A diacylglycerol O-acyltransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75907]
EC 2.3.1.20;
ACAT-related gene product 1;
Acyl-CoA retinol O-fatty-acyltransferase;
ARAT;
Retinol O-fatty-acyltransferase;
2.3.1.76;
Diglyceride acyltransferase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 11 (78.57) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| azd3988 | Homo sapiens (human) | IC50 | 0.0183 | 4 | 4 |
| a-922500 | Homo sapiens (human) | IC50 | 0.0143 | 5 | 6 |
| azd7687 | Homo sapiens (human) | IC50 | 100.0883 | 4 | 6 |
| pf-04620110 | Homo sapiens (human) | IC50 | 0.0256 | 7 | 7 |
| pradigastat | Homo sapiens (human) | IC50 | 0.0605 | 2 | 2 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| 2-acylglycerol O-acyltransferase activity | molecular function | Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. [PMID:4016575, RHEA:16741] |
| diacylglycerol O-acyltransferase activity | molecular function | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. [EC:2.3.1.20] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| acyltransferase activity | molecular function | Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| retinol O-fatty-acyltransferase activity | molecular function | Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester. [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| specific granule membrane | cellular component | The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| monoacylglycerol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [ISBN:0198506732] |
| triglyceride metabolic process | biological process | The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. [ISBN:0198506732] |
| triglyceride biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. [ISBN:0198506732] |
| lipid storage | biological process | The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] |
| very-low-density lipoprotein particle assembly | biological process | The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle. [GOC:BHF, GOC:mah] |
| long-chain fatty-acyl-CoA metabolic process | biological process | The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [ISBN:0198506732] |
| retinol metabolic process | biological process | The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] |
| diacylglycerol metabolic process | biological process | The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [PMID:11481335] |
| fatty acid homeostasis | biological process | Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. [GOC:BHF, GOC:rl] |