isoxazoles has been researched along with Insulin Resistance in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, DR; Cha, JJ; Han, JY; Han, SY; Kang, YS; Song, HK | 1 |
| Abd El-Aty, AM; Jeong, JH; Jung, TW; Kim, TJ; Lee, HJ; Pyun, DH | 1 |
| Chen, S; Gong, H; Zhan, B; Zhang, Y | 1 |
| Guan, M; Li, N; Song, J; Sun, S; Wang, R; Zhang, J; Zhang, X; Zhao, Z | 1 |
| Ballon, JS; Contreras, I; Freyberg, R; Freyberg, Z; Leibel, RL; Lieberman, JA; Mayer, LE; Pajvani, UB; Rosenbaum, M | 1 |
| Fan, B; Hu, J; Hu, S; Huang, M; Li, Y; Liao, Z; Peterson, BS; Tang, J; Wei, N; Xu, D; Xu, Y; Yao, M; Yuan, T; Yue, W; Zhou, W | 1 |
| Aboul-Fotouh, S; Elgayar, N | 1 |
| Iwamura, T; Kainoh, M; Kawai, K; Kumagai, H; Nakaki, J; Nitta, A; Okazaki, S; Sakami, S; Sato, M; Sekiya, Y; Takahashi, T; Yagi, M | 1 |
| Amin, SG; Bisson, WH; Brocker, CN; Desai, D; Gavrilova, O; Gonzalez, FJ; Jiang, C; Krausz, KW; Li, J; Liu, Y; Lv, Y; Patterson, AD; Shi, J; Xie, C | 1 |
| Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Mencarelli, A; Palladino, G; Renga, B | 1 |
| Barr, AM; Boyda, HN; Hawkes, E; Honer, WG; Jin, CH; Pang, CC; Procyshyn, RM; Wong, D | 1 |
| Yamanouchi, T | 1 |
| Groff, MA; Lo, MW; Riffel, KA; Song, H; Wenning, L | 1 |
| Barrera, G; Edwards, PA; Gonzalez, FJ; Lee, FY; Lee, H; Vales, C; Willson, TM; Zhang, Y | 1 |
| Abdelkarim, M; Cariou, B; Caron, S; Duran-Sandoval, D; Fruchart, JC; Gonzalez, FJ; Grefhorst, A; Kuipers, F; Staels, B; Torpier, G; van Dijk, TH; van Harmelen, K | 1 |
| Matsui, K; Shibata, T; Wakitani, K; Yonemori, F | 2 |
| Hasegawa, M; Makino, H; Nishimiya, T; Ochi, M; Onuma, H; Osawa, H; Tang, Y | 1 |
| Abe, I; Eto, K; Fujishima, M; Nakamura, Y; Ohya, Y | 1 |
| Shinkai, H | 1 |
2 review(s) available for isoxazoles and Insulin Resistance
| Article | Year |
|---|---|
[Chemical structures and pharmacological characteristics of novel non-thiazolidinedione insulin sensitizer (JTT-501, FK614)].
Topics: Animals; Blood Glucose; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Lipid Metabolism; Oxadiazoles; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
[The chemical structure and pharmacological properties of a novel isoxazolidinedione insulin sensitizer, JTT-501].
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Isoxazoles; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors | 2001 |
3 trial(s) available for isoxazoles and Insulin Resistance
| Article | Year |
|---|---|
Effects of bilateral Pecto-intercostal Fascial Block for perioperative pain management in patients undergoing open cardiac surgery: a prospective randomized study.
Topics: Adult; Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Hospitalization; Humans; Insulin Resistance; Intensive Care Units; Isoxazoles; Length of Stay; Male; Middle Aged; Nerve Block; Pain Measurement; Pain, Postoperative; Prospective Studies; Sufentanil; Ultrasonography, Interventional | 2021 |
Pathophysiology of drug induced weight and metabolic effects: findings from an RCT in healthy volunteers treated with olanzapine, iloperidone, or placebo.
Topics: Adolescent; Adult; Antipsychotic Agents; Blood Glucose; Body Weight; Double-Blind Method; Dyslipidemias; Eating; Energy Metabolism; Female; Glucose Tolerance Test; Healthy Volunteers; Humans; Insulin; Insulin Resistance; Isoxazoles; Lipids; Male; Obesity; Olanzapine; Piperidines; Weight Gain; Young Adult | 2018 |
A randomized, 12-week study of the effects of extended-release paliperidone (paliperidone ER) and olanzapine on metabolic profile, weight, insulin resistance, and β-cell function in schizophrenic patients.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Body Weight; Delayed-Action Preparations; Female; Follow-Up Studies; Humans; Insulin Resistance; Insulin-Secreting Cells; Isoxazoles; Lipid Metabolism; Male; Olanzapine; Paliperidone Palmitate; Prospective Studies; Pyrimidines; Schizophrenia; Time Factors; Young Adult | 2013 |
15 other study(ies) available for isoxazoles and Insulin Resistance
| Article | Year |
|---|---|
Farnesoid X receptor (FXR) agonist ameliorates systemic insulin resistance, dysregulation of lipid metabolism, and alterations of various organs in a type 2 diabetic kidney animal model.
Topics: Adipose Tissue; Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Insulin Resistance; Isoxazoles; Kidney; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear | 2021 |
Valdecoxib improves lipid-induced skeletal muscle insulin resistance via simultaneous suppression of inflammation and endoplasmic reticulum stress.
Topics: Animals; Cell Line; Cyclooxygenase 2 Inhibitors; Diet, High-Fat; Endoplasmic Reticulum Stress; Inflammation Mediators; Insulin Resistance; Isoxazoles; Lipids; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Sulfonamides | 2021 |
Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cytokine Receptor gp130; Diet; Down-Regulation; Fatty Acids, Nonesterified; Glucose; Hydrazines; Insulin Resistance; Interleukin-6; Isoxazoles; Janus Kinases; Lipolysis; Lysophospholipids; Mice; Obesity; Phosphoric Diester Hydrolases; Propionates; Quinoxalines; Signal Transduction; STAT3 Transcription Factor | 2017 |
Atypical antipsychotics such as risperidone, but not paliperidone, worsen vascular endothelial function via upregulation of adhesion molecules VCAM-1, ICAM-1, and E-selectin in diabetic rats.
Topics: Animals; Antipsychotic Agents; Aorta; Blood Pressure; Cell Adhesion Molecules; Chemokine CCL2; Cytokines; Diabetes Mellitus, Experimental; Diet, High-Fat; E-Selectin; Endothelium, Vascular; Glucose; Insulin Resistance; Isoxazoles; Lipids; Male; Paliperidone Palmitate; Pyrimidines; Rats; Rats, Wistar; Risperidone; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2013 |
HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Administration, Oral; Animals; Azepines; Carbenoxolone; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Obesity; Pioglitazone; Thiazolidinediones; Triazoles | 2014 |
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
Topics: Adolescent; Adult; Aged; Animals; Ceramides; Cholic Acids; Diet, High-Fat; Fatty Liver; Female; Glycine; Humans; Ileum; Insulin Resistance; Intestinal Mucosa; Isoxazoles; Liver; Male; Mice; Middle Aged; Obesity; Receptors, Cytoplasmic and Nuclear; Young Adult | 2015 |
FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity.
Topics: Acyl-CoA Oxidase; Animals; Apoptosis; Bile Acids and Salts; Blood Glucose; Cardiovascular Diseases; Chenodeoxycholic Acid; Dyslipidemias; Fibrosis; Hyperinsulinism; Hyperlipidemias; Insulin Resistance; Isoxazoles; Lipid Metabolism; Liver; Myocardium; Obesity; PPAR alpha; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Risk Factors; RNA, Messenger; Triglycerides | 2013 |
Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapine.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Dibenzocycloheptenes; Fasting; Female; Glucose Clamp Technique; Glucose Tolerance Test; Heterocyclic Compounds, 4 or More Rings; Hyperinsulinism; Insulin Resistance; Isoxazoles; Metabolism; Olanzapine; Piperidines; Rats; Rats, Sprague-Dawley | 2013 |
Fully automated liquid-liquid extraction for the determination of a novel insulin sensitizer in human plasma by heated nebulizer and turbo ionspray liquid chromatography-tandem mass spectrometry.
Topics: Automation; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Isoxazoles; Nebulizers and Vaporizers; Propionates; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
Topics: 3-Hydroxybutyric Acid; Adenoviridae; Animals; Blood Glucose; Blotting, Northern; Blotting, Western; Cholesterol; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Etoposide; Gluconeogenesis; Glucose; Glycogen; Hepatocytes; Hyperglycemia; Hyperlipidemias; Insulin; Insulin Resistance; Isoxazoles; Lipids; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Models, Statistical; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors; Triglycerides | 2006 |
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; DNA-Binding Proteins; Fatty Acids, Nonesterified; Female; Gene Expression Regulation; Glucose; Glucose Tolerance Test; Homeostasis; Homozygote; Insulin; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; Muscle, Skeletal; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors | 2006 |
JTT-501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non-genetic insulin-resistant models.
Topics: Animals; Blood Glucose; Disease Models, Animal; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Hyperglycemia; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Insulin Resistance; Isoxazoles; Leptin; Lipids; Male; Obesity; Oxidation-Reduction; Phosphorylation; Proteins; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptor, Insulin; Triglycerides | 1998 |
Triglyceride-lowering effect of a novel insulin-sensitizing agent, JTT-501.
Topics: Animals; Blood Glucose; Body Weight; Dietary Fats; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Isoxazoles; Male; Pioglitazone; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Triglycerides | 1999 |
Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in the obese, diabetic KKAy mouse.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Blotting, Western; Cyclic Nucleotide Phosphodiesterases, Type 3; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epididymis; Fatty Acids; Female; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Insulin; Insulin Resistance; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; RNA, Messenger; Triglycerides | 2001 |
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
Topics: Analysis of Variance; Animals; Barium; Calcium; Chromans; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; Insulin Resistance; Ion Channels; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Potassium Channels; Prostaglandin D2; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |