bimoclomol profile

bimoclomol: RN given for (+-)-isomer; induces stress proteins; has cytoprotective effects [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	9576891
CHEMBL ID	2104595
SCHEMBL ID	49046
MeSH ID	M0282408

Synonym
bimoclomol
130493-03-7
bimoclomol [inn]
unii-9iyf14814m
(+-)-n-(2-hydroxy-3-piperidinopropoxy)nicotinimidoyl chloride
9iyf14814m ,
CHEMBL2104595
brlp-42
abt-822
bimoclomol [who-dd]
(+/-)-n-(2-hydroxy-3-piperidinopropoxy)nicotinimidoyl chloride
SCHEMBL49046
3-pyridinecarboximidoyl chloride, n-[2-hydroxy-3-(1-piperidinyl)propoxy]-
NMOVJBAGBXIKCG-VKAVYKQESA-N
n-[(2-hydroxy-3-piperidin-1-ylpropyl)oxy]pyridine-3-carboximidoyl chloride
CS-7475
HY-U00398
DB06258
(3z)-n-(2-hydroxy-3-piperidin-1-ylpropoxy)pyridine-3-carboximidoyl chloride
MS-24278
AKOS040740727

Research Excerpts

Overview

Bimoclomol is a novel antiischemic compound acting against peripheral vascular complications of diabetes mellitus (neuropathy, retinopathy, and nephropathy) It improves cell survival under experimental stress conditions partly by increasing intracellular heat shock proteins (HSPs)

Excerpt	Reference	Relevance
"Bimoclomol (BIM), is a stress proteins coinducer, that acts synergistically with a mild stressor to activate cytoprotective stress proteins. "	( Bimoclomol ameliorates mercuric chloride nephrotoxicity through recruitment of stress proteins. Bianchi, R; Borsani, E; Lavazza, A; Rezzani, R; Ricci, F; Rodella, LF; Stacchiotti, A, 2006)	3.22
"Bimoclomol (BRLP-42) is a novel antiischemic compound acting against peripheral vascular complications of diabetes mellitus (neuropathy, retinopathy, and nephropathy). "	( Bimoclomol protects against vascular consequences of experimental subarachnoid hemorrhage in rats. Erdö, F; Erdö, SL, 1998)	3.19
"Bimoclomol is a new compound that improves cell survival under experimental stress conditions partly by increasing intracellular heat shock proteins (HSPs). "	( Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Cox, BF; Polakowski, JS; Wegner, CD, 2002)	3.2

Effects

Excerpt	Reference	Relevance
"Bimoclomol has been shown to increase an inducible member of the heat shock protein 70 family (HSP70) and cytoprotect in vitro. "	( Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats. Burke, SE; Cox, BF; Daniell, KM; Diaz, GJ; Lubbers, NL; Polakowski, JS; Wegner, CD, 2002)	2.27

Treatment

Bimoclomol pretreatment significantly diminished the consequences of vascular disorders associated with diabetes mellitus. Pretreatment with bimoclumol for 24 h significantly increased survival of cells.

Excerpt	Reference	Relevance
"Bimoclomol pretreatment significantly diminished the consequences of vascular disorders associated with diabetes mellitus."	( Multilateral in vivo and in vitro protective effects of the novel heat shock protein coinducer, bimoclomol: results of preclinical studies. Jednákovits, A; Nánási, PP, 2001)	1.25
"Pretreatment with bimoclomol for 24 h significantly increased survival of cells."	( Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Cox, BF; Polakowski, JS; Wegner, CD, 2002)	2.08

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (26.32)	18.2507
2000's	14 (73.68)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (10.53%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (89.47%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
thioctic acid Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.	2.03	1	dithiolanes; heterocyclic fatty acid; thia fatty acid	fundamental metabolite; geroprotector
gyki 52466 GYKI 52466: an AMPA (non-NMDA) receptor antagonist; structure given in first source	1.99	1	benzodiazepine
methoxamine Methoxamine: An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.. methoxamine : An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine .	2	1	amphetamines	alpha-adrenergic agonist; antihypotensive agent
3,3'-iminodipropionitrile 3,3'-iminodipropionitrile: lathyrogen; RN refers to parent cpd; blocks axoplasmic transport of neurofilament proteins with subsequent axon swelling typical of some motor neuron diseases	1.99	1
mercuric chloride Mercuric Chloride: Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.. mercury dichloride : A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.	7.03	1	mercury coordination entity	sensitiser
captopril Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.. captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.	2	1	alkanethiol; L-proline derivative; N-acylpyrrolidine; pyrrolidinemonocarboxylic acid	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	1.99	1	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
herbimycin herbimycin: herbicidal antibiotic produced by Streptomyces sp.; see also herbimycin B; structure for herbimycin A in second source. herbimycin : A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.	3.09	1	1,4-benzoquinones; lactam; macrocycle	antimicrobial agent; apoptosis inducer; herbicide; Hsp90 inhibitor; tyrosine kinase inhibitor

Condition	Relationship Strength	Studies
Diabetes Mellitus, Adult-Onset [description not available]	2.03	1
Insulin Sensitivity [description not available]	2.03	1
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	2.03	1
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	2.03	1
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	2.03	1
Exertional Heat Illness [description not available]	1.99	1
Alloxan Diabetes [description not available]	2.4	2
Heart Disease, Ischemic [description not available]	4.07	3
Myocardial Ischemia A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).	4.07	3
Brain Swelling [description not available]	1.99	1
Hemorrhage, Subarachnoid [description not available]	1.99	1
Brain Edema Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)	1.99	1
Subarachnoid Hemorrhage Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.	6.99	1
Anesthesia A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.	1.99	1
Diabetic Retinopathy Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.	1.99	1
Degenerative Diseases, Central Nervous System [description not available]	2.91	1
Cerebral Ischemia [description not available]	2.91	1
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	2.91	1
Neurodegenerative Diseases Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.	2.91	1
Blood Pressure, High [description not available]	2	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2	1
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	2	1
Muscle Relaxation That phase of a muscle twitch during which a muscle returns to a resting position.	2	1
Coronary Heart Disease [description not available]	2	1
Coronary Disease An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.	2	1
Ischemia A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.	2	1
Complications of Diabetes Mellitus [description not available]	2.92	1
Injury, Myocardial Reperfusion [description not available]	2.92	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.92	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.01	1
Cardiovascular Stroke [description not available]	2.01	1
Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	2.01	1

bimoclomol

Description

Cross-References

Synonyms (21)

Research Excerpts

Overview

Effects

Treatment

Research

Studies (19)

Market Indicators

Research Demand Index: 18.94

Study Types

bimoclomol

Description

Cross-References

Synonyms (21)

Research Excerpts

Overview

Effects

Treatment

Research

Studies (19)

Market Indicators

Research Demand Index: 18.94

Study Types

Related Drugs (8)

Related Conditions (32)