronn, LK; Jenkins, AB; Mangelsdorf, BL; Radhakutty, A; Samocha-Bonet, D; Smith, MD; Thompson, CH, 2016) |
| "Men with the metabolic syndrome but without diabetes received prednisolone 30 mg once daily plus sitagliptin 100 mg once daily (n=14), prednisolone (n=12) or sitagliptin alone (n=14) or placebo (n=12) for 14 days in a double-blind 2 × 2 randomized-controlled study." | 5.19 | Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial. ( Diamant, M; Heymans, MW; Mari, A; Muskiet, MH; Ouwens, DM; Pouwels, PJ; van Genugten, RE; van Raalte, DH, 2014) |
| " We sought to test the hypothesis that tapering of prednisolone (TAP) the first year after renal transplantation improves insulin sensitivity (IS), and to assess the effect of complete steroid withdrawal (SW) on IS in patients on a cyclosporine-based immunosuppressive regimen." | 5.11 | Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal. ( Egeland, T; Hartmann, A; Hjelmesaeth, J; Jenssen, T; Lund, K; Midtvedt, K; Paulsen, D, 2004) |
| "Treatment with prednisolone induced insulin resistance (Homeostasis Model Assessment index: placebo vs." | 5.10 | Preferential stimulation of abdominal subcutaneous lipolysis after prednisolone exposure in humans. ( Christiansen, JS; Dall, R; Gravholt, CH; Møller, N; Schmitz, O, 2002) |
| "Prednisolone treatment led to insulin resistance as expected (HOMA-S; prednisolone vs placebo; 1." | 5.10 | Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans. ( Dall, R; Hollingdal, M; Juhl, CB; Pørksen, N; Schmitz, O; Sturis, J; Veldhuis, JD, 2002) |
| "Arterial stiffness is not affected by low dose prednisolone per se, but is negatively associated with peripheral insulin sensitivity." | 3.85 | Low dose prednisolone and insulin sensitivity differentially affect arterial stiffness and endothelial function: An open interventional and cross-sectional study. ( Burt, MG; Greenfield, JR; Mangelsdorf, BL; Petersons, CJ; Poljak, A; Smith, MD; Thompson, CH, 2017) |
| "These data suggest that increased postprandial GIP and glucagon responses may occur as a consequence of insulin resistance and/or reduced glucose tolerance." | 3.77 | Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects. ( Bagger, JI; Hansen, KB; Holst, JJ; Knop, FK; Vilsbøll, T, 2011) |
| " The present studies were conducted to characterize consequences of chronic treatment with the synthetic glucocorticoid prednisolone on insulin sensitivity and blood glucose kinetics in mice." | 3.76 | Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice. ( Bloks, VW; Dokter, WH; Grefhorst, A; Groen, AK; Kuipers, F; Laskewitz, AJ; Reijngoud, DJ; van Dijk, TH; van Lierop, MJ, 2010) |
| " Intravenous boluses of cyclophosphamide (IVCY) with oral prednisolone and cyclosporin A induced remission of SLE, and a subsequent disappearance of anti-insulin receptor autoantibodies, followed by a recovery of glucose intolerance." | 3.76 | Type B insulin resistance complicated with systemic lupus erythematosus. ( Aramaki, T; Eguchi, K; Fujikawa, K; Ida, H; Iwamoto, N; Kawakami, A; Kawashiri, SY; Nakamura, H; Origuchi, T; Tamai, M, 2010) |
| "To evaluate the insulin sensitivity (IS) and levels of peptides with impact on IS in polymyalgia rheumatica (PMR) before and after prednisolone treatment." | 3.76 | Insulin sensitivity and related cytokines, chemokines, and adipokines in polymyalgia rheumatica. ( Galbo, H; Kreiner, F, 2010) |
| "Insulin resistance was successfully induced by a large dose of prednisolone in male rats." | 3.75 | Acute effect of electroacupuncture at the Zusanli acupoints on decreasing insulin resistance as shown by lowering plasma free fatty acid levels in steroid-background male rats. ( Chang, SL; Cheng, JT; Ho, WJ; Lee, YC; Lin, JG; Lin, RT; Tzeng, CY, 2009) |
| "Our results indicate that obesity, distribution of obesity, and prednisolone treatment are the predominant determinants of insulin resistance long term after transplantation." | 3.74 | Determinants of insulin resistance in renal transplant recipients. ( Bakker, SJ; de Jong, PE; de Vries, AP; Gans, RO; Gansevoort, RT; Oterdoom, LH; Ploeg, RJ; van der Heide, JJ; van Son, WJ, 2007) |
| " In the univariate model, BMI, daily prednisolone dose, creatinine clearance, hypertension, number of antihypertensive agents, and use of diuretics or beta-blockers were negatively associated with ISI(TX) (P < 0." | 3.71 | Insulin resistance after renal transplantation: impact of immunosuppressive and antihypertensive therapy. ( Hartmann, A; Hjelmesaeth, J; Jenssen, T; Midtvedt, K, 2001) |
| " She was treated with prednisolone, and < 1 year later she presented with marked hyperglycemia." | 3.70 | Successful treatment with plasmapheresis, cyclophosphamide, and cyclosporin A in type B syndrome of insulin resistance. Case report. ( Bremell, T; Eliasson, B; Eriksson, JW; Fowelin, J; Fredriksson, L; Yu, ZW, 1998) |
| "We performed a post-hoc analysis of a randomised, placebo-controlled, double blind, dose-response intervention study involving 32 healthy males (age: 22 ± 3 years; BMI 22." | 2.87 | The osteoblast: Linking glucocorticoid-induced osteoporosis and hyperglycaemia? A post-hoc analysis of a randomised clinical trial. ( Brands, M; de Jongh, RT; den Heijer, M; Heijboer, AC; Serlie, MJ; van Bommel, EJM; van Raalte, DH, 2018) |
| "In a randomized, placebo-controlled, double-blind, dose-response intervention study, 32 healthy males (aged 22 ± 3 years; body mass index 22." | 2.78 | No difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men. ( Aerts, JM; Brands, M; Diamant, M; João Ferraz, M; Sauerwein, HP; Serlie, MJ; van Raalte, DH; Verhoeven, AJ, 2013) |
| "Treatment with prednisolone at both dosages reduced CRP levels significantly." | 2.77 | Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction. ( Bijlsma, JW; den Uyl, D; Diamant, M; Dijkmans, BA; Hoes, JN; Lems, WF; Nurmohamed, MT; van Raalte, DH, 2012) |
| "Pioglitazone was effective in decreasing serum HCV RNA at day-14 (n = 10; difference of means = 205,618 IU/ml; 95% CI 26,600 to 384,600; P<0." | 2.77 | Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. ( Buck, M; Chojkier, M; Donohue, M; Elkhayat, H; Sabry, D, 2012) |
| "In a randomized, placebo-controlled, double-blind, dose-response intervention study, 32 healthy males (age: 22 ± 3 years; BMI 22." | 2.77 | Angiopoietin-like protein 4 is differentially regulated by glucocorticoids and insulin in vitro and in vivo in healthy humans. ( Brands, M; Diamant, M; Kersten, S; Mudde, K; Sauerwein, HP; Serlie, MJ; Stienstra, R; van Raalte, DH, 2012) |
| "Treatment with prednisolone (PSL), mycophenolate mofetil (MMF), and tacrolimus (TAC) resulted in improved SLE activity and glucose intolerance with the reduction of anti-insulin receptor autoantibodies." | 1.72 | Effect of a multitarget therapy with prednisolone, mycophenolate mofetil, and tacrolimus in a patient with type B insulin resistance syndrome complicated by lupus nephritis. ( Asano, T; Fujita, Y; Furuya-Yashiro, M; Kiko, Y; Kobayashi, H; Matsumoto, H; Matsuoka, N; Migita, K; Oda, A; Saito, K; Sasajima, T; Sato, S; Shimabukuro, M; Shio-Yano, K; Tanabe, H; Temmoku, J; Watanabe, H, 2022) |
| " In conclusion, long-term intake of fructose and prednisolone by male rats are more detrimental to glucose and lipid homeostasis than if ingested separately and the benefits of treatment interruption are broader than fish oil treatment." | 1.62 | Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration. ( Brunetta, HS; Chagas, TR; da Silva, JS; Nunes, EA; Rafacho, A; Santos, CD; Zoccal, DB, 2021) |
| "A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control." | 1.42 | Severe Insulin-resistant Diabetes due to Insulin Antibodies Associated with Eosinophilia. ( Nagao, M; Nakajima, Y; Oikawa, S; Sugihara, H; Takaya, M; Takemitsu, S; Uchigata, Y, 2015) |
| "Prednisolone treatment aggravated fasting hyperglycemia and hyperinsulinemia caused by high-fat feeding, resulting in a higher homeostatic assessment model of insulin resistance." | 1.38 | Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance. ( Bloks, VW; Dokter, WH; Grefhorst, A; Groen, AK; Kuipers, F; Laskewitz, AJ; Reijngoud, DJ; Schreurs, M; van Dijk, TH; van Lierop, MJ, 2012) |
| " Prednisolone dosage was increased from 10 to 60 mg/day." | 1.36 | Type B insulin resistance syndrome with systemic lupus erythematosus. ( Gohda, T; Horikoshi, S; Ohsawa, I; Sato, N; Shirato, I; Takagi, M; Tomino, Y; Yamaguchi, Y, 2010) |
| "He was diagnosed as having acute promyelocytic leukemia, and treated with all-trans retinoic acid." | 1.31 | [Hypokalemic periodic paralysis during treatment of acute promyelocytic leukemia]. ( Kariya, T; Shionoiri, C; Yoneyama, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (7.55) | 18.7374 |
| 1990's | 4 (7.55) | 18.2507 |
| 2000's | 13 (24.53) | 29.6817 |
| 2010's | 28 (52.83) | 24.3611 |
| 2020's | 4 (7.55) | 2.80 |
| Authors | Studies |
|---|---|
| Temmoku, J | 1 |
| Asano, T | 1 |
| Saito, K | 1 |
| Matsumoto, H | 1 |
| Fujita, Y | 1 |
| Furuya-Yashiro, M | 1 |
| Matsuoka, N | 1 |
| Oda, A | 1 |
| Tanabe, H | 1 |
| Sato, S | 1 |
| Shio-Yano, K | 1 |
| Sasajima, T | 1 |
| Kiko, Y | 1 |
| Kobayashi, H | 1 |
| Watanabe, H | 1 |
| Shimabukuro, M | 1 |
| Migita, K | 1 |
| Noguchi, K | 1 |
| Nakai, Y | 1 |
| Mizuno, S | 1 |
| Isayama, H | 1 |
| Hirano, K | 1 |
| Kanai, S | 1 |
| Nakamura, T | 1 |
| Uchino, R | 1 |
| Takahara, N | 1 |
| Kogure, H | 1 |
| Tada, M | 1 |
| Koike, K | 1 |
| Hirota, Y | 1 |
| Suwanai, H | 1 |
| Yamauchi, T | 1 |
| Kadowaki, T | 1 |
| Santos, CD | 1 |
| da Silva, JS | 1 |
| Brunetta, HS | 1 |
| Chagas, TR | 1 |
| Zoccal, DB | 1 |
| Nunes, EA | 1 |
| Rafacho, A | 1 |
| van Bommel, EJM | 1 |
| de Jongh, RT | 1 |
| Brands, M | 4 |
| Heijboer, AC | 1 |
| den Heijer, M | 1 |
| Serlie, MJ | 4 |
| van Raalte, DH | 7 |
| Pranger, IG | 1 |
| Muskiet, MHA | 1 |
| Kema, IP | 1 |
| Diamant, M | 6 |
| Bakker, SJL | 1 |
| Muskiet, FAJ | 1 |
| Parker, L | 1 |
| Lin, X | 1 |
| Garnham, A | 1 |
| McConell, G | 1 |
| Stepto, NK | 1 |
| Hare, DL | 1 |
| Byrnes, E | 1 |
| Ebeling, PR | 1 |
| Seeman, E | 1 |
| Brennan-Speranza, TC | 1 |
| Levinger, I | 1 |
| Nordheim, E | 1 |
| Birkeland, KI | 1 |
| Åsberg, A | 3 |
| Hartmann, A | 5 |
| Horneland, R | 1 |
| Jenssen, T | 5 |
| Chen, PW | 1 |
| Lin, C | 1 |
| Chen, CD | 1 |
| Chen, WY | 1 |
| Mao, FC | 1 |
| Fleuren, WW | 1 |
| Linssen, MM | 1 |
| Toonen, EJ | 1 |
| van der Zon, GC | 1 |
| Guigas, B | 1 |
| de Vlieg, J | 1 |
| Dokter, WH | 4 |
| Ouwens, DM | 2 |
| Alkema, W | 1 |
| Petersons, CJ | 2 |
| Mangelsdorf, BL | 4 |
| Jenkins, AB | 2 |
| Poljak, A | 2 |
| Smith, MD | 4 |
| Greenfield, JR | 2 |
| Thompson, CH | 4 |
| Burt, MG | 4 |
| van Genugten, RE | 1 |
| Muskiet, MH | 1 |
| Heymans, MW | 1 |
| Pouwels, PJ | 1 |
| Mari, A | 2 |
| von Düring, ME | 1 |
| Bollerslev, J | 1 |
| Godang, K | 1 |
| Eide, IA | 1 |
| Dahle, DO | 1 |
| Yaşar Bilge, NŞ | 1 |
| Kaşifoğlu, N | 1 |
| Kaşifoğlu, T | 1 |
| Şahin, F | 1 |
| Gönüllü, E | 1 |
| Korkmaz, C | 1 |
| Takaya, M | 1 |
| Nagao, M | 1 |
| Takemitsu, S | 1 |
| Nakajima, Y | 1 |
| Sugihara, H | 1 |
| Uchigata, Y | 1 |
| Oikawa, S | 1 |
| Radhakutty, A | 2 |
| Drake, SM | 2 |
| Samocha-Bonet, D | 2 |
| Heilbronn, LK | 2 |
| Segal, T | 1 |
| Webb, E | 1 |
| Viner, R | 1 |
| Pusey, C | 1 |
| Wild, G | 1 |
| Allgrove, J | 1 |
| Lupsa, BC | 1 |
| Chong, AY | 1 |
| Cochran, EK | 1 |
| Soos, MA | 2 |
| Semple, RK | 1 |
| Gorden, P | 1 |
| Lin, RT | 1 |
| Tzeng, CY | 1 |
| Lee, YC | 1 |
| Ho, WJ | 1 |
| Cheng, JT | 1 |
| Lin, JG | 1 |
| Chang, SL | 1 |
| Roohk, DJ | 1 |
| Varady, KA | 1 |
| Turner, SM | 1 |
| Emson, CL | 1 |
| Gelling, RW | 1 |
| Shankaran, M | 1 |
| Lindwall, G | 1 |
| Shipp, LE | 1 |
| Scanlan, TS | 1 |
| Wang, JC | 1 |
| Hellerstein, MK | 1 |
| Nofrate, V | 1 |
| Bunck, MC | 1 |
| van Iersel, T | 1 |
| Elassaiss Schaap, J | 1 |
| Nässander, UK | 1 |
| Heine, RJ | 1 |
| Sato, N | 1 |
| Ohsawa, I | 1 |
| Takagi, M | 1 |
| Gohda, T | 1 |
| Horikoshi, S | 1 |
| Shirato, I | 1 |
| Yamaguchi, Y | 1 |
| Tomino, Y | 1 |
| Laskewitz, AJ | 2 |
| van Dijk, TH | 2 |
| Bloks, VW | 2 |
| Reijngoud, DJ | 2 |
| van Lierop, MJ | 2 |
| Kuipers, F | 2 |
| Groen, AK | 2 |
| Grefhorst, A | 2 |
| Kawashiri, SY | 1 |
| Kawakami, A | 1 |
| Fujikawa, K | 1 |
| Iwamoto, N | 1 |
| Aramaki, T | 1 |
| Tamai, M | 1 |
| Nakamura, H | 1 |
| Origuchi, T | 1 |
| Ida, H | 1 |
| Eguchi, K | 1 |
| Hansen, KB | 3 |
| Vilsbøll, T | 3 |
| Bagger, JI | 2 |
| Holst, JJ | 2 |
| Knop, FK | 3 |
| Kreiner, F | 1 |
| Galbo, H | 1 |
| den Uyl, D | 1 |
| Nurmohamed, MT | 1 |
| Lems, WF | 1 |
| Bijlsma, JW | 1 |
| Hoes, JN | 1 |
| Dijkmans, BA | 1 |
| Kappelgaard, P | 1 |
| Larsen, M | 1 |
| Chojkier, M | 1 |
| Elkhayat, H | 1 |
| Sabry, D | 1 |
| Donohue, M | 1 |
| Buck, M | 1 |
| Schreurs, M | 1 |
| Mudde, K | 1 |
| Stienstra, R | 1 |
| Sauerwein, HP | 2 |
| Kersten, S | 1 |
| João Ferraz, M | 1 |
| Verhoeven, AJ | 1 |
| Aerts, JM | 1 |
| Gravholt, CH | 1 |
| Dall, R | 2 |
| Christiansen, JS | 1 |
| Møller, N | 1 |
| Schmitz, O | 2 |
| Midtvedt, K | 2 |
| Hjelmesaeth, J | 3 |
| Lund, K | 1 |
| Paulsen, D | 1 |
| Egeland, T | 1 |
| Coll, AP | 1 |
| Morganstein, D | 1 |
| Jayne, D | 1 |
| O'Rahilly, S | 1 |
| Burke, J | 1 |
| Oterdoom, LH | 1 |
| de Vries, AP | 1 |
| Gansevoort, RT | 1 |
| van Son, WJ | 1 |
| van der Heide, JJ | 1 |
| Ploeg, RJ | 1 |
| de Jong, PE | 1 |
| Gans, RO | 1 |
| Bakker, SJ | 1 |
| Müller, F | 1 |
| Leatherdale, BA | 1 |
| Ingram, DA | 1 |
| Dixon, K | 1 |
| Ishizuka, T | 2 |
| Nagashima, T | 1 |
| Kajita, K | 2 |
| Miura, A | 2 |
| Yamamoto, M | 1 |
| Itaya, S | 1 |
| Kanoh, Y | 2 |
| Ishizawa, M | 2 |
| Murase, H | 1 |
| Yasuda, K | 2 |
| Eriksson, JW | 1 |
| Bremell, T | 1 |
| Eliasson, B | 1 |
| Fowelin, J | 1 |
| Fredriksson, L | 1 |
| Yu, ZW | 1 |
| Mingrone, G | 1 |
| DeGaetano, A | 1 |
| Pugeat, M | 1 |
| Capristo, E | 1 |
| Greco, AV | 1 |
| Gasbarrini, G | 1 |
| Kern, W | 1 |
| Stange, EF | 1 |
| Fehm, HL | 1 |
| Klein, HH | 1 |
| Shionoiri, C | 1 |
| Kariya, T | 1 |
| Yoneyama, A | 1 |
| Kimura, M | 1 |
| Muto, N | 1 |
| Yoshida, C | 1 |
| Miyachi, Y | 1 |
| Hollingdal, M | 1 |
| Juhl, CB | 1 |
| Sturis, J | 1 |
| Veldhuis, JD | 1 |
| Pørksen, N | 1 |
| Kawanishi, K | 1 |
| Kawamura, K | 1 |
| Nishina, Y | 1 |
| Goto, A | 1 |
| Okada, S | 1 |
| Cawley, MI | 1 |
| Browne, DS | 1 |
| Rastogi, GK | 1 |
| Singhal, KC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism and Beta-Cell Dysfunction in Males With the Metabolic Syndrome X: A Randomized, Placebo-controlled, Double-blind Intervention Study With a 2x2 Factorial Design[NCT00721552] | 82 participants (Actual) | Interventional | 2008-10-31 | Completed | |||
| Incretin Physiology and Beta-Cell Function Before and After Treatment With Steroid Hormone in Healthy Individuals[NCT00713440] | 10 participants (Actual) | Interventional | 2008-07-31 | Completed | |||
| Multicenter, Randomized, Controlled Clinical Trial Research Evaluating the Use of Combination Therapy of Glucocorticoids and Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis[NCT03525028] | 138 participants (Anticipated) | Interventional | 2018-11-01 | Recruiting | |||
| A Randomized, Partially Blinded, Pilot Study of the Effects of Pioglitazone on HCV RNA in Overweight Subjects With Chronic HCV Genotypes 1 or 4 Infection.[NCT01157975] | Phase 2 | 0 participants (Actual) | Interventional | 2008-10-31 | Withdrawn (stopped due to Study was completed in another site) | ||
| TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study[NCT03272854] | 606 participants (Actual) | Observational [Patient Registry] | 2001-08-31 | Active, not recruiting | |||
| ACtive Care After Transplantation, a Lifestyle Intervention in Renal Transplant Recipients[NCT01047410] | 221 participants (Actual) | Interventional | 2010-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for prednisolone and Insulin Resistance
| Article | Year |
|---|---|
Autoimmune forms of hypoglycemia.
Topics: Aged; Autoantibodies; Autoimmune Diseases; Glucocorticoids; Humans; Hypoglycemia; Insulin; Insulin R | 2009 |
New-onset posttransplantation diabetes mellitus: insulin resistance or insulinopenia? Impact of immunosuppressive drugs, cytomegalovirus and hepatitis C virus infection.
Topics: Antihypertensive Agents; Cytomegalovirus Infections; Diabetes Mellitus; Hepatitis C; Humans; Immunos | 2005 |
[Glucocorticoid-induced diabetes mellitus in gastrointestinal diseases].
Topics: Adolescent; Adult; Aged; Child; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Gastroi | 1999 |
[Lipid metabolism in Cushing's syndrome].
Topics: Cardiovascular Diseases; Cushing Syndrome; Humans; Hyperlipidemias; Insulin Resistance; Lipid Metabo | 2001 |
14 trials available for prednisolone and Insulin Resistance
| Article | Year |
|---|---|
The osteoblast: Linking glucocorticoid-induced osteoporosis and hyperglycaemia? A post-hoc analysis of a randomised clinical trial.
Topics: Adult; Blood Glucose; Dose-Response Relationship, Drug; Double-Blind Method; Glucocorticoids; Humans | 2018 |
Influence of prednisolone on parameters of de novo lipogenesis and indices for stearoyl-CoA- and Δ6- desaturase activity in healthy males: A Post-hoc analysis of a randomized, placebo-controlled, double-blind trial.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Blood Glucose; Cholesterol Esters; Double-Bli | 2018 |
Glucocorticoid-Induced Insulin Resistance in Men Is Associated With Suppressed Undercarboxylated Osteocalcin.
Topics: Adult; Exercise; Glucocorticoids; Humans; Insulin Resistance; Male; Muscle, Skeletal; Osteocalcin; P | 2019 |
Effects of low-dose prednisolone on hepatic and peripheral insulin sensitivity, insulin secretion, and abdominal adiposity in patients with inflammatory rheumatologic disease.
Topics: Adiposity; Aged; Anti-Inflammatory Agents; Carbohydrate Metabolism; Female; Glucose; Glucose Clamp T | 2013 |
Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; F | 2014 |
Effect of acute and chronic glucocorticoid therapy on insulin sensitivity and postprandial vascular function.
Topics: Aged; Arthritis, Rheumatoid; Blood Glucose; Cross-Sectional Studies; Drug Administration Schedule; F | 2016 |
Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men.
Topics: Adult; Blood Glucose; C-Peptide; Double-Blind Method; Drug Administration Schedule; Glucocorticoids; | 2010 |
Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Glucose; | 2012 |
Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study.
Topics: Adult; Antiviral Agents; Blood Glucose; Chemical and Drug Induced Liver Injury; Cytokines; Female; G | 2012 |
Angiopoietin-like protein 4 is differentially regulated by glucocorticoids and insulin in vitro and in vivo in healthy humans.
Topics: Adult; Angiopoietin-Like Protein 4; Angiopoietins; Dexamethasone; Dose-Response Relationship, Drug; | 2012 |
No difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men.
Topics: Adult; Blood Glucose; Ceramides; Dose-Response Relationship, Drug; Double-Blind Method; Energy Metab | 2013 |
Preferential stimulation of abdominal subcutaneous lipolysis after prednisolone exposure in humans.
Topics: Abdomen; Adipose Tissue; Adult; Blood Glucose; C-Peptide; Calorimetry, Indirect; Cross-Over Studies; | 2002 |
Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal.
Topics: Body Weight; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Glucocorticoids; Graft Rejection; H | 2004 |
Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans.
Topics: Adult; Area Under Curve; Blood Glucose; Body Mass Index; C-Peptide; Cross-Over Studies; Double-Blind | 2002 |
35 other studies available for prednisolone and Insulin Resistance
| Article | Year |
|---|---|
Effect of a multitarget therapy with prednisolone, mycophenolate mofetil, and tacrolimus in a patient with type B insulin resistance syndrome complicated by lupus nephritis.
Topics: Humans; Immunosuppressive Agents; Insulin Resistance; Lupus Nephritis; Male; Middle Aged; Mycophenol | 2022 |
Insulin secretion improvement during steroid therapy for autoimmune pancreatitis according to the onset of diabetes mellitus.
Topics: Aged; Anti-Inflammatory Agents; Atrophy; Autoimmune Pancreatitis; Blood Glucose; C-Peptide; Diabetes | 2020 |
Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Blood Glucose; Female; Humans; Hype | 2020 |
Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration.
Topics: Adipose Tissue; Adiposity; Animals; Fish Oils; Fructose; Glucocorticoids; Glucose; Homeostasis; Huma | 2021 |
Preserved insulin secretion and kidney function in recipients with functional pancreas grafts 1 year after transplantation: a single-center prospective observational study
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; Glucose Toleran | 2018 |
Chromium levels in insulin-sensitive tissues and the thigh bone are modulated by prednisolone and high-fat diets in mice.
Topics: Adipose Tissue; Animals; Chromium; Diet, High-Fat; Insulin Resistance; Mice; Mice, Inbred C57BL; Pre | 2013 |
Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Animals; Deoxyglucose; Gene Expression; Glucocorticoids; Immun | 2013 |
Visceral fat is better related to impaired glucose metabolism than body mass index after kidney transplantation.
Topics: Absorptiometry, Photon; Adult; Aged; Blood Glucose; Body Composition; Body Mass Index; Cross-Section | 2015 |
The role of methotrexate and low-dose prednisolone on adiponectine levels and insulin resistance in patients with rheumatoid arthritis naïve to disease-modifying antirheumatic drugs.
Topics: Adiponectin; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Glucose; Dr | 2016 |
Severe Insulin-resistant Diabetes due to Insulin Antibodies Associated with Eosinophilia.
Topics: Aged; Antibodies; Blood Glucose; Diabetes Mellitus, Type 2; Eosinophilia; Glucocorticoids; Humans; H | 2015 |
Effects of prednisolone on energy and fat metabolism in patients with rheumatoid arthritis: tissue-specific insulin resistance with commonly used prednisolone doses.
Topics: Adipocytes; Aged; Arthritis, Rheumatoid; Calorimetry, Indirect; Energy Metabolism; Fatty Acids, None | 2016 |
Low dose prednisolone and insulin sensitivity differentially affect arterial stiffness and endothelial function: An open interventional and cross-sectional study.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Blood Glucose; Cross-Sectional Studies; Drug Admi | 2017 |
Severe insulin resistance secondary to insulin antibodies: successful treatment with the immunosuppressant MMF.
Topics: Blood Glucose; Child; Diabetes Mellitus, Type 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; I | 2008 |
Acute effect of electroacupuncture at the Zusanli acupoints on decreasing insulin resistance as shown by lowering plasma free fatty acid levels in steroid-background male rats.
Topics: Acupuncture Points; Animals; Blood Glucose; Disease Models, Animal; Electroacupuncture; Fatty Acids, | 2009 |
Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone.
Topics: Adipose Tissue; Animals; Bone and Bones; Cell Death; Cell Proliferation; Collagen; Gene Expression P | 2010 |
Type B insulin resistance syndrome with systemic lupus erythematosus.
Topics: Biopsy; Dose-Response Relationship, Drug; Follow-Up Studies; Glucocorticoids; Humans; Insulin; Insul | 2010 |
Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice.
Topics: Algorithms; Animals; Blood Glucose; Eating; Energy Metabolism; Fasting; Fibroblast Growth Factors; G | 2010 |
Type B insulin resistance complicated with systemic lupus erythematosus.
Topics: Autoantibodies; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Glucose Intolerance; Huma | 2010 |
Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects.
Topics: Adult; Area Under Curve; Blood Glucose; Body Weight; C-Peptide; Diet; Glucagon; Glucagon-Like Peptid | 2010 |
Insulin sensitivity and related cytokines, chemokines, and adipokines in polymyalgia rheumatica.
Topics: Adiponectin; Aged; Aged, 80 and over; Blood Glucose; Case-Control Studies; Chemokine CCL2; Chemokine | 2010 |
Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects.
Topics: Adult; Area Under Curve; Blood Glucose; C-Peptide; Diet; Energy Intake; Fasting; Gastric Inhibitory | 2011 |
Electroretinography in healthy subjects in relation to systemic glucocorticoid intake.
Topics: Adult; Electroretinography; Follow-Up Studies; Glucocorticoids; Glucose Tolerance Test; Humans; Hype | 2012 |
Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Dietary Fats; Hyperglycemia; Insulin Resistance; M | 2012 |
Successful treatment of Type B insulin resistance in a patient with otherwise quiescent systemic lupus erythematosus.
Topics: Adult; Diabetes Complications; Female; Glucocorticoids; Humans; Hyperglycemia; Hypoglycemic Agents; | 2005 |
Determinants of insulin resistance in renal transplant recipients.
Topics: Adult; Aged; Body Composition; Body Mass Index; Cardiovascular Diseases; Exercise; Female; Follow-Up | 2007 |
Determinants of insulin resistance in renal transplant recipients.
Topics: Adult; Aged; Body Composition; Body Mass Index; Cardiovascular Diseases; Exercise; Female; Follow-Up | 2007 |
Determinants of insulin resistance in renal transplant recipients.
Topics: Adult; Aged; Body Composition; Body Mass Index; Cardiovascular Diseases; Exercise; Female; Follow-Up | 2007 |
Determinants of insulin resistance in renal transplant recipients.
Topics: Adult; Aged; Body Composition; Body Mass Index; Cardiovascular Diseases; Exercise; Female; Follow-Up | 2007 |
Recurrent insulin resistance.
Topics: Chlorpropamide; Diabetes Mellitus; Female; Humans; Insulin; Insulin Resistance; Middle Aged; Prednis | 1980 |
Effect of glucocorticoid receptor antagonist RU 38486 on acute glucocorticoid-induced insulin resistance in rat adipocytes.
Topics: Adipocytes; Animals; Biological Transport; Brain; Deoxyglucose; Dexamethasone; Glucocorticoids; Horm | 1997 |
Successful treatment with plasmapheresis, cyclophosphamide, and cyclosporin A in type B syndrome of insulin resistance. Case report.
Topics: Adipocytes; Animals; Autoantibodies; Combined Modality Therapy; Cyclophosphamide; Cyclosporine; Fema | 1998 |
The steroid resistance of Crohn's disease.
Topics: Adult; Binding Sites; Crohn Disease; Drug Resistance; Glucocorticoids; Glucose; Humans; Hydrocortiso | 1999 |
[Hypokalemic periodic paralysis during treatment of acute promyelocytic leukemia].
Topics: Adult; Antineoplastic Agents; Dietary Carbohydrates; Humans; Hyperinsulinism; Hypokalemia; Insulin R | 2000 |
Glucocorticoid-induced insulin resistance associates with activation of protein kinase C isoforms.
Topics: Adipocytes; Animals; Biological Transport; Cell Membrane; Cell Separation; Cells, Cultured; Corticos | 2001 |
Insulin resistance after renal transplantation: impact of immunosuppressive and antihypertensive therapy.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bl | 2001 |
Successful immunosuppressive therapy in insulin resistant diabetes caused by anti-insulin receptor autoantibodies.
Topics: Autoantibodies; C-Peptide; Cyclophosphamide; Diabetes Complications; Diabetes Mellitus; Female; Gluc | 1977 |
Insulin resistance and thrombocytopenic purpura occurring in the same patient.
Topics: Autoimmune Diseases; Blood Platelets; Diabetes Complications; Female; Humans; Insulin Antibodies; In | 1970 |
Young insulin-refractory diabetics.
Topics: Adolescent; Adult; Age Factors; Diabetes Mellitus; Female; Humans; Insulin; Insulin Resistance; Male | 1969 |