metyrapone has been researched along with Insulin Resistance in 7 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In 12 healthy men, 4-5 wk of rosiglitazone increased insulin sensitivity during insulin infusion but did not change 11beta-HSD1 mRNA or activity in sc adipose tissue, and insulin sensitization was unaffected by glucocorticoid blockade with a combination of metyrapone and RU38486." | 5.12 | Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men. ( Andrew, R; Homer, NZ; Karpe, F; Stimson, RH; Tan, GD; Wake, DJ; Walker, BR, 2007) |
| "Active Cushing's syndrome is associated with insulin resistance induced by the high and prolonged circulating level of glucocorticoids." | 2.46 | Management of diabetes mellitus in Cushing's syndrome. ( Munir, A; Newell-Price, J, 2010) |
| "Thus, hypoglycemia is followed by prolonged (6- to 8-h) insulin resistance." | 1.28 | Combined effect of growth hormone and cortisol on late posthypoglycemic insulin resistance in humans. ( Attvall, S; Fowelin, J; Lager, I; Smith, U; Von Schenck, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, L | 1 |
| Thompson, LH | 1 |
| Zhao, L | 1 |
| Messina, JL | 1 |
| Ismail, AA | 1 |
| Munir, A | 1 |
| Newell-Price, J | 1 |
| RUVALCABA, RH | 1 |
| SAMOLS, E | 1 |
| KELLEY, VC | 1 |
| Wake, DJ | 1 |
| Stimson, RH | 1 |
| Tan, GD | 1 |
| Homer, NZ | 1 |
| Andrew, R | 1 |
| Karpe, F | 1 |
| Walker, BR | 1 |
| Fowelin, J | 1 |
| Attvall, S | 1 |
| Von Schenck, H | 1 |
| Smith, U | 1 |
| Lager, I | 1 |
| Rao, NS | 1 |
| Pearce, J | 1 |
1 review available for metyrapone and Insulin Resistance
| Article | Year |
|---|---|
Management of diabetes mellitus in Cushing's syndrome.
Topics: Cushing Syndrome; Diabetes Mellitus; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Insulin Resista | 2010 |
2 trials available for metyrapone and Insulin Resistance
| Article | Year |
|---|---|
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adult; Aged; Cortisone; Cross-Over Studies; Double-Blin | 2007 |
Hypothalamic-pituitary-adrenal axis studies in migraine with special reference to insulin sensitivity.
Topics: Adult; Blood Glucose; Clinical Trials as Topic; Female; Humans; Hydrocortisone; Hypoglycemia; Hypoth | 1971 |
4 other studies available for metyrapone and Insulin Resistance
| Article | Year |
|---|---|
Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury.
Topics: Acute Disease; Animals; Corticosterone; Fatty Acids, Nonesterified; Hemorrhage; Hormone Antagonists; | 2009 |
On the diagnosis and investigation of adrenal insufficiency in adults.
Topics: Adrenal Insufficiency; Adult; Diagnostic Techniques, Endocrine; Glucagon; Humans; Hypothalamic Disea | 2010 |
LIPOATROPHIC DIABETES. I. STUDIES CONCERNING ENDOCRINE FUNCTION AND CARBOHYDRATE METABOLISM.
Topics: Adolescent; Carbohydrate Metabolism; Diabetes Mellitus, Lipoatrophic; Diabetes Mellitus, Type 1; Dru | 1965 |
Combined effect of growth hormone and cortisol on late posthypoglycemic insulin resistance in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids, Nonesterified; Female; Glucose; Humans; Hydrocortiso | 1989 |